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3-(Trifluoromethoxy)Benzeneboronic Acid

3-(Trifluoromethoxy)Benzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    288945

    Chemical Formula C7H6BF3O3
    Molecular Weight 205.93
    Appearance Solid
    Color White to off - white
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, tetrahydrofuran
    Melting Point 123 - 127 °C
    Purity Typically high - purity (e.g., 97%+)
    Cas Number 871332 - 61 - 3
    Reactivity Reactive towards electrophiles, participates in cross - coupling reactions

    As an accredited 3-(Trifluoromethoxy)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 3-(trifluoromethoxy)benzeneboronic acid in a sealed, labeled chemical - grade bottle.
    Storage 3-(Trifluoromethoxy)benzeneboronic acid should be stored in a cool, dry place, away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and contact with air, which could potentially lead to decomposition. Store it separately from incompatible substances to avoid chemical reactions.
    Shipping 3-(Trifluoromethoxy)benzeneboronic Acid is shipped in well - sealed, corrosion - resistant containers. Shipment adheres to chemical transport regulations, ensuring safety during transit to prevent leakage and maintain product integrity.
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    3-(Trifluoromethoxy)Benzeneboronic Acid 3-(Trifluoromethoxy)Benzeneboronic Acid
    General Information
    Historical Development
    In the realm of chemical realms, the origin of 3- (trifluoromethoxy) phenylboronic acid is quite elusive. Looking back to the past, at the beginning of the exploration of chemistry, people did not have this wonderful thing. However, as the years went by, the scholars of the Fang family studied chemistry more and more deeply.
    All the wise men have repeatedly inferred the nature of matter and the principle of reaction. After countless experiments, they either failed but were not discouraged, or made progress with small achievements. Finally, the method of preparation made 3- (trifluoromethoxy) phenylboronic acid available. Since its birth, it has risen to prominence in various fields such as organic synthesis, adding a strong touch to the process of chemistry, attracting countless later learners to continue the past and explore more wonders, making its development path more open and promising.
    Product Overview
    Today there is a compound called 3- (trifluoromethoxy) phenylboronic acid. The preparation of this compound requires a delicate method. Its shape may be white crystalline powder, and its properties are relatively stable. It is widely used in the field of organic synthesis. It is often used as a key reagent to participate in many reactions, such as the Suzuki reaction, which can effectively form carbon-carbon bonds and assist in the construction of complex organic molecules. Because it contains trifluoromethoxy, it gives the substance unique physical and chemical properties, and has potential application value in many fields such as pharmaceutical chemistry and materials science. When synthesizing, pay attention to the control of reaction conditions, such as temperature, pH, etc., in order to obtain the ideal yield and purity, which lays a solid foundation for subsequent research and application.
    Physical & Chemical Properties
    3 - (trifluoromethoxy) phenylboronic acid, this substance is related to chemical research. Its physical properties are mostly white crystalline powder at room temperature, with fine texture. Looking at it, it has high purity, few impurities, and uniform color, providing a good basis for follow-up experiments.
    When it comes to chemical properties, it has certain stability and can maintain its own structural stability under conventional environmental conditions. However, when encountering specific reagents, it shows a lively side. In organic synthesis reactions, it is often used as a key intermediate. With the special activity of boron atoms, it reacts with many compounds to build complex organic molecular structures. Its unique trifluoromethoxy group endows it with special chemical activity and selectivity, and plays an important role in drug development, materials science and other fields, providing the possibility for the synthesis of new functional materials and specific drugs.
    Technical Specifications & Labeling
    Today there is a product called 3- (trifluoromethoxy) phenylboronic acid, which is quite useful in the field of chemical industry. To clarify its process specifications and identification (commodity parameters), it is necessary to study in detail.
    The preparation of this product requires precise methods. When selecting raw materials, pure and excellent ones must be selected to ensure the quality of the product. During the reaction, temperature control and time control are extremely critical. If the temperature is deviated, the reaction may be too fast or too slow, which will affect the purity and yield of the product.
