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3-Nitro-4-(Trifluoromethoxy)Bromobenzene

3-Nitro-4-(Trifluoromethoxy)Bromobenzene

Hongda Chemical

    Specifications

    HS Code

    411132

    Chemical Formula C7H3BrF3NO3
    Molecular Weight 290.00
    Appearance Colorless to light yellow liquid
    Boiling Point 218 - 220°C
    Melting Point N/A
    Density 1.836 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents
    Flash Point 100°C
    Vapor Pressure Low
    Stability Stable under normal conditions
    Hazard Class Irritant

    As an accredited 3-Nitro-4-(Trifluoromethoxy)Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 3 - nitro - 4 - (trifluoromethoxy)bromobenzene packaged in a sealed glass bottle.
    Storage 3 - nitro - 4 - (trifluoromethoxy)bromobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents and reducing agents to avoid potential chemical reactions. This storage method helps maintain its stability and safety.
    Shipping 3 - nitro - 4 - (trifluoromethoxy)bromobenzene is shipped in sealed, corrosion - resistant containers. Strict adherence to hazardous chemical shipping regulations ensures safe transportation, with proper labeling and handling to prevent spills.
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    3-Nitro-4-(Trifluoromethoxy)Bromobenzene 3-Nitro-4-(Trifluoromethoxy)Bromobenzene
    General Information
    Historical Development
    Wenfu 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene, its origin is also. At the beginning, all the sages dedicated themselves to the field of chemistry and strived for new things. At the beginning, the wise paid attention to the possibility of this combination, and after months and years of poverty, they tried it repeatedly.
    At the beginning, the skills were not refined, and the results were impure, but everyone was unremitting. Years pass, the technology gradually matures, and the preparation method is better. In the past, the preparation was difficult, the yield was quite low, and the impurities disturbed it.
    To later generations, scholars carried on the ambitions of their predecessors, improved the process, and the equipment became more and more sophisticated. So the yield gradually increased, and the quality became better. Therefore, 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene is gradually used in chemical engineering, and it is an important substance for various synthesis. It has made great achievements in the progress of chemistry, and its development process is a good story in the academic world.
    Product Overview
    3-Nitro-4- (trifluoromethoxy) bromobenzene, Product Overview
    3-nitro-4- (trifluoromethoxy) bromobenzene is a crucial chemical in the field of organic synthesis. Its molecular structure is unique, and the introduction of nitro and trifluoromethoxy gives the substance special chemical activities and properties.
    This compound usually has a light yellow to light brown crystalline powder in appearance and has certain solubility in specific organic solvents. In organic synthesis reactions, it can be used as a key intermediate. With the reactivity of bromine atoms on the benzene ring, it can interact with a variety of reagents through reactions such as nucleophilic substitution, and then construct more complex organic molecular structures.
    In many fields such as medicine, pesticide research and development, and materials science, 3-nitro-4- (trifluoromethoxy) bromobenzene has shown potential application value. In the field of medicine, it may help to synthesize drug molecules with specific biological activities; in the field of pesticides, it may be used to create new pesticides with high efficiency, low toxicity and environmental friendliness. During the synthesis process, precise control of reaction conditions is crucial, including temperature, reactant ratio, and catalyst selection, to ensure the purity and yield of the product.
    Physical & Chemical Properties
    3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene is an important compound in organic synthesis. Its physical properties are unique. It is solid at room temperature and has a specific melting point and boiling point. The melting point is accurately determined to provide key parameters for chemical experiments and help control the reaction conditions.
    Its chemical properties are active, and the presence of nitro and trifluoromethoxy groups on the benzene ring makes the compound exhibit unique reactivity. Nitro has strong electron absorption, which affects the electron cloud density of the benzene ring, making it prone to nucleophilic substitution. The special structure of the trifluoromethoxy group also has a significant impact on its chemical properties, giving it a certain stability and special reaction tendency. In many chemical reactions, 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene can be used as a key raw material to participate in the construction of complex organic molecular structures, and has broad application prospects in the field of organic synthesis.
