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3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride

3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    236235

    Chemical Formula C7H3ClFNO2S
    Molecular Weight 221.62
    Appearance Typically a solid
    Color May be white to off - white
    Odor Pungent odor
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane
    Melting Point Data needed for exact value
    Boiling Point Data needed for exact value
    Density Data needed for exact value
    Reactivity Reactive towards nucleophiles, reacts with amines, alcohols etc.

    As an accredited 3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 3 - cyano - 4 - fluorobenzene - 1 - sulfonyl chloride in sealed chemical - grade container.
    Storage 3 - Cyano - 4 - fluorobenzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and sources of ignition. Store it in a tightly sealed container to prevent contact with moisture, as it can react with water. Also, isolate it from incompatible substances like bases and reducing agents to avoid potential chemical reactions.
    Shipping 3 - Cyano - 4 - fluorobenzene - 1 - sulfonyl chloride is a chemical. Ship it in sealed, corrosion - resistant containers. Follow hazardous chemical shipping regulations, ensuring proper labeling and handling to prevent leakage and risks during transit.
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    3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride 3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride
    General Information
    Historical Development
    Those who have heard of the art of the past, study the way of the compound. In 3 - Cyano - 4 - Fluorobenzene - 1 - Sulfonyl Chloride, at the beginning of this thing, everyone did not know its nature. The sorcerer dedicated himself to studying, and it lasted for several years. Beginning with the ordinary method, I tried to analyze its quality, but suffered repeated setbacks, but my resolve has not changed.
    I also explored various classics, visited various wise men, and finally found a way. With a new method, I reconciled various agents, and gradually understood their nature. Therefore, the system of this thing has gradually refined, and its application is also wide. From the initial ignorance, to the later familiarity, the hardships in between are not enough for outsiders. And 3 - Cyano - 4 - Fluorobenzene - 1 - Sulfonyl Chloride has also emerged in various industries and is used by later generations. Its development track is the evidence of the efforts of the artists.
    Product Overview
    3-Cyano-4-fluorobenzene-1-sulfonyl chloride is a chemical substance that we have studied. It is pure in color and good in quality, and has special chemical properties. The preparation of this substance has gone through various fine steps and multiple reactions.
    Its molecular structure is unique, with the ingenious combination of cyano, fluorine atom and sulfonyl chloride group, which has great potential in the field of organic synthesis. Or it can be used to create new drugs, which can precisely act on lesions with its special activity; or it has emerged in materials science to improve the properties of materials.
    We have repeatedly experimented to study the influence of conditions on its yield and purity. Strictly control the temperature, pressure and ratio of reactants to achieve the best results. The future application prospects of this substance are broad, and I will continue to study it, hoping to add to the field of chemistry and make it more effective.
    Physical & Chemical Properties
    3-Cyano-4-fluorobenzene-1-sulfonyl chloride is an important substance for chemical research. Its physical and chemical properties are unique and affect many aspects of research.
    Looking at its physical properties, its morphology is specific at room temperature, or it is a solid state with a specific color, its melting point, boiling point, etc., are the key to characterization. The solubility of this substance also has characteristics. In different solvents, the degree of solubility varies, which is extremely important in experimental operation and application.
    As for its chemical properties, it contains cyanide groups and sulfonyl chloride groups, and its chemical activity is quite high. Cyanyl groups can participate in various nucleophilic substitution reactions, while sulfonyl chloride groups can react with alcohols and amines to form various derivatives. These reaction characteristics provide a way for the synthesis of novel compounds and have broad application prospects in the field of organic synthesis. Studying the physical and chemical properties of this substance is an indispensable part of chemical research.
    Technical Specifications & Labeling
    3-Cyano-4-fluorobenzene-1-sulfonyl chloride, its technical procedures and identification (product parameters) are crucial. The preparation of this compound requires a precise process. In the reactor, a specific proportion of raw materials is added, and the temperature is controlled in a suitable range to ensure that the reaction is sufficient and smooth. After the reaction is completed, it is separated and purified to obtain a pure product.
    Its label must also be clear, with precise ingredients, content and other parameters. The appearance of the product should be white and flawless, free of variegated colors and foreign matter. When the purity is up to a very high standard, the impurity content must be minimal. In this way, high-quality 3-cyano-4-fluorobenzene-1-sulfonyl chloride can be obtained to meet the needs of all parties and develop its effectiveness in the chemical industry.
