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What are the chemical properties of 3-Fluorobenzenethiolate?
3-Fluorobenzenethiolate is one of the organic compounds with unique chemical properties. It is in the anionic form and originates from the deprotonation of 3-Fluorobenzenethiol.
From the perspective of reactivity, the sulfur atom of this anion has a high electron density and is rich in nucleophilicity. Because the outer layer of the sulfur atom has a lone pair of electrons, it is easy to attack the electrophilic reagent, and then the nucleophilic substitution reaction occurs. For example, when it encounters a halogenated hydrocarbon, the sulfur atom will attack the carbon atom of the halogenated hydrocarbon, and the halogen atom will leave to form a new sulfur-containing organic compound. This reaction is often used in organic synthesis to construct carbon-sulfur bonds and is an important means for the preparation of many sulfur-containing functional
Furthermore, although fluorine atoms in 3-Fluorobenzenethiolate do not directly participate in most nucleophilic reactions, they have a great influence on the distribution of molecular electron clouds. Fluorine atoms are extremely electronegative and have a strong electron-absorbing induction effect, which can reduce the electron cloud density of benzene rings and increase the difficulty of electrophilic substitution reactions on benzene rings. At the same time, this electron-absorbing effect can stabilize the negative charge of sulfur atoms and improve the stability of 3-Fluorobenzenethiolate, so that they can exist in a relatively stable state under some reaction conditions and participate in various organic transformation processes.
In addition, 3-Fluorobenzenethiolate can also participate in metal coordination reactions under appropriate conditions. Sulfur atoms can be used as ligands to form coordination bonds with metal ions by virtue of their lone pairs of electrons to form metal complexes. Such complexes have shown unique properties in the field of catalysis or materials science. For example, some metal complexes can act as catalysts for specific organic reactions, opening up new avenues for organic synthesis chemistry.
What are the common uses of 3-Fluorobenzenethiolate?
3 - Fluorobenzenethiolate is the ionic form of an organic compound. In the field of chemical industry and scientific research, it has many common uses.
First, in organic synthesis, it is often used as a nucleophilic reagent. Because sulfur atoms have solitary pair electrons and are rich in nucleophilic activity, they can react with many electrophilic reagents. For example, when they meet halogenated hydrocarbons, they can form carbon-sulfur bonds according to the mechanism of nucleophilic substitution. This is an important path for building sulfur-containing organic compounds and can be used to create organic molecules with special structures and properties, such as bioactive molecules and drug intermediates.
Second, in the field of materials science, it also has its application. Due to its structure containing benzene ring and fluorine atoms, it is endowed with specific electronic properties and spatial structure. It can participate in the molecular design of materials, such as the preparation of organic semiconductor materials with special optoelectronic properties. Through its integration with other conjugated structures, it can regulate the energy band structure of materials and improve the carrier mobility. It has great potential in the research and development of organic Light Emitting Diodes, field effect transistors and other devices.
Furthermore, in the field of coordination chemistry, 3-Fluorobenzenethiolate can act as ligands. Its sulfur atoms can coordinate with metal ions to form metal complexes. These complexes may have unique catalytic properties, optical properties or magnetic properties. For example, some metal-3-Fluorobenzenethiolate complexes can be used as homogeneous catalysts to exhibit high catalytic activity and selectivity in organic reactions.
And because of its fluorine-containing atoms, the compounds involved may have good stability and hydrophobicity. In surface modification techniques, it can be used to change the properties of the material surface, such as improving the material's anti-fouling and corrosion resistance. In the construction of self-assembled monolayers, 3-Fluorobenzenethiolate can be sequentially arranged on the surface of the substrate, endowing the substrate with special surface chemical properties, laying the foundation for many fields, such as sensors, biomedical materials, etc.
What is the preparation method of 3-Fluorobenzenethiolate?
The preparation of 3-fluorobenzene thiophenate is an important issue in the field of organic synthesis. To obtain this compound, the following method is often followed.
First, 3-fluorobrobenzene is used as the starting material, which is conducive to subsequent reactions due to the activity of bromine atoms. The reaction of 3-fluorobrobenzene with metal magnesium in an anhydrous ether environment is called the Grignard reaction. The magnesium atom is inserted between the carbon-bromine bond to form the Grignard reagent of 3-fluorophenyl magnesium bromide. This reagent has high activity and lays the foundation for subsequent reactions.