    Technical Specifications & Labeling
    Today there is a product called 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene. To make this product, its technical specifications and identification (product parameters) are the key.
    To make this product, you need to follow a specific method. Prepare all kinds of raw materials first, with precise proportions and orderly operation. The reaction conditions, temperature and pressure are fixed, and there should be no slight difference. In this way, you can get a product with uniform texture.
    As for the label, its properties should be clearly marked, and its color, taste and state should be clearly marked. Also remember its key parameters, such as melting point, boiling point, purity, etc. This is all about the use of the product, so that the user can see it at a glance, so that there is no mistake. Technical specifications and logos can be combined to ensure the quality of this product and meet all requirements.
    Preparation Method
    The raw materials, production process, reaction steps and catalytic mechanism of 3-Nitro-4- (Trifluoromethoxy) Bromobenzene prepared today need to be studied in detail. First, take an appropriate amount of p-bromophenol, use it as the starting material, and place it in the reaction kettle. Add an appropriate amount of potassium carbonate and use it as an acid binding agent to assist the reaction. Then slowly inject the trifluoromethoxylation reagent, and control the temperature within a certain range to make the two fully react. This reaction step requires strict operation, control of temperature and reagent dosage.
    After the reaction is completed, the crude product is obtained by separation and purification. After recrystallization with a suitable solvent, pure 3-Nitro-4- (Trifluoromethoxy) Bromobenzene is obtained. In terms of catalytic mechanism, potassium carbonate effectively promotes the reaction and improves the yield. The whole preparation process is closely linked to each other, which is related to the purity and yield of the product, and cannot be slack.
    Chemical Reactions & Modifications
    There is now a chemical substance, named 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene. In the field of chemistry, its reaction and modification are crucial.
    Looking at this substance, its structure is unique, and it contains nitro, trifluoromethoxy and bromine atoms, which make it have special chemical properties. The strong electron absorption of nitro groups, or the electron cloud density of the benzene ring, affects the electrophilic substitution reaction. The introduction of trifluoromethoxy increases its lipid solubility and stability.
    To change its properties, a variety of reactions can be used. Nucleophilic substitution, with appropriate nucleophilic reagents, or with bromine atoms, to obtain new derivatives. Reduction of nitro groups can change its chemical activity and function.
    The control of various reaction conditions, such as temperature, solvent, and catalyst, has a significant impact on the product. Finding precise conditions can optimize the yield and purity of the product, which is of great significance for chemical synthesis and industrial preparation. This is all about the chemical reaction and modification of 3-Nitro-4- (Trifluoromethoxy) Bromobenzene.
    Synonyms & Product Names
    Today there is a thing called 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene. This thing has attracted much attention in our chemical research. There are also a number of synonyms, which are commonly used in the academic community. Due to the convenience of research, the names may be different, but they all refer to this thing.
    As for the trade name, it is also determined by the industry to identify this product, so that when parties trade and study, they can identify this thing. This trade name is of great significance in the market circulation, production and application, and people call it by this name to clarify what kind of substance is involved.
    3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene, its synonym and trade name, are the logos of the field of chemistry, helping us to clearly understand and accurately use this material, which is indispensable for scientific research and production.
    Safety & Operational Standards
    3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene Safety and Operation Specifications
    Husband 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene, an organic compound, is occasionally involved in chemical research and industrial production. Its safety and operation specifications are related to the safety of the experimenter and endanger the smoothness of the experiment, which cannot be ignored.
    #1. Storage Regulations
    This compound should be placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. Because of its certain chemical activity, it should be separated from oxidants, reducing agents, etc., and should not be mixed, so as not to initiate chemical reactions and cause danger. The storage container must be tightly sealed to prevent leakage, and should be clearly labeled, indicating the name of the compound and relevant warning information.
    #2. Operation Requirements
    When operating, the experimenter must wear appropriate protective equipment. Wear experimental clothes and protective gloves, and the material must be able to resist the erosion of the compound. Protective glasses or masks should be worn on the face to protect the eyes and face. The operation should be carried out in a fume hood to ensure that harmful gases are discharged in time and will not endanger the experimenter.
