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What is the main use of 3-Fluorobenzene-1,2-Dicarboxylate?
3-Fluorobenzene-1,2-dicarboxylate is widely used in the field of organic synthesis.
First, it can be used as a key monomer in the preparation of polymer materials with special properties. Taking the synthesis of polyester polymers as an example, 3-fluorobenzene-1,2-dicarboxylate is introduced into the polymer backbone. The characteristics of fluorine atoms, such as high electronegativity and small atomic radius, can make the polymer have characteristics such as enhanced chemical corrosion resistance and improved thermal stability. This is because the chemical bond energy formed by fluorine atoms and adjacent atoms is higher, which can resist the attack of external chemicals, and the molecular structure is more stable in high temperature environments.
Second, in medicinal chemistry, 3-fluorobenzene-1,2-dicarboxylate can be used as an important synthesis intermediate. The design and synthesis of many drug molecules requires the construction of specific benzene ring structures and the introduction of fluorine atoms to regulate the lipid solubility, biological activity and metabolic stability of drugs. The specific functional groups and fluorine atoms of 3-fluorobenzene-1,2-dicarboxylate provide an ideal starting structure for the construction of drug molecules. Through a series of organic reactions, the molecular structure can be precisely modified and expanded, so as to develop drugs with better curative effect and less side effects.
Third, in the field of materials science, this compound is used to prepare liquid crystal materials. The introduction of fluorine atoms can effectively adjust the polarity and spatial arrangement of molecules, which in turn affects the temperature range and phase transition characteristics of liquid crystal phases. The prepared liquid crystal materials have potential application value in display technology and can improve display effects, such as improving contrast, response speed and other performance indicators.
Fourth, in terms of organic optoelectronic materials, 3-fluorobenzene-1,2-dicarboxylate can participate in the synthesis of organic Light Emitting Diode (OLED) materials or organic solar cell materials. Its unique electronic structure and fluorine atom effect help to adjust the photoelectric properties of materials, such as improving carrier transport efficiency and luminous efficiency, etc., providing new ways and possibilities for the development of new optoelectronic materials.
What are the physical properties of 3-Fluorobenzene-1,2-Dicarboxylate?
3-Fluorobenzene-1,2-dicarboxylate, this is an organic compound. Looking at its physical properties, under normal temperature and pressure, it is mostly in the form of a solid state. However, due to the interaction of various groups in the molecular structure, the melting point is not high, and it is easy to melt into a liquid state when heated. Its color is often close to colorless or very light, and its appearance is like a transparent crystal or fine powder, and the purpose is clear and discernible.
When it comes to solubility, this compound has both a polar carboxyl ester structure and a non-polar benzene ring structure in the molecule, so its performance in organic solvents is quite unique. In polar organic solvents such as acetone and ethanol, it can exhibit a certain solubility, because the polar part and the solvent molecules can form intermolecular forces, such as hydrogen bonds, dipole-dipole interactions, etc., to help it disperse in the solvent. In non-polar organic solvents such as n-hexane, although the benzene ring can have a weak interaction with the non-polar solvent, the existence of the polar part limits its solubility, so the degree of solubility is limited.
Furthermore, its density is slightly larger than that of water. If mixed with water, it will sink to the bottom after standing still. Its volatility is low. Due to the strong intermolecular forces, the energy required for molecules to escape from the liquid phase and enter the gas phase is quite high. At room temperature, it is difficult to evaporate into the air, which also makes it relatively stable during storage and use, and it is not easy to be lost due to volatilization. Its smell is weak, and it is difficult for ordinary people to detect it without deliberately getting close to it. This is also due to its low volatility and the influence of molecular structure on odor emission.
Is the chemical properties of 3-Fluorobenzene-1,2-Dicarboxylate stable?
The chemical properties of 3-fluorobenzene-1,2-dicarboxylate are related to its stability, which is a key issue in chemical research and industrial applications.
Looking at the structure of this compound, fluorine atoms have unique electronic effects. Fluorine is extremely electronegative, and on the benzene ring, it can affect the electron cloud density distribution of the benzene ring through induction and conjugation effects. These electronic effects may have a significant impact on the reactivity and stability of 3-fluorobenzene-1,2-dicarboxylate.
