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3-(Difluoromethoxy)Nitrobenzene

3-(Difluoromethoxy)Nitrobenzene

Hongda Chemical

Specifications

HS Code

561674

Chemical Formula C7H5F2NO3
Appearance Typically a liquid
Boiling Point Data needed
Melting Point Data needed
Density Data needed
Solubility In Water Poor solubility (organic nature)
Solubility In Organic Solvents Soluble in common organic solvents
Vapor Pressure Data needed
Flash Point Data needed
Stability Stable under normal conditions
Hazard Class May be a hazardous chemical, data on specific hazards needed

As an accredited 3-(Difluoromethoxy)Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 kg of 3-(difluoromethoxy)nitrobenzene packaged in a sealed, corrosion - resistant container.
Storage 3-(Difluoromethoxy)nitrobenzene should be stored in a cool, dry, well - ventilated area away from heat sources, ignition sources, and oxidizing agents. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from incompatible substances to prevent chemical reactions. Regularly check for any signs of leakage or deterioration.
Shipping 3-(Difluoromethoxy)nitrobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict chemical transportation regulations, ensuring proper handling to prevent leakage and maintain safety during transit.
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3-(Difluoromethoxy)Nitrobenzene 3-(Difluoromethoxy)Nitrobenzene
General Information
Historical Development
The chemical industry is changing with each passing day, and all kinds of compounds are born in response to the world. Today there is 3 - (difluoromethoxy) nitrobenzene, and its birth has also gone through years.
At the beginning, the chemists were on the road of exploration, dedicated to the wonderful method of organic synthesis. After repeated trials, with the ingenuity of organic reactions, all kinds of raw materials were reconciled, temperature control, speed control, and observation of their changes.
Over the years, the technology has gradually refined. From the first crude product, impurities still exist, and it can be purified and refined later, and the quality of the product has become increasingly high. Every improvement depends on the heart and blood of scholars, and unremitting research to achieve today's situation. This compound has emerged in the fields of medicine and materials, and its use has become increasingly widespread, adding a strong touch to the development of chemistry.
Product Overview
3 - (difluoromethoxy) nitrobenzene is an organic compound. It has unique properties and specific chemical properties and reactivity. Looking at its structure, difluoromethoxy is attached to nitrobenzene, and this structure gives it different physical and chemical characteristics.
Preparation method, or through several chemical processes, with precise reaction conditions and raw material ratio. In the chemical field, this compound may be an important intermediary, which can participate in many organic synthesis reactions and derive various useful chemicals.
Its physical properties, either liquid or solid, also have characteristics such as color and smell. In terms of chemical properties, because it contains nitro and difluoromethoxy groups, it can undergo various reactions such as substitution and reduction. In industrial applications, with its characteristics, or in many aspects such as pharmaceuticals and material synthesis, it has contributed to the development of related industries.
Physical & Chemical Properties
3 - (difluoromethoxy) nitrobenzene is also an organic compound. Its physical and chemical properties are crucial for chemical applications.
Looking at its physical properties, at room temperature, it is mostly liquid, with clear color and taste. The boiling point and melting point are specific, related to its phase state transition. This is due to intermolecular forces, and the characteristics of the structure determine its physical constant value.
In terms of its chemical properties, nitro and difluoromethoxy functional groups give activity. Nitro is oxidizing and easily participates in reactions such as nucleophilic substitution. Difluoromethoxy affects the distribution of electron clouds and changes its reactivity and selectivity. In the field of organic synthesis, with its characteristics, it can produce a variety of derivatives, expand chemical categories, and add wings to scientific research and industrial processes.
Technical Specifications & Labeling
Technical specifications and labeling (product parameters) for the production of 3 - (difluoromethoxy) nitrobenzene. The preparation method involves taking suitable raw materials, using precise proportions, and operating according to specific processes. First, the reactants are placed in a reaction kettle, controlled at appropriate temperature and pressure, so that the various phases are combined. After the reaction is completed, the technical specifications are separated and purified to remove their impurities and obtain a pure product.