    When taking 3-Nitro-4- (Trifluoromethoxy) Bromobenzene, the action should be steady and accurate to avoid spilling. If it spills accidentally, take emergency measures immediately. A small amount of spillage can be absorbed by inert materials such as sand and vermiculite, and properly disposed of after collection. If a large amount of spillage, it is necessary to evacuate personnel, seal the scene, and deal with it by professionals.
    #3. Emergency measures
    If the skin is accidentally exposed to the compound, the contaminated clothing should be removed immediately, rinsed with a large amount of flowing water for at least 15 minutes, and then seek medical treatment. If it splashes into the eye, it should also be rinsed with a large amount of water immediately, blinking while flushing, and then rushed to the hospital. If it inhales its volatile gas, it should be quickly moved to a fresh air place to keep the respiratory tract unobstructed. If breathing difficulties, oxygen should be given; if breathing stops, artificial respiration should be administered immediately and rushed to the hospital.
    In short, in the research and use of 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene, strict adherence to safety and operating standards can ensure the safety of the experiment and all goes well.
    Application Area
    Wenfu 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene is widely used. In the field of medicine, it can be used as an intermediate to help synthesize special drugs, treat various diseases, and be a good prescription for the world. In the field of agrochemistry, it can produce high-efficiency pesticides, protect the crops of the field, control the disturbance of pests, and protect the hope of a bumper harvest. In the field of materials science, you can participate in the production of special materials, endowing them with specificity and meeting diverse needs. Looking at its application, it is all for the benefit of the world, for the benefit of people, and it is a treasure of the chemical industry. It glows and heats up in various fields and should not be underestimated.
    Research & Development
    I am committed to the research of 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene. At the beginning, to explore its synthesis method, through various attempts, with specific reagents, according to delicate proportions, and following suitable reaction conditions, a feasible method was obtained.
    Then observe its properties, observe its physical properties, measure its melting point, boiling point, etc., to clarify its solubility in different solvents. Then study its chemical activity, explore its reaction with various reagents, and understand its reaction mechanism.
    As for the application prospect, this compound has great potential in the fields of medicine and materials. In medicine, it can be used as a key intermediate to assist in the creation of new drugs; in materials, it can contribute to the research and development of functional materials. I will continue to study it in the hope of expanding its uses, promoting its development, and contributing to the progress of the chemical field.
    Toxicity Research
    Toxicity Study of 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene
    The taste of the substance is related to the safety of use. Now in 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene this substance, a detailed study of toxicity.
    Looking at its structure, the nitro group and the fluoroxy group are combined with the benzene ring. Nitro groups are often active, or involved in toxicological changes. And fluorine-containing groups, because of their strong electronegativity, can also change the activity and toxicity of the substance.
    Experimentally, into the animal body, to observe its physiological signs. Or see the difference in its biochemical indicators, damage to organs. At the cellular level, or disturb its metabolism, disrupt the arrival of its genes.
    However, the toxicity is clear, not just one end. Dosage, duration, and contact path are all related to the appearance of its toxic effect. This investigation also shows that its poison is used carefully, to protect the health, to avoid the harm of poison, and to protect the environment.
    Future Prospects
    Fu 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene is a chemical product we are dedicated to researching. Looking at its future development, the prospects are quite promising.
    In today's world, science and technology are developing rapidly, and the chemical industry is also changing with each passing day. This product has unique properties and has potential uses in many industries. In materials science, it may help to develop new high-performance materials to meet the needs of future technology; in pharmaceutical chemistry, it may provide key intermediates for the creation of new drugs and help to overcome difficult diseases.
    Our scientific researchers should be enterprising and explore unremitting. In-depth study of its properties, optimization of synthesis processes, and strive to improve product quality and yield. We firmly believe that in the future, 3 - Nitro - 4 - (Trifluoromethoxy) Bromobenzene will be able to shine, contribute to the progress of the chemical industry and the improvement of human life, and lead us to a bright future.
    Where to Buy 3-Nitro-4-(Trifluoromethoxy)Bromobenzene in China?
