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3-Fluoro-2-Methylbenzeneboronic Acid

3-Fluoro-2-Methylbenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

240074

Chemical Formula C7H8BO3F
Molar Mass 169.95 g/mol
Appearance White to off - white solid
Melting Point 143 - 147 °C
Solubility In Water Slightly soluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
Pka Around 8 - 9
Boiling Point Decomposes before boiling
Density Approx. 1.3 g/cm³
Stability Stable under normal conditions, but moisture - sensitive

As an accredited 3-Fluoro-2-Methylbenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 10 grams of 3 - fluoro - 2 - methylbenzeneboronic acid packaged in a sealed vial.
Storage 3 - Fluoro - 2 - methylbenzeneboronic acid should be stored in a cool, dry place, away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption, as boronic acids can react with water. Store separately from oxidizing agents and incompatible substances to avoid potential chemical reactions. Ensure proper labeling for easy identification.
Shipping 3 - Fluoro - 2 - methylbenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring proper handling to prevent spills and maintain product integrity during transit.
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3-Fluoro-2-Methylbenzeneboronic Acid 3-Fluoro-2-Methylbenzeneboronic Acid
General Information
Historical Development
3-Fluoro-2-methylphenylboronic acid, the development of this substance has gone through years. At the beginning, the chemical masters studied and explored, and in the field of organic synthesis, they gradually realized its properties. In the past, the synthesis method was still simple, and the yield was not abundant. However, many wise men worked tirelessly and worked hard for many years to improve the process. Or change the conditions of the reaction, or choose a better reagent. Today, the synthesis technique is becoming more and more exquisite, and the yield has also increased significantly. This compound has emerged in many fields such as pharmaceutical research and development, material creation, and its function is gradually emerging. Its historical evolution, like a long river rushing, started from the end of the micro, and finally became today's grand view, adding a wonderful flower to the garden of chemistry, benefiting many disciplines, and contributing to the progress of science and technology.
Product Overview
3-Fluoro-2-methylphenylboronic acid is also an organic compound. Its shape or white powder is relatively stable in nature. This compound is widely used in the field of organic synthesis. It is often used as a coupling reaction reagent. It can react with halogenated aromatics, olefins, etc. to form carbon-carbon bonds and help synthesize many complex organic molecules. Because it contains boron, fluorine and other atoms, it is endowed with unique electronic properties and reactivity. The synthesis method is either obtained by the reaction of Grignard reagent with borate ester, or prepared by other specific organic synthesis paths. The study of this compound has potential significance in the development of new drugs, materials science, and many other aspects, and is expected to promote the progress and development of related fields.
Physical & Chemical Properties
The physicochemical properties of 3-fluoro-2-methylphenylboronic acid are particularly critical. Looking at its morphology, at room temperature, it is mostly white to white crystalline powder, which is an intuitively observable physical property. Its melting point, after fine determination, is about a specific range. This value is crucial in the identification and purification process.
Talking about chemical properties, the substance contains boron atoms, which makes it have a certain reactivity. In the field of organic synthesis, it can be used as a key intermediate to couple and react with many electrophilic reagents. The presence of fluorine atoms and methyl groups affects the distribution of molecular electron clouds, resulting in its unique reactivity and selectivity. These various physical and chemical properties lay an important foundation for their application in chemical research and industrial production.
Technical Specifications & Labeling
Today there is a product called 3 - Fluoro - 2 - Methylbenzeneboronic Acid. Its process specifications and identification (product parameters) are the key. The preparation of this product requires precise process procedures. From the selection of raw materials, it is necessary to be pure and free of impurities. The quality of its quality is related to the quality of the finished product.
In the reaction process, temperature, duration, and reagent ratio are all key. If the temperature is high, the reaction will be too fast, or the product will be impure; if the temperature is low, the reaction will be slow and time-consuming. The control of the time should not be neglected. If the time is not reached, the reaction will not be completed, and the product will be difficult to form; if it is too late, side reactions may occur, which will damage its quality. On the
logo, detailed product parameters, such as purity geometry, impurity geometry, and physical properties, need to be clear. This is the product's identity certificate, which shows the quality of the product for the user to inspect, in order to suit its use, in line with the essence of the process specifications and labels.
Preparation Method
This product is made of 3-Fluoro-2-Methylbenzeneboronic Acid. The raw materials and production process, reaction steps, and catalytic mechanism are the key.
First take fluoro-o-xylene as the raw material, with an appropriate amount of borate ester, according to a certain proportion, into the clean reactor. Using palladium compounds as catalysts, under an inert gas atmosphere, the temperature is controlled by about 120 to 150 degrees Celsius, which is the precise control of the heat in the ancient recipe. When the number of reactions is numbered, the reaction state is closely observed, such as the ancient alchemist paying attention to the changes in the furnace.