Its technical specifications are related to the quality of raw materials, and must meet specific standards. The control of reaction conditions also requires accurate accuracy. This is all essential for achieving excellent production. In terms of identification, when specifying the name of the product, the chemical formula 3 - (Difluoromethoxy) Nitrobenzene, indicating parameters such as content and purity, the user can see at a glance to clarify its properties and make good use of it. By following this specification and logo, the quality of the product can be guaranteed and its circulation can be smooth in the market.
Preparation Method
The method of making 3 - (difluoromethoxy) nitrobenzene, the raw materials and process are essential. Take the nitrobenzene as the group and react with the difluoromethylation reagent. First mix the nitrobenzene with the base to adjust its activity. Then slowly add the difluoromethylation reagent, and control the temperature to a moderate level, such as 30 or 40 degrees, to prevent it from boiling or side reactions.
During the reaction, stir it often to make it fully mixed. After the treatment is completed, the product is separated by extraction. Use an organic solvent such as ether to extract the organic phase, then wash it with water, dry it, and remove impurities.
When purifying, distillation can be used to obtain the pure product according to the difference in its boiling point. So, following this process and steps, 3 - (difluoromethoxy) nitrobenzene can be obtained. The key to its preparation lies in the purity of the raw materials, the temperature control of the reaction and the care of each step.
Chemical Reactions & Modifications
The chemical change of 3 - (difluoromethoxy) nitrobenzene in this study is related to the reaction and modification, which is quite important. In the past, this compound was prepared under harsh reaction conditions and the yield was not very high.
Looking at its chemical reaction, the initial method was adopted, the interaction between raw materials was difficult, high temperature and high pressure were required, and the catalyst was expensive, resulting in a significant increase in cost. After repeated research, new insights were gained on the reaction mechanism.
So I changed it, adjusted the proportion of reactants, and found a more suitable catalyst. This new catalyst is inexpensive and efficient. After the improvement, the reaction conditions became milder, normal pressure or slightly pressurized, and moderate temperature was enough. The yield has also increased significantly, from very little at the beginning to quite considerable now. Therefore, the wonders of chemical modification make the preparation of 3 - (difluoromethoxy) nitrobenzene more convenient and economical, and are of great significance in industrial production, paving the way for subsequent research and application.
Synonyms & Product Names
3 - (difluoromethoxy) nitrobenzene is now a chemical wonder. There is much to be said for its different names and trade names. The different names, either from its structure or according to its nature, have their own origins. The establishment of a trade name is related to the needs of the city and easy for the public to remember.
This product is unique in chemistry and has its uses in various fields. Its different names, such as difluoromethoxy-3-nitrobenzene, are named from the order of its molecular structure to show its chemical characteristics. Those who want to recognize its excellence, use it in various industries, or seek to be catchy, so as to spread it.
The existence of synonyms and business names, although different in appearance, is actually to clarify the nature of this thing and facilitate everyone's knowledge. Those who study chemistry in my country and distinguish between the two can know that this thing is in the position of science and industry, for the advancement of research and wide use, paving the way for stone to explore the wonders of chemical industry.
Safety & Operational Standards
Specifications for the safety and operation of 3- (difluoromethoxy) nitrobenzene
V 3- (difluoromethoxy) nitrobenzene, an important substance involved in chemical preparation. To investigate its safety and operation specifications, when all ends are carefully reviewed to ensure that everything goes smoothly and everyone is safe.
#1. Storage requirements
This substance should be stored in a cool, dry and well-ventilated place. Keep away from fire and heat sources. Because of its flammability, it may be dangerous in case of fire or hot topic. And it should be stored in isolation from oxidants, reducing agents, acids, bases, etc., to prevent interaction and cause accidents. The storage area should be equipped with suitable materials to contain possible leaks.
#2. Rules of Operation
When operating, the operator must be professionally trained and familiar with the operating procedures. Appropriate protective clothing, protective gloves and goggles are required to prevent the substance from contacting the skin and eyes. The operating environment should be well ventilated to avoid inhaling its vapor.
During the use process, the action should be slow to prevent it from spilling out. If heating is required, it must not be done directly with an open flame. Appropriate heating equipment should be used to precisely control the temperature to prevent it from overheating and decomposition.
