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3-Fluoro-4-Chloro-1-Bromobenzene

3-Fluoro-4-Chloro-1-Bromobenzene

Hongda Chemical

Specifications

HS Code

226189

Chemical Formula C6H3BrClF
Molar Mass 225.44 g/mol
Appearance Colorless to light yellow liquid
Boiling Point Approx. 180 - 185 °C
Density Approx. 1.81 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, ether
Flash Point Approx. 72 °C
Vapor Pressure Low vapor pressure at room temperature

As an accredited 3-Fluoro-4-Chloro-1-Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 3 - fluoro - 4 - chloro - 1 - bromobenzene packaged in a sealed glass bottle.
Storage Store 3 - fluoro - 4 - chloro - 1 - bromobenzene in a cool, well - ventilated area, away from heat and ignition sources. Keep it in a tightly closed container to prevent leakage. Since it is a potentially hazardous chemical, store it separately from oxidizing agents, acids, and bases. Label the storage container clearly for easy identification and safety.
Shipping 3 - fluoro - 4 - chloro - 1 - bromobenzene is a chemical. For shipping, it must be in proper, sealed containers. Label containers clearly with hazard info. Ship via carriers compliant with chemical transport regulations to ensure safe transit.
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3-Fluoro-4-Chloro-1-Bromobenzene 3-Fluoro-4-Chloro-1-Bromobenzene
General Information
Historical Development
3-Fluoro-4-chloro-1-bromobenzene is also an organic chemical. Its origin can be traced back to the beginning of chemistry in the past. At that time, all the sages worked hard to analyze the physical properties and explore the wonderful principle of chemical combination.
At the beginning, it was difficult to obtain this compound, because the technique was not prepared, and the material was difficult to find. However, all the sages were determined, and went through countless trials and errors, gradually understanding the method of its synthesis. Beginning with the technique of halogenation, in sequence, the atoms of fluorine, chlorine and bromine were ingeniously introduced into the benzene ring.
The years have passed, and the technique has become more and more exquisite. From the simple method, it has evolved into an efficient and precise process. In the past, it took a long time and cost a lot of money, but now it can be obtained in a short time. Its application is also gradually expanding, and it shows extraordinary ability in the fields of medicine and materials. It is a treasure of chemistry in this world. It depends on the efforts of predecessors to have today's prosperity.
Product Overview
3 - Fluoro - 4 - Chloro - 1 - Bromobenzene is an organic compound. It is a colorless liquid with a special odor. The structure of this compound, on the benzene ring, fluorine, chlorine and bromine atoms are arranged in an orderly manner.
In the field of chemical research, its synthesis method has attracted much attention. It can be prepared by a specific organic reaction with suitable raw materials and delicate steps. The control of the reaction conditions, such as temperature, pressure and catalyst selection, is crucial, and it is related to the purity and yield of the product.
3-Fluoro-4-Chloro-1-Bromobenzene can be used as a key intermediate in organic synthesis due to the characteristics of halogen atoms in its structure. It can participate in many reactions, such as nucleophilic substitution, coupling reactions, etc., and then derive a variety of organic compounds. It has potential application value in medicine, pesticides, materials and other fields, and has promising prospects.
Physical & Chemical Properties
3-Fluoro-4-chloro-1-bromobenzene is also an organic compound. Its physical properties, at room temperature, are colorless to pale yellow liquids with a special odor. Its boiling point is considerable, about [X] ° C, due to intermolecular forces. As for the melting point, it is about [X] ° C, reflecting the characteristics of its crystal structure.
Regarding chemical properties, in this compound, bromine, chlorine, and fluorine atoms give their unique reactivity. Halogen atoms on the benzene ring can initiate nucleophilic substitution reactions. The high electronegativity of fluorine atoms changes the density of ortho-electron clouds, which affects the reaction check point. Chlorine and bromine atoms also participate in many organic reactions, such as interacting with nucleophiles to form new chemical bonds, which are widely used in the field of organic synthesis. They are important raw materials for chemists to explore the mechanism of organic reactions and create new compounds.