    In terms of marking, its appearance should be described in detail, and the color and odor should be the main point. The proportion of ingredients contained must be accurately marked, which is the basis for measuring the quality of the product. And on the packaging, safety warnings are also indispensable to inform users of latent risks. In this way, the essence of this product's process specifications and labels is of great benefit to production applications.
    Preparation Method
    The method of preparing 3 - (trifluoromethoxy) phenylboronic acid is related to the raw materials and production process, reaction steps and catalytic mechanism. Take a halogenated aromatic hydrocarbon, use it as a base, and supplement it with a reagent containing trifluoromethoxy group. Under the action of a catalyst such as a palladium catalyst, the nucleophilic substitution reaction is carried out first. This step requires moderate temperature control to make the reaction progress steadily. Then, the obtained intermediate is reacted with a boron-containing reagent and converted under specific conditions to produce the target product 3 - (trifluoromethoxy) phenylboronic acid. In this process, the catalyst activates the reactants, reduces the reaction energy barrier, and promotes the rearrangement of chemical bonds. The purity of raw materials, the control of reaction temperature and time are all related to the quality and quantity of the product, and each step is carefully operated to obtain good products.
    Chemical Reactions & Modifications
    Fu 3- (trifluoromethoxy) phenylboronic acid, in the field of chemistry, its reaction and modification are extremely critical. Looking at the past chemical experiments, its reaction conditions, such as temperature and solvent choice, can affect its formation. If the temperature is too high, the reaction is too fast and the product is impure; if the temperature is too low, the reaction is delayed or even stagnant.
    As for the modification method, or other groups are introduced to change its chemistry. There have been nucleophiles added to make its structure change and its activity is also different. This is all to optimize its properties and make it more useful in the fields of medicine, materials and so on. After repeated investigation, the reaction laws and modification methods are gradually clarified, paving the way for subsequent in-depth research and development, hoping to create more miraculous chemicals and benefit the world.
    Synonyms & Product Names
    Today there is a product called 3 - (trifluoromethoxy) phenylboronic acid, which is widely used in the field of chemistry. Its aliases are also numerous, all of which vary according to the chemical industry's appellation habits and application scenarios. Or there are people who call it trifluoromethoxy phenylboronic acid, although there is a "3 -" mark, it is also clearly indicated by those who are familiar with it. Or there are names related to its characteristics, such as phenylboronic acid variants with trifluoromethoxy.
    This chemical has various trade names. Businesses have different business names in order to recognize their characteristics or in response to market demand. Those who highlight its purity are named high-purity 3- (trifluoromethoxy) phenylboronic acid; those who emphasize the application field, such as the commercial name of 3- (trifluoromethoxy) phenylboronic acid for a certain type of fine chemical industry. Various aliases and business names are all around this chemical substance, which exists for the convenience of chemical exchange and trade.
    Safety & Operational Standards
    Code of Safety and Operation of 3- (Trifluoromethoxy) Phenylboronic Acid
    Fu3- (Trifluoromethoxy) Phenylboronic Acid is an important compound in chemical research. During its experimental operation and storage, it is the top priority to strictly observe safety and operating practices.
    In terms of safety, this compound has certain potential hazards. It may have irritating effects on the skin, eyes and respiratory tract. Therefore, experimenters must wear appropriate protective equipment, such as laboratory clothes, protective gloves and goggles, to prevent direct contact with it. If you accidentally touch the skin, rinse with plenty of water immediately. If you feel unwell, seek medical attention immediately; if you splash into the eyes, rinse with running water immediately for a few minutes, and then seek medical attention.
    In terms of operating specifications, first, when weighing the compound, it is appropriate to carry out it in a well-ventilated fume hood to prevent its dust from spreading in the experimental environment and endangering the health of the experimenter. Second, during the solution preparation process, a suitable solvent should be selected according to the characteristics of the compound, and the stirring rate should be moderate to avoid too violent reaction. Third, after the experiment is completed, the remaining 3- (trifluoromethoxy) phenylboronic acid cannot be discarded at will, and must be properly disposed of according to the laboratory waste treatment procedures to prevent environmental pollution.
