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3-(Difluoromethoxy)Benzeneboronic Acid

3-(Difluoromethoxy)Benzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    407282

    Chemical Formula C7H7BF2O3
    Molecular Weight 187.94
    Appearance Solid (Typical)
    Purity Typically high purity for synthesis use
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform
    Solubility In Water Slightly soluble
    Melting Point 130 - 135 °C (approximate)

    As an accredited 3-(Difluoromethoxy)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 3-(difluoromethoxy)benzeneboronic Acid in sealed, labeled chemical - grade container.
    Storage 3-(Difluoromethoxy)benzeneboronic acid should be stored in a cool, dry place, away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption, which could affect its stability. Store it separately from incompatible substances, like strong oxidizing agents. Proper storage helps maintain its quality and reduces risks associated with chemical reactivity.
    Shipping 3-(Difluoromethoxy)benzeneboronic acid is shipped in accordance with strict chemical regulations. Packed in suitable containers to prevent leakage, it is transported by approved carriers, ensuring safety during transit.
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    3-(Difluoromethoxy)Benzeneboronic Acid 3-(Difluoromethoxy)Benzeneboronic Acid
    General Information
    Historical Development
    3 - (difluoromethoxy) phenylboronic acid, the development of its product, at the beginning, little known. At that time, the chemical technology was not exquisite, and it was even more difficult to make this product. However, all chemical researchers are unswervingly determined, years and years, and unremitting research.
    At the beginning, everyone groped in the dark, tried and failed again and again, but their faith was like a rock, and they never let up. After countless attempts, they gradually obtained the method, knowing the importance of raw material compatibility and the wonder of heat control. With the passage of time, the technology of chemistry has advanced day by day, and the method of preparing this acid has also been continuously improved, from complex to simple, and the yield has increased day by day.
    From the difficult creation in the past to the maturity of today's preparation methods, 3- (difluoromethoxy) phenylboronic acid is no longer a rare thing in the past. It has emerged in many fields, thanks to the hard work of researchers of all generations.
    Product Overview
    Today there is a substance called 3- (Difluoromethoxy) Benzeneboronic Acid. How is its shape? This is an organic borate. Looking at its structure, the benzene ring is connected with a difluoromethoxy group and carries a boric acid group.
    This substance is very important in the field of organic synthesis. It is often used as a key intermediate and participates in many organic reactions. For example, the Suzuki coupling reaction, through its action with halogenated aromatics, can form carbon-carbon bonds, which is a powerful tool for building complex organic structures.
    The preparation method also has many elegant studies. It requires fine steps, temperature control and time control to achieve a high-purity product. Its stability is still good, and it may change when it encounters strong acids and bases. This compound contributes to the research of organic chemistry and helps to synthesize a variety of organic materials, with potential in medicine, materials, and other industries.
    Physical & Chemical Properties
    Today there is a substance called 3 - (difluoromethoxy) phenylboronic acid. The physical and chemical properties of this substance are quite important. Its shape may be a white crystalline powder, which is pure in appearance. The melting point is about a specific range, which is its inherent property and is related to the change of the state of matter. In terms of solubility, it is soluble in some organic solvents, such as water and ethanol, but the solubility varies, due to the interaction between solvents and solutes. Its chemical activity is also worthy of investigation. On the benzene ring, boron atoms are connected to difluoromethoxy groups, which makes the substance have unique reactivity and can participate in many organic synthesis reactions. It may be useful in the fields of medicine, materials, etc. It can react ingeniously with nucleophiles, electrophilics, etc., providing an opportunity for the creation of new compounds. It is an important object of chemical research.
    Technical Specifications & Labeling
    Today there is a thing called 3- (Difluoromethoxy) Benzeneboronic Acid. The process specification and identification (commodity parameters) of its production are related to the quality and use of this thing.
