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3-Chloro-4-Fluorobenzenesulfonyl Chloride

3-Chloro-4-Fluorobenzenesulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    841895

    Name 3-Chloro-4-Fluorobenzenesulfonyl Chloride
    Chemical Formula C6H3Cl2FO2S
    Molar Mass 231.05 g/mol
    Appearance Colorless to light yellow liquid

    As an accredited 3-Chloro-4-Fluorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 3 - chloro - 4 - fluorobenzenesulfonyl chloride packaged in a sealed glass bottle.
    Storage 3 - Chloro - 4 - fluorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat and ignition sources. It must be stored in a tightly - sealed container, preferably made of corrosion - resistant materials due to its reactive nature. Keep it separate from incompatible substances like bases, reducing agents, and water to prevent dangerous reactions.
    Shipping 3 - Chloro - 4 - fluorobenzenesulfonyl chloride is a hazardous chemical. Shipping requires proper packaging in accordance with regulations, likely in sealed, corrosion - resistant containers, and labeled clearly for safe transportation.
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    3-Chloro-4-Fluorobenzenesulfonyl Chloride 3-Chloro-4-Fluorobenzenesulfonyl Chloride
    General Information
    Historical Development
    I have heard of the chemical industry, there are many categories, and the changes in matter are endless. Today there is 3 - Chloro - 4 - Fluorobenzenesulfonyl Chloride, which originated from the exploration of scientific research, and at the beginning, it was only an attempt in various experiments.
    At that time, various sages worked hard in the field of chemistry, hoping to come up with a new product. After months of hard work and several preparations, this compound was obtained. When it was first obtained, it was not known what its potential was, but it was only recorded in the book for later investigation.
    Then, with the deepening of research, its properties gradually became apparent, and it emerged in the field of organic synthesis. Due to its special structure, it can be cleverly combined with other things, so it has gradually attracted attention in chemical production and drug development. Since its birth, after years, it has continuously improved the production method, improved the quality, and helped the industry to advance. Its development path is like a prairie fire, gradually becoming a big view.
    Product Overview
    3-Chloro-4-fluorobenzenesulfonyl chloride is one of the important substances involved in my chemical research. Its color may be light, and its state is often liquid, with specific rationalization. Looking at its structure, chlorine and fluorine atoms are connected to benzene rings and sulfonyl chloride groups, and this unique structure endows it with different chemical activities.
    In the process of synthesis, it is obtained through various reaction steps. Its preparation requires precise temperature control and selection of appropriate reagents and conditions to preserve yield and purity. And because of its active nature, when storing and using, be careful to prevent it from undue reactions with other substances.
    This compound has great potential in the fields of medicine and materials. In the research and development of medicine, or as a key intermediate, it can help to form new drugs with specific effects; in the creation of materials, it may give materials specificity. We researchers should do our best to explore its potential and contribute to the advancement of science and technology.
    Physical & Chemical Properties
    3-Chloro-4-fluorobenzenesulfonyl chloride, the physical and chemical properties of this substance are particularly important. Its color is usually colorless to slightly yellow, like a liquid, and it has a certain fluidity. Its boiling point is about a specific range, depending on its gasification state. The melting point is also fixed, indicating the boundary of its solidification. In terms of solubility, it is soluble in some organic solvents, and this property affects its dispersion in various reaction systems and the degree of participation in the reaction. And its chemical activity is quite high, the sulfonyl chloride group is active, and it is easy to react with many reagents, or form new compounds, or initiate functional group transformation. It is widely used in the field of organic synthesis and can be a key raw material for the preparation of various organic products. It is a substance that cannot be ignored in chemical research and production.
    Technical Specifications & Labeling
    Today there is a product named 3-chloro-4-fluorobenzenesulfonyl chloride. Its process specifications and identification (product parameters) are the key. The process specifications are related to the preparation of this product, from the selection of raw materials, the accurate ratio, to the reaction conditions, temperature, duration, pressure and other factors, all of which must be specified in detail to ensure that each system meets the expectations. Those who mark, indicate the name, composition, characteristics, especially safety warnings, so that users are aware of the risk and cautious.
    The color, odor and other physical properties of this product must be clearly marked. Its chemical properties, the response to other things, and the stability should not be ignored. The product parameters detail the purity, impurity limit, etc., as proof of quality. In accordance with this process specification and labeling regulations, only good products can be made, and those who guarantee safety are safe. This is the most important way in the chemical industry.
    Preparation Method
    To prepare 3-chloro-4-fluorobenzene sulfonyl chloride, the method is as follows: First, take the raw material, prepare chlorobenzene, fluoride, sulfonating agent, etc. To prepare, first react with chlorobenzene and fluoride according to suitable process conditions. This step requires temperature control, pressure and reaction time to obtain 3-chloro-4-fluorobenzene. Then, take 3-chloro-4-fluorobenzene and react with the sulfonating agent, which is a key step. During the reaction, observe the reaction process in detail and adjust it according to the phenomenon. The amount of sulfonating agent, reaction temperature and time are all related to the purity and yield of the product. After the reaction is completed, the impurities are removed by separation and purification, and finally 3-chloro-4-fluorobenzenesulfonyl chloride is obtained. During the process, each step is closely interlocked, and each step is carried out carefully to ensure the best product.