Technical Specifications & Labeling
3-Fluoro-4-chloro-1-bromobenzene is an important object of chemical substance research. Its process specification and identification (product parameters) are the key. The process specification needs to specify the preparation method, and the selection of raw materials must be pure, such as the quality of fluorine source, chlorine source, and bromine source, which is related to the purity of the product. The reaction conditions must also be precise. Temperature, pressure, and catalyst dosage all affect the yield and quality. The identification (product parameters) should detail the physical and chemical properties, melting point, boiling point, density geometry, solubility, and contain purity data, impurity geometry, all need to be clear, this is the basis for research and application, according to this specification and identification, in order to have a proper understanding and application of 3-fluoro-4-chloro-1-bromobenzene.
Preparation Method
The method of making 3 - Fluoro - 4 - Chloro - 1 - Bromobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. First, the raw materials need to be carefully selected, with suitable halogenated aromatics as the base, supplemented by specific fluorine sources, chlorine sources and bromine sources. The production process controls the temperature, pressure and time of the reaction.
At the beginning of the reaction, the halogenated aromatics and the fluorine source are co-placed in a special reactor, and the temperature is adjusted to a moderate level to promote the fluorination reaction. Then, the chlorine source and the bromine source are added in sequence, and the temperature and duration of each step of the reaction are precisely controlled. The reaction steps are also heavy. After fluorination, the intermediate product needs to be purified, and the heterogeneity should be removed and the chlorine source and bromine source should be introduced.
In the catalytic mechanism, a high-efficiency catalyst is selected to reduce the energy barrier of the reaction and speed up the reaction process. Metal salts or organic ligands are used as catalysts, and the activity check point is used to complex with the reactants, changing the reaction route and increasing the yield and purity of the products. In this way, 3-Fluoro-4-Chloro-1-Bromobenzene of high quality can be obtained.
Chemical Reactions & Modifications
3 - Fluoro - 4 - Chloro - 1 - Bromobenzene is an important compound in organic synthesis. Its chemical properties and reactions are often of concern to our chemical researchers.
In many reactions, this compound exhibits unique reactivity. Its fluorine, chlorine and bromine atoms change the electron cloud density distribution of the benzene ring due to electronegativity and atomic radius differences, which in turn affects the reactions such as electrophilic substitution and nucleophilic substitution.
In order to improve its properties, we have tried to explore with different reagents and conditions. For example, adjust the reaction temperature, pressure, or change the type of catalyst to see its effect on the reaction rate and product selectivity.
After many experiments, it was found that moderate increase of temperature, electrophilic substitution reaction rate accelerated, and side reactions also increased. The addition of specific catalysts can significantly increase the yield of the target product, improve its reaction performance, and lay a good foundation for subsequent synthesis and application.
Synonyms & Product Names
Today there is a thing called 3 - Fluoro - 4 - Chloro - 1 - Bromobenzene. This thing has a wide range of uses in the field of chemistry. Its synonyms need to be studied in detail.
Check the books, its aliases may be named according to its structural properties. The name of the chemical substance is based on its atomic composition or its functional group. This 3 - Fluoro - 4 - Chloro - 1 - Bromobenzene is named because it contains fluorine (Fluoro), chlorine (Chloro), and bromine (Bromo) elements on the benzene ring.
Its commercial name may vary slightly depending on the manufacturer and the use. However, no matter what the name is, it refers to this specific compound. When chemists explore this thing, they must understand its synonyms and commodity names, so that they can obtain its details. Only in experiments and production can they be correct. This is the essence of chemical research, which is also related to academic accuracy and the smoothness of the industry.
Safety & Operational Standards
"3-Fluoro-4-chloro-1-bromobenzene"
This article discusses 3-fluoro-4-chloro-1-bromobenzene, which is related to safety and operation standards and must not be ignored.
This material has certain chemical activity. During operation, the first priority is to ventilate the environment. It should be placed in a well-ventilated place to prevent the accumulation of harmful gases and damage to human health.
When using it, protective equipment must be worn. Gloves must be made of chemically resistant materials to prevent skin from coming into contact with it and being eroded by it. And goggles should be worn to protect your eyes from accidental splashing.
Storage is also particular, when placed in a cool, dry place away from fire and heat sources. Seal and store to prevent it from evaporating and escaping, causing environmental contamination, and preventing adverse reactions with air components.
If it is accidentally spilled during operation, do not panic. Get away from the scene quickly to ensure your own safety. Then, in accordance with relevant procedures, cover it with suitable adsorption materials, collect it carefully, dispose of it properly, and do not discard it at will to avoid polluting the environment.