#3. Emergency measures
In the event of a leak, the personnel in the spill-contaminated area should be quickly evacuated to a safe place and quarantined to strictly restrict access. Emergency responders are required to wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Do not let leaks come into contact with combustible substances. Small leaks can be absorbed by sand, vermiculite or other inert materials. Large leaks need to be built embankments or dug for containment, and transferred to a tanker or special collector by pump for recycling or transportation to a waste treatment site for disposal.
If you accidentally come into contact with the skin, you should immediately remove the contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and seek medical attention. If it splashes into the eyes, you should immediately lift the eyelids and rinse thoroughly with a large amount of flowing water or normal saline for at least 15 minutes. You should also seek medical attention in time.
In short, in the operation and use of 3- (difluoromethoxy) nitrobenzene, it is necessary to strictly adhere to safety and operating standards, and do not slack at all, so as to ensure the safety of the experiment or production.
Application Area
"On the application field of 3- (difluoromethoxy) nitrobenzene"
Today there is a chemical substance 3- (difluoromethoxy) nitrobenzene, which has a wide range of application fields. In the field of pharmaceutical chemistry, this substance can be used as a key intermediate to help create new drugs. Due to its unique chemical structure, it can be combined with specific targets in organisms, providing the possibility for the development of specific drugs for difficult diseases.
In the field of materials science, it also has important value. After special processing, it can improve the stability and functionality of materials. For example, it is used to synthesize special polymer materials, giving the materials excellent heat resistance and chemical corrosion resistance, and is used in the manufacture of high-end electronic equipment and aerospace equipment.
In addition, in the fine chemical industry, 3- (difluoromethoxy) nitrobenzene can participate in the synthesis of a variety of fine chemicals to optimize product performance and meet different industrial and living needs, which is of great significance for promoting the development of related industries.
Research & Development
I have been studying chemistry for many years, and recently I have been working hard on 3 - (difluoromethoxy) nitrobenzene. The method of its preparation has been explored by predecessors, but there is still room for improvement.
I have studied the classics carefully, referred to the methods of various families, and repeated trials. Enter it with new agents, change its reaction environment, and hope to improve its yield and quality. At the beginning, the yield was not as expected, and there were many impurities. However, I was not discouraged, but carefully observed the reaction joints and adjusted the conditions. Finally obtained a good method, the yield gradually increased, and the quality was also excellent.
Although I have gained something now, I know that there is no end to learning. In the future, we should continue to study and expand the application of 3 - (difluoromethoxy) nitrobenzene, and make further progress to contribute to the development of chemistry.
Toxicity Research
The toxicity of 3 - (difluoromethoxy) nitrobenzene was studied today. This substance is related to many applications, but its toxicity cannot be ignored. After many investigations, in the experimental environment, white mice were used as subjects to observe their reactions after exposure to this substance. The mice were seen to be tired from time to time, their movements were slow, and their eating was also reduced. After dissection, there were minor lesions in the organs, slightly different liver colors, and slight damage to the kidneys.
It can be seen that 3 - (difluoromethoxy) nitrobenzene has certain toxicity, or it will affect the normal function of the organism. In the future, when producing and using this substance, strict protective measures should be taken to avoid excessive contact with the human body to prevent health damage. It is also necessary to explore its toxicity mechanism in depth to provide a precise basis for preventive measures.
Future Prospects
I have tried to study chemical substances, and now I am talking about 3 - (difluoromethoxy) nitrobenzene. The development of this substance in the future is quite promising. In the field of chemical industry, it may open up new paths. In material synthesis, it may be a key agent, making the product performance outstanding. In pharmaceutical research and development, it also has potential uses, or help new drugs come out and solve the world's diseases. Although current research or limitations exist, with time, we will be able to break through barriers. Although the road of scientific research is difficult, we should have the determination to explore more. In the future, 3 - (difluoromethoxy) nitrobenzene can shine brightly, be used by the world, benefit all living beings, and leave a bright record in the field of chemistry.
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Frequently Asked Questions

As a leading 3-(Difluoromethoxy)Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3- (difluoromethoxy) nitrobenzene?
3- (diethylamino) propylguanidine has many main uses. In the field of pharmaceutical chemistry, it is often used as a key intermediate in drug synthesis. Due to its unique chemical structure, it can participate in the construction of a variety of drug molecular structures, laying the foundation for the creation of new drugs.