    As a trusted 3-Nitro-4-(Trifluoromethoxy)Bromobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3-Nitro-4-(Trifluoromethoxy)Bromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 3-Nitro-4- (Trifluoromethoxy) Bromobenzene?
    3-Nitro-4- (trifluoromethoxy) bromobenzene is a crucial organic compound in the field of organic synthesis. It has a wide range of uses and is often a key intermediate in the synthesis of many specific drugs in the field of medicinal chemistry. Taking the synthesis of a new type of antihypertensive drug as an example, 3-nitro-4- (trifluoromethoxy) bromobenzene is ingeniously chemically converted to introduce specific functional groups to build the core structure of drug active molecules, laying the foundation for the development of high-efficiency and low-toxicity antihypertensive drugs.
    In the field of pesticide chemistry, this compound also plays an important role. The creation of many new pesticides relies on it as a starting material. After a series of reactions, pesticide products with high insecticidal and bactericidal properties can be prepared, which can effectively protect crops from pests and diseases and ensure agricultural harvests.
    In the field of materials science, 3-nitro-4- (trifluoromethoxy) bromobenzene can participate in the synthesis of special polymer materials. By polymerizing with other monomers, the material is endowed with unique properties, such as excellent heat resistance, chemical stability, etc., and is widely used in high-end fields such as aerospace, electronics and electrical appliances to meet the strict needs of modern technology for high-performance materials. In summary, 3-nitro-4- (trifluoromethoxy) bromobenzene plays an indispensable role in the development of organic synthesis-related industries due to its diverse and important uses, and continues to promote innovation and progress in the fields of medicine, pesticides, and materials.
    What are the synthesis methods of 3-Nitro-4- (Trifluoromethoxy) Bromobenzene?
    There are several methods for the synthesis of 3-nitro-4- (trifluoromethoxy) bromobenzene. First, the benzene derivative containing trifluoromethoxy is used as the starting material, and it is obtained through the steps of nitration and halogenation. First, take an appropriate amount of trifluoromethoxy benzene, place it in a suitable reaction vessel, use the mixed acid of concentrated sulfuric acid and concentrated nitric acid as the nitrifying agent, and slowly add the mixed acid under low temperature and stirring conditions to introduce nitro groups into the benzene ring. This process requires attention to temperature control to prevent side reactions from occurring. After the nitrification reaction is completed, the trifluoromethoxy benzene product containing nitro groups is obtained by separation and purification. Then, the product is halogenated with a brominating reagent, such as bromine, in a suitable catalyst, such as iron powder or iron tribromide, in a suitable solvent, heated and refluxed for a certain period of time, so that the bromine atom replaces the hydrogen atom at a specific position of the benzene ring, and finally obtains 3-nitro-4- (trifluoromethoxy) bromobenzene, and then the product is purified by distillation and recrystallization.
    Second, the bromine-containing benzene derivative can be started, and the trifluoromethoxy group is first introduced, and then nitrified. Bromobenzene is taken as the starting material, and a suitable trifluoromethoxylation reagent, such as potassium trifluoromethoxy, is reacted in an organic solvent, such as N, N-dimethylformamide (DMF), at an appropriate temperature to generate bromobenzene derivatives containing trifluoromethoxy. After that, this product is used as the substrate, and a similar nitration method is used as above. Under the action of mixed acid, the reaction conditions are controlled to introduce the nitro group into the benzene ring, so as to obtain the target product 3-nitro-4- (trifluoromethoxy) bromobenzene. The corresponding separation and purification operations are also required to obtain the purified product. The two methods have their own advantages and disadvantages, and the actual synthesis needs to be based on the availability of raw materials, cost and reaction conditions and other factors to choose.
    What are the physical properties of 3-Nitro-4- (Trifluoromethoxy) Bromobenzene?
    3-Nitro-4- (trifluoromethoxy) bromobenzene, this substance is an organic compound, and its physical properties are quite characteristic. Looking at its form, it is mostly colorless to light yellow liquid under normal conditions. When the texture is pure, it is clear and transparent, and no impurities are mixed in it.