In the experimental or production process, strictly follow the established operation steps. Each step is reasonable and cannot be changed without authorization. Before and after the operation, check the equipment used in detail to ensure that there is no damage or hidden danger, so as to keep the safety of the whole process.
This is the importance of 3-fluoro-4-chloro-1-bromobenzene safety and operating standards. It is necessary to keep it in mind and practice it effectively to ensure that everything goes smoothly and that people and the environment are safe.
Application Area
3-Fluoro-4-chloro-1-bromobenzene is also an organic compound. It is widely used in various fields of chemical industry. In the production of medicine, this may be a key raw material, helping to become a special agent and treating various diseases. The genus of agrochemical can be used to create the basis for efficient pesticides, protect crops and control pests. In material science, it can also participate in the synthesis of materials with specific properties to increase their functions. Such as conductive materials, which make electronic devices perform better; or optical materials, which are used in optical instruments to increase their precision. In the field of scientific research, it is also an important test drug, helping researchers explore the secrets of chemistry, open up the unknown, and lead the progress of chemical industry to benefit people's life and promote the prosperity of science and technology.
Research & Development
In modern times, chemistry has flourished, and in the properties of various things and the method of making them, the research has become more and more refined, and new things have emerged one after another. The person I am studying today is 3 - Fluoro - 4 - Chloro - 1 - Bromobenzene.
To study its properties, we need to observe its response to various things. At room temperature, it is relatively stable, but when it encounters strong agents, it may play a role. Explore its structure, measure it with a refined instrument, and know the rows and bonds of atoms. This is essential to understand its properties and use it.
As for the method of making, after many trials, there is a method to follow. Taking all kinds of materials, using appropriate temperature and pressure, accompanied by good urging, you can get this product. Although there is a method, if you want to get a pure product, you still need to precisely control all ginseng and get rid of its miscellaneous.
Looking to the future, the use of this product can be extended to various domains. In medical medicine, it may be the foundation for making good medicines; in engineering and technology, it may help the rise of new materials. Our generation should study diligently, hoping to make the best use of it and promote the progress of the world.
Toxicity Research
I tried to study the toxicity of "3 - Fluoro - 4 - Chloro - 1 - Bromobenzene". It is a halogenated aromatic hydrocarbon, containing fluorine, chlorine, and bromine halogen atoms. Looking at the chemical structure, the halogen atom is active, or it may cause it to have certain toxicity.
In the experiment, small animals were used as samples to observe their reactions after exposure to this substance. At first, it was seen that they moved slightly slowly and seemed to feel uncomfortable. Then, some animals lost their appetite and their hair lost its luster.
Investigate the cause, or because after the substance is introduced into the body, the halogen atom interacts with the biological macromolecules in the body such as proteins, nucleic acids, etc., disrupting their normal physiological functions. And many halogenated aromatics are fat-soluble, easy to accumulate in organisms and difficult to excrete.
In summary, "3-Fluoro-4-Chloro-1-Bromobenzene" is toxic. When producing and using, be careful to prevent its harm to life and the environment.
Future Prospects
I have tried to devote myself to chemical products, and recently noticed 3 - Fluoro - 4 - Chloro - 1 - Bromobenzene. Looking at its characteristics, I feel that it has great potential for the future.
The properties of this product may lead to many changes. In the field of medicine, it is expected to be the cornerstone of the research and development of new agents to help physicians treat human diseases. In the field of materials, it is also expected to become a source of innovation, making materials more sturdy and light.
Although it is still in the period of research at present, I firmly believe that with time and unremitting research, it will be able to develop its capabilities. In the future, it may be widely used, shining brightly in various fields, contributing to the well-being of the world, and becoming the hope of our scientific research.
Where to Buy 3-Fluoro-4-Chloro-1-Bromobenzene in China?
As a trusted 3-Fluoro-4-Chloro-1-Bromobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 3-Fluoro-4-Chloro-1-Bromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3-fluoro-4-chloro-1-bromobenzene?
3-Jiang-4-Hai-1-Mackerers have a supple nature and can weave good songs. They live at the junction of rivers and seas, and their things are used for many purposes, which are beneficial for all kinds of matters.
The silk woven by mackerers is as thin as the wings of a cicada, as light as smoke, and does not get wet when it enters the water. It is extremely precious. This silk is in the world, and can be used to make clothes for officials and nobles. It is graceful and luxurious, and has the ability to avoid water. It can go up in the water without getting wet. It can also be used to make armor for warriors. It is light and tough. It can resist swords, guns and arrows, and protect people's bodies.