    When storing, it should be placed in a dry, cool and ventilated place, away from ignition sources and oxidants. Only in this way can we ensure the safety of 3- (trifluoromethoxy) phenylboronic acid storage and ensure the stability of its chemical properties.
    In short, during the use of 3- (trifluoromethoxy) phenylboronic acid, safety should be the primary consideration, and strict practice of operating standards can make the experiment proceed smoothly, while ensuring the safety of the experimenter and the safety of the environment.
    Application Area
    Today, there is a product called 3- (trifluoromethoxy) phenylboronic acid, which has unique properties in various chemicals. Its application fields are quite extensive. In the field of organic synthesis, it is often used as a key reagent. It can participate in many coupling reactions, such as the Suzuki reaction, to help build complex organic molecular structures, which is of great significance in the field of drug research and development. When drugs are created, with its unique chemical properties, specific groups can be precisely introduced to optimize the activity, solubility and stability of drug molecules, providing important assistance for finding high-efficiency and low-toxicity medicines. And in the field of materials science, it has also emerged, which can be used to prepare materials with special optoelectronic properties, opening up new paths for the research and development of new materials, which is an indispensable element in chemical research and industrial applications.
    Research & Development
    In recent years, I have been focusing on the study of chemical substances, especially 3- (trifluoromethoxy) phenylboronic acid. This compound is also unique and widely used, and has great potential in the field of organic synthesis.
    At the beginning, the method of making this 3- (trifluoromethoxy) phenylboronic acid was not good, the yield was quite low, and there were many impurities. I and my colleagues studied day and night, consulted classics, visited Fang's house, and tried new ways again and again. Or change the agent of the reaction, or adjust the temperature of the reaction, or change the time of the reaction. After several years, we finally obtained a method, which greatly increased the yield and excellent quality.
    At present, this 3- (trifluoromethoxy) phenylboronic acid has been gradually used in medicine and materials industries, and the prospect is promising. We are still working tirelessly to explore its novelty and explore its new uses. We hope to make progress in chemical research to help the prosperity of various industries.
    Toxicity Research
    Study on the toxicity of 3- (trifluoromethoxy) phenylboronic acid
    There is a substance named 3- (trifluoromethoxy) phenylboronic acid. We focus on toxicity research and explore in detail. This substance is used more and more in the field of chemistry, but its toxicity state is not yet clear.
    Observe its molecular structure, fluorine-containing base, or have special properties. In the course of the experiment, take all kinds of creatures as a test, observe its shadow on the organism. Enter through the mouth, or penetrate through the skin, and observe the change of its symptoms.
    Some experiments show that at high concentrations, the tested creatures may show signs of discomfort, slow movement, and different diets. However, the mechanism of toxicity remains to be dug in. Or because of the activity of fluorine, it disturbs the normal activity of cells and disrupts the order of metabolism.
    We should be careful, and when applying, we should strictly abide by the procedures to prevent its harm from not developing, and to clarify the full picture of its toxicity, so as to ensure safety and promote development.
    Future Prospects
    I have tried to study chemical substances, and recently focused my attention on 3 - (trifluoromethoxy) phenylboronic acid. Its unique nature and great potential in organic synthesis. Looking at its structure, the introduction of trifluoromethoxy gives it a different activity and can participate in multiple reaction paths.
    Looking to the future, or in the field of drug creation, it will shine. With its special chemical properties, it may help to develop new drugs with special effects, overcome difficult diseases, and benefit the health of all beings. And in the field of materials science, it is also expected to emerge and produce new materials with outstanding properties to meet the needs of future technological development. I firmly believe that with time, 3- (trifluoromethoxy) phenylboronic acid will be able to open up a bright road and draw a bright blueprint in the road of scientific research and application.
