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What are the main uses of 3-Fluoro-2-Methylbenzeneboronic Acid?
3-Fluoro-2-methylphenylboronic acid has a wide range of uses. In the field of organic synthesis, it is often a key reagent for building carbon-carbon bonds. Gein-phenylboronic acids can participate in many important chemical reactions, such as the Suzuki coupling reaction. In this reaction, 3-fluoro-2-methylboronic acid can form new carbon-carbon bonds with halogenated aromatics or olefins under palladium-catalyzed conditions and in the presence of bases, thereby synthesizing organic molecules with diverse structures. This is of great significance for the field of medicinal chemistry. With the help of such reactions, chemists can follow design ideas to connect different structural units to create new drug molecules with specific activities.
In the field of materials science, it also has important functions. Organic conjugated molecules synthesized by Suzuki coupling reaction may have unique photoelectric properties. Such materials may be applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells. The molecular structure constructed by 3-fluoro-2-methylphenylboronic acid can regulate the electronic transport and fluorescence emission of materials, thereby improving the performance of optoelectronic devices.
In addition, in agricultural chemistry, some compounds based on phenylboronic acid structure exhibit certain biological activities. or can be used as the lead structure of new pesticides or plant growth regulators. 3-Fluoro-2-methylphenylboronic acid is helpful for the development of more efficient and environmentally friendly agricultural chemicals due to the existence of its own fluorine atoms and methyl groups, or the unique biological activities and physicochemical properties of the derived compounds.
What are the physical properties of 3-Fluoro-2-Methylbenzeneboronic Acid?
3-Fluoro-2-methylphenylboronic acid is an important reagent commonly used in the field of organic synthesis. Its physical properties are quite characteristic. Looking at its appearance, it is often white to light yellow solid, which is easy to store and use. As far as the melting point is concerned, it is between 138-142 ° C. This specific melting point provides an important basis for the identification of its purity and the control of related reaction conditions.
The solubility of this substance is also regular. In common organic solvents, such as ether, tetrahydrofuran, etc., it has good solubility. This property allows it to fully contact and mix with other reactants in many organic reaction systems, thus promoting the efficient progress of the reaction. In water, its solubility is relatively limited. However, by moderately adjusting the pH of the system and other conditions, its solubility in water can be fine-tuned to meet specific reaction requirements.
From the perspective of stability, 3-fluoro-2-methylphenylboronic acid can remain relatively stable under conventional environmental conditions. However, it should be noted that it is more sensitive to humidity and prone to hydrolysis and other reactions after moisture, resulting in structural changes and reduced activity. Therefore, it is necessary to ensure a dry environment when storing. It is usually recommended to store it in a dryer to maintain its quality and performance. In addition, high temperatures and strong oxidants can also pose a threat to its stability, and contact with such substances should be avoided.
What is the synthesis method of 3-Fluoro-2-Methylbenzeneboronic Acid?
The most common method for preparing 3-fluoro-2-methylphenylboronic acid is to use 3-fluoro-2-methylbromobenzene as the starting material. First, 3-fluoro-2-methylbromobenzene is reacted with strong base reagents such as n-butyllithium under low temperature and a protective gas such as nitrogen. The n-butyllithium undergoes a lithium-halogen exchange reaction with the bromine atom to form the corresponding aryl lithium reagent. This aryl lithium reagent is highly active, and then borates are added, such as trimethyl borate. The aryl lithium reagent will carry out nucleophilic attack on trimethyl borate, forming an intermediate product. After the reaction is completed, the intermediate product can be converted into the target product 3-fluoro-2-methylphenylboronic acid through the hydrolysis step, usually treated with a dilute acid solution. Finally, the pure 3-fluoro-2-methylphenylboronic acid is obtained by separation and purification methods such as extraction and column chromatography.
Another method can use the coupling reaction catalyzed by transition metals. The reaction of 3-fluoro-2-methylhalobenzene (the halogen atom can be chlorine, bromine or iodine) and diphenylboronyl alcohol borate as raw materials is carried out in a suitable solvent in the presence of transition metal catalysts and ligands such as palladium. The ligand can assist the stable existence of the metal catalyst and enhance its catalytic activity. During the reaction, halogenated benzene is coupled with diphenacol borate to form the corresponding borate ester derivative. Subsequent hydrolysis steps can also obtain 3-fluoro-2-methylphenylboronic acid, which also needs to be separated and purified to achieve high purity.
3-Fluoro-2-Methylbenzeneboronic precautions when storing Acid
3-Fluoro-2-methylphenylboronic acid is a commonly used reagent in organic synthesis. When storing this substance, many things need to be paid attention to.
Bear the brunt, the temperature of the storage environment is very important. It should be placed in a cool place, and the temperature should be maintained between 2-8 ° C. This is due to excessive temperature, or the decomposition and deterioration of the substance, which will damage its chemical properties and purity, and then affect the subsequent use effect.
Furthermore, the humidity cannot be ignored. It is necessary to ensure that the storage environment is dry to avoid moisture. Because it has a certain degree of hygroscopicity, if the environmental humidity is high, it is easy to absorb water and affect the quality, or even cause chemical reactions, resulting in its failure.
Third, the substance is sensitive to air, especially to prevent it from being in contact with oxygen for a long time. Therefore, when storing, a well-sealed container should be used, such as a sealed glass bottle or a plastic bottle with a sealing gasket, etc., to minimize contact with air to prevent oxidation and other reactions.
In addition, the storage place must be kept away from fire sources, heat sources and strong oxidants. 3-Fluoro-2-methylphenylboronic acid in case of open flame, hot topic or contact with strong oxidants, there is a risk of combustion and explosion, which not only endangers storage safety, but also causes serious harm to surrounding personnel and the environment in the event of an accident. When storing 3-fluoro-2-methylphenylboronic acid, careful attention should be paid to factors such as temperature, humidity, air and surrounding environment, so as to ensure the quality and stability of the substance and achieve the desired effect when used.
3-Fluoro-2-Methylbenzeneboronic the market price of Acid
The market price of 3-fluoro-2-methylphenylboronic acid is difficult to determine quickly.
First, the trend of supply and demand is the key. If there are many people who want it, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop automatically. For example, if at some point, many pharmaceutical companies develop new drugs and need this material as a raw material, such as crucian carp, the price will rise.
Second, the production cost also has a significant impact. The price of raw materials, the simplicity of the production process, and the amount of energy consumption are all related to costs. If the raw materials are scarce and expensive, or the production process is complex and requires a lot of manpower and material resources, the cost will be high, and the price in the market will also be high.
Third, the state of competition should not be underestimated. The number of merchants producing this product in the market, whether the competition is fierce or not, is related to pricing. If there are many merchants and the competition is fierce, each merchant will compete for a share, or reduce the price to attract customers; if the market is almost monopolized, the pricing power is in the hands of a few, and the price may be high.
Fourth, external factors such as policies and regulations, and the international trade situation can also affect prices. For example, tariff adjustments and stricter environmental protection policies may increase costs and supply changes, which in turn affect prices.
Therefore, to know the exact market price, you need to often look at the chemical product trading platform, consult suppliers, or check industry reports to get a more accurate price. However, at this moment, it is difficult to determine the exact market price with a few words.