    Chemical Reactions & Modifications
    After studying the anti-modification of 3 - Chloro - 4 - Fluorobenzenesulfonyl Chloride. This compound has special properties, and its anti-oxidation, or nuclear substitution, or addition elimination, and the general way, each has its own reasons.
    Under normal conditions, its chlorosulfonyl activity is high, and it is easy to reduce the reaction of nuclei such as alcohols and amines, and to derive many derivatives. However, its reaction rate is low, and it is about the same for each reaction piece, such as the degree of resistance, solubility, and catalysis.
    To modify this compound, you can start with its molecules. The location and location of the whole substituent can be changed to change its anti-activity. For example, the introduction of donator subgroups may increase their anti-nuclear activity; conversely, donator subgroups may make them more anti-nuclear.
    Therefore, to explore the anti-chemical modification of 3-Chloro-4-Fluorobenzenesulfonyl Chloride, it is still to be further studied in this field.
    Synonyms & Product Names
    3-Chloro-4-fluorobenzenesulfonyl chloride is also a chemical substance. Its synonyms are also important in the academic world. This substance, or another name, is known to all colleagues in the academic world.
    Looking at the ancient books, the names of the same thing may have been determined by the ancestors of the past, and they also have different names as the years pass. For those who trade names, merchants take them for the convenience of identification and promotion.
    Synonyms of the same thing, each with its own origin. Or because of the order of discovery, scholars from all over the world have different names; or because of differences in technology, the names are different. Business names are mostly commercial considerations, hoping to attract attention and facilitate their circulation.
    For my chemistry students, it is important to be familiar with their synonyms and business names. It can help accurate communication, avoid confusion, and is beneficial to scientific research and production.
    Safety & Operational Standards
    3-Chloro-4-fluorobenzenesulfonyl chloride is also a chemical product. Its safe production and operation specifications cannot be ignored.
    This substance has certain risks and is related to the safety of the operator and the safety of the environment. When operating, the following norms must be followed. First, the operator wears suitable protective equipment, such as corrosion-resistant clothing and gloves, and is equipped with goggles and gas masks to prevent it from connecting with the body or inhaling its volatile gas.
    In terms of storage, it should be placed in a cool, dry and well-ventilated place to avoid fire and hot topics. Do not store with reactive materials to prevent accidents.
    As for the operation process, it must be carried out in the fume hood to ensure the circulation of air. When dissolving or diluting this product, it should be slowly added and stirred constantly to avoid its sharp reaction. If it is accidentally splashed on the body during operation, rinse it with a large amount of water quickly, and then apply appropriate medicine; if inhaled, quickly move to a place with fresh air, and apply first aid if necessary.
    Anyone who uses this 3-chloro-4-fluorobenzenesulfonyl chloride should be familiar with this safety and operation specification to ensure that everything goes smoothly and is not at risk. In this way, the safety of chemical research can be obtained and the prosperity of the industry can be promoted.
    Application Area
    3-Chloro-4-fluorobenzenesulfonyl chloride is also a chemical substance. Its application field is quite wide. In the field of medicine, it is often the key raw material for the synthesis of special drugs. Because of its unique chemical structure, it can help drugs act precisely on the target and improve the efficacy.
    In the material industry, this substance can optimize the material properties. Or increase the stability of the material, or give it special chemical activity to meet the needs of different scenarios. Furthermore, in the fine chemical industry, it is also an important intermediate for the preparation of high-end chemicals. Through clever chemical reactions, many high value-added products can be derived. Therefore, 3-chloro-4-fluorobenzenesulfonyl chloride plays an important role in many application fields and promotes the development and progress of various fields.
    Research & Development
    I have been focusing on the study of chemical substances for a long time, and now I am discussing 3-chloro-4-fluorobenzenesulfonyl chloride. It has a unique position in the field of chemical research.
    At the beginning, the exploration of its properties was very laborious. After repeated tests, it was proved that its physical and chemical properties, such as melting point, boiling point, solubility, etc., were recorded in detail.
    Then, study its synthesis path. Try a variety of methods to optimize the process and improve the yield and purity. After unremitting efforts, some gains have been made, and the synthesis method is gradually improving.
    Furthermore, consider its application prospects. In organic synthesis, it can be used as a key intermediate, providing the possibility for the preparation of many fine chemicals.
    Looking to the future, I will continue to conduct in-depth research and hope to make breakthroughs in the performance improvement and new application expansion of 3-chloro-4-fluorobenzenesulfonyl chloride, so as to promote the development of this chemical substance and contribute to the chemical field.
    Toxicity Research
    The industry of chemical industry is deeply explored in substances. Today there is a product called 3-Chloro-4-Fluorobenzenesulfonyl Chloride. I have devoted myself to studying its toxicity and know that this is a priority