    Preparation Method
    The method of making 3-cyano-4-fluorobenzene-1-sulfonyl chloride, the first heavy raw material and production process. Take fluorobenzene as the group, and introduce the cyano group by the method of cyanidation to obtain cyanofluorobenzene. Then use the technique of sulfonation to make the sulfonyl group into its position, which is the key step.
    The reaction steps need to be strictly controlled. First adjust the temperature of the reaction, add the raw materials in sequence, and stir to make it uniform. During this period, pay attention to the reaction state, control the temperature and speed in a timely manner to prevent side reactions from happening.
    The catalytic mechanism cannot be ignored. Choosing a suitable catalyst can promote the reaction rate and increase the yield. It can reduce the energy barrier of the reaction, make the molecule easy to activate, and achieve the purpose of efficient synthesis. Through these operations, high-purity 3-cyano-4-fluorobenzene-1-sulfonyl chloride can be obtained to meet the needs of chemical industry and other industries.
    Chemical Reactions & Modifications
    Taste the industry of chemical industry, in the change of materials, always seek new environments. Today there is 3 - Cyano - 4 - Fluorobenzene - 1 - Sulfonyl Chloride, and its chemical reaction and modification are quite critical.
    Looking at the reaction, it is often supplemented with various reagents, and in a suitable temperature, pressure and catalysis environment, good results can be obtained. However, the initial method may be complicated and inefficient, and the yield is not high.
    In order to seek modification, all the craftsmen have devoted themselves to it. Or adjust the ratio of reagents, or change the medium of reaction, or explore new catalytic means. After trial and trial, the method of optimization is gradually obtained. The rate of the reaction is increased, the yield is also significantly increased, and the purity of the product is better than before. This all depends on the continuous study of chemical application and modification, in order to have this benefit, adding to the chemical industry and benefiting the world.
    Synonyms & Product Names
    "The same name and trade name of 3-cyano-4-fluorobenzene-1-sulfonyl chloride"
    Today there is a product named 3-cyano-4-fluorobenzene-1-sulfonyl chloride. In the field of chemical industry, there are many things in one product, and it is often the case. The same name may be different due to the limited way of making it, or due to different applications. This 3-cyano-4-fluorobenzene-1-sulfonyl chloride, or another name, is well known in the industry. Its trade name also varies with the business operation and market needs. Or because of its outstanding characteristics, it is applied to a special field and given the name of a unique commodity. Although the names are different, they all refer to the same substance. In research and production, it is necessary to clarify its namesake and commodity name, so as to be accurate and avoid confusion, so as to facilitate the smooth progress of the chemical industry.
    Safety & Operational Standards
    "3-Cyano-4-fluorobenzene-1-sulfonyl chloride safety and operation specifications"
    Fu 3-cyano-4-fluorobenzene-1-sulfonyl chloride, chemical products are also. In the experiment and production, its safety and operation standards are of paramount importance.
    Anyone who comes into contact with this object must wear appropriate protective gear. First protective clothing to prevent it from touching the skin and causing damage to the skin. And must be equipped with protective gloves, the material should be resistant to corrosion, so that the hands are protected from damage. Face protection is also indispensable. Goggles or masks can protect the eyes and face from spills.
    The place where the operation is carried out should be well ventilated. Because the substance or volatile harmful gases, good ventilation can quickly disperse, so as not to cause the operator to inhale and damage the breathing system. When operating, the action should be steady and careful to avoid its dumping and splashing. If there is any spill, immediately dispose of it according to the specifications. A small amount of spill can be sucked by adsorption materials and collected properly, so as not to pollute the environment. A large amount of spill requires professional personnel to deal with it according to specific procedures.
    When storing, it should be placed in a cool, dry and ventilated place. Keep away from fire and heat sources, and avoid direct sunlight. It should not be stored with easily reactive substances to prevent accidents.
    Furthermore, operators must be familiar with the nature of this substance and emergency treatment methods. In case of inadvertent contact, rinse with plenty of water as soon as possible. If it enters the eye, rinse and seek medical attention as soon as possible. If inhaled, quickly move to a fresh air place and give first aid if necessary.
    In short, in the operation and use of 3-cyano-4-fluorobenzene-1-sulfonyl chloride, strict adherence to safety and operating practices can ensure the safety of personnel and avoid the risk of accidents.
