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3-Chloro-5-Fluorobenzenemethanol

3-Chloro-5-Fluorobenzenemethanol

Hongda Chemical

Specifications

HS Code

286989

Name 3-Chloro-5-Fluorobenzenemethanol
Molecular Formula C7H6ClFO
Molecular Weight 160.57
Appearance Typically a solid or viscous liquid (varies)
Boiling Point Estimated around 230 - 250 °C (approximate, can vary based on purity and conditions)
Melting Point Data may vary, approximate range could be around 40 - 60 °C
Density No exact common value, density around 1.3 - 1.4 g/cm³ (approximate)
Solubility In Water Poorly soluble in water
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane
Flash Point Estimated to be relatively high, above 100 °C (approximate)
Purity Can be sold in various purity levels, often 95%+ in commercial products
Cas Number 115011-74-6

As an accredited 3-Chloro-5-Fluorobenzenemethanol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 3 - chloro - 5 - fluorobenzenemethanol packaged in a sealed plastic bottle.
Storage 3 - Chloro - 5 - fluorobenzenemethanol should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly sealed container to prevent moisture absorption and evaporation. Label the storage container clearly to avoid misidentification. Store in a location where it is inaccessible to unauthorized personnel.
Shipping 3 - chloro - 5 - fluorobenzenemethanol is shipped in properly sealed containers. Packaging adheres to chemical transport regulations. It's transported under conditions that prevent exposure, ensuring safety during transit.
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3-Chloro-5-Fluorobenzenemethanol 3-Chloro-5-Fluorobenzenemethanol
General Information
Historical Development
3-Chloro-5-fluorobenzyl alcohol is also an organic compound. Its traces can be traced back to the past. At the beginning, various sages explored the field of organic synthesis and gradually paid attention to this thing. At that time, the technology of chemistry was not as sophisticated as it is today, and the road to synthesis was full of thorns.
However, the craftsmen continued to study, and with wisdom and perseverance, they overcame many difficulties. From simple raw materials, through complex reactions, this compound was gradually obtained. With the passage of time, the chemical technology improved day by day, the synthesis method became better and the yield gradually increased. From the initial ignorance and temptation to the later familiarity, the development of this compound has also witnessed the vigorous evolution of chemical science, paving the way for many subsequent research and applications.
Product Overview
The product of 3-chloro-5-fluorobenzyl alcohol
3-chloro-5-fluorobenzyl alcohol is also an organic compound. It may be a colorless to pale yellow liquid with specific chemical properties.
This substance is widely used in the field of organic synthesis. It can be used as a key intermediate for the preparation of a variety of drugs, pesticides and fine chemicals. In drug development, through specific chemical reactions, or the construction of biologically active molecular structures, it is expected to show therapeutic effects on specific diseases.
The way of synthesis, Chang Wai specifies the chemical method and reaction conditions. Through careful regulation of the proportion of reactants, temperature, catalyst and other factors, to achieve efficient and high-purity synthesis.
However, its preparation and use also need to pay attention to safety matters. Due to its chemical properties, or certain toxicity, corrosiveness, etc., when operating, follow strict safety procedures to protect the safety of the experimenter and prevent harm to the environment.
Physical & Chemical Properties
3-Chloro-5-fluorobenzyl alcohol is also an organic compound. Its physical properties have a specific state. At room temperature, it is either a solid state or a liquid state. Looking at its crystalline state, it has a pure color and uniform texture. Its melting and boiling point is fixed due to intermolecular forces. If it melts, it can be self-solidified and liquid at a specific temperature; when boiling, it can be liquid and gas at the corresponding temperature. This is a characterization of its physical properties.
In this compound, the chlorine and fluorine atoms are electronegative, resulting in a special electron cloud density distribution of the benzene ring, and the activity is also different. Its hydroxyl group can be involved in many reactions, such as esterification, co-location with acid, and under specific conditions, it can form esters, because the lone electron of the oxygen atom in the hydroxyl group is nucleophilic. And because of the side of the halogen atom, it can initiate nucleophilic substitution. Under appropriate reagents and conditions, the halogen atom can be replaced by other groups, which are all important physical and chemical properties of 3-chloro-5-fluorobenzyl alcohol.