Then, the obtained 3-fluorophenyl magnesium bromide is reacted with carbon disulfide. The sulfur atoms in carbon disulfide are nucleophilic and undergo nucleophilic addition reaction with Grignard reagents. After this step, a sulfur-containing group is introduced into the benzene ring to generate the corresponding intermediate product.
Finally, the intermediate product is acidified with an appropriate acid (such as hydrochloric acid). During the acidification process, the intermediate product undergoes hydrolysis and is converted into 3-fluorothiophenol. Then 3-fluorothiophenol is reacted with a base (such as sodium hydroxide), and the acid-base is neutralized to obtain 3-fluorothiophenol salt. In the preparation process of
, it is crucial to maintain an anhydrous ether environment, because water will destroy Grignard's reagent. The control of reaction temperature and time cannot be ignored, and it needs to be fine-tuned according to the actual reaction conditions to ensure the high efficiency of the reaction and the purity of the product. In this way, 3-fluorothiophenol salts with higher yield and purity can be obtained.
3-Fluorobenzenethiolate what are the precautions in storage and transportation?
3-Fluorobenzene thiophenate is a chemical substance. When storing and transporting, you must pay attention to many matters.
Bear the brunt of it. When storing, you must choose a cool and dry place. The reason is that 3-fluorobenzene thiophenate is resistant to moisture or heat. If it is placed in a high temperature and humid environment, it may cause qualitative change and damage its chemical properties. If it is placed in a leaking room, it will easily change and cannot be used.
Furthermore, the choice of its container is crucial. It should be stored in a corrosion-resistant material. 3-Fluorobenzene thiophenate may be corrosive. If the container is not resistant, it may cause leakage and harm the surroundings. Taking the iron barrel as an example, if it is not resistant to corrosion and the wall of the barrel is eroded and penetrated, the material will leak out, which will not only pollute the environment but also cause danger.
During transportation, it is important to drive slowly and steadily. 3-Fluorobenzenthiophenol salt may be unstable in nature, and the vibration will be too bumpy and dramatic, which may lead to reactions and accidents. Such as driving on a mountain road, it is bumpy and abnormal, and the material will vibrate inside, or cause accidents.
It needs to be isolated from other things. It cannot be mixed with oxidants, acids, etc. Because of its chemical properties, it is easy to react violently when it encounters them. If gunpowder catches fire, it will cause serious trouble.
Protective equipment is also indispensable. People involved in storage and transportation, in front of suitable protective equipment, such as chemical protective clothing, gloves, masks, etc., to prevent accidental contact and injury to their bodies.
And emergency measures must be prepared. If there is a leak, etc., know how to deal with it quickly. For example, prepare adsorbed materials in order to take care of the leaked materials in time to prevent their spread and cause greater harm. In this way, 3-fluorothiophenol salt can be stored and transported safely.
What is the impact of 3-Fluorobenzenethiolate on the environment and people?
3 - Fluorobenzenethiolate are organic compounds and the like. The impact on the environment and the human body is quite important to the world.
Looking at the environment, if this compound is released in nature, or circulated in water, soil, and atmosphere. Its chemical properties cause it to enter the soil, or interact with various components in the soil, causing changes in the chemical properties of the soil, or hindering the uptake of nutrients by plant roots, which is unfavorable to plant growth and development. And if it enters the water body, it may poison aquatic organisms and cause aquatic ecological imbalance. In the atmosphere, it may participate in photochemical reactions, which will damage air quality and cause severe weather such as smog.
As for the human body, it enters the body through breathing, diet, and skin contact. After entering the body, or with biological molecules in the body, such as proteins, nucleic acids, etc., the normal physiological function of cells is disrupted. Or disturb the endocrine system, cause hormone imbalance, and affect physiological processes such as reproduction and development. And long-term exposure to it may increase the risk of cancer, damage the immune system, and weaken the body's ability to control disease.
Therefore, in the production and use of 3-Fluorobenzenethiolate, caution should be taken. Comprehensive protection measures must be set up to reduce its release in the environment and reduce the chance of human exposure, so as to ensure ecological safety and human health.