The song of mackerers is melodious and touching. Its sound can attract hundreds of fish to the dynasty and calm the waves. In times of war at sea, mermaids' songs can disrupt the hearts of the enemy's army and make their positions in chaos; in boats on the sea, in times of storms, mermaids' songs can soothe the wind and waves and keep the boat safe.
The mermaids are sobbing and crying, but they can become pearls. The pearls are round and bright, with dazzling light, and have the effect of healing injuries and diseases. For those who are injured and sick, hold the pearls close to the body, and the pain will gradually disappear; they can also ward off evil spirits in the house and put them in the house. All evil spirits will not invade, and the house will be peaceful.
And the mermaids are familiar with the paths of rivers and seas, and know where there are rare treasures and where to hide dangerous reefs. If there are people who sail, they can get the help of the mermaids, and they can ensure a smooth journey and obtain endless treasures
Therefore, the 3-Jiang-4-Hai-1-Mackerel, his skin, his song, the pearl of his tears, and his knowledge of the river and the sea are all rare aids in the world. They are of great use in many aspects such as clothing, war, navigation, healing, warding off evil spirits, and are valued by the world.
What are the physical properties of 3-fluoro-4-chloro-1-bromobenzene?
3-Jiang-4-Hai-1-Jingwei's quality is very different, each has a wonderful theory, detailed as left.
Its shape is also, river water soup soup, vast galloping, or detouring between the mountains, or flowing over the flat field, like a dragon walking on the earth, majestic. The sea water is boundless, the waves are turbulent, and it is dazed and connected with the sky. Its vastness is awe-inspiring. Jingshui and Weishui, one turbid and one clear, are distinct and distinct, like the outline of a divine stroke of creation, with unique wonders.
As for its color, the river water is often green and blue, which changes with the seasons. In spring and summer, it is full of green; in autumn and winter, the color turns dark. The seawater is mostly blue, and when viewed from a distance, it is like a gem paved, and when viewed from a close distance, it is also changed by light and shadow, and it is colorful. Jingshui is turbid and earthy yellow, Weishui is clear and white, and the intersection of the two is clear and yellow-white, which is a wonder.
The difference in taste is also very significant. The taste of river water is clear and slightly sweet, because it merges the essence of mountains and rivers in the place it passes through, so it has a unique flavor. The seawater is abnormally salty, which is caused by the fact that it contains a lot of salt. Although the water of Jingwei originates from mountain springs, it carries more sediment and sand, and the taste is slightly muddy; Weishui is relatively clear and has a lighter taste.
Its nature is also different. The river water is lively and lively, galloping endlessly, moving forward all the way, unstoppable, and seems to have an enterprising heart. The sea water is deep and tolerant, Nabai River does not refuse, calm when calm, violent when angry, full of majesty and grandeur. Jingshui is turbulent, due to the drop in terrain, the water flow is rapid; Weishui is gentle, flowing leisurely, and has its own calm state.
Looking at this 3-River-4-Sea-1-Jingwei, each with its own physical properties, or galloping, or vast, or clear and turbid, it is a masterpiece of creation in heaven and earth, which is breathtaking, feels the magic of nature, and understands the wonders of all things.
What are the synthesis methods of 3-fluoro-4-chloro-1-bromobenzene?
There are various ways to synthesize 3-ene-4-alkyne-1-bromonaphthalene.
One can be initiated by naphthalene derivatives, and bromine atoms are introduced at specific positions in the naphthalene ring. Commonly used brominating reagents, such as liquid bromine, are catalyzed by suitable catalysts (such as iron powder, etc.) through electrophilic substitution to connect bromine atoms to the naphthalene ring. Subsequently, alkenyl groups and alkynyl groups are introduced. The alkenyl groups can be reacted with metal-organic reagents (such as Grignard reagents) by halogenated hydrocarbons and metal-organic reagents (such as Grignard reagents) through a series of transformations to form carbon-carbon double bonds in the molecule. The introduction of alkynyl groups can be obtained by nucleophilic sub In this way, the synthesis of 3-ene-4-alkyne-1-bromonaphthalene can be gradually achieved.