Technical Specifications & Labeling
Today there is a thing, name 3 - Chloro - 5 - Fluorobenzenemethanol. To clarify its technical specifications and identification (product parameters), you should consider it carefully. The technical specifications of this thing are related to its quality, its quantity, and its properties. The quality, the identification of pure impurities, the geometry of impurities, must be accurately determined to meet the needs of the use. The quantity, the number, and the proportion of content must be clear. For sex, physical and chemical properties, the degree of melting and boiling, and the ability to dissolve are all key.
As for the logo, the name should be clearly stated, the book is correct, and a clear chemical formula should be attached to prove it. Product parameters should not be ignored, such as production batch, shelf life, etc., should be detailed, and the user can follow this, without the risk of error. In this way, the technical specifications and labels of this product can be obtained, and it is also necessary for research and development and use.
Preparation Method
The method of preparing 3-chloro-5-fluorobenzyl alcohol is related to the raw materials and production process, reaction steps and catalytic mechanism, and cannot be careless.
Take an appropriate amount of 3-chloro-5-fluorobenzoic acid as the initial raw material, dissolve it in a specific alcohol solvent, and add an appropriate amount of reducing agent, such as sodium borohydride or lithium aluminum hydride. Under the condition of low temperature and stirring evenly, slowly add the reducing agent dropwise, which is a key step in the reaction. Due to the high activity of the reducing agent, the operation needs to be cautious to prevent overreaction.
After the dropwise addition is completed, maintain the reaction temperature and continue to stir to make the reaction fully proceed. In this process, the reaction process can be closely monitored by thin-layer chromatography or other suitable analytical means. After the reaction is completed, the reaction system is neutralized in a dilute acid solution, and then extracted and separated. The organic phase is taken, and the pure 3-chloro-5-fluorobenzyl alcohol product is obtained by drying and distillation under reduced pressure.
In terms of catalytic mechanism, the reducing agent provides hydrogen negative ions in the reaction to attack the carboxyl group of 3-chloro-5-fluorobenzoic acid. After a series of electron transfer and chemical bond rearrangement, the conversion of carboxyl group to alcohol hydroxyl group is achieved. In this way, the product of 3-chloro-5-fluorobenzyl alcohol can be obtained.
Chemical Reactions & Modifications
I am committed to the chemical research of 3-Chloro-5-Fluorobenzenemethanol. The chemical reaction and modification of this compound are the key to scientific research.
Looking at the reaction, the chlorine and fluorine atoms on the benzene ring can be substituted through specific reagents and conditions, which is the basis for modification. If attacked with nucleophiles, chlorine atoms can easily become other groups. This reaction is delicate and depends on the reaction rate and product purity.
However, there are often problems in the reaction, and side reactions occur frequently, resulting in impure products. Therefore, the improved method requires precise regulation of the reaction temperature, time and the ratio of reagents. If the temperature changes slightly, the reaction direction may be different; if the time is improper, the product may overreact.
In order to optimize the modification, the effect of the catalyst is also investigated. Suitable catalysts can increase the reactivity and reduce side reactions. After repeated experiments, several agents can be found to optimize the reaction, so that the product performance is better and the yield is also increased. This is all obtained from the chemical reaction and modification of 3-Chloro-5-Fluorobenzenemethanol in chemical research.
Synonyms & Product Names
3-Chloro-5-fluorobenzyl alcohol is also a chemical product. The same name and trade name are quite important in the industry. Looking at the ancient Fang family, when it comes to various compounds, it also attaches great importance to their names. Today, 3-chloro-5-fluorobenzyl alcohol has the same name, or it may be called according to its structure and characteristics. The trade name is related to the circulation of the city, and it is a sign of its entry into the market. Gu Yun: "If the name is not correct, it will not go well." The same is true for the same name and trade name of the compound. Only by knowing its name can we know its quality and use. It is beneficial to research, produce and sell. Therefore, the exploration of the same name and commercial name of 3-chloro-5-fluorobenzyl alcohol is an indispensable task for chemical researchers.
Safety & Operational Standards
Specifications for safety and operation of 3-chloro-5-fluorobenzyl alcohol
Fu 3-chloro-5-fluorobenzyl alcohol is also a substance commonly encountered in chemical preparation. Its properties are related to the safety of the experiment, and the rules of operation depend on the orderly operation, which cannot be ignored.