After the reaction is completed, extract it with an organic solvent, and then separate and purify it by distillation. This step imitates the ancient method of purifying medicinal pills, removing its impurities and leaving its essence. The final product is pure 3-Fluoro-2-Methylbenzeneboronic Acid, whose catalytic mechanism is palladium catalyst to activate the raw material, promote the rearrangement and combination of its chemical bonds, just like the ancient recipe with spirit catalysis, into its magic pill. The whole process is rigorous and orderly, in order to make a good product.
Chemical Reactions & Modifications
There is now a chemical thing, named 3 - Fluoro - 2 - Methylbenzeneboronic Acid. In the field of chemical research, its reaction and modification are crucial.
To observe its chemical properties, we want to change its quality and optimize the reaction process. In the past, we were good at chemistry, and we studied it diligently to understand the law of material reaction. The same is true for this thing today.
To make its reaction better, we may need to adjust the temperature of its environment and control the amount of its reactants to explore the optimal situation. As for modification, we must observe the structure of its molecules, think about the connection of its atoms, or add or subtract, and hope to obtain new quality.
In the field of research, we must be rigorous and consistent, and use scientific methods to seek the wonders of reaction and modification, so as to contribute to the progress of chemistry and make progress in the future.
Synonyms & Product Names
3-Fluoro-2-methylphenylboronic acid is unique and useful in the field of our chemical research. Its synonymous name is also the main point of investigation. Although it is called "3-fluoro-2-methylphenylboronic acid", it may have other names in the world.
Looking at the past, the names of chemical substances often vary from time to place. Or according to its structure, production method, or according to the person who discovered it, the way it was used, and get different names. In this product, its synonymous name may help us better clarify its essence and origin.
And the name of the product is also an important sign. Different companies sell this product, and its product name may be different. This is not only related to the business logo, but also related to the characteristics and quality of the product. Seeking its synonymous name and trade name is still a way to explore, and it can pass through the deep forest of chemical knowledge, which is beneficial to research and application.
Safety & Operational Standards
3-Fluoro-2-methylphenylboronic acid is of paramount importance due to its safety and operating standards. In the field of experiment, specific rules should be followed.
First words Store, when placed in a cool, dry and well-ventilated place. Keep away from fire and heat sources to prevent accidents. Its chemical activity is active and easy to react with many substances, so it must be isolated from oxidizing agents, acids, alkalis, etc., and must not be mixed to avoid danger.
When operating, the experimenter must wear appropriate protective equipment. Wear protective clothing, protective gloves, and goggles are also indispensable to prevent them from touching the skin, eyes, and harming the body. The operation should be carried out in the fume hood to ensure air circulation and avoid the accumulation of harmful gases.
When taking it, the action must be gentle and precise. According to the required dosage of the experiment, use the appropriate equipment. Do not take more waste, and do not take less and miss the experiment. When weighing, use a precise balance to ensure that the dosage is correct.
If it accidentally touches the skin, rinse it with a large amount of flowing water as soon as possible. The rinsing time should be long to remove its residue. If it enters the eye, it is even more urgent to rinse it with a large amount of water, and then seek medical treatment. Do not delay.
After the experiment is completed, do not discard the residue at will. According to relevant regulations, collect it in categories and dispose of it properly to avoid polluting the environment. The utensils used should also be cleaned in time to ensure cleanliness for next use.
In short, in the use of 3-fluoro-2-methylphenylboronic acid, safety and standards should be kept in mind at all times to ensure the smooth operation of the experiment and the safety of personnel and the environment.
Application Area
3-Fluoro-2-methylphenylboronic acid has a wide range of application fields. In the process of pharmaceutical synthesis, it can be a key intermediate to help create new medicines, cure various diseases, and save the world. In the field of material chemistry, through specific reactions, materials with special properties can be prepared, or with excellent optical and electrical properties, used in high-tech products. In the field of organic synthesis, it is like a magic wand, which helps to construct complex organic molecules and expand the boundaries of organic chemistry. Just like the ancient talents, they can display their talents in different situations, contribute to various fields, promote their progress and development, and make this chemical substance shine in many application fields and play a crucial role.
Research & Development
In recent years, in the field of organic synthesis, this compound of 3 - Fluoro - 2 - Methylbenzeneboronic Acid has gradually attracted the attention of our chemical researchers. It has a unique structure and has extraordinary performance in many reactions, so it is of great significance to explore its research and development.
Initially, the synthesis of this compound was complicated and the yield was low. However, the researchers are determined to repeatedly test and improve the method. After unremitting efforts to optimize the reaction conditions, such as selecting suitable solvents and catalysts, and controlling the precise temperature, the yield gradually rises and the purity reaches a higher level.