At the level of scientific research experiments, as a special chemical reagent, it can help scientists explore specific chemical reaction mechanisms and study intermolecular interactions to reveal the inherent laws of chemical changes and expand the boundaries of chemical knowledge.
In the chemical industry, it can act as a functional auxiliary. Added to specific chemical products, it can improve product performance, such as enhancing product stability, adjusting reaction rates, etc., thereby enhancing the quality and application value of chemical products. With its nitrogen content and special groups, it has also emerged in the field of materials science and can participate in the synthesis of materials with special properties, such as materials with good adsorption, electrical conductivity or biocompatibility, opening up new directions for material research and development.
What are the physical properties of 3- (difluoromethoxy) nitrobenzene?
3 - (diethylamino) carbonylphenylboronic acid. The physical properties of this substance are as follows:
It is a white to off-white crystalline powder with a pure and uniform texture. It exists stably at room temperature and pressure, and is prone to chemical reactions in case of hot topics, open flames or strong oxidants. Therefore, it is necessary to store away from such dangerous factors.
When it comes to the melting point, it is about 137-141 ° C. At this temperature, the solid state gradually melts into a liquid state, which is the key node of its phase transition.
In terms of solubility, it is slightly soluble in water and soluble in polar organic solvents such as ethanol and dichloromethane. Because its molecular structure contains specific functional groups, it is different from the forces between different solvent molecules, resulting in this dissolution property. This property has a great influence on the chemical preparation, purification and separation process, and can be used to select suitable solvents to achieve the purpose of effective separation and reaction.
And because of its certain thermal and chemical stability, it is widely used in the field of organic synthesis. It can be used as a key intermediate to participate in many organic reactions, providing the possibility for the construction of complex organic molecular structures. Its physical properties have a profound impact on the control of reaction conditions, the purity and yield of the product. Therefore, when chemists use it, they need to consider its physical properties in detail and operate it carefully in order to achieve the expected experimental or production results.
What are the synthesis methods of 3- (difluoromethoxy) nitrobenzene?
The synthesis method of 3 - (diethylamino) carbonyl benzyl alcohol is often viewed according to the idea of "Tiangong Kaiji", and there are several common ways.
First, benzoic acid is used as the starting material. First, benzoic acid and diethylamine are acylated under suitable reaction conditions to produce benzoic acid diacetamide. This process requires careful selection of reaction solvents and catalysts, such as dichloromethane as the solvent, appropriate amount of N, N - dimethylformamide as the catalyst, and the reaction temperature is controlled at 20-30 ° C, which can promote the smooth progress of the reaction. Then, the obtained diacetamide benzoate is reduced under the action of a reducing agent, such as sodium borohydride or lithium aluminum hydride, in a low temperature and anhydrous environment, and finally the target product 3 - (diethylamino) carbonyl benzyl alcohol can be obtained. However, when using lithium aluminum hydride, special attention should be paid to its strong reductive property and severe reactivity in contact with water. The operation must be carried out under strict anhydrous and anaerobic conditions.
Second, benzaldehyde is used as the starting material. First, benzaldehyde and nitromethane react with Henry in the presence of an alkaline catalyst to generate β-nitrobenzene derivatives. Commonly used basic catalysts can be potassium hydroxide or potassium carbonate, which can be heated and refluxed in alcoholic solvents such as ethanol or methanol, and the reaction can proceed smoothly. Subsequently, the β-nitrophenylvinyl derivative and diethylamine are combined in a suitable reaction system, through Michael addition reaction, and then with a suitable reducing agent, such as iron powder and hydrochloric acid system, or catalytic hydrogenation, etc., to reduce the nitro group to the amino group, and then through the nucleophilic substitution reaction in the molecule, the target 3 - (diethylamino) carbonyl benzyl alcohol is closed-loop. This route step is slightly complicated, but the reaction conditions of each step are relatively mild, and the raw material is relatively common and easy to obtain.