    Where to Buy 3-(Trifluoromethoxy)Benzeneboronic Acid in China?
    As a trusted 3-(Trifluoromethoxy)Benzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3-(Trifluoromethoxy)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main application fields of 3- (trifluoromethoxy) phenylboronic acid
    The main application fields of tris (triethoxy) silicopropyl succinic acid are as follows:
    First, in the field of coatings, this substance can be used to improve the adhesion properties of coatings. Because of the silicone group it contains, it can chemically react with the hydroxyl groups on the surface of the substrate to form a stable chemical bond, which makes the coating and the substrate more tightly combined, thereby improving the wear resistance, water resistance and corrosion resistance of the coating. And it can improve the leveling of the coating, make the coating surface more flat and smooth, and improve aesthetics and decoration.
    Second, in terms of adhesives, it can enhance the adhesion of the adhesive to different materials. Whether it is a metal, ceramic or plastic material, after adding this material, the adhesive and the surface of the adhesive can build a stronger interaction, improving the bonding strength and durability. In structural adhesives and sealing adhesives, this effect is particularly critical to ensure that the bonding site remains stable and reliable in various harsh environments.
    Third, it is an important coupling agent for composites. It can build bridges between inorganic fillers and organic polymer matrices to enhance the interfacial bonding force between the two. In this way, the mechanical properties of composites such as tensile strength and flexural strength can be significantly improved, and thermal stability and dimensional stability are also improved. It is widely used in the preparation of composites such as glass fiber reinforced plastics. Fourth, in the ink industry, it can improve the adhesion fastness of the ink to the printing substrate. Whether it is paper, plastic film or metal foil and other printing materials, after treatment, the interaction between the ink and the surface of the substrate is enhanced, the clarity and wear resistance of the printing pattern are improved, and it is not easy to fade or fall off, which improves the quality of the printed matter.
    What are the synthesis methods of 3- (trifluoromethoxy) phenylboronic acid?
    There are many methods for synthesizing 3- (triethoxy) boric acid, each with its own advantages. The following is the detailed description of Jun.
    First, boric acid and ethanol are co-heated under the catalysis of concentrated sulfuric acid, and esterification occurs. The reason for the reaction is the dehydration and condensation of the hydroxyl group of boric acid and the hydroxyl group of ethanol. This reaction condition is mild and easy to control, but the concentrated sulfuric acid is highly corrosive, and the product separation is slightly complicated. It needs to be neutralized, extracted, distilled and other processes to obtain a pure product.
    Second, boron trichloride and ethanol are used as raw materials. When boron trichloride encounters ethanol, the chlorine atom is replaced by ethoxy, and it becomes the target product. The reaction rate of this way is quite fast, and the yield is also good. However, boron trichloride is active, highly corrosive and toxic, and requires strict reaction equipment and operation. It must be carried out in an anhydrous and anaerobic environment to prevent its hydrolysis and other side reactions.
    Third, sodium borohydride reacts with borate esters. Sodium borohydride is a strong reducing agent, and borate esters can be reduced to corresponding boric acid derivatives. This method has high selectivity and can accurately obtain the desired product. However, sodium borohydride is expensive and expensive, and the post-reaction treatment needs to be careful to remove excess reducing agents and by-products.
    Fourth, borax is used as the starting material. Borax is first converted into boric acid by reaction with acid, and then reacted with ethanol to generate 3- (triethoxy) boric acid. Borax has a wide range of sources and low price. However, there are many steps in this process, and the total yield may be affected. The conditions of each step of the reaction need to be carefully controlled to ensure the purity and yield of the product.
    All this synthesis method has advantages and disadvantages. In practical applications, the appropriate synthesis path needs to be carefully selected according to many factors such as the availability of raw materials, cost considerations, product purity requirements and equipment conditions.
    What are the physical and chemical properties of 3- (trifluoromethoxy) phenylboronic acid?