Today, 3 - Fluoro - 2 - Methylbenzeneboronic Acid is widely used in medicine, materials and other fields. We must continue to study its potential and expand the scope of application, so as to contribute to the development of chemistry and promote it to new heights.
Toxicity Research
I try to study the toxicity of 3 - Fluoro - 2 - Methylbenzeneboronic Acid. Looking at the structure of its molecules, boron and fluorine are both indispensable parts of chemistry. Boron, in biological systems, is beneficial in moderation, and toxic in excess. The same is true of fluorine. Although it is beneficial to the health of human teeth and bones, it is harmful if it is overdone.
Study this substance and test its toxicity by various methods. In cell experiments, observe its effect on cells, and see that it may cause cell growth to be hindered and morphological changes. In animal experiments, observe its effect on animal physiology, such as changes in body weight and organs.
In summary, 3 - Fluoro - 2 - Methylbenzeneboronic Acid has certain toxicity, and when using and producing, we should be careful to prevent its harm to organisms and the environment, so that safety is the first priority, not lightly.
Future Prospects
I try to research 3 - Fluoro - 2 - Methylbenzeneboronic Acid. It has great potential in the field of organic synthesis. Looking at the development of chemistry today, new technologies have emerged, and this compound may be able to shine on the road of new drug research and development. With advanced synthesis methods, it may be able to be precisely prepared to improve yield and purity. In the future, it may be cleverly compatible with other things to give birth to special drugs and solve patients' diseases. Or in the field of materials science, emerge and contribute to the creation of new materials. With time and advanced technology, its application will be more far-reaching, and the prospect will be shining, which is promising.
Where to Buy 3-Fluoro-2-Methylbenzeneboronic Acid in China?
As a trusted 3-Fluoro-2-Methylbenzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 3-Fluoro-2-Methylbenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3-Fluoro-2-Methylbenzeneboronic Acid?
3-Fluoro-2-methylphenylboronic acid has a wide range of uses. In the field of organic synthesis, it is often a key reagent for building carbon-carbon bonds. Gein-phenylboronic acids can participate in many important chemical reactions, such as the Suzuki coupling reaction. In this reaction, 3-fluoro-2-methylboronic acid can form new carbon-carbon bonds with halogenated aromatics or olefins under palladium-catalyzed conditions and in the presence of bases, thereby synthesizing organic molecules with diverse structures. This is of great significance for the field of medicinal chemistry. With the help of such reactions, chemists can follow design ideas to connect different structural units to create new drug molecules with specific activities.
In the field of materials science, it also has important functions. Organic conjugated molecules synthesized by Suzuki coupling reaction may have unique photoelectric properties. Such materials may be applied to optoelectronic devices such as organic Light Emitting Diodes (OLEDs) and organic solar cells. The molecular structure constructed by 3-fluoro-2-methylphenylboronic acid can regulate the electronic transport and fluorescence emission of materials, thereby improving the performance of optoelectronic devices.
In addition, in agricultural chemistry, some compounds based on phenylboronic acid structure exhibit certain biological activities. or can be used as the lead structure of new pesticides or plant growth regulators. 3-Fluoro-2-methylphenylboronic acid is helpful for the development of more efficient and environmentally friendly agricultural chemicals due to the existence of its own fluorine atoms and methyl groups, or the unique biological activities and physicochemical properties of the derived compounds.
What are the physical properties of 3-Fluoro-2-Methylbenzeneboronic Acid?
3-Fluoro-2-methylphenylboronic acid is an important reagent commonly used in the field of organic synthesis. Its physical properties are quite characteristic. Looking at its appearance, it is often white to light yellow solid, which is easy to store and use. As far as the melting point is concerned, it is between 138-142 ° C. This specific melting point provides an important basis for the identification of its purity and the control of related reaction conditions.
The solubility of this substance is also regular. In common organic solvents, such as ether, tetrahydrofuran, etc., it has good solubility. This property allows it to fully contact and mix with other reactants in many organic reaction systems, thus promoting the efficient progress of the reaction. In water, its solubility is relatively limited. However, by moderately adjusting the pH of the system and other conditions, its solubility in water can be fine-tuned to meet specific reaction requirements.
From the perspective of stability, 3-fluoro-2-methylphenylboronic acid can remain relatively stable under conventional environmental conditions. However, it should be noted that it is more sensitive to humidity and prone to hydrolysis and other reactions after moisture, resulting in structural changes and reduced activity. Therefore, it is necessary to ensure a dry environment when storing. It is usually recommended to store it in a dryer to maintain its quality and performance. In addition, high temperatures and strong oxidants can also pose a threat to its stability, and contact with such substances should be avoided.
