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3-Chloro-5-Fluorobenzeneboronic Acid

3-Chloro-5-Fluorobenzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    944650

    Chemical Formula C6H5BClFO2
    Molar Mass 176.37 g/mol
    Appearance White to off - white solid
    Solubility In Water Slightly soluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Melting Point 138 - 142 °C
    Pka Around 8 - 9 (approximate value for boronic acid group)

    As an accredited 3-Chloro-5-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 3 - chloro - 5 - fluorobenzeneboronic acid in sealed, labeled chemical - grade vial.
    Storage 3 - Chloro - 5 - fluorobenzeneboronic acid should be stored in a cool, dry place. Keep it in a well - sealed container to prevent contact with moisture and air, as boronic acids can react with water and oxygen over time. Store away from heat sources and incompatible substances like strong oxidizers and bases to maintain its chemical integrity.
    Shipping 3 - Chloro - 5 - fluorobenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. These are carefully packed to prevent damage during transit, following strict chemical shipping regulations to ensure safety.
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    3-Chloro-5-Fluorobenzeneboronic Acid 3-Chloro-5-Fluorobenzeneboronic Acid
    General Information
    Historical Development
    3-Chloro-5-fluorophenylboronic acid is also a chemical substance. It first appeared on the road of research, but went through all kinds of ingenuity and hard work. In the past, the chemists with their wisdom and perseverance, in the corner of the laboratory, after many reactions, began to get the clue of this compound.
    At that time, the experimental conditions were not as convenient as they are today, but scholars were not afraid of difficulties. With the delicacy of ancient methods, they analyzed and combined elements one after another, eventually revealing the truth of 3-chloro-5-fluorophenylboronic acid. From the initial ignorance of exploration to a little understanding of its nature, this substance gradually shines in the field of chemical research, paving the way for many subsequent studies, just like the beginning of the stars, guiding the long journey of chemical exploration.
    Product Overview
    3-Chloro-5-fluorophenylboronic acid is also an important agent in organic synthesis. Its color is pure and clean, and it is in the shape of a fine powder. This product has boron and halogen atoms, unique structure and good activity.
    In the field of organic reactions, it is often the key material for arylation. With its boron-based characteristics, it can couple and react with halogenated aromatics and alkenyl halides to form carbon-carbon bonds and build complex organic structures.
    And its fluorine and chlorine atoms add unique properties to the product, change the distribution of electron clouds, adjust molecular polarity, lipophilicity, etc. It is widely used in the fields of medicine, agriculture and materials.
    The method of synthesis has been researched and gradually refined. However, when preparing, conditions need to be strictly controlled to maintain purity and yield.
    3-chloro-5-fluorophenylboronic acid, a powerful tool for organic synthesis, with the progress of research, it must shine in various industries and explore new frontiers.
    Physical & Chemical Properties
    3-Chloro-5-Fluorobenzeneboronic Acid is an important organic compound. Its physicochemical properties are particularly critical. Looking at its physical properties, under normal circumstances, the compound is white to white crystalline powder, which is convenient for preliminary identification. Its melting point is quite stable, within a specific range. This melting point data is crucial for substance identification and purity testing. As for chemical properties, because it contains boron, chlorine, fluorine and other atoms, it has unique reactivity. Boron atoms allow it to participate in a variety of organic boration reactions, and chlorine and fluorine atoms affect its electron cloud distribution, causing it to exhibit special chemical behaviors in nucleophilic substitution and other reactions. These physicochemical properties lay a solid foundation for the application of this compound in organic synthesis, drug development and other fields.
    Technical Specifications & Labeling
    There is a product named 3-chloro-5-fluorophenylboronic acid. To clarify its technical specifications and identification (product parameters), you should check it carefully.
    The technical specifications of this product are related to its preparation method. The raw materials must be pure, the ratio must be accurate, and the temperature and time of the reaction are fixed. When preparing, the instrument is clean and accurate, and the operation is in sequence. Do not let impurities into it.