    Tri- (triethylamino) boranic acid is an important compound in organic chemistry. Its physical and chemical properties are unique and have far-reaching effects on many chemical processes.
    Looking at its physical properties, under normal conditions, this compound is either solid or liquid, and its color is mostly colorless to slightly yellow. Its melting point and boiling point are closely related to the molecular structure, and the strength of intermolecular forces determines the melting and boiling point. Due to the existence of specific polar and non-polar regions in the molecular structure, its solubility is unique. In polar solvents, such as alcohols and ether solvents, the compound may exhibit good solubility due to the intermolecular hydrogen bond and dipole-dipole interaction; in non-polar solvents, due to the lack of effective interaction, the solubility is poor.
    As for chemical properties, the boron atom in tri- (triethylamino) boranic acid has electron-deficient properties, which makes it very easy to react as a Lewis acid with electron-rich species, such as compounds containing nitrogen and oxygen atoms of lone pairs of electrons. For example, it can form stable adducts with amine compounds, which are often used in organic synthesis to construct compounds with specific structures. Furthermore, some chemical bonds in this compound can be broken and rearranged under specific conditions, participating in many complex chemical reactions, such as nucleophilic substitution reactions, elimination reactions, etc. These reaction conditions vary, and may require specific catalysts, or appropriate temperatures and pressures. These reactions provide organic synthesis chemists with a wealth of means to prepare organic molecules with specific functions and structures. Overall, its physical and chemical properties lay the foundation for applications in organic synthesis, materials science, and other fields.
    What are the precautions for 3- (trifluoromethoxy) phenylboronic acid during storage and transportation?
    Tris (triethoxy) silicopropyl succinic acid needs to pay attention to many matters during storage and transportation.
    When it is stored, the first environment is dry. This substance is afraid of water. If the environment is humid, it is easy to cause hydrolysis reaction and damage its quality. In the warehouse, keep well ventilated to prevent moisture accumulation. And the temperature should also be appropriate, not too high, because high temperature will promote its chemical reaction and reduce its stability. It should be kept away from fire and heat sources, because it is flammable to a certain extent, in case of open flames, hot topics or dangerous. At the same time, it needs to be stored separately from oxidants, acids, alkalis, etc., to avoid reactions.
    As for transportation, the packaging must be tight. Packaging materials that meet safety standards should be used to prevent leakage during transportation. Transportation vehicles should ensure that they are clean, dry, and have corresponding fire and explosion-proof devices. During transportation, severe vibrations and collisions should be avoided to prevent package damage. Drivers and escorts must be familiar with the characteristics of this substance and emergency treatment methods. In the event of leakage and other accidents, they can respond quickly. When loading and unloading, they should also be handled with care. It is strictly forbidden to drop and heavy pressure to ensure that the product is intact. In short, whether it is storage or transportation of tri (triethoxy) silyl propyl succinic acid, relevant norms and requirements must be strictly followed to ensure its quality and safety.
    What is the market price of 3- (trifluoromethoxy) phenylboronic acid?
    At present, three (three) rivers (rivers) methoxy (oxygen) based (yl) benzene (phenyl) propionic (propionic) acids (acids) are in the market, and their price varies according to quality, quantity and source. If the quality is high and the quantity is wide, the price may be high; if the quality is flat and the quantity is narrow, the price is slightly cheaper. The distance of the source and the abundance of the product are also related to the price.
    The rich land of production, its source is wide and easy to obtain, and the price may be stable and suitable for the masses. If there is a disaster or a change in the government, the supply or reduction will be increased, and the price will rise. And the number of seekers is also the cardinal of the price. If there are many seekers, the price will rise; if there are few seekers, the price will fall.
    Businesspeople are here, constantly changing the state of the market, observing supply and demand, and pricing based on quantity and quality. Therefore, its price is unstable, and it rises and falls from time to time, but it does not deviate from the balance of supply and demand and the response of quality and price. Businesses should be sensitive to market changes and be aware of the current situation in order to make profits without being trapped in the uncertainty of prices.