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What are the main uses of 3-Fluoro-6-Nitro-O-Xylene, 2, 3-Dimethyl-1-Fluoro-4-Nitrobenzene?
3-Fluoro-6-nitro-o-xylene (3-Fluoro-6-Nitro-O-Xylene) is 2,3-dimethyl-1-fluoro-4-nitrobenzene (2,3-Dimethyl-1-Fluoro-4-Nitrobenzene), which is widely used.
In the field of organic synthesis, it is often used as a key intermediate. Cover because of its molecular structure of fluorine atoms, nitro and methyl groups have unique reactivity. Nitro groups can be reduced into amino groups, which are key functional groups in the preparation of nitrogen-containing organic compounds, such as intermediates for the synthesis of various drugs and dyes. Fluorine atoms can significantly change the physical and chemical properties of compounds after being introduced into organic molecules due to their high electronegativity, such as improving the stability and lipophilicity of compounds. In the field of pesticides and pharmaceutical research and development, the biological activity and pharmacokinetic properties of molecules can be optimized.
It can also be seen in the field of materials science. After a specific reaction, it is connected to the main chain or side chain of a polymer, which can give the material special properties. Such as the preparation of fluoropolymers, it has good chemical resistance, low surface energy and other characteristics, and is widely used in coatings, plastics and other fields, which can improve the service life and performance of materials.
Furthermore, in the manufacture of fine chemical products, it is an important raw material. With its unique structure, a series of fine chemicals with high added value can be derived to meet the needs of electronics, daily chemical and other industries for special chemicals.
In conclusion, 3-fluoro-6-nitro-o-xylene (2,3-dimethyl-1-fluoro-4-nitrobenzene), with its unique structure, plays an indispensable role in many fields such as organic synthesis, materials science and fine chemicals, and promotes technological innovation and product upgrading in related industries.
What are the physical properties of 3-Fluoro-6-Nitro-O-Xylene, 2, 3-Dimethyl-1-Fluoro-4-Nitrobenzene
3-Fluoro-6-nitro-o-xylene (3-Fluoro-6-Nitro-O-Xylene), also known as 2,3-dimethyl-1-fluoro-4-nitrobenzene (2,3-Dimethyl-1-Fluoro-4-Nitrobenzene), is one of the organic compounds. Its physical properties are quite important and related to many practical applications.
First, the appearance, under room temperature and pressure, it is mostly colorless to light yellow liquid form, the texture is more uniform, and it has a certain fluidity. This color and morphological property can be used as a basis for preliminary identification in industrial production and laboratory operations.
The melting point is about -10 ° C to -5 ° C. The value of the melting point indicates that at relatively low temperatures, the compound will transform from a solid state to a liquid state. This property needs to be carefully considered in storage and transportation. If the temperature is not properly controlled, or its phase state changes, it will affect the quality.
In terms of boiling point, it is roughly in the range of 230 ° C to 240 ° C. A higher boiling point means that a higher temperature is required to transform it from a liquid state to a gas state. This property is of critical significance in chemical operations such as distillation and separation. Operators need to precisely control the temperature to achieve effective separation and purification of the substance.
In addition, the density is about 1.25g/cm ³, which is slightly heavier than water. When the substance is mixed with water, it will sink to the bottom of the water. This property has a great impact on the choice of separation and disposal methods in reaction systems involving the aqueous phase or wastewater treatment.
As for solubility, it is insoluble in water, but soluble in common organic solvents such as ethanol, ether, acetone, etc. This solubility characteristic determines the selection range of organic solvents when reacting with this compound as a raw material, and also provides ideas for using solubility differences in the product separation and purification stages.
These physical properties of 3-fluoro-6-nitro-o-xylene (2,3-dimethyl-1-fluoro-4-nitrobenzene) play an important guiding role in many fields such as chemical production, organic synthesis, analysis and testing, and relevant practitioners need to understand them in detail before they can make good use of them.
3-Fluoro-6-Nitro-O-Xylene, 2, what are the chemical properties of 3-Dimethyl-1-Fluoro-4-Nitrobenzene
3-Fluoro-6-nitro-o-xylene (3-Fluoro-6-Nitro-O-Xylene), also known as 2,3-dimethyl-1-fluoro-4-nitrobenzene (2,3-Dimethyl-1-Fluoro-4-Nitrobenzene), is an organic compound. Its chemical properties are unique and quite interesting.
First, its physical properties are usually liquid or solid, with specific melting points and boiling points. Due to the influence of fluorine, nitro and other groups in the molecular structure, its melting boiling point is different from that of general aromatics. The density may be different from that of common organic solvents, and the solubility is also related to molecular polarity, and the solubility is different in polar solvents and non-polar solvents.
