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What are the main uses of 3-Fluorobenzenesulfonamide?
3-Fluorobenzenesulfonamide has a wide range of uses. In the field of medicine, it is often a key raw material for the creation of new drugs. Due to its unique chemical structure, it can interact with specific biological targets, so it is widely used in the development of antibacterial, anti-inflammatory and anti-tumor drugs. Medicinal chemists use it to modify drug molecules to improve drug activity, selectivity and bioavailability.
In the field of materials science, 3-fluorobenzenesulfonamide also has important uses. It can be used as a functional additive to improve the properties of polymer materials. For example, adding specific polymers can enhance the stability, wear resistance and corrosion resistance of materials. This property makes it very popular in the production of materials such as coatings, plastics and fibers. The improved materials have better performance and a wider range of application scenarios.
Furthermore, in the field of organic synthesis, 3-fluorobenzenesulfonamide is an extremely important intermediate. With its active chemical properties, it can participate in many organic reactions to construct complex organic molecular structures. Organic synthesis chemists use it to synthesize various organic compounds with special structures and functions, providing important support for the creation of new materials, pesticides and fine chemicals.
In the research and development of pesticides, 3-fluorobenzenesulfonamide also plays a role. By modifying its structure, pesticide varieties with high-efficiency insecticidal, bactericidal or herbicidal activities can be created. Such pesticides can not only effectively prevent and control crop diseases and pests, but also reduce the adverse impact on the environment and help the sustainable development of agriculture.
In summary, 3-fluorobenzenesulfonamide has important uses in many fields such as medicine, materials, organic synthesis and pesticides, and is of great significance to promote technological progress and industrial development in various fields.
What are the physical properties of 3-Fluorobenzenesulfonamide?
3-Fluorobenzenesulfonamide is a kind of organic compound. Its physical properties are as follows:
Looking at its appearance, under room temperature and pressure, it is mostly white to off-white crystalline powder, which makes it easier to handle and weigh in many operations. As for the color, it is white and pure, and the off-white is also close to pure white. This pure color may suggest its higher purity.
When it comes to the melting point, it is usually between 104 and 108 degrees Celsius. The melting point is one of the important physical constants of a substance. This specific melting point range can be used to identify the compound and is also a key indicator of its change during heating. When the temperature rises to this range, 3-fluorobenzenesulfonamide gradually converts from a solid state to a liquid state. This phase transition process is of great significance for its applications in chemical production, material preparation and other fields.
Its solubility is also an important physical property. 3-fluorobenzenesulfonamide is slightly soluble in water, but it exhibits good solubility in organic solvents such as ethanol and acetone. This property makes it widely used in the field of organic synthesis. Researchers can choose suitable solvents to achieve specific reactions or perform separation and purification operations based on its solubility. The good solubility in organic solvents such as ethanol and acetone provides convenient conditions for its participation in various organic reactions, which greatly expands its application scope in organic synthesis chemistry.
Furthermore, 3-fluorobenzenesulfonamide has certain stability, and its chemical structure and properties can be maintained relatively stable under conventional storage conditions. However, it should be noted that although its stability is acceptable, it should still avoid contact with strong oxidants, strong bases and other substances to prevent chemical reactions from occurring and causing their properties to change. This stability feature provides certain convenience for its storage and transportation process. As long as it follows the basic storage requirements, it can ensure that its quality is not too affected.
In summary, the physical properties of 3-fluorobenzenesulfonamide, such as appearance, melting point, solubility and stability, play a crucial role in its applications in many fields such as chemical engineering, medicine, and materials.
What are 3-Fluorobenzenesulfonamide synthesis methods?
The synthesis of 3-fluorobenzenesulfonamide has been known for a long time, and is described in detail below.
First, 3-fluorobenzenesulfonamide is used as the starting material. First, 3-fluorobenzenesulfonamide is mixed with concentrated sulfuric acid and slowly heated to cause a sulfonation reaction between the two. This process requires careful control of temperature and reaction time to prevent overreaction. After the reaction is completed, the reaction mixture is cooled to obtain 3-fluorobenzenesulfonate. Subsequently, this sulfate is reacted with sodium nitrite at low temperature to form a diazonium salt. This diazonium salt is extremely unstable and needs to be reacted with sodium sulfite immediately to convert it into sodium 3-fluorobenzenesulfonate. Finally, 3-fluorobenzenesulfonate can be obtained by treating sodium 3-fluorobenzenesulfonate with acid.