#1. Storage requirements
This substance should be stored in a cool, dry and well-ventilated place. Avoid open fires and hot topics to prevent unexpected risks. Cover its properties or flammable, or change with heat, endangering the surroundings. The reservoir must be tightly closed to avoid mixing with air, moisture and other objects, causing its quality to change. If stored in an improper place with high temperature and humidity, it may cause decomposition and deterioration, damage its use and increase risk.
#2. How to use
When taking 3-chloro-5-fluorobenzyl alcohol, protective equipment must be worn. Such as chemical-resistant gloves to prevent touching the body and hurting the skin; wear protective goggles to avoid splashing it on the eyes and harming the eyes. When taking the device, clean and dry, so as not to mix impurities and mess with its properties. The amount should be accurate, according to the experimental needs, not more or less. More will be expensive and increase risk, and less will not achieve the expected effect.
#3. Rules of operation
During operation, the experimental room must be well ventilated. Set up a ventilated device to expel harmful vapors and keep the air fresh. The operation table should be neat and orderly, and no sundries should be stored to avoid hindering the operation and causing mistakes. When heating this substance, use appropriate methods and strictly control the temperature. Do not overheat to prevent decomposition, fire, etc. When stirring, the speed should also be appropriate to avoid liquid splashing. If the operation is wrong, such as material pouring, take emergency measures immediately. Small sprinklers should be collected with adsorbed materials and disposed of properly; large sprinklers should leave the scene quickly and report to the supervisor for professional management.
#Fourth, the principle of waste
After the experiment is completed, the remaining 3-chloro-5-fluorobenzyl alcohol and the waste it contains should not be discarded at will. When collected in accordance with environmental protection regulations, it should be collected by classification. Hand it over to a professional waste treatment institution and dispose of it in an appropriate way. It must not be dumped in the sink or garbage, which will pollute the environment and harm the ecology.

Husband safety and operating standards, in the research and use of 3-chloro-5-fluorobenzyl alcohol, such as a boat's cart, and a car's wheel. If you keep it, you will go smoothly, and if you violate it, you will be at risk. All researchers should be engraved in their hearts, be cautious in their work, and ensure the safety of
Application Area
3-Chloro-5-fluorobenzyl alcohol is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it is often a key intermediate in the synthesis of specific drugs. Because of its unique chemical structure, it can participate in various reactions to obtain drugs with specific curative effects and cure various diseases.
In materials science, it also has its place. It can be integrated into polymer materials through specific processes to give materials such as better stability and corrosion resistance, and expand the application range of materials for the manufacture of high-end equipment, special containers, etc.
In addition, in the field of fine chemicals, 3-chloro-5-fluorobenzyl alcohol can be used as a raw material for the preparation of special fragrances and dyes, and its reaction can generate unique substances to meet the market demand for characteristic chemical products and contribute to the development of many industries.
Research & Development
On the road of chemical research, I have been focusing on 3-chloro-5-fluorobenzyl alcohol for a long time. This compound has a delicate structure and unique characteristics, and has high potential value in the field of organic synthesis.
I began to explore its reaction mechanism. After many experiments, I observed its changes under different conditions. With a rigorous attitude, I recorded each result in detail and analyzed its laws. I also studied its new synthesis method, striving to improve the yield and optimize the process.
In terms of application expansion, I have also thought a lot. Thinking about it may be used to create new drugs or make a name for myself in materials science. I hold the heart of research and development, hoping to contribute to the development of 3-chloro-5-fluorobenzyl alcohol, making it shine in the forest of science, and bringing new opportunities and breakthroughs to the industry.
Toxicity Research
It is very important to investigate the toxicity of 3-chloro-5-fluorobenzyl alcohol. We will investigate in detail to clarify its properties.
After a series of experiments, observe its effects on various organisms. In small animal experiments, observe its reaction after ingesting this chemical. It may show signs of slow movement and reduced eating, and some organs are also abnormally characterized, or it may be damaged to the body.
Review its impact in the environment, in water, soil and other media, or react with other substances, affecting ecological balance. However, to determine its precise toxicity, more in-depth studies are needed, taking into account factors such as different doses, durations, and individual differences in organisms. Future follow-up studies can better clarify its toxicity and provide a solid basis for protection and application.
Future Prospects
Wuguanfu 3 - Chloro - 5 - Fluorobenzenemethanol This product has extraordinary potential. In the future development, it is expected to shine in various fields.
Today's chemical research is changing with each passing day. This compound has a unique structure and may be able to make a name for itself in the development of medicine. It can be used as a key intermediate to help create new drugs to cure many difficult diseases and save people from pain.