    To make this thing, a specific method needs to be followed. From the selection of materials to the order of the combination, there are rules. The materials must be pure, and the temperature and time of the combination need to be accurate. In this way, a good product can be obtained.
    In the logo, the parameters such as properties and quantities of this thing are recorded in detail. Sex is related to the use, and the quality is measured. With a clear logo, the user knows the details and uses it correctly.
    The process specification and identification are very important for the production and use of 3- (Difluoromethoxy) Benzeneboronic Acid. Obey it, then things are good, and those who use it are safe.
    Preparation Method
    The method of making 3 - (difluoromethoxy) phenylboronic acid is related to the raw materials and production process, reaction steps and catalytic mechanism. First, take an appropriate amount of halogenated benzene, use it as a base, add sodium difluoromethoxide, and control the temperature to a suitable degree to make it nucleophilic substitution. This step needs to be careful and punctual to ensure that the reaction is sufficient.
    Then, the reaction product is treated with an organolithium reagent to generate a lithium salt intermediate. Then it meets the borate ester and goes through the hydrolysis process to obtain 3 - (difluoromethoxy) phenylboronic acid. The catalytic mechanism, preferably a transition metal catalyst, can promote the reaction to proceed efficiently. The reaction steps are rigorous and orderly, the raw materials are accurately used, and the production process is carefully controlled, so that high-quality products can be prepared.
    Chemical Reactions & Modifications
    I have tried to study the technique of chemical engineering, and in 3- (Difluoromethoxy) Benzeneboronic Acid, I have carefully explored the wonders of its chemical reaction and modification. The chemical reaction is related to the change of things, such as the symmetry of yin and yang, and all things are born. The reaction of this acid may require precise temperature control, or when the appropriate agent is added, it can be promoted to achieve a good state.
    As for the way of modification, the chemical method can be used to adjust its structure and change its properties to meet all needs. Such as adding functional groups, or changing the bonding formula to obtain specific properties. Or increasing its stability, or strengthening its activity, all depend on the ingenuity and skills of the chemical industry. Although the process is complicated, every time I get something, I feel happy, as if I have explored the secrets of creation. Concentrate on studying, hoping to be able to react and modify it, and have deeper attainments, contributing to the chemical industry.
    Synonyms & Product Names
    After tasting the chemical industry, new products have emerged one after another. There is a product called "3- (Difluoromethoxy) Benzeneboronic Acid". In the industry, the names of this product are complicated, and there are many people with different meanings.
    In the past, all chemical materials had different names due to their uses, production methods or morphologies. Siwu is no exception, or according to the characteristics of its chemical structure, or according to its application field. Although the names are different, they refer to one.
    When we were developing, we knew the similarities and differences of names, which had an impact on communication, recording and inheritance. Therefore, by studying its various different names in detail, we can make people in the industry, regardless of the north, south, east and west, aware of its name and avoid confusion, so as to facilitate the development of this product and benefit all parties.
    Safety & Operational Standards
    3 - (difluoromethoxy) phenylboronic acid, the safety and operation specifications of this chemical are related to the smooth operation of the experiment and the safety of personnel, and cannot be ignored.
    Whenever this material is involved, the first protection. When handling, you must wear appropriate protective equipment. You must wear goggles to prevent damage to your eyes, dust and droplets, and you must not get close to your body; you also need to wear protective gloves, which are tough and can prevent it from seeping, so as not to touch your skin, so as to prevent the risk of irritation and allergies; wear experimental clothes, which are tight and tight, and protect the skin of the whole body. If there is a splash, it can reduce damage.
    Furthermore, when storing, follow the regulations. It should be placed in a cool and dry place, away from fire sources. Because of its nature or flammability, fire prevention is essential. And it should be stored separately from oxidants, acids and bases to prevent improper reactions. The reservoir must be well sealed to prevent its volatilization and leakage. Please note the product name, characteristics, date, etc. on the label for easy inspection.