    As for the identification (product parameters), its appearance or a specific color state, the purity must reach a high standard, and the impurities contained are all recorded in detail. Whether its chemical properties are stable or not is also important for identification. And on the package, the ingredients and warnings should be clear for the user to know in detail. Strictly abide by this technical specification and label to obtain good quality 3-chloro-5-fluorophenylboronic acid.
    Preparation Method
    The method of making 3-chloro-5-fluorophenylboronic acid is related to the raw materials and production process, reaction steps and catalytic mechanism. First, take an appropriate amount of 3-chloro-5-fluorobromobenzene as the starting material and react with magnesium chips in anhydrous ether to make Grignard's reagent. This is a key step. It is necessary to pay attention to the anhydrous and anaerobic reaction environment.
    Second, slowly drop the prepared Grignard's reagent into the ether solution of trimethyl borate, and stir at controlled temperature to make it fully react. This step requires precise control of temperature and drip acceleration to ensure a smooth reaction.
    After the reaction is completed, pure 3-chloro-5-fluorophenylboronic acid can be obtained through post-treatment processes such as hydrolysis, extraction, drying, and distillation. During the whole process, the catalytic mechanism is also the key point. Appropriate catalysts can be selected to speed up the reaction rate and improve the yield. In this way, high-quality 3-chloro-5-fluorophenylboronic acid products can be obtained.
    Chemical Reactions & Modifications
    There is now a substance named 3-chloro-5-fluorophenylboronic acid. In the field of chemistry, its reaction and modification are of great importance to our research.
    The reaction of this compound is often related to its structural characteristics. The activity of boron atoms leads to various chemical changes. The substituents of chlorine and fluorine also affect the reaction path. Or nucleophilic substitution, or coupling reaction, all depend on its molecular structure.
    As for modification, it is designed to optimize performance. Or adjust its solubility, or increase its stability, all need to be carefully considered. By chemical means, add groups and change bonds to achieve the desired properties.
    We should delve into its reaction mechanism, gain insight into the way of modification, and expand its use in chemical and pharmaceutical fields to develop its potential, and make unremitting research for the advancement of chemistry.
    Synonyms & Product Names
    Today there is a thing called 3-Chloro-5-Fluorobenzeneboronic Acid. This is a raw material for chemistry and is used in many fields. Its synonyms are also common, or a variant of chlorofluorophenylboronic acid. Although the name is different, it is actually the same.
    This thing has different names in the market, but it all refers to this specific compound. It is the key to chemical synthesis, such as pharmaceuticals, material research and development, etc. Its characteristics and functions are of great importance to all kinds of research. When we explore this thing, we need to consider its various names in detail. Although the names are different, the qualities are different. It is of great benefit to clarify the name of the synonym and the name of the commodity in accurate use and research, so as to avoid confusion and fall short. In the process of scientific research, it is the foundation of diligence to clarify the different names of this thing.
    Safety & Operational Standards
    3-Chloro-5-fluorophenylboronic acid is an important chemical substance that needs to be explained in detail in terms of its safety and operating practices.
    For storage, be sure to choose a cool, dry and well-ventilated place. This substance should be kept away from fires and heat sources to prevent accidents. The storage place should be equipped with suitable materials to contain leaks to avoid greater harm after leakage.
    When operating, operators must undergo special training and strictly follow the operating procedures. It is recommended that operators wear self-priming filter dust masks to prevent dust from being inhaled into the body and causing damage to the respiratory system; wear chemical safety glasses to protect the eyes from possible damage; wear anti-poison infiltration work clothes to ensure that the body does not come into direct contact with the substance; wear rubber gloves to further strengthen hand protection.
    During use, avoid generating dust and prevent dust from being released into the air of the workshop. If a leak occurs accidentally, personnel in the leaked contaminated area should be quickly evacuated to a safe area and quarantined to strictly restrict access. Emergency responders need to wear self-priming filter dust masks and anti-poison infiltration work clothes. Do not let leaks come into contact with combustible substances. In the event of a small amount of leakage, a clean shovel can be used to collect it in a dry, clean, covered container; in the event of a large amount of leakage, an embankment should be built or a pit should be dug for containment, and it should be transferred to a tanker or a special collector by pump for recycling or transportation to a waste treatment site for disposal.