And it can also be used in the field of materials science. Or it can be cleverly designed to produce new materials with excellent performance, which can be used in cutting-edge industries such as electronics and aviation, and promote science and technology to make great progress.
Furthermore, in chemical production, if the synthesis process can be optimized, the yield and purity can be improved, it will be able to reduce costs and increase its market competitiveness.
I firmly believe that with time and the unremitting research of scientific researchers, 3 - Chloro - 5 - Fluorobenzenemethanol will be able to demonstrate its endless value and open up new horizons for the well-being of mankind.
Where to Buy 3-Chloro-5-Fluorobenzenemethanol in China?
As a trusted 3-Chloro-5-Fluorobenzenemethanol manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 3-Chloro-5-Fluorobenzenemethanol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the chemistry of 3-Chloro-5-Fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol, an organic compound, has unique physical and chemical properties and is widely used in the field of organic synthesis.
Let's talk about its physical properties first. Under normal conditions, 3-chloro-5-fluorobenzyl alcohol is either a colorless to light yellow liquid or a solid state, which is related to its purity and ambient temperature. It has a certain odor, but the specific odor description is difficult to unify, and it depends on personal olfactory perception. Its melting point, boiling point and other physical constants are of great significance for the identification and separation of this compound. Unfortunately, more accurate data are not provided, so it is difficult to describe in detail.
When it comes to chemical properties, chlorine atoms and fluorine atoms in this molecule are connected to the benzene ring, which causes the electron cloud density of the benzene ring to change and affects the reactivity. Because the electronegativity of chlorine and fluorine atoms is greater than that of carbon, the electron cloud of the benzene ring is biased towards the halogen atom, which reduces the electrophilic substitution activity of the benzene ring. However, such reactions can still occur under certain conditions. For example, when reacting with electrophilic reagents, the localization effect of halogen atoms determines the substituent to enter the benzene ring position.
Furthermore, the alcohol hydroxyl groups it contains are chemically active. It can be esterified with acids to form corresponding ester compounds. If reacting with acetic acid, under the action of a catalyst, 3-chloro-5-fluorophenylmethyl acetate and water are At the same time, the hydroxyl group can be oxidized, and under the action of mild oxidizing agents, it can be converted into aldehyde groups to generate 3-chloro-5-fluorobenzaldehyde; strong oxidizing agents can be further oxidized to carboxyl groups to obtain 3-chloro-5-fluorobenzoic acid.
In addition, halogen atoms in 3-chloro-5-fluorobenzyl alcohol can participate in nucleophilic substitution reactions. Under suitable nucleophilic reagents and reaction conditions, chlorine atoms or fluorine atoms can be replaced to form new carbon-heteroatomic bonds and synthesize organic compounds with diverse structures. This property makes 3-chloro-5-fluorobenzyl alcohol an important intermediate in organic synthesis, which is widely used in the fields of drugs, pesticides and materials.
What are the main uses of 3-Chloro-5-Fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol, an organic compound, is widely used in the chemical and pharmaceutical fields.
In the chemical field, it is often a key intermediate in organic synthesis. It can be converted into other organic compounds through many chemical reactions. For example, by reacting with specific reagents, ester compounds can be formed. Such ester compounds have important applications in flavors, coatings and other industries. In fragrances, it can impart a unique smell; in coatings, it can improve the properties of coatings, such as improving their weather resistance and adhesion.
In the pharmaceutical field, 3-chloro-5-fluorobenzyl alcohol has extraordinary effects. The construction of many drug molecules requires this as the starting material. Because of the chlorine atoms and fluorine atoms, it can change the physical and chemical properties of drug molecules, such as lipophilicity, stability, etc., which in turn affect the biological activity and pharmacokinetic properties of drugs. Studies have shown that compounds containing such structures have potential activities in the treatment of certain diseases. For example, in the development of anti-tumor drugs, related derivatives may have specific inhibitory effects on tumor cells, or in the research of antibacterial drugs, they can enhance the inhibitory and killing ability of drugs against bacteria.
In summary, 3-chloro-5-fluorobenzyl alcohol is of great significance in the chemical and pharmaceutical industries, providing an important material basis for the development of related fields.
What is 3-Chloro-5-Fluorobenzenemethanol synthesis method?