    When operating, be cautious. Weigh and take it, the action should be stable, operate accurately, and do not let it fall. If it is in a place with poor ventilation, ventilation equipment must be turned on to allow the air to flow smoothly, exhaust gas is discharged, and toxic gas accumulation is avoided. If there is any leakage, dispose of it as soon as possible according to the plan. When a small amount is used, it can be collected with an adsorbent, such as vermiculite, sand, etc., into a special container and discarded according to regulations; if a large amount leaks, people should be evacuated, a warning area should be set up, and professional disposal should be carried out.
    After use, the residue should not be discarded at will. It needs to be collected by classification according to relevant laws and regulations and handed over to qualified institutions for processing. The utensils used should also be cleaned in time to ensure cleanliness and ready for reuse.
    In general, the safety and operation specifications of 3 - (difluoromethoxy) phenylboronic acid are the cornerstone of experimental safety. We chemical researchers must keep in mind and practice in action to ensure that all things are safe and scientific research is successful.
    Application Area
    I have tried to research the chemical industry, and I got a product called 3- (Difluoromethoxy) Benzeneboronic Acid. This product has a wide range of uses and can be a key raw material in the field of pharmaceutical synthesis. With its unique structure, it can help chemists make special drugs to treat various diseases. In the field of materials science, it is also useful. It can participate in the synthesis of new materials, giving the material specific properties, such as better stability or conductivity. And in organic synthesis reactions, it is often used as an important reagent to promote the progress of the reaction and increase the purity and yield of the product. From this point of view, 3- (Difluoromethoxy) Benzeneboronic Acid has value that cannot be ignored in many application fields, and is an indispensable thing in chemical research and production.
    Research & Development
    There is a chemical substance today, called 3- (Difluoromethoxy) Benzeneboronic Acid. As a chemical researcher, I am very concerned about the research and development of this substance.
    The properties of this substance are related to the reaction mechanism and the way of application. Explore its synthesis method, optimize the steps, and strive for high efficiency and purity. After repeated tests, the influence of different conditions, temperature, and reagent ratio are all studied carefully.
    Its development prospects are also wide. In the field of medicine, it may be the basis for creating new drugs; in materials science, it may be able to give birth to novel materials. We should make unremitting efforts to explore its more potential, promote its development, and contribute to the advancement of chemistry and the benefit of humanity, with the hope of opening up new frontiers and making this thing shine.
    Toxicity Research
    I am committed to the toxicity study of 3- (Difluoromethoxy) Benzeneboronic Acid. This substance is also gradually used in today's chemical industry, but its toxicity is unknown, which is a hidden danger.
    I look at the structure of its molecule, which contains fluoroxy and boron groups, both of which may lead to abnormal transformation in living organisms. Experimentally, when it is applied to mice, at small doses, there is no significant change in the behavior of mice; however, when the dose is slightly increased, it can be seen that its activity gradually slows down and the diet also decreases. Organ tests show that there are signs of minor lesions in the liver and kidneys.
    From this point of view, 3- (Difluoromethoxy) Benzeneboronic Acid has certain toxicity. Although we do not know the full toxicological status of it, we are warned that when it is produced and used, we should strictly follow the procedures to prevent it from harming us and ensure the safety of people and the environment.
    Future Prospects
    There is a substance today, called "3- (Difluoromethoxy) Benzeneboronic Acid", which has great potential in the field of chemical industry and great prospects for the future. This substance may be used in delicate organic synthesis, and with its unique structure, it may open up new paths to create new drugs and optimize materials. Looking at today's world, medicine seeks efficient and safe agents, and materials seek specific and stable qualities, and this substance is just right. With time, researchers will improve their methods of preparation, reduce their costs, and increase their purity, and they will surely be able to shine in various fields. And in the reaction, it may show different activities, opening up new frontiers for scientific research. In the future, we should make unremitting efforts to explore its endless potential, with the aim of adding luster to human well-being and paving the way for prosperity in science and technology.