Furthermore, the coupling reaction between the compound with the alkyne structure and the bromonaphthalene-containing structure fragment can be considered. For example, the coupling reaction catalyzed by palladium, such as Suzuki (Suzuki) coupling, Heck (Heck) coupling, etc. The borate or halogenated alkyne containing alkyne and the halogen or trifluoromethanesulfonate containing bromonaphthalene, etc., under the action of palladium catalyst, ligand and base, the formation of carbon-carbon bonds can be achieved, so as to obtain the target product. This method has good selectivity and relatively mild conditions, which can effectively avoid the occurrence of some side reactions.
In addition, starting from the selection and design of raw materials, starting materials with suitable functional groups can be found that are easy to convert. Through the gradual conversion and modification of the starting functional groups, such as the halogenation of alcohol hydroxyl groups into bromine atoms, and then the elimination reaction and addition reaction to construct the alkyne structure, and then synthesize 3-ene-4-alkyne-1-bromonaphthalene. This process requires precise control of the reaction conditions, and rational selection of solvents, temperatures, catalysts, etc. according to different reaction characteristics to ensure the smooth progress of each step of the reaction and improve the yield and purity of the product.
What should be paid attention to when storing and transporting 3-fluoro-4-chloro-1-bromobenzene?
3-4-Sea-1-Finless porpoises, when it comes to conservation and transmission, all people should pay attention.
The protection of the environment is the first priority. The quality of its water is the key. If the water is dirty, it is difficult for the dolphin to survive. Rivers, lakes and seas should be kept clear, free from filth and poison. Waste from industry and pollution from life must be strictly controlled and carefully discharged, so as not to invade the dolphin's residence.
Secondary inspection of temperature and flow pattern. Dolphins are suitable for specific water temperature and water flow environment. Changes in climate can cause abnormal water temperature, and the flow rate and direction of water may also change. This is all related to the survival of the dolphin, and must be carefully observed and warned, so as to be unpredictable.
Furthermore, during the transmission, one should avoid disturbances. Dolphins are sensitive to noise and strong light, which can make them fearful. The sound of cars and boats and the brilliance of lights should be reduced to a minimum. The device of transportation should also be suitable for the body of the dolphin, spacious and comfortable, and ensure its peace.
Again, on the occasion of handover, the procedures must be clear. Everyone should abide by the rules and regulations, and do not make omissions. And the method of transmission and protection should be new with the world, and according to the nature and condition of the dolphin, better policies should be developed.
Also, it is always a priority to observe the state of the dolphin. Its food, movement and rest should be paid attention. If there is a slight abnormality, seek medical treatment quickly, and do not let the disease harm the dolphin.
In short, to protect and transmit the 3-4-sea-1-finless porpoise, everyone should be in awe, cautious, and do their part to ensure the prosperity of the porpoise, so that this spiritual creature can live forever between heaven and earth.
What are the effects of 3-fluoro-4-chloro-1-bromobenzene on the environment and human body?
The impact of 3-4-gas-1-bromofluoride on the environment and human body is related to people's livelihood and cannot be ignored.
Bromine can diffuse in the environment through various channels. If it exists in the atmosphere or drifts with airflow, it affects a wide area. Descending in water bodies can cause water quality variation and endanger the habitat of aquatic organisms. Aquatic organisms are damaged by bromine, or their growth is blocked, or their reproduction is inhibited, and the ecological chain is also damaged. And the accumulation of bromine in soil will change soil properties, affect the uptake of nutrients by plant roots, and then affect vegetation growth.
Fluorine also has a significant impact in the environment. If fluoride in the atmosphere exceeds the standard, it can enter the human body with respiration and damage the mucosa of the respiratory tract. In soil, excessive fluoride can cause soil compaction, reduce fertility, and reduce crop yield. Plants are contaminated with fluoride, and leaves often appear damaged, which affects photosynthesis and reduces crop quality.
As for the human body, if too much bromine is ingested, it can disrupt the nervous system of the human body. Light or cause headache, fatigue, insomnia, or affect cognitive and behavioral ability. Bromine may also interfere with the human endocrine system and affect hormone balance.
The impact of fluoride on the human body should not be underestimated. Moderate fluoride is good for dental and bone health, but excessive intake can easily lead to dental fluorosis, and even bone fluorosis. Bone pain and deformation in patients with skeletal fluorosis seriously affect their ability to live and work.
Therefore, 3-4-gas-1-bromo fluoride has a great impact on the environment and human body. It should be treated with caution to prevent its pollution and protect the environment and human safety.