As a leading 3-Chloro-5-Fluorobenzenemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemistry of 3-Chloro-5-Fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol, an organic compound, has unique physical and chemical properties and is widely used in the field of organic synthesis.
Let's talk about its physical properties first. Under normal conditions, 3-chloro-5-fluorobenzyl alcohol is either a colorless to light yellow liquid or a solid state, which is related to its purity and ambient temperature. It has a certain odor, but the specific odor description is difficult to unify, and it depends on personal olfactory perception. Its melting point, boiling point and other physical constants are of great significance for the identification and separation of this compound. Unfortunately, more accurate data are not provided, so it is difficult to describe in detail.
When it comes to chemical properties, chlorine atoms and fluorine atoms in this molecule are connected to the benzene ring, which causes the electron cloud density of the benzene ring to change and affects the reactivity. Because the electronegativity of chlorine and fluorine atoms is greater than that of carbon, the electron cloud of the benzene ring is biased towards the halogen atom, which reduces the electrophilic substitution activity of the benzene ring. However, such reactions can still occur under certain conditions. For example, when reacting with electrophilic reagents, the localization effect of halogen atoms determines the substituent to enter the benzene ring position.
Furthermore, the alcohol hydroxyl groups it contains are chemically active. It can be esterified with acids to form corresponding ester compounds. If reacting with acetic acid, under the action of a catalyst, 3-chloro-5-fluorophenylmethyl acetate and water are At the same time, the hydroxyl group can be oxidized, and under the action of mild oxidizing agents, it can be converted into aldehyde groups to generate 3-chloro-5-fluorobenzaldehyde; strong oxidizing agents can be further oxidized to carboxyl groups to obtain 3-chloro-5-fluorobenzoic acid.
In addition, halogen atoms in 3-chloro-5-fluorobenzyl alcohol can participate in nucleophilic substitution reactions. Under suitable nucleophilic reagents and reaction conditions, chlorine atoms or fluorine atoms can be replaced to form new carbon-heteroatomic bonds and synthesize organic compounds with diverse structures. This property makes 3-chloro-5-fluorobenzyl alcohol an important intermediate in organic synthesis, which is widely used in the fields of drugs, pesticides and materials.
What are the main uses of 3-Chloro-5-Fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol, an organic compound, is widely used in the chemical and pharmaceutical fields.
In the chemical field, it is often a key intermediate in organic synthesis. It can be converted into other organic compounds through many chemical reactions. For example, by reacting with specific reagents, ester compounds can be formed. Such ester compounds have important applications in flavors, coatings and other industries. In fragrances, it can impart a unique smell; in coatings, it can improve the properties of coatings, such as improving their weather resistance and adhesion.
In the pharmaceutical field, 3-chloro-5-fluorobenzyl alcohol has extraordinary effects. The construction of many drug molecules requires this as the starting material. Because of the chlorine atoms and fluorine atoms, it can change the physical and chemical properties of drug molecules, such as lipophilicity, stability, etc., which in turn affect the biological activity and pharmacokinetic properties of drugs. Studies have shown that compounds containing such structures have potential activities in the treatment of certain diseases. For example, in the development of anti-tumor drugs, related derivatives may have specific inhibitory effects on tumor cells, or in the research of antibacterial drugs, they can enhance the inhibitory and killing ability of drugs against bacteria.
In summary, 3-chloro-5-fluorobenzyl alcohol is of great significance in the chemical and pharmaceutical industries, providing an important material basis for the development of related fields.
What is 3-Chloro-5-Fluorobenzenemethanol synthesis method?
The synthesis of 3-chloro-5-fluorobenzyl alcohol requires several delicate reaction steps. First, 3-chloro-5-fluorobenzoic acid is used as the starting material, which is the key starting material. It is reacted with lithium aluminum hydride in a suitable organic solvent, such as anhydrous tetrahydrofuran, at a low temperature and in a nitrogen-protected environment. Lithium aluminum hydride is highly reducible and can reduce the carboxyl group (-COOH) of benzoic acid to hydroxymethyl (-CH 2O OH). This step requires careful temperature control to prevent overreaction. After the reaction is completed, the excess lithium aluminum hydride can be removed by hydrolysis treatment to obtain a mixed system containing the target product.