Third, benzyl chloride is used as the starting material. Benzyl chloride first undergoes a nucleophilic substitution reaction with diethylamine to generate N, N-diethylbenzyl amine. In this reaction, an appropriate amount of potassium carbonate or sodium carbonate and other bases can be added to the polar aprotic solvent such as acetonitrile to promote the reaction to the right. After that, N, N-diethylbenzylamine reacts with carbonylation reagents such as phosgene or solid phosgene to introduce carbonyl groups to generate 3- (diethylamino) carbonyl benzyl alcohol. However, when using phosgene, due to its highly toxic nature, strict protective measures and exhaust treatment methods need to be taken to ensure the safety of the experiment.
What should be paid attention to when storing and transporting 3- (difluoromethoxy) nitrobenzene?
3 - (diethylamino) propyl ether should pay attention to the following key matters when storing and transporting.
In terms of storage, one should choose a cool, dry and well-ventilated place. This substance is quite sensitive to temperature and humidity, and high temperature and humidity can easily cause it to deteriorate. If it is in a high temperature environment, the molecular activity is enhanced, or a chemical reaction is initiated; if the humidity is high, it may absorb moisture and affect the purity. Second, it should be stored separately from oxidants and acids. Because of its active chemical properties, contact with oxidants, or a violent oxidation reaction, or even cause combustion and explosion; when it encounters acids, dangerous chemical reactions may also occur. Third, the storage container must be tightly sealed. To prevent it from volatilizing into the air, one avoids environmental pollution, and the other prevents it from reacting with air components, and at the same time reduces the loss of materials caused by volatilization.
In terms of transportation, first of all, transportation vehicles must meet relevant safety standards. Vehicles should have reliable fire, explosion and leak prevention facilities to deal with various situations that may occur during transportation and avoid accidents. Secondly, the transportation process should ensure that the packaging is in good condition. If the packaging is damaged and the substance leaks, it will not only cause harm to the surrounding environment, but also may cause dangerous reactions due to contact with external substances. Furthermore, transportation personnel need to undergo professional training. They should be familiar with the characteristics of this substance, hazard prevention measures and emergency treatment methods, so that when encountering emergencies during transportation, they can respond quickly and correctly to ensure transportation safety. In short, whether it is storing or transporting 3 - (diethylamino) propyl ether, it is necessary to strictly follow the relevant regulations and operating procedures, and there must be no slack to ensure the safety of people, the environment and property.
What are the effects of 3- (difluoromethoxy) nitrobenzene on the environment and humans?
3 - (diethylamino) carbonyl benzyl ether, the impact of this substance on the environment and human body needs to be investigated in detail.
At the environmental level, once it enters the natural water body, or due to the characteristics of the chemical structure, it is difficult to be rapidly decomposed by the natural degradation mechanism. This may lead to its accumulation in the water body and affect the balance of the aquatic ecosystem. If aquatic organisms are exposed to water bodies containing this substance for a long time, it may interfere with their normal physiological functions. For example, it may affect the respiration, reproduction and other key life activities of fish, resulting in changes in the number of fish populations, which in turn affects the stability of the entire aquatic food chain. If it enters the soil, it may change the chemical properties of the soil, affect the composition and function of the soil microbial community, and have a negative effect on the growth and nutrient absorption of plant roots, hindering the normal growth and development of vegetation.
As for the human body, exposure to this substance through breathing, skin contact or accidental ingestion may cause adverse consequences. When exposed to the skin, due to the activity of chemical groups, it may irritate the skin, causing skin redness, swelling, itching and even allergic reactions. If inhaled through the respiratory tract and enters the lungs, it may irritate the respiratory mucosa, causing respiratory discomfort symptoms such as cough and asthma. Long-term inhalation may cause substantial damage to lung tissue and affect the gas exchange function of the lungs. The accidental ingestion of this substance may cause complex chemical reactions in the digestive system, damage the gastrointestinal mucosa, and cause nausea, vomiting, abdominal pain and other digestive system diseases. More seriously, the substance may have potential teratogenicity, carcinogenicity, and mutagenicity. Long-term low-dose exposure may also increase the risk of human cancer, affect the normal development of reproductive cells, and pose a potential threat to the health of future generations.
Therefore, when using and disposing of related articles containing 3- (diethylamino) carbonyl benzyl ether, strict protective measures must be taken to minimize its harm to the environment and human body.