3-Fluoro-4-nitrobenzenesulfonyl chloride is a useful chemical raw material in organic synthesis. Its main uses probably have the following ends.
The first is often used as a key intermediate in the field of pharmaceutical synthesis. The design and construction of drug molecules require the introduction and transformation of specific functional groups. The sulfonyl chloride group, fluorine atom and nitro group of 3-fluoro-4-nitrobenzenesulfonyl chloride are all highly active functional groups. Sulfonyl chloride can react with many compounds containing active hydrogen, such as alcohols and amines, to form sulfonamides, sulfonates and other structures. These structures are widely present in many drug molecules and play a crucial role in regulating the activity, solubility, stability and other properties of drugs. For example, when developing some antibacterial drugs, the introduction of this compound can optimize the binding ability of the drug to the target and improve the antibacterial effect.
Furthermore, it also plays an important role in the field of pesticide synthesis. The creation of pesticides requires precise regulation of their biological activity and environmental adaptability. The functional groups introduced by 3-fluoro-4-nitrobenzenesulfonyl chloride can endow pesticide molecules with unique chemical and physical properties. The introduction of fluorine atoms can enhance the lipid solubility of the molecule, making it easier to penetrate biofilms and improve the effect on pests or pathogens. Nitro groups can change the electron cloud distribution of molecules, affect their chemical reactivity, and help improve the insecticidal, bactericidal or herbicidal activity of pesticides. The synthesis of many new and efficient pesticides relies on this compound to participate in the reaction to construct molecular structures with ideal activity.
In addition, in the field of materials science, it also has its uses. For example, when preparing some polymer materials with special functions, 3-fluoro-4-nitrobenzenesulfonyl chloride can participate in the polymerization reaction as a functional monomer. The functional groups it contains can copolymerize with other monomers, thereby introducing specific functional groups into the polymer chain. These functional groups can endow polymer materials with special properties such as photoresponsiveness, thermal stability, and chemical stability, expanding the application range of polymer materials in optics, electronics, aerospace, and other fields.

3-Fluoro-4-nitrobenzenesulfonyl chloride is an organic compound with unique physical properties. It is mostly solid at room temperature, and it may be a white to light yellow crystalline powder.
The melting point is about a specific temperature range, but the exact value will vary depending on the measurement method and conditions. The substance exhibits a certain solubility in organic solvents. Organic solvents such as dichloromethane, chloroform, and toluene are soluble in this compound, but in water, its solubility is very small. Because its molecular structure contains hydrophobic benzene rings, fluorine atoms, nitro groups, and sulfonyl chloride groups, it is difficult to dissolve in polar water.
The color and shape of its appearance are also affected by purity. If the purity is high, it is mostly white or almost white powder; if it contains impurities, the color may darken, light yellow or even darker. Because its molecules contain highly reactive groups such as nitro and sulfonyl chloride, it is chemically active. When storing, pay attention to environmental conditions. It should be placed in a dry, cool and well-ventilated place to avoid contact with water, alkalis and other reactive substances to prevent deterioration or dangerous reactions.