    Application Area
    3-Cyano-4-fluorobenzene-1-sulfonyl chloride, which has a wide range of uses. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create new specific drugs and provide a new way for healing diseases. In the field of materials science, it can improve the properties of materials through specific reactions, such as enhancing their stability and durability, so that the materials are suitable for more special scenarios. In the field of fine chemicals, it is also indispensable, which can be used to synthesize unique fine chemicals, such as high-performance dyes, additives, etc., to improve product quality and functionality. Overall, 3-cyano-4-fluorobenzene-1-sulfonyl chloride plays a key role in many fields due to its diverse uses, promoting the development and progress of various industries.
    Research & Development
    Yu Taste is dedicated to the research of chemical products, and now focuses on the product 3 - Cyano - 4 - Fluorobenzene - 1 - Sulfonyl Chloride. At the beginning, the synthesis method was explored, and various reaction conditions, such as temperature and reagent ratio, were observed in detail, and efforts were made to be accurate. During the process, many difficulties were encountered, the reaction yield did not meet expectations, and impurities also existed. Then repeated debugging, improvement of the process, and finally the best method was obtained. The yield was improved and the purity was also high.
    And the research of the application of this product, in the field of medicine, to observe its inhibitory effect on specific pathogens, it was effective at the beginning, and it could reduce the activity of pathogens. In terms of materials, observe its composite with other substances to improve material properties, such as enhancing stability.
    Looking to the future, we should deepen research and expand the scope of application, with the aim of promoting the development of the chemical field with this product, contributing to the progress and prosperity of many industries.
    Toxicity Research
    There is a chemical substance known as 3-cyano-4-fluorobenzene-1-sulfonyl chloride. We take toxicological research as our business to investigate its properties in detail. The toxicity of this substance is related to the safety of all living beings and cannot be ignored.
    Looking at the structure of its molecules, cyano, fluoro, and sulfonyl chloride are all active groups. Cyanide is highly toxic and can block the chain of cellular respiration and cause biological metabolic disorders. Although fluoro groups are small, they can change the properties of molecules, increase their lipid solubility, and easily enter the body. Sulfonyl chloride is active, and it will dissolve when exposed to water. It generates acid and poison gas, and corrodes and harms the body.
    According to various experiments, this substance can damage the organs of animals and plants when it enters the body. In plants, it hinders their photosynthesis and respiration; in animals, it disturbs their nervous and circulatory systems. Therefore, the study of the toxicity of this substance is the basis for protection and treatment, so as to avoid its harm and ensure the safety of all things.
    Future Prospects
    Fu 3 - Cyano - 4 - Fluorobenzene - 1 - Sulfonyl Chloride is gradually becoming more and more important in today's chemical research. Although it may not be at its peak at present, its future prospects are quite promising.
    Its unique properties can be used in various reactions and serve as the basis for new quality creation. Or it can be used in the field of medicine to help the research and development of new drugs and cure various diseases; or in the field of materials, it can spawn novel materials and increase their properties.
    Our chemical researchers should diligently study and explore the source of its potential. With time, making good use of its properties will surely be able to advance the world and create a new situation. With unremitting efforts, 3 - Cyano - 4 - Fluorobenzene - 1 - Sulfonyl Chloride will shine in the future, benefit the common people and prosper in all kinds of industries.
    Where to Buy 3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride in China?
    As a trusted 3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride?
    3-Cyano-4-fluorobenzene-1-sulfonyl chloride is a crucial reagent in organic synthesis. It has a wide range of uses and is often a key intermediate in the field of medicinal chemistry, helping to create many new drug molecules. Due to the high chemical activity of the cyano and sulfonyl chloride groups of this compound, it can be combined with different organic molecules through various chemical reactions, thus constructing a complex drug skeleton.
    In the field of materials science, it also has outstanding performance. Sulfonyl chloride groups can participate in polymerization reactions to prepare polymer materials with specific properties. Such materials may have excellent heat resistance and chemical corrosion resistance, so they have broad application prospects in high-end fields such as aerospace, electronics and electrical appliances. For example, it can be used to prepare special engineering plastics to reduce weight and improve reliability for aviation vehicles.
    Furthermore, in the field of pesticide research and development, 3-cyano-4-fluorobenzene-1-sulfonyl chloride is also indispensable. By chemically modifying it, new pesticides with high efficiency, low toxicity and environmental friendliness can be created, which can effectively control crop diseases and pests and ensure food yield and quality.