Then, the product needs to be separated and purified. First, the product is extracted with an organic solvent to enrich the product in the organic phase, and then by column chromatography, silica gel is used as the stationary phase, and a suitable eluent is selected, such as the mixture of petroleum ether and ethyl acetate. According to the difference in the partition coefficient between the product and the impurities in the stationary phase and the mobile phase, 3-chloro-5-fluorobenzyl alcohol is separated one by one. After this fine operation, the pure 3-chloro-5-fluorobenzyl alcohol product can be obtained.
Another method is to use 3-chloro-5-fluorobromobenzene as the starting material and first react with magnesium chips to make Grignard reagent. This reaction also needs to be carried out in an anhydrous and anaerobic environment to ensure the stability of Grignard reagent. Then, the obtained Grignard reagent is reacted with polyformaldehyde, and then hydrolyzed to obtain 3-chloro-5-fluorobenzyl alcohol. This route also needs to pay attention to the control of reaction conditions at each step, such as reaction temperature, reactant ratio, etc., in order to make the synthesis smooth and obtain satisfactory yield and purity.
What are the precautions in storage and transportation of 3-Chloro-5-Fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol is also an organic compound. When storing and transporting, be sure to pay attention to many matters.
The first to bear the brunt, when storing, it must choose a cool and dry place. This is because it is afraid of moisture and heat, and it is easy to deteriorate in a high temperature and humid environment. Due to the chemical structure of the compound, it is easy to chemically react under humid and hot conditions, damaging its purity and quality. For example, if left in hot flashes for a long time, it may cause it to hydrolyze and form other impurities.
Furthermore, the storage place should be well ventilated. If the ventilation is not smooth, the volatile gas of this compound will not disperse, or the local concentration will be too high, which may cause an explosion, and the operator will inhale it when taking it, which is also harmful to health.
As for transportation, it needs to be properly packaged. When using a sealed and chemically resistant container to prevent leakage. If it leaks outside, it will not only pollute the environment, but also be toxic and corrosive, or endanger surrounding organisms. And during transportation, severe vibration and collision should be avoided, because the compound may trigger a reaction due to vibration, which will damage its stability.
In addition, strict labeling is required regardless of storage or transportation. Show that it is 3-chloro-5-fluorobenzyl alcohol and label its dangerous characteristics, such as toxic, corrosive, etc. In this way, the operator is aware of its characteristics and operates with caution to avoid accidents. In general, when storing and transporting 3-chloro-5-fluorobenzyl alcohol, pay attention to the above things, so that the security is safe and the quality is not damaged.
What is the market price of 3-Chloro-5-Fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol, the price of this product in the market is difficult to determine. Its price often changes due to various reasons, and the supply and demand of the market, the production process, and the quality are all the main reasons.
Looking at the market conditions in the past, if you want its high-quality products, the price for fine chemical or pharmaceutical developers may be high. The difficulty of its production and the complexity of the work make it costly, and the price follows. In the past, the price in the market could reach tens of gold per gram, or even hundreds of gold, depending on the purity and demand.
If it is of ordinary industrial grade, it is used for general chemical synthesis, and the price may be slightly lower. Although it also needs to be prepared by chemical methods, the quality requirement is not as severe as that of pharmaceutical grade, so the price varies from a few gold per gram to a few dozen gold.
However, the market is unstable, and the price is also uncertain. In the near future, if the supply exceeds the demand, or the production increases greatly due to the improvement of the process, the price will drop; on the contrary, if the supply is prosperous but less, or the raw materials are rare, the price will rise. In order to know the exact price, you must check the current market conditions and consult the chemical supplier before you can obtain an accurate number.