The method of preparing 3-fluoro-4-nitrobenzene sulfonyl chloride takes several ways.
First, 3-fluoro-4-nitrobenzene is used as the starting material. First, 3-fluoro-4-nitrobenzene is co-heated with fuming sulfuric acid, and after a sulfonation reaction, 3-fluoro-4-nitrobenzene sulfuric acid can be obtained. At this time of reaction, it is necessary to control the temperature appropriately, usually within a certain temperature range, so that the reaction can proceed smoothly, and a higher yield of sulfonic acid products can be obtained. Then, the obtained 3-fluoro-4-nitrobenzenesulfonic acid is co-heated with sulfoxide chloride to convert the sulfonic acid group into a sulfonyl chloride group. In this step, sulfoxide chloride is both a reactant and often a solvent. An appropriate amount of catalyst, such as N, N-dimethylformamide (DMF), can be added to the reaction system to accelerate the reaction. After heating the reflux number, the reaction is completed, and the excess sulfoxide chloride is removed by distillation, and then 3-fluoro-4-nitrobenzenesulfonyl chloride is obtained.
Second, 3-fluoroaniline can also be used as the starting material. N-acetyl-3-fluoroaniline is obtained by reacting 3-fluoroaniline with acetic anhydride to protect the amino group. This protective step prevents the amino group from being affected in subsequent reactions. After that, N-acetyl-3-fluoroaniline is nitrified, and a mixed acid (a mixture of nitric acid and sulfuric acid) is used as a nitrifying reagent. Under specific temperatures and conditions, nitro groups are introduced at the para-position of the benzene ring to generate N-acetyl-3-fluoro-4-nitroaniline. 3-Fluoro-4-nitroaniline is obtained by hydrolysis of N-acetyl group with acid or base as catalyst. Then, by diazotization reaction, 3-fluoro-4-nitroaniline is treated with sodium nitrite and hydrochloric acid to obtain diazonium salt. Finally, the diazonium salt is co-heated with sodium sulfite and copper sulfate, and the sulfonic acid group is introduced through Sandmeier reaction, and then treated with sulfoxide chloride to obtain 3-fluoro-4-nitrobenzenesulfonyl chloride.
All kinds of production methods have their own advantages and disadvantages. In actual preparation, the appropriate method should be carefully selected according to factors such as the availability of raw materials, cost, difficulty of reaction conditions and yield.

3-Fluoro-4-nitrobenzenesulfonyl chloride is a commonly used reagent in organic synthesis. When storing it, there are several important items that need to be paid attention to.
First of all, it should be noted that this substance is extremely sensitive to moisture. If exposed to humid air, it is very easy to hydrolyze. After hydrolysis, its chemical properties change greatly, and it is no longer the original reagent, causing the synthesis reaction to be disturbed and it is difficult to achieve the desired effect. Therefore, it must be stored in a dry place, and a desiccant can be placed in the storage place to keep the environment dry. After taking it, the container should be sealed immediately to prevent moisture from invading the way.
Second rule, 3-fluoro-4-nitrobenzenesulfonyl chloride is highly corrosive. Contact with it can damage the skin, eyes and respiratory tract. When storing, it must be stored in a corrosion-resistant container, and the material of the container must be able to withstand its corrosion and not react with it chemically. In addition, the storage place must be far away from the place where people often go to prevent accidental contact.
Furthermore, this compound is easily decomposed when heated and may even cause danger. Therefore, the storage temperature should be low and should not be placed in a place with high temperature or direct sunlight. The ideal storage temperature is between -20 ° C and 0 ° C. In this way, its chemical stability can be maintained and the storage period can be extended.
In addition, 3-fluoro-4-nitrobenzenesulfonyl chloride is a hazardous chemical, and storage management must be in accordance with relevant regulations and safety standards. The storage area should be equipped with appropriate emergency treatment equipment, such as eyewash, shower equipment, etc., in case of leakage or contact accident, it can be disposed of immediately. And storage records must be kept in detail, indicating the quantity, storage date, access, etc., for traceability and management.

3-Fluoro-4-nitrobenzenesulfonyl chloride, in the market, its price varies for many reasons. The first to bear the brunt is the difficulty of its preparation. If the preparation method is complicated, requires multiple processes, uses rare raw materials, and consumes huge amounts of manpower and material resources, its price will be high.
Furthermore, the situation of market supply and demand also affects its price. If there are many people who want it, but there are few suppliers, it is in a state of shortage, and its price will rise; on the contrary, if the supply exceeds the demand, the price will fall.
In addition, the cost control and pricing strategies of different manufacturers are also different. Large factories with good reputation and fine craftsmanship have excellent product quality and slightly higher pricing; while small factories compete for the market, or reduce their prices.
And regional differences also have an impact. In places with convenient transportation and industrial concentration, the cost may be low and the price may be low; in remote places, the price may be high due to high transportation costs.
If you want to know the market price, you should consult chemical product suppliers or check chemical product trading platforms to get real-time and accurate prices. Looking at the current chemical market conditions, the price ranges from hundreds to thousands of yuan per kilogram. This is only an approximate number. The actual price will vary according to the above factors.