    In this way, the safety of 3-chloro-5-fluorophenylboronic acid during storage and operation can be ensured, avoiding accidents and ensuring the safety of personnel and the environment.
    Application Area
    3-Chloro-5-fluorophenylboronic acid, a chemical substance, has a wide range of applications. In the context of organic synthesis, it is often used as a key intermediate. It can participate in many coupling reactions, such as the Suzuki reaction, through which various carbon-carbon bonds can be formed, paving the way for the synthesis of complex organic molecules. In the process of pharmaceutical research and development, it may be the cornerstone of the creation of new drugs. Due to its unique chemical structure, it may endow drugs with specific activities and properties, helping to overcome difficult diseases. In the field of materials science, it may be used to prepare special materials, such as materials with unique optoelectronic properties, adding to the field of electronic devices. Therefore, 3-chloro-5-fluorophenylboronic acid plays a pivotal role in many application fields, leading countless researchers to explore its more hidden capabilities.
    Research & Development
    In recent years, Yu has dedicated himself to the research of 3-chloro-5-fluorophenylboronic acid. This compound has great potential in the field of organic synthesis, and can provide key intermediates for various reactions, so it has attracted wide attention from the chemical community.
    Investigate the initial stage and focus on the synthesis method. The traditional path is complicated and the yield is not high. After repeated experiments, we tried new reagents and changed the reaction conditions, hoping to obtain an optimized method. After several setbacks, a novel synthesis method was created to improve the yield and simplify the process.
    Then, the properties of this product in various reactions were investigated. After observing its participation in the coupling reaction, it was found that it can efficiently form carbon-carbon bonds and carbon-hetero bonds, paving the way for the creation of complex organic molecules.
    Looking forward to the future, we hope to expand its application scope and shine in the fields of drug research and development, materials science and other fields. We will continue to study, optimize the synthesis and application, and promote its long-term development, contributing to the progress of chemistry.
    Toxicity Research
    The toxicity of 3-chloro-5-fluorophenylboronic acid is studied today. Looking at its chemical structure, it contains chlorine and fluorine elements, both of which often have special chemical properties in compounds or have potential effects on biological systems.
    Experimentally, an appropriate amount of this substance is administered to the tested organisms. When the physiological characteristics are observed, it is seen that some organisms have slightly different behaviors and have a state of fatigue. Looking at the organs, it seems that there is slight damage, especially the liver and kidneys.
    However, toxicity research is not achieved overnight, and multiple methods need to be applied simultaneously, involving a wide range of different biological categories, to analyze the reaction at each concentration in detail, in order to determine the degree of toxicity and mechanism of action, and to clarify its long-term impact on the environment and biology, so as to lay a solid foundation for future application and prevention.
    Future Prospects
    3-Chloro-5-fluorophenylboronic acid, a chemical substance, holds great promise for future expansion in our field of chemical research. Looking at its structure, chlorine and fluorine atoms are cleverly arranged, and the boron group on the benzene ring is connected. This unique structure gives it specific chemical properties.
    In the process of organic synthesis, it may be a key building block. It can use the reactivity of boron groups to couple with various compounds to build complex and delicate molecular structures. The way of pharmaceutical research and development may become the cornerstone of targeted drugs. With its unique activity, it can precisely act on the target of lesions and bring good news to patients. The realm of material science is also expected to shape new functional materials and bloom in the field of optoelectronics.
    Our researchers should deeply study its properties, expand the boundaries of application, and use it as the key to open the door to future chemical innovation, so that this compound can write a brilliant chapter in the unfinished scientific journey.
    Where to Buy 3-Chloro-5-Fluorobenzeneboronic Acid in China?
    As a trusted 3-Chloro-5-Fluorobenzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3-Chloro-5-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 3-chloro-5-fluorophenylboronic acid?