In terms of chemical properties, fluorine atoms have strong electronegativity, which makes the electron cloud density distribution of the benzene ring change, so that the electron cloud density of the benzene ring is relatively reduced, so the electrophilic substitution reaction activity is different from that of the ordinary benzene ring. Nitro is a strong electron-absorbing group, which further reduces the electron cloud density of the benzene ring, making it more difficult for the benzene ring to undergo electrophilic substitution reaction, and the localization effect makes the subsequent substitution reaction mainly occur in the meta-site. However, when encountering nucleophiles, fluorine atoms can be used as a leaving group to undergo nucleophilic substitution reaction. Because the carboan
In addition, methyl groups in molecules can undergo some common reactions, such as being oxidized under specific conditions, or participating in free radical reactions. Since this compound contains fluorine, nitro and other functional groups, it can be used as a key intermediate in the field of organic synthesis. It is used in the synthesis of fine chemicals such as drugs, pesticides and materials. It is an important part of organic synthetic chemistry and is of great significance in the modern chemical industry.
What are the synthesis methods of 3-Fluoro-6-Nitro-O-Xylene, 2, 3-Dimethyl-1-Fluoro-4-Nitrobenzene
3-Fluoro-6-nitro-o-xylene (3-Fluoro-6-Nitro-O-Xylene) is 2,3-dimethyl-1-fluoro-4-nitrobenzene (2,3-Dimethyl-1-Fluoro-4-Nitrobenzene), which is synthesized as follows:
The starting material is optional o-xylene, and the o-xylene is first nitrified. The o-xylene is placed in an appropriate reactor, and under low temperature conditions, the mixed acid is slowly added (concentrated sulfuric acid and concentrated nitric acid are mixed in a certain proportion). This process requires strict control of the reaction temperature, because it is an exothermic reaction, and excessive temperature can easily lead to side reactions such as polynitro substitution. Nitric acid in the mixed acid provides nitro-positive ions, which attack the o-xylene ring under the catalysis of concentrated sulfuric acid to generate 6-nitro-o-xylene.
Next, the fluorination reaction of 6-nitro-o-xylene is carried out. Suitable fluorinating reagents, such as Selectfluor, can be selected. In an organic solvent such as acetonitrile, 6-nitro-o-xylene and a fluorinating reagent are added, and an appropriate amount of base is added as a catalyst, such as potassium carbonate. The reaction process requires stirring and controlling the temperature and reaction time. The fluorine atom in the fluorinating reagent replaces the hydrogen atom at a specific position on the benzene ring, and finally generates 3-fluoro-6-nit
Another starting material is 2,3-dimethylaniline. First, 2,3-dimethylaniline is diazotized, and in a low temperature acidic environment, it reacts with sodium nitrite to form a diazonium salt. After that, the diazonium salt is reacted with fluoroboronic acid to form a fluoroboronic acid diazonium salt precipitation. After filtration and washing, the diazonium salt of fluoroboronic acid is heated and decomposed, and the fluorine atom replaces the diazo group to form 2,3-dimethyl-1-fluorobenzene. Then 2,3-dimethyl-1-fluorobenzene is nitrified. Using a method similar to the above-mentioned nitration of o-xylene, mixed acids are added under suitable conditions to obtain 3-fluoro-6-nitro-o-xylene. In the
synthesis process, the products of each step need to be separated and purified, and distillation, extraction, column chromatography and other means can be used to ensure the purity and yield of the final product.
3-Fluoro-6-Nitro-O-Xylene, 3-Dimethyl-1-Fluoro-4-Nitrobenzene what to pay attention to when storing and transporting
3-Fluoro-6-nitro-o-xylene (3-Fluoro-6-Nitro-O-Xylene) is 2,3-dimethyl-1-fluoro-4-nitrobenzene (2,3-Dimethyl-1-Fluoro-4-Nitrobenzene). When storing and transporting this material, many key matters need to be paid attention to.
When storing, choose the first environment. When placed in a cool place, it can avoid high temperature to evaporate and decompose, and keep its chemical properties stable. And the dry place can prevent adverse reactions such as hydrolysis caused by moisture and maintain its purity. The warehouse must be well ventilated. If the ventilation is poor, volatile gases will accumulate, or risk explosion and poisoning.
The selection of containers is also crucial. Corrosion-resistant materials should be selected, because the compound contains active groups such as fluorine and nitro groups, ordinary materials or react with them to cause leakage. Sealed containers can prevent air and moisture from invading and ensure their quality.
During transportation, the packaging must be solid and stable. The road is bumpy or the container is damaged, so filling with buffer materials is essential, such as foam, sponge, etc., to reduce vibration and shock. And transportation vehicles need to be specially equipped with ventilation and fire protection equipment to prepare for emergencies.
Personnel should be professionally trained in operation. Handle with caution during loading and unloading to avoid damage to the container due to rough handling. The temperature and humidity are closely monitored throughout the transportation process, and an early warning mechanism is set up to exceed the appropriate range for immediate treatment.
Only by paying attention to the above points in an all-round way can the storage and transportation of 3-fluoro-6-nitro-o-xylene be safe and smooth, avoid accidents, and ensure the safety of personnel and the environment.