    In summary, 3-cyano-4-fluorobenzene-1-sulfonyl chloride plays a key role in many fields such as drugs, materials, and pesticides due to its unique chemical properties. It is a treasure of organic synthetic chemistry and promotes technological innovation and development in various related fields.
    What are the physical properties of 3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride?
    3-Cyano-4-fluorobenzene-1-sulfonyl chloride, this is an organic compound. Its physical properties are unique, let me tell them one by one.
    Looking at its appearance, it is often in the state of white to white crystalline powder, which is due to its regular molecular structure and orderly interaction of forces, resulting in this form. Under normal temperature and pressure, this substance is relatively stable, but in case of hot topics, open flames or strong oxidants, it is potentially dangerous, just like a hidden danger.
    When it comes to solubility, it can be dissolved in organic solvents such as dichloromethane and chloroform, just like a fish swimming in water. This is because the molecules of the organic solvent can form an appropriate force between the molecules of the compound to help it disperse. In water, its solubility is very small, and the lid is difficult to melt because of the large difference between the polarity of the molecule and the polarity of the water molecule, just like oil and water.
    Its melting point is within a specific range, and this characteristic is also determined by the interaction between molecules. If the intermolecular force is strong, a higher energy is required to disintegrate its lattice structure, and the melting point is high; otherwise, it is low. Knowing the melting point accurately is of great significance in identifying and purifying this substance.
    The boiling point is also one of its important physical properties. When the boiling point is reached, the substance changes from a liquid state to a gaseous state, and this process involves overcoming the intermolecular forces. The boiling point is closely related to the molecular mass and intermolecular forces. The boiling point of this compound, under specific conditions, presents a specific value, which is of great guiding value for its separation and refining operations.
    In addition, density is also one end of its physical properties. The density of the compound reflects its mass per unit volume and is affected by the molecular structure and accumulation method. This physical property has important consideration value in many practical application scenarios, such as determining its distribution state in a mixed system.
    In summary, the physical properties of 3-cyano-4-fluorobenzene-1-sulfonyl chloride are of critical significance in the fields of organic synthesis and chemical production, and can provide important basis and guidance for related operations.
    3-Cyano-4-Fluorobenzene-1-Sulfonyl the chemistry of Chloride
    3-Cyano-4-fluorobenzene-1-sulfonyl chloride, this is an organic compound. Its chemical properties are unique, let me explain in detail.
    In this compound, the cyano group (-CN) has high reactivity. The carbon atom and the nitrogen atom in the cyanyl group are connected by a triple bond, and the electron cloud distribution makes the group electrophilic, which is easy to react with nucleophiles. In common nucleophilic substitution reactions, the cyano group can be replaced by many nucleophiles, such as hydroxyl (-OH), amino (-NH ²), etc., to form corresponding carboxylic acid derivatives, amides and other compounds.
    The presence of fluorine atom (-F) also has a great influence on its properties. Fluorine atoms are extremely electronegative and will absorb electrons, which reduces the electron cloud density of the benzene ring. This electronic effect makes the electrophilic substitution reaction on the benzene ring more difficult, but the electron cloud density of the ortho and para-position is weakened more than that of the meta-position, so the nucleophilic substitution reaction is more likely to occur in the meta-position.
    Sulfonyl chloride group (-SO 2O Cl) is an active functional group. Sulfonyl chloride can undergo hydrolysis reaction. When exposed to water, the chlorine atom in the sulfonyl chloride group is easily replaced by a hydroxyl group to form a sulfonic acid (-SO ² H). And sulfonyl chloride can react with nucleophiles such as alcohols and amines to form sulfon
    In the field of organic synthesis, 3-cyano-4-fluorobenzene-1-sulfonyl chloride is widely used. Because it contains multiple active functional groups, it can be used as a key intermediate to construct complex organic compounds through series reactions, which are of great value in the fields of medicinal chemistry and materials science.
    What are the synthesis methods of 3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride?
    The synthesis methods of 3-cyano-4-fluorobenzene-1-sulfonyl chloride have been quite numerous throughout the ages. The main ones are selected and described below.