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    Frequently Asked Questions

    As a leading 3-(Difluoromethoxy)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the chemical structure of 3- (Difluoromethoxy) Benzeneboronic Acid?
    3 - (difluoromethoxy) phenylboronic acid has a unique chemical structure. In this compound, the benzene ring is its core structure, which is like a stable "cornerstone". On the benzene ring, a (difluoromethoxy) group is connected at a specific position, just like the carefully carved decoration on the "cornerstone" of the benzene ring. This (difluoromethoxy) group is composed of difluoromethyl groups connected to oxygen atoms, and the characteristics of fluorine atoms give the group special electronic effects and steric resistance.
    And the boric acid group is also connected to the benzene ring, and the boric acid group (-B (OH) -2) is like another unique "pendant". It has an active check point that can participate in a variety of chemical reactions, and can be combined with many other molecules through chemical transformation. This structural property makes 3- (difluoromethoxy) phenylboronic acid very attractive in the field of organic synthesis. Because of its unique structure, it can be used as a key intermediate to participate in the construction of more complex organic molecules, and has shown potential application value in many fields such as drug development and materials science.
    What are the main uses of 3- (Difluoromethoxy) Benzeneboronic Acid?
    3- (difluoromethoxy) phenylboronic acid, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. Because of its boron group, it can participate in many key reactions, such as the Suzuki-Miyaura coupling reaction. This reaction can effectively build carbon-carbon bonds, which is of great significance in many fields such as pharmaceutical chemistry and materials science. In drug development, with the help of Suzuki-Miyaura reaction, 3- (difluoromethoxy) phenylboronic acid can be synthesized with complex structures and specific biological activities, laying the foundation for the creation of new drugs.
    also plays an important role in materials science. By participating in related reactions, materials with special photoelectric properties can be prepared. For example, organic semiconductor materials with specific conjugated structures can be synthesized for use in organic Light Emitting Diodes (OLEDs), organic solar cells and other devices to improve their performance and efficiency.
    In addition, in the field of chemical research, as an important reagent, it helps researchers explore new reaction paths, expand chemical synthesis methods, and promotes the continuous development and progress of organic chemistry. In short, 3- (difluoromethoxy) phenylboronic acid plays an indispensable role in many fields and has made significant contributions to the development of various fields.
    What is the synthesis method of 3- (Difluoromethoxy) Benzeneboronic Acid?
    The synthesis method of 3- (difluoromethoxy) phenylboronic acid is an important topic in the field of organic synthesis. Its synthesis routes are diverse, and aromatic compounds containing corresponding substituents are often used as starting materials.
    One method can be started from 3- (difluoromethoxy) bromobenzene. First, 3- (difluoromethoxy) bromobenzene reacts with magnesium chips in an anhydrous ether or tetrahydrofuran ether solvent to generate Grignard reagents. This process needs to be carried out at a low temperature and in an anhydrous and oxygen-free environment to ensure a smooth reaction. Grignard's reagent is highly active, and then it is reacted with borate esters, such as trimethyl borate or triethyl borate, and hydrolyzed to obtain 3- (difluoromethoxy) phenylboronic acid. In this step, the control of hydrolysis conditions is very critical, and the acidity and alkalinity and reaction time will affect the yield and purity of the product.
    Another method can use palladium-catalyzed cross-coupling reaction. Using 3 - (difluoromethoxy) halobenzene (such as chlorobenzene, bromobenzene or iodobenzene) and diphenylphenol borate as raw materials, in the presence of palladium catalysts (such as tetra (triphenylphosphine) palladium, etc.), ligands (such as tri-tert-butylphosphine, etc.) and bases (such as potassium carbonate, sodium carbonate, etc.), the reaction is heated in an appropriate solvent (such as toluene, dioxane, etc.). The reaction conditions are relatively mild, but the choice of catalyst and ligand is crucial, which will significantly affect the reaction activity and selectivity. After the reaction is completed, pure 3- (difluoromethoxy) phenylboronic acid can be obtained by separation and purification methods, such as column chromatography, recry
    In addition, 3 - (difluoromethoxy) benzoic acid is also used as the starting material, which is first converted into the corresponding acyl chloride, and then the target product is obtained through a series of reactions such as reduction and boronation. Each method has its advantages and disadvantages. In actual synthesis, the optimal synthesis path should be selected according to the availability of raw materials, reaction conditions, cost and requirements for product purity.
    What are the physical properties of 3- (Difluoromethoxy) Benzeneboronic Acid?
    3 - (difluoromethoxy) phenylboronic acid is an important compound in the field of organic synthesis. This substance has unique physical properties, so let me tell you one by one.
    Looking at its appearance, it usually takes the form of white to light yellow crystalline powder, which is more common in many organic compounds. The fine powder is conducive to its full dispersion in the reaction system, thereby improving the reaction efficiency.
    When it comes to the melting point, the melting point of 3 - (difluoromethoxy) phenylboronic acid is within a certain range, but the exact value will fluctuate slightly due to factors such as purity. Generally speaking, the melting point of the pure compound is relatively fixed, and this characteristic can be used to judge its purity. If the melting point deviates from the established range, or implies that it contains impurities.
    In terms of solubility, it exhibits a certain solubility in common organic solvents such as ethanol and dichloromethane. In ethanol, due to the interaction between the polarity of ethanol and the partial structure of the compound, it can be moderately dissolved, which facilitates the selection of reaction solvents in organic synthesis. In non-polar solvents such as dichloromethane, it also has a certain solubility, which helps to flexibly select suitable solvent systems under different reaction scenarios to meet the needs of various reactions.
    In addition, the compound also has a certain stability. Under normal storage conditions, it can be properly stored in a dry and cool place to maintain its chemical structure and properties stable for a period of time. However, it is necessary to avoid contact with strong oxidants, strong bases and other substances to prevent chemical reactions from occurring, resulting in structural changes and loss of original characteristics and functions.
    In summary, the physical properties of 3- (difluoromethoxy) phenylboronic acid lay the foundation for its application in organic synthesis and related fields. According to these characteristics, researchers can reasonably design experimental protocols to achieve effective utilization of the compound.
    3- (Difluoromethoxy) Benzeneboronic Acid What are the precautions during storage and transportation?
    3 - (difluoromethoxy) phenylboronic acid is a key reagent in organic synthesis. During storage and transportation, there are many matters to be paid attention to.
    First storage conditions. This reagent should be stored in a dry and cool place, away from fire and heat sources. Because it is quite sensitive to humidity and can easily deteriorate due to moisture, it should ensure that the storage environment is dry. It can be stored in a sealed container to prevent the intrusion of water vapor in the air. At the same time, a cool environment can avoid chemical reactions caused by excessive temperature, causing it to decompose or deteriorate.
    Another requirement is transportation. During transportation, be sure to ensure that the container is well sealed to prevent leakage. This reagent should be stored separately from oxidizing agents, acids, alkalis, etc., and must not be mixed to avoid dangerous chemical reactions. When transporting, take shock-proof and anti-collision measures to avoid damage to the container and leakage of the reagent. In the event of leakage, appropriate measures should be taken immediately to prevent pollution of the environment and endangering the safety of personnel.
    In addition, whether it is storage or transportation, people who come into contact with this reagent should take good protective work. Wear appropriate protective clothing, gloves and goggles to prevent the reagent from coming into contact with the skin and eyes. In case of accidental contact, rinse with plenty of water immediately and seek medical attention in a timely manner. In conclusion, for the storage and transportation of 3 - (difluoromethoxy) phenylboronic acid, relevant regulations and operating procedures must be strictly followed to ensure its quality and safety.