    When it comes to odor, it has a special aromatic smell, but this fragrance is not pleasant, slightly irritating, and easy to feel uncomfortable when smelled. If exposed to the environment containing this substance for a long time, or damage to the olfactory system.
    Its boiling point is determined under specific conditions and is within a certain temperature range. This boiling point value is crucial for separating and purifying the substance in the chemical process, and is related to the temperature control of distillation and other operations. The melting point is also an important physical parameter, indicating the critical temperature required for the transformation from solid to liquid. Under the corresponding temperature, the substance is solid, stable and tangible.
    In terms of solubility, in common organic solvents, such as ethanol, ether, etc., it shows a certain solubility and can be miscible or partially miscible with it. However, in water, its solubility is extremely low and it is almost insoluble. This property is closely related to the polarity of the molecule. Because of its molecular structure, the force between water molecules is weak, so it is insoluble in water. The density of
    is also a significant physical property. Compared with water, its density is higher. If it is placed in the same container as water, it will sink to the bottom of the water. This property can be used to assist in the effective separation of substances when it involves chemical operations such as liquid-liquid separation. These are all important physical properties of 3-nitro-4- (trifluoromethoxy) bromobenzene, which are of great significance in chemical synthesis, analysis and testing.
    Is 3-Nitro-4- (Trifluoromethoxy) Bromobenzene Chemically Stable?
    The stability of the chemical properties of 3-nitro-4 - (trifluoromethoxy) bromobenzene depends on many factors and cannot be generalized.
    This compound contains functional groups such as nitro, bromine atom and trifluoromethoxy group. Nitro has strong electron absorption, which can reduce the electron cloud density of the benzene ring, resulting in changes in its chemical activity. Due to the influence of nitro groups, the benzene ring is more prone to nucleophilic substitution reactions, but it is more difficult in electrophilic substitution reactions than benzene.
    Bromine atom is a halogen atom. Although it has certain electronegativity, it can be substituted on the benzene ring under suitable conditions or replaced by nucleophilic reagents. The difficulty of this substitution reaction is also related to the interaction of other groups on the benzene ring.
    Trifluoromethoxy is a strong electron-withdrawing group, and its existence further reduces the electron cloud density of the benzene ring, which has a significant impact on the stability and reactivity of the compound.
    Under normal conditions, if there is no specific reagent and conditions to initiate the reaction, 3-nitro-4- (trifluoromethoxy) bromobenzene is relatively stable. In case of special conditions such as high temperature, strong acid-base, strong oxidizing agent or reducing agent, its structure may change and participate in various chemical reactions.
    If it is in an environment where light or a specific catalyst exists, it may also initiate free radical reactions, etc., resulting in changes in its stability. Therefore, the chemical stability of 3-nitro-4- (trifluoromethoxy) bromobenzene depends on the specific environment and conditions encountered.
    What is the price range of 3-Nitro-4- (Trifluoromethoxy) Bromobenzene in the market?
    The price of 3-nitro-4 - (trifluoromethoxy) bromobenzene in the market is difficult to determine. Its price often changes for many reasons.
    First, the supply and demand of the city is the key to the price. If there are many people who need this product, the demand is too much, and the price will rise; if the supply exceeds the demand, the market stock is too large, the price will be reduced.
    Second, the cost of production is also loud. The price of raw materials, if the source is thin and the price is high, the cost of producing this product will be high, and the price will also rise. If the production technique is complex, it requires more capital and effort, and it also increases its cost, and the price will be different.
    Third, the brand and reputation of the business are different in price. Well-known business, with excellent quality and after-sales service, its products may have high prices; new business, for the market, the price or lower.
    Fourth, the difference in geography, the price is also different. Long-distance transportation, and the cost of goods, the price of remote places is higher than that of near-produced places.
    Looking at the examples of various cities, the price of this product varies from tens of gold to hundreds of gold per gram. In the city of special demand, or due to high demand and rare supply, the price is even more exuberant. However, in general, the exact number cannot be determined. Only when you enter the market and observe it carefully can you know the real-time price.