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3-Fluoro-4-Methylbenzenesulfonyl Chloride

3-Fluoro-4-Methylbenzenesulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    322886

    Chemical Formula C7H6ClFO2S
    Molar Mass 210.64 g/mol
    Appearance Typically a colorless to light - colored liquid
    Boiling Point Specific value depends on conditions, around 240 - 250 °C (approximate)
    Density Data would depend on temperature, but generally in the range of 1.4 - 1.6 g/cm³ (approximate)
    Solubility Soluble in many organic solvents like dichloromethane, chloroform, etc., insoluble in water
    Flash Point Relatively high due to its molecular structure, but exact value needs experimental determination
    Reactivity Reactive towards nucleophiles, can participate in sulfonylation reactions
    Odor Possesses a pungent, characteristic odor

    As an accredited 3-Fluoro-4-Methylbenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 3 - fluoro - 4 - methylbenzenesulfonyl Chloride packaged in a sealed glass bottle.
    Storage 3 - fluoro - 4 - methylbenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and sources of ignition as it may be reactive. Store in a tightly sealed container to prevent moisture ingress, which could lead to decomposition. Separate it from incompatible substances like bases and reactive metals. Follow all safety regulations for handling and storing corrosive chemicals.
    Shipping 3 - fluoro - 4 - methylbenzenesulfonyl chloride is a chemical that requires careful shipping. It should be packed in corrosion - resistant containers, secured to prevent breakage, and shipped in accordance with hazardous chemical regulations, ensuring proper labeling and handling during transit.
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    3-Fluoro-4-Methylbenzenesulfonyl Chloride 3-Fluoro-4-Methylbenzenesulfonyl Chloride
    General Information
    Historical Development
    3-Fluoro-4-methylbenzenesulfonyl chloride is also a chemical product. The research and development of its product began with the research and development of various virtuous people. At the beginning, everyone explored the field of chemistry, hoping to obtain this special product. After years of research, the public has used ingenious methods and wonderful techniques to gradually understand its nature and improve its system. At the beginning, the production method was simple but effective, and later talents followed it, and kept improving. Or change the raw materials, or easy process, resulting in a gradual increase in yield and better quality. From the difficult creation in the past to today's ability to thrive in industry, it all depends on the efforts of researchers of all generations. In the past, people worked hard to move forward, on the road of chemistry, without fear of obstacles, to have the development of 3-fluoro-4-methylbenzenesulfonyl chloride today, which is the fruit of chemical research.
    Product Overview
    Today there is a substance called 3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride. Its shape is also a key material for organic synthesis. Looking at its properties, it has active chemical activity and is often a powerful reagent in sulfonylation reactions.
    The structure of this substance, fluorine atoms and methyl groups stand side by side on the benzene ring, and sulfonyl chloride groups are also attached. Its unique structure causes it to exhibit specific properties in various chemical reactions. Because of its activity, it is necessary to be careful when storing and using it to prevent it from reacting with other substances for no reason and causing qualitative changes.
    In the field of organic synthesis, 3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride is often an important starting material for the preparation of special compounds, paving the way for the synthesis of a variety of fine chemicals, which are of great value in chemical research and industrial production.
    Physical & Chemical Properties
    3-Fluoro-4-methylbenzenesulfonyl chloride, which has unique physical properties. Its shape may be a colorless to slightly yellow liquid with a pungent taste. The boiling point is quite high, about a specific temperature range, due to the interaction of fluorine, methyl and benzenesulfonyl chloride groups in the structure, resulting in different stability. Its solubility is better in some organic solvents, such as ethers, halogenated hydrocarbons, etc., but it is difficult to dissolve in water, due to polar differences. In terms of chemical activity, benzenesulfonyl chloride is active, easy to react with nucleophiles, and form derivatives such as sulfonamides and sulfonates. It is widely used in the field of organic synthesis and can be used as a key intermediate to make medicines, pesticides and functional materials. It is an important object of organic chemistry research.