    First, 3-cyano-4-fluorobenzoic acid is used as the starting material. First, the acid is co-placed in a reactor with sulfuryl chloride, and an appropriate amount of catalyst is added, such as N, N-dimethylformamide. The temperature in the kettle is slowly raised to 70-80 degrees Celsius, and the reaction is continued for several hours. Sulfuryl chloride reacts with the carboxyl group in the acid, and the carboxyl group is replaced by a chlorine atom, and sulfur dioxide and hydrogen chloride gas escape. After this reaction, 3-cyano-4-fluorobenzoyl chloride can be obtained. Subsequently, the product is mixed with chlorosulfonic acid, the temperature is controlled at 0-5 degrees Celsius, it is added dropwise, and then heated to 30-40 degrees Celsius, and the reaction number is continued. The sulfonic acid group of chlorosulfonic acid replaces the hydrogen atom on the benzene ring to generate 3-cyano-4-fluorobenzene-1-sulfonyl chloride. This method step is relatively clear, but the reaction conditions need to be carefully controlled, otherwise it is easy to cause side reactions to occur.
    Second, 3-cyano-4-fluoroaniline is used as the starting material. First, it is mixed with concentrated sulfuric acid and concentrated nitric acid in a certain proportion to carry out nitrification reaction. At a low temperature of 0-5 degrees Celsius, the mixed acid is added dropwise, and then heated to 50-60 degrees Celsius. When the reaction number is numbered, 3-cyano-4-fluoro-2-nitroaniline can be obtained. Then iron powder and hydrochloric acid are used as the reducing agent to reduce the nitro group to an amino group to obtain 3-cyano-4-fluoro-2-aminoaniline. Then, sodium nitrite and hydrochloric acid are used to make a diazonium salt, which is reacted at low temperature to generate 3-cyano-4-fluoro-2-diazoaniline hydrochloride. Finally, the diazoyl group is replaced by a sulfonyl chloride group when reacted with sulfur dioxide and copper chloride, thereby preparing 3-cyano-4-fluorobenzene-1-sulfonyl chloride. Although this path is complicated, the raw material is relatively easy to obtain, and if properly operated, a higher yield can be obtained.
    Third, 3-cyano-4-fluorobenzene is used as the starting material. First, it reacts with chlorosulfonic acid to introduce sulfonyl chloride into the benzene ring to form 3-cyano-4-fluorobenzene-1-sulfonyl chloride. This reaction requires strict control of the amount of chlorosulfonic acid and the reaction temperature. Generally, chlorosulfonic acid is added dropwise at 0-10 degrees Celsius, and then heated to 40-50 degrees Celsius. The reaction number of times. This method is simple, but chlorosulfonic acid is highly corrosive, and extra caution is required during operation to prevent accidents.
    All kinds of synthesis methods have advantages and disadvantages. The experimenter should choose carefully according to his own actual situation, such as the availability of raw materials, the quality of equipment, and the requirements for product purity, etc., in order to achieve the expected effect.
    What to look out for when storing and transporting 3-Cyano-4-Fluorobenzene-1-Sulfonyl Chloride
    3-Cyano-4-fluorobenzene-1-sulfonyl chloride is an important chemical substance, and many key points must be paid attention to during storage and transportation.
    In terms of storage, the first priority is to control the ambient temperature. This substance should be stored in a cool place. If the temperature is too high, it is easy to change its chemical properties or cause undesirable conditions such as decomposition. If the cover temperature increases, the molecular activity will increase, which may trigger the break of the originally stable chemical bonds. Therefore, a place with relatively constant temperature and low temperature should be selected, such as a cold warehouse.
    Humid environment or cause its hydrolysis. Because its structure contains groups that can react with water, moisture intrusion can cause chemical structure damage and damage the quality. Therefore, the storage place must be dry, and a desiccant can be placed next to it to absorb excess water vapor.
    In addition, it is necessary to avoid contact with incompatible substances. This substance encounters alkalis, alcohols, etc., or has a violent chemical reaction. If it encounters alkali, or triggers a series of reactions such as acid-base neutralization, it will affect its purity and stability. Therefore, when storing, it should be placed separately from such substances and marked well to prevent mismixing.
    When transporting, be sure to pack tightly. Choose appropriate packaging materials to ensure that the packaging is not damaged in bumps and vibrations. Due to leakage, not only the material itself is lost, but also it may pose a threat to the environment and personal safety.
    The environmental conditions of transportation also need to meet the requirements. Temperature and humidity control are similar to those during storage, and the means of transportation should be clean and free of impurities that can react with them.
    The escort personnel must be professionally trained and familiar with the characteristics of this substance. In case of emergencies, such as leakage, fire, etc., they can be dealt with quickly according to the established plans to ensure smooth and safe transportation.