What is the synthesis method of 3-Fluoro-2-Methylbenzeneboronic Acid?
The most common method for preparing 3-fluoro-2-methylphenylboronic acid is to use 3-fluoro-2-methylbromobenzene as the starting material. First, 3-fluoro-2-methylbromobenzene is reacted with strong base reagents such as n-butyllithium under low temperature and a protective gas such as nitrogen. The n-butyllithium undergoes a lithium-halogen exchange reaction with the bromine atom to form the corresponding aryl lithium reagent. This aryl lithium reagent is highly active, and then borates are added, such as trimethyl borate. The aryl lithium reagent will carry out nucleophilic attack on trimethyl borate, forming an intermediate product. After the reaction is completed, the intermediate product can be converted into the target product 3-fluoro-2-methylphenylboronic acid through the hydrolysis step, usually treated with a dilute acid solution. Finally, the pure 3-fluoro-2-methylphenylboronic acid is obtained by separation and purification methods such as extraction and column chromatography.
Another method can use the coupling reaction catalyzed by transition metals. The reaction of 3-fluoro-2-methylhalobenzene (the halogen atom can be chlorine, bromine or iodine) and diphenylboronyl alcohol borate as raw materials is carried out in a suitable solvent in the presence of transition metal catalysts and ligands such as palladium. The ligand can assist the stable existence of the metal catalyst and enhance its catalytic activity. During the reaction, halogenated benzene is coupled with diphenacol borate to form the corresponding borate ester derivative. Subsequent hydrolysis steps can also obtain 3-fluoro-2-methylphenylboronic acid, which also needs to be separated and purified to achieve high purity.
3-Fluoro-2-Methylbenzeneboronic precautions when storing Acid
3-Fluoro-2-methylphenylboronic acid is a commonly used reagent in organic synthesis. When storing this substance, many things need to be paid attention to.
Bear the brunt, the temperature of the storage environment is very important. It should be placed in a cool place, and the temperature should be maintained between 2-8 ° C. This is due to excessive temperature, or the decomposition and deterioration of the substance, which will damage its chemical properties and purity, and then affect the subsequent use effect.
Furthermore, the humidity cannot be ignored. It is necessary to ensure that the storage environment is dry to avoid moisture. Because it has a certain degree of hygroscopicity, if the environmental humidity is high, it is easy to absorb water and affect the quality, or even cause chemical reactions, resulting in its failure.
Third, the substance is sensitive to air, especially to prevent it from being in contact with oxygen for a long time. Therefore, when storing, a well-sealed container should be used, such as a sealed glass bottle or a plastic bottle with a sealing gasket, etc., to minimize contact with air to prevent oxidation and other reactions.
In addition, the storage place must be kept away from fire sources, heat sources and strong oxidants. 3-Fluoro-2-methylphenylboronic acid in case of open flame, hot topic or contact with strong oxidants, there is a risk of combustion and explosion, which not only endangers storage safety, but also causes serious harm to surrounding personnel and the environment in the event of an accident. When storing 3-fluoro-2-methylphenylboronic acid, careful attention should be paid to factors such as temperature, humidity, air and surrounding environment, so as to ensure the quality and stability of the substance and achieve the desired effect when used.
3-Fluoro-2-Methylbenzeneboronic the market price of Acid
The market price of 3-fluoro-2-methylphenylboronic acid is difficult to determine quickly.
First, the trend of supply and demand is the key. If there are many people who want it, but the supply is small, the price will rise; on the contrary, if the supply exceeds the demand, the price will drop automatically. For example, if at some point, many pharmaceutical companies develop new drugs and need this material as a raw material, such as crucian carp, the price will rise.
Second, the production cost also has a significant impact. The price of raw materials, the simplicity of the production process, and the amount of energy consumption are all related to costs. If the raw materials are scarce and expensive, or the production process is complex and requires a lot of manpower and material resources, the cost will be high, and the price in the market will also be high.
Third, the state of competition should not be underestimated. The number of merchants producing this product in the market, whether the competition is fierce or not, is related to pricing. If there are many merchants and the competition is fierce, each merchant will compete for a share, or reduce the price to attract customers; if the market is almost monopolized, the pricing power is in the hands of a few, and the price may be high.
Fourth, external factors such as policies and regulations, and the international trade situation can also affect prices. For example, tariff adjustments and stricter environmental protection policies may increase costs and supply changes, which in turn affect prices.
Therefore, to know the exact market price, you need to often look at the chemical product trading platform, consult suppliers, or check industry reports to get a more accurate price. However, at this moment, it is difficult to determine the exact market price with a few words.