The synthesis of 3-chloro-5-fluorobenzyl alcohol requires several delicate reaction steps. First, 3-chloro-5-fluorobenzoic acid is used as the starting material, which is the key starting material. It is reacted with lithium aluminum hydride in a suitable organic solvent, such as anhydrous tetrahydrofuran, at a low temperature and in a nitrogen-protected environment. Lithium aluminum hydride is highly reducible and can reduce the carboxyl group (-COOH) of benzoic acid to hydroxymethyl (-CH 2O OH). This step requires careful temperature control to prevent overreaction. After the reaction is completed, the excess lithium aluminum hydride can be removed by hydrolysis treatment to obtain a mixed system containing the target product.
Then, the product needs to be separated and purified. First, the product is extracted with an organic solvent to enrich the product in the organic phase, and then by column chromatography, silica gel is used as the stationary phase, and a suitable eluent is selected, such as the mixture of petroleum ether and ethyl acetate. According to the difference in the partition coefficient between the product and the impurities in the stationary phase and the mobile phase, 3-chloro-5-fluorobenzyl alcohol is separated one by one. After this fine operation, the pure 3-chloro-5-fluorobenzyl alcohol product can be obtained.
Another method is to use 3-chloro-5-fluorobromobenzene as the starting material and first react with magnesium chips to make Grignard reagent. This reaction also needs to be carried out in an anhydrous and anaerobic environment to ensure the stability of Grignard reagent. Then, the obtained Grignard reagent is reacted with polyformaldehyde, and then hydrolyzed to obtain 3-chloro-5-fluorobenzyl alcohol. This route also needs to pay attention to the control of reaction conditions at each step, such as reaction temperature, reactant ratio, etc., in order to make the synthesis smooth and obtain satisfactory yield and purity.
What are the precautions in storage and transportation of 3-Chloro-5-Fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol is also an organic compound. When storing and transporting, be sure to pay attention to many matters.
The first to bear the brunt, when storing, it must choose a cool and dry place. This is because it is afraid of moisture and heat, and it is easy to deteriorate in a high temperature and humid environment. Due to the chemical structure of the compound, it is easy to chemically react under humid and hot conditions, damaging its purity and quality. For example, if left in hot flashes for a long time, it may cause it to hydrolyze and form other impurities.
Furthermore, the storage place should be well ventilated. If the ventilation is not smooth, the volatile gas of this compound will not disperse, or the local concentration will be too high, which may cause an explosion, and the operator will inhale it when taking it, which is also harmful to health.
As for transportation, it needs to be properly packaged. When using a sealed and chemically resistant container to prevent leakage. If it leaks outside, it will not only pollute the environment, but also be toxic and corrosive, or endanger surrounding organisms. And during transportation, severe vibration and collision should be avoided, because the compound may trigger a reaction due to vibration, which will damage its stability.
In addition, strict labeling is required regardless of storage or transportation. Show that it is 3-chloro-5-fluorobenzyl alcohol and label its dangerous characteristics, such as toxic, corrosive, etc. In this way, the operator is aware of its characteristics and operates with caution to avoid accidents. In general, when storing and transporting 3-chloro-5-fluorobenzyl alcohol, pay attention to the above things, so that the security is safe and the quality is not damaged.
What is the market price of 3-Chloro-5-Fluorobenzenemethanol?
3-Chloro-5-fluorobenzyl alcohol, the price of this product in the market is difficult to determine. Its price often changes due to various reasons, and the supply and demand of the market, the production process, and the quality are all the main reasons.
Looking at the market conditions in the past, if you want its high-quality products, the price for fine chemical or pharmaceutical developers may be high. The difficulty of its production and the complexity of the work make it costly, and the price follows. In the past, the price in the market could reach tens of gold per gram, or even hundreds of gold, depending on the purity and demand.
If it is of ordinary industrial grade, it is used for general chemical synthesis, and the price may be slightly lower. Although it also needs to be prepared by chemical methods, the quality requirement is not as severe as that of pharmaceutical grade, so the price varies from a few gold per gram to a few dozen gold.
However, the market is unstable, and the price is also uncertain. In the near future, if the supply exceeds the demand, or the production increases greatly due to the improvement of the process, the price will drop; on the contrary, if the supply is prosperous but less, or the raw materials are rare, the price will rise. In order to know the exact price, you must check the current market conditions and consult the chemical supplier before you can obtain an accurate number.