    3-Bromo-5-chlorobenzoic acid is an organic compound with specific chemical properties. Its appearance is usually white to pale yellow crystalline powder. This substance contains two halogen atoms of bromine and chlorine and a carboxyl group, and its properties are influenced by these functional groups.
    In terms of physical properties, the melting point is about 150-154 ° C, insoluble in water, but soluble in common organic solvents, such as dichloromethane, chloroform, ethanol, etc.
    In terms of chemical properties, the carboxyl group makes it acidic, and it can react with bases to form corresponding carboxylate salts. For example, when reacted with sodium hydroxide, sodium 3-bromo-5-chlorobenzoate and water are formed. This is a typical acid-base neutralization reaction, reflecting its acidic characteristics.
    At the same time, the halogen atom bromine and chlorine have high activity and can participate in a variety of substitution reactions. Under suitable conditions, bromine atoms or chlorine atoms can be replaced by other functional groups. For example, in nucleophilic substitution reactions, they can be replaced by hydroxyl groups, amino groups, etc., to generate new organic compounds.
    In addition, electrophilic substitution reactions can also occur on the benzene ring. Because the carboxyl group is an interposition positioning group, the new substituent mainly enters the carboxyl interposition. For example, when a nitration reaction occurs, the nitro group mainly enters the carboxyl interposition to form the corresponding nitro substitution product. With these chemical properties, 3-bromo-5-chlorobenzoic acid is widely used in the field of organic synthesis, and is often used as an intermediate to synthesize fine chemicals such as pharmaceuticals, pesticides, and dyes.
    What are the main uses of 3-chloro-5-fluorophenylboronic acid?
    3-5-penteneheptanedioic acid is an important raw material for the synthesis of multi-effect compounds. Due to its special chemical properties, it can be cleverly transformed into molecules with specific physiological activities. For example, it can be used to treat cardiovascular diseases, it can improve blood lipid and centering functions; it can also be used to develop anti-tumor compounds, and it can inhibit tumor growth through the interaction of tumor and cell generation.
    In terms of material science, this acid can be used to synthesize polymer materials with special properties. Polymerization can form polymers with mechanical properties and chemical resistance. This polymer can be used in the aerospace field to provide high-quality and high-quality materials for large-scale and high-performance components. It can also be used in automotive engineering to fabricate high-performance components and improve the performance of steam.
    In chemical research, 3-5-pentenheptanedioic acid is often used as a reaction to explore new chemical reactions. Due to its large number of active functionalities, it can be used to enrich chemical reactions and provide new ideas for the development of chemical synthesis methods. Researchers can expand the scope of chemical synthesis by manipulating their reaction components, specifying them, and developing more efficient and reliable synthesis strategies.
    What are the synthesis methods of 3-chloro-5-fluorophenylboronic acid?
    3-Bromo-5-fluorobenzoic acid is an important intermediate in organic synthesis and is widely used in the field of medicinal chemistry. Its synthesis methods are diverse, as follows:
    First, 3-bromo-5-fluorotoluene is used as the starting material and the target product is obtained by oxidation reaction. It is often achieved with strong oxidants, such as potassium permanganate, potassium dichromate, etc., under suitable solvents and reaction conditions. The key to this reaction is to control the reaction temperature and the amount of oxidant to avoid excessive oxidation and increase side reactions. For example, 3-bromo-5-fluorotoluene is dissolved in an appropriate amount of glacial acetic acid, slowly added dropwise to potassium permanganate aqueous solution, maintaining the reaction temperature at 80-90 ° C. After several hours of reaction, 3-bromo-5-fluorobenzoic acid can be obtained by separation and purification.
    Second, it is prepared by the carboxylation reaction of halogenated aromatics. First, 3-bromo-5-fluorobenzene is reacted with magnesium chips in anhydrous ether to form a Grignard reagent, followed by carbon dioxide gas, and then acidified to obtain the target product. This process requires a strict anhydrous and anaerobic environment to ensure the stability of Grignard reagents. For example, under the protection of nitrogen, magnesium chips are added to anhydrous ethyl ether, and 3-bromo-5-fluorobromophenyl ether solution is slowly added dropwise. After initiating the reaction, carbon dioxide is introduced at low temperature, the reaction is completed, dilute hydrochloric acid is added to acidify, and the product is obtained by extraction, distillation and other operations.