From the perspective of steric hindrance, although fluorine atoms are small in size, their substitution at specific positions in the benzene ring will still change the molecular spatial configuration. This may affect the intermolecular interactions, such as hydrogen bonds, van der Waals forces, etc., which are then related to the stability of the compound.
In common chemical environments, 3-fluorobenzene-1,2-dicarboxylate exhibits a certain stability. Under conventional temperature and pressure, if there is no specific chemical reagent or external conditions to excite, its molecular structure can remain relatively stable. However, when encountering strong oxidizing agents or reducing agents, its structure can be changed due to the reactivity of the benzene ring and carboxyl group, or due to chemical reactions.
And because of its carboxylate structure, it can be ionized in aqueous solution and exhibit corresponding ionic properties. This ionization process may be affected by the pH of the solution, which further affects its chemical stability and reactivity.
In summary, the chemical stability of 3-fluorobenzene-1,2-dicarboxylate is not absolute, but a combination of factors. Under specific conditions, it is necessary to comprehensively consider its structural characteristics, environment and other factors before its stability can be accurately judged.
What is the preparation method of 3-Fluorobenzene-1,2-Dicarboxylate?
The preparation of 3-fluorobenzene-1,2-dicarboxylic acid esters is a very important issue in the field of organic synthesis. To prepare this compound, a common way is to use fluorobenzene derivatives as starting materials and convert them through a series of delicate chemical reactions.
First, 3-fluoro-o-xylene can be taken as the initial material. This substance is first oxidized by a suitable oxidizing agent, such as potassium permanganate, potassium dichromate and other strong oxidizing agents. Under suitable reaction conditions, such as specific temperature, pH and reaction time, its side chain methyl is oxidized to carboxylic groups to obtain 3-fluorobenzene-1,2-dicarboxylic acid. Subsequently, the resulting 3-fluorobenzene-1,2-dicarboxylic acid is esterified with corresponding alcohols, such as methanol, ethanol, etc., in the presence of a catalyst such as concentrated sulfuric acid. This reaction requires controlling conditions such as temperature and the proportion of reactants, heating and refluxing for a certain period of time, so that the two can fully react to generate 3-fluorobenzene-1,2-dicarboxylic acid esters.
Second, 3-fluorobenzoic acid can also be used as a starting material. First, it is prepared into a corresponding acid chloride, and chlorination reagents such as thionyl chloride can be used to react with it. After forming an acid chloride, it reacts with an o-hydroxybenzoate compound. This reaction needs to be carried out under appropriate alkaline conditions, such as the environment of organic bases such as pyridine, in order to promote the smooth occurrence of the reaction, and then generate the target product 3-fluorobenzene-1,2-dicarboxylate.
During the preparation process, each step of the reaction needs to precisely control the reaction conditions. Due to factors such as temperature, pH, ratio of reactants and reaction time, the yield and product purity of the reaction are greatly affected. And after each step of the reaction, it is often necessary to use separation and purification methods such as extraction, distillation, and recrystallization to obtain high-purity products, so as to meet the needs of subsequent experiments or industrial applications.
What is the price range of 3-Fluorobenzene-1,2-Dicarboxylate in the market?
I don't have the exact number of "3 - Fluorobenzene - 1,2 - Dicarboxylate" in the market price range. This is because the price of the compound often varies with many factors.
First, purity is the key factor. If the purity is extremely high and almost perfect, it can be used in high-end scientific research experiments, and its price will be high; on the contrary, if the purity is slightly lower, it is suitable for scenarios with slightly slower requirements, and the price may be slightly reduced.
Second, the situation of supply and demand determines the price. If the market demand for it is strong and the supply is limited, if a large demand for it emerges in a scientific research field, the output will not be sufficient, and the price will rise; if the supply exceeds the demand, the price may decline.
Third, the difficulty of preparation also affects the price. If the preparation requires complex processes, rare raw materials, and harsh conditions, the cost must be high, resulting in a high price; if the preparation is relatively simple, the cost is controllable, and the price may be close to the people.
Fourth, the purchase quantity varies. For bulk purchases, merchants may give preferential prices due to economies of scale; for small purchases, the unit price may be high.
Because the specific purity, market supply and demand, preparation details, and purchase quantity of this compound are not known, it is difficult to determine its market price range. If you want to know the details, you can consult chemical product suppliers, reagent sales platforms, or refer to relevant industry reports to get a more accurate price.