Second, 3-fluorobenzene is used as the starting material. The 3-fluorobenzene is reacted with magnesium chips in anhydrous ether to form a Grignard reagent. The Grignard reagent reacts with sulfur dioxide gas to generate 3-fluorobenzenesulfonate magnesium salt. After that, it is oxidized to 3-fluorobenzenesulfonate with an appropriate oxidizing agent, and then acidified to obtain 3-fluorobenzenesulfonamide.
Third, 3-fluorobenzoic acid is used as the starting material. First, 3-fluorobenzoic acid is converted into 3-fluorobenzoyl chloride, which can be achieved by reacting with thionyl chloride. Then 3-fluorobenzoyl chloride is reacted with thiourea to form an intermediate. After a series of reactions such as hydrolysis, 3-fluorobenzenesulfonamide can finally be obtained.
The synthesis method has its own advantages and disadvantages. It is necessary to choose carefully according to the actual situation, such as the availability of raw materials, the difficulty of reaction conditions, and the purity of the product.
What is the price range of 3-Fluorobenzenesulfonamide in the market?
The price range of 3-fluorobenzenesulfonamide in the market is difficult to determine quickly. This is because the price of chemical products is often influenced by many factors.
The first to bear the brunt is the cost of raw materials. The preparation of 3-fluorobenzenesulfonamide requires specific starting materials. The fluctuation of raw material prices is directly related to product costs. If raw materials are scarce or supply channels change, the price will change. For example, if the price of fluoride raw materials required for preparation rises due to production reduction in the place of origin, the cost of 3-fluorobenzenesulfonamide will also increase, which in turn will cause its market price to fluctuate.
Furthermore, the trend of market supply and demand is also key. If the demand for 3-fluorobenzenesulfonamide increases sharply at some point, such as the development of new formulas in the pharmaceutical, pesticide and other industries, the dosage of it will rise sharply, and the supply will be difficult for a while, and the price will rise. On the contrary, if the demand is low, the manufacturer may reduce the price in order to reduce the inventory.
The production process and technical level also affect the price. Advanced technology can improve production efficiency, reduce energy consumption, and improve product purity, but the research and development and application of advanced technology require a huge investment. If the manufacturer adopts high-end technology, the product cost may be high, and the price will also increase accordingly; while the technology is backward, although the cost may be low, the product quality may not be sufficient, and the price is also limited.
In addition, regional factors should not be underestimated The price of 3-fluorobenzenesulfonamide varies in different places due to transportation costs, tax policies, and degree of market competition. Such as remote places, where transportation costs are high, the price may be higher than that in areas with convenient transportation.
Overall, the price range of 3-fluorobenzenesulfonamide in the market may vary from time to time and from place to place, ranging from tens of yuan per kilogram to hundreds of yuan. It is difficult to determine a fixed price range.
What are 3-Fluorobenzenesulfonamide storage conditions?
3-Fluorobenzenesulfonamide is one of the organic compounds. The key to its storage is related to the stability and effectiveness of this substance.
Store this 3-fluorobenzenesulfonamide, the first choice of its device. It is appropriate to use a sealed capacity, such as a glass bottle or a plastic bottle with a tight lid. Because the sealed device can prevent external moisture, air, etc. from disturbing. If exposed to humid air, or cause hydrolysis, damage its quality.
For the second time, the storage place is also important. When placed in a cool and dry place, avoid direct sunlight. Heat and light can both promote its transformation. Under high temperature, the reaction speed, or cause decomposition; light can also be the temptation of the reaction, damage its structure. Therefore, it is suitable for dark and warm storage to ensure its stability.
In addition, it is also necessary to be separated from other objects. Do not coexist with strong oxidizing substances or strong acid and alkali agents. Cover the properties of 3-fluorobenzenesulfonamide, or react with stains, and it is dangerous. If it encounters strong oxidation, or the risk of explosion; if it encounters with acid and alkali, or the reaction is initiated, change its quality.
Also, it should always be checked whether its contents are complete during storage. If there is a leak, move the other device and place the leak to prevent it from being scattered in the four, causing contamination and risk.
In general, when storing 3-fluorobenzenesulfonamide, it is necessary to use a sealed device to dry it and avoid light, avoid other dangerous objects, and check its device frequently, so as to ensure the quality of this object for later use.