    Third, palladium-catalyzed cross-coupling reaction is used. Using 3-bromobenzoic acid as raw material, it is coupled with fluorine-containing reagents under the action of palladium catalyst to introduce fluorine atoms, and then 3-bromo-5-fluorobenzoic acid is synthesized. This method requires high reaction conditions and catalysts, and requires precise control of reaction parameters. For example, using palladium acetate as a catalyst and bipyridine as a ligand, under the basic condition of potassium carbonate, 3-bromobenzoic acid and fluorinated reagent are reacted in N, N-dimethylformamide solvent, and the product is separated and purified.
    All synthetic methods have advantages and disadvantages. In practical application, it is necessary to comprehensively consider factors such as raw material cost, reaction conditions, yield and purity to choose an appropriate method.
    What are the precautions for storing and transporting 3-chloro-5-fluorophenylboronic acid?
    3-%-5-tryptamine succinic acid should pay attention to the following things in storage and storage:
    First, the degree is very important. This compound is sensitive to temperature and should be stored in a low temperature environment. Generally, it is recommended to refrigerate, usually at 2 to 8 degrees Celsius. If the temperature is high, it may cause its chemical properties to change, reduce activity, or cause damage. If it is hot in summer, it is necessary to maintain a low temperature with high efficiency, such as using dry ice to help keep cold and avoid its decomposition due to high temperature.
    Second, moisture-proof should not be ignored. It has a certain degree of absorption, and the moisture environment is easy to make it absorb moisture, and the influence is high and qualitative. For storage, it should be placed in dry air, and the package should have good moisture resistance. For example, sealed plastic bags, glass bottles, etc., can be added to dry air, and it should also be protected from rain and moisture.
    Third, avoid light. 3-% -5-tryptamine succinic acid is easily decomposed by light. The storage container should be made of dark-proof materials such as brown bottles, and it should also be prevented from direct light. It can be shielded from light-shielding materials such as shading cloths.
    Fourth, it should be separated from oxygen. This compound is easily oxidized, and it can be used in dark air. For storage and storage, inert water can be used. For example, inert water such as nitrogen can be filled in the packaging container to remove oxygen and extend the shelf life.
    Fifth, it should be stored separately. It cannot be mixed with oxidizing and acidic substances. Because of its chemical properties, it will not be active, and it will be connected or caused by strong reactions, which will cause danger. When stored separately, it should also be used in containers to avoid cross-contamination.
    What is the market price range for 3-chloro-5-fluorophenylboronic acid?
    3-%-5-tryptamine succinic acid, which is a chemical product of the industry. However, the market price is low, and it fluctuates due to various factors, so as to determine the quality.
    First, its production cost is of paramount importance. The cost of raw materials, the complexity of the production process, etc., all affect its cost. If raw materials are scarce and available, the cost of high-quality technology is high, and the cost will be high, and the cost will also be higher.
    Second, the supply and demand of the market is low. If the demand for this chemical product is strong in the fields of industry and scientific research, and the supply is limited, the price will rise; conversely, if the demand is low and the supply is abundant, the price may decline.
    Third, the quality of the product is also high. High-quality, high-quality 3-%-5-tryptamine succinic acid, because of its ability to meet high-end scientific research and applications, is naturally more expensive than ordinary products.
    Generally speaking, in the scientific research market, its price may range from 10 yuan to 100 yuan per gram. However, the price depends on factors such as the price, price, and quantity of the transaction. If it is a large amount of cost, it may be able to obtain a certain price benefit due to the modulus effect; and a small amount and urgently needed cost, or the price may be high. Therefore, in order to know its quality, it is appropriate to contact chemical raw material suppliers and scientific research sales platforms.