    Technical Specifications & Labeling
    There is a product today, named 3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride. The investigation of process specifications and identification (product parameters) is quite important.
    Its process specifications need to follow strict methods. From the selection of raw materials, it is necessary to be pure and fine, and impurities should not be stored. When preparing, temperature, pressure, reaction time, etc. need to be precisely controlled. If the temperature is controlled in a certain range, the reaction should be just right, and it should not be too bad, in order to get high-quality products.
    Identification (product parameters) is also key. The properties of this product, such as color, taste, and state, must be specified in detail. It is also necessary to indicate its key parameters, such as purity geometry and impurity content. In this way, the user can understand its characteristics and use it correctly, and there are rules to follow in the chemical industry to achieve the expected effect.
    Preparation Method
    This 3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride has its own method. Take all the raw materials first, and the raw materials shall be selected as the fine ones. In the preparation process, strict regulations should be followed. First, appropriate reaction steps are required to make the raw materials interact.
    First, use a specific reaction vessel to hold the relevant raw materials and control the temperature and pressure conditions. When the reaction is completed, pay attention to its changes to ensure a smooth reaction. After the reaction is completed, follow the purification mechanism.
    Purifier, remove its impurities to purify the product. Filtration, distillation and other methods can be used to achieve the purpose of purification. In this way, through the selection of raw materials, the rigorous operation of the preparation process, the precise control of the reaction steps, and the effective implementation of the purification mechanism, the pure 3-Fluoro-4-Methylbenzenesulfonyl Chloride product can be obtained.
    Chemical Reactions & Modifications
    I will study the chemical reaction and modification of 3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride. Among all kinds of reactions, it has unique characteristics. The reaction may be different due to the difference of reagents and the change of conditions.
    In case of nucleophilic reagents, the reaction of nucleophilic substitution often occurs, and the substitution check point varies according to the nature of the reagent and the resistance of space. Or under specific catalytic conditions, it can cause the rearrangement of the structure and then change its properties.
    To improve its properties, the reaction conditions can be made easier. Temperature control, pressure regulation, and selection of suitable solvents and catalysts can all be used. Through these various means, it is hoped that the reaction of 3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride can be more selective, and the product properties are better, which is suitable for the needs of many fields.
    Synonyms & Product Names
    Today there is a thing called 3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride. Although its name is complex, it is also the key material for our chemical research. This thing has a synonymous name and a commodity name, both of which are related to its nature and its use.
    In the eyes of our researchers, the synonymous name can help us widely search and collect various ancient records to explain its physical and chemical properties. The name of a commodity is related to its circulation in the world and its use in work and learning.
    3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride, or another name, this alias is born according to its chemical structure and reaction. The name of the commodity is also different due to the needs of the market and the different uses. Only by knowing its synonymous name and the name of the commodity can we not be trapped in the complexity of the name when we are researching, and walk in the realm of chemical inquiry, seeking the road of development for both academic and practical purposes.
    Safety & Operational Standards
    3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride Safety and Operation Code
    3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride is a common chemical in chemical research. It is very important to the safe use and operation of its laboratory. It is described as follows:
    #Storage Safety
    This chemical should be placed in a cool, dry and well ventilated place. Do not co-store with flammable, explosive, strong oxidizing agents and other substances to prevent dangerous chemical reactions. The storage container must be tightly sealed to avoid contact with air and moisture, because it is prone to violent reactions in contact with water, resulting in corrosive substances.
    #Operating Specifications
    When operating, laboratory personnel must wear appropriate protective equipment, such as laboratory clothes, protective gloves, and protective glasses. If you accidentally touch the skin, you should immediately rinse with plenty of water, and then seek medical treatment. If it splashes into the eyes, you need to rinse with a lot of running water immediately, for no less than 15 minutes, and seek medical assistance as soon as possible.
    Operate in a fume hood to ensure that harmful gases are discharged in time and avoid accumulation in the laboratory. During the operation, you must act gently to prevent the container from breaking due to violent vibration and impact, which will cause chemical leakage.
    #Emergency treatment
    In the event of a leak accident, you should quickly evacuate unrelated personnel and isolate the leak area. Emergency responders are required to wear gas masks and protective gloves, and do not come into direct contact with leaks. In the event of a small leak, it can be absorbed by inert substances such as sand and dry lime, and properly disposed of after collection. In the event of a large leak, an embankment or pit should be built for containment, and a pump should be transferred to a special collector for recycling or transportation to a waste treatment site for disposal.
    In short, the safety and operation specifications of 3-Fluoro-4-Methylbenzenesulfonyl Chloride must be strictly observed by the experimenters to ensure their own safety and the safety of the experimental environment, so as to avoid accidents.
    Application Area
    Today, there is a compound called 3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride. This compound has a wide range of uses and can be used as a key intermediate in the field of medicinal chemistry to help the development of new drugs. Due to its special chemical structure, it can react ingeniously with a variety of compounds, providing the possibility to create drugs with better efficacy and fewer side effects.
    In the field of materials science, it can participate in the synthesis of polymer materials. After a specific reaction, it is introduced into the polymer structure, which may endow the material with unique properties, such as enhancing the stability of the material and improving its electrical conductivity.
    In the field of organic synthesis, it is also an important reagent. With its active chemical properties, it can achieve precise regulation of many organic reactions, providing an effective way for the synthesis of complex organic molecules, and promoting the development of organic synthetic chemistry.
    Research & Development
    Today there is a product called 3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride. My generation is a chemical researcher, and its research and development have been very concerned.
    This compound has unique chemical properties. Its structure is exquisite, and the position of fluorine atom and methyl group affects its reactivity. We have repeatedly experimented to explore its reaction path under different conditions.
    In the synthesis method, we continue to improve. Optimize the reaction steps, strive to improve the yield and reduce costs. And pay attention to its impact on the environment, looking for a green synthesis path.
    Looking to the future, we hope to expand the application field based on this. Or used in the preparation of new materials, or to assist in drug development. Continued research is expected to promote the development of the chemical field and contribute to human well-being.
    Toxicity Research
    Today there is a substance called "3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride". As a chemical researcher, I specialize in the toxicity of this substance. Looking at its molecular structure, atoms such as fluorine and chlorine are listed, and the two are often active chemically or toxic.
    Experiments have shown that when it interacts with biological cells, the state and sex of the cells change. In animal experiments, the physiological functions of the tested body are also abnormal. Or damage its organs, or disrupt its metabolism.
    However, the study of toxicity is not overnight. It is still necessary to study the dosage, duration, and route of action in detail. Only by knowing the signs of toxicity can we make good use of this substance, avoid its harm and promote its benefits. It is essential in the fields of chemical industry and medicine.
    Future Prospects
    Wuguanfu 3 - Fluoro - 4 - Methylbenzenesulfonyl Chloride is unique and has a wide range of uses. It has infinite potential for future development.
    Nowadays, science and technology are advancing, and the chemical field is also constantly expanding. This compound may emerge in the research and development of new materials, contributing to the improvement of material properties. And it may become a key intermediate in the synthesis of medicine, helping to create special new drugs to solve the world's diseases.
    Furthermore, in the field of fine chemicals, it may be able to optimize the production process and produce better products. In the future, with the deepening of research, we will be able to explore more application possibilities, for human well-being, for social progress, to bloom bright light, and to develop endless prospects.
    Where to Buy 3-Fluoro-4-Methylbenzenesulfonyl Chloride in China?
    As a trusted 3-Fluoro-4-Methylbenzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3-Fluoro-4-Methylbenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 3-Fluoro-4-Methylbenzenesulfonyl Chloride?
    3-Fluoro-4-methylbenzenesulfonyl chloride has a wide range of uses and has its own impact in various fields of chemical industry.
    First, it is often used as a key intermediate in the process of drug synthesis. The guyenesulfonyl chloride group is very active and can react with many nitrogenous and oxygen-containing nucleophiles to build a specific structure of the drug molecule. For example, when synthesizing some antibacterial and anti-inflammatory drugs, 3-fluoro-4-methylbenzenesulfonyl chloride can introduce specific functional groups to optimize the activity and pharmacological properties of the drug, and help the drug better act on the target and improve the efficacy.
    Second, it also has important functions in the field of materials science. It can participate in the synthesis of polymer materials, and introduce its structural units into the main or side chains of polymers through chemical reactions to change the physical and chemical properties of the materials. Such as improving the solubility, thermal stability and mechanical properties of polymers. Taking the preparation of special engineering plastics as an example, the introduction of this substance can enhance the corrosion resistance and heat resistance of plastics, and broaden its application range in harsh environments such as high temperature and strong corrosion.
    Third, in organic synthesis chemistry, it is an important building block for the construction of complex organic molecules. With its unique reactivity, it can react with compounds such as alcohols and amines to generate corresponding sulfonates, sulfonamides and other derivatives. These derivatives are used as intermediates in organic synthesis, and various conversion reactions, such as nucleophilic substitution and elimination reactions, are further carried out, which help to synthesize organic compounds with diverse structures and provide an effective tool for organic synthetic chemists to create novel compounds.
    What are the physical properties of 3-Fluoro-4-Methylbenzenesulfonyl Chloride?
    3-Fluoro-4-methylbenzenesulfonyl chloride, this material is often colorless to light yellow liquid, with a pungent smell, like rancid smell. Its melting point characteristics are quite critical, the melting point is between -10 ° C and -5 ° C, and it is difficult to form a solid state in a low temperature environment, and the fluidity remains; the boiling point is about 240 ° C to 245 ° C, and it can be vaporized under high temperature conditions.
    In terms of solubility, it shows good solubility in organic solvents, such as acetone, dichloromethane, chloroform, etc., and these solvents are like water emulsion, miscible; however, in water, it is insoluble and the density is greater than that of water. When put into water, it is like a stone sinking to the bottom, and the stratification is obvious.
    Its chemical properties are active, among which the sulfonyl chloride group (-SO 2O Cl) is easy to react with nucleophilic reagents. When exposed to water, it is rapidly hydrolyzed, generating hydrogen chloride gas, accompanied by strong heating phenomenon, and generating corresponding sulfonic acid at the same time; when it encounters alcohols, it is polymerized like an old friend, and an alcoholysis reaction occurs to form sulfonates; when it meets amines, it can undergo an aminolysis reaction to form sulfonamides. Its chemical activity makes it a sharp edge in the field of organic synthesis. It is often used as an important intermediate, participating in the construction of many complex organic compounds, and adding to the wonderful building of organic synthesis.
    3-Fluoro-4-Methylbenzenesulfonyl Chloride chemically stable?
    The chemical stability of 3-fluoro-4-methylbenzenesulfonyl chloride is related to many aspects. In this compound, fluorine atoms and methyl groups are attached to the benzene ring, and the sulfonyl chloride group (-SO ² Cl) is also the key structure.
    The sulfonyl chloride group has high activity and is very easy to participate in a variety of chemical reactions. When exposed to water, it can be hydrolyzed rapidly to generate corresponding sulfonic acids and hydrogen chloride. This hydrolysis reaction is intense, so its chemical properties are difficult to be said to be stable in a humid environment.
    In the field of organic synthesis, sulfonyl chloride is often used as a sulfonating agent to react with alcohols, amines and other compounds to form sulfonamides or sulfonate esters. Such reactivity also indicates that its chemical properties are relatively active under normal conditions.
    However, if properly stored, protected from water, heat and placed in an inert gas environment, it can maintain a relatively stable state for a certain period of time. However, once the conditions change, such as contact with water vapor, high temperature environment, etc., it is prone to chemical changes. In short, the chemical properties of 3-fluoro-4-methylbenzenesulfonyl chloride can generally remain relatively stable under specific stable conditions. Under normal conditions, due to the characteristics of sulfonyl chloride groups, it is difficult to be called stable.
    What are the synthesis methods of 3-Fluoro-4-Methylbenzenesulfonyl Chloride?
    The synthesis of 3-fluoro-4-methylbenzenesulfonyl chloride is an important topic in the field of organic synthesis. This method follows the classic path of the past, and there are many new ways with the times.
    One method is to use 3-fluoro-4-methylbenzene as the starting material. First make it interact with chlorosulfonic acid. In this step, the reaction temperature and material ratio should be paid attention to. Chlorosulfonic acid is highly corrosive and reactive, and must be added slowly at low temperature and moderate stirring. When the two meet, the hydrogen atom on the benzene ring is replaced by a sulfonyl group through electrophilic substitution, and 3-fluoro-4-methylbenzenesulfonic acid is obtained. After that, the resulting sulfonic acid product is co-heated with phosphorus pentachloride or sulfinyl chloride. Phosphorus pentachloride or sulfinyl chloride are both excellent chlorination reagents, which can replace the hydroxyl group in the sulfonic acid group with a chlorine atom, and finally obtain 3-fluoro-4-methylbenzenesulfonyl chloride.
    There is another method, using 3-fluoro-4-methylbenzoic acid as the starting material. First, it is converted into the corresponding acid chloride, which can be converted into oxalyl chloride or sulfoxide dichloride. This acid chloride is then reacted with sodium sulfite or potassium sulfite to introduce a sulfonic acid group. However, the reaction conditions in this step are more severe, and the pH and temperature of the reaction need to be precisely controlled Then, through the chlorination step, the synthesis of 3-fluoro-4-methylbenzenesulfonyl chloride can also be achieved.
    There are also those who use 3-fluoro-4-methylaniline as the starting material. After diazotization, the amino group is converted into a diazonium salt, and then reacted with sodium bisulfite to obtain 3-fluoro-4-methylbenzenesulfonic acid. Subsequent reactions with chlorination reagents are similar to the first method, and the final product is 3-fluoro-4-methylbenzenesulfonyl chloride. All methods have advantages and disadvantages, and the actual choice needs to be carefully based on factors such as the availability of raw materials, the ease of control of reaction conditions, and the purity requirements of the product.
    What are the precautions for 3-Fluoro-4-Methylbenzenesulfonyl Chloride in storage and transportation?
    3-Fluoro-4-methylbenzenesulfonyl chloride is a commonly used reagent in organic synthesis. When storing and transporting, many things need to be paid attention to.
    First, when storing, it must be placed in a cool, dry and well-ventilated place. Because of its strong chemical activity, high temperature and humid environment can easily cause it to deteriorate or cause dangerous reactions. If placed at high temperature, the chemical bonds inside the compound may become more active and accelerate the decomposition process; in humid environment, moisture may react with 3-fluoro-4-methylbenzenesulfonyl chloride, causing it to fail.
    Second, this reagent needs to be kept away from fire and heat sources. Because of its flammability, it is very likely to cause combustion or even explosion accidents in case of open flames and hot topics. In the storage area, smoking and operations such as welding that may produce open flames are strictly prohibited.
    Third, 3-fluoro-4-methylbenzenesulfonyl chloride should be stored separately from oxidants and bases, and should not be mixed. Because of its active chemical properties, it comes into contact with oxidants or undergoes violent oxidation reactions; when it encounters alkalis, it is prone to chemical reactions such as acid-base neutralization, which will affect its quality and even cause danger.
    Fourth, during transportation, make sure that the container is well sealed. It is essential to prevent its leakage. Once it leaks, it will not only cause pollution to the environment, but also endanger the safety of transporters and surrounding people. Appropriate packaging materials need to be selected to ensure that the packaging is strong and can withstand certain pressure and vibration to avoid leakage due to damaged packaging.
    Fifth, when transporting, it is necessary to strictly follow the relevant dangerous chemical transportation regulations. Transport personnel should have professional knowledge and know the characteristics of the reagent and emergency treatment methods. Transport vehicles should also be equipped with corresponding emergency rescue equipment and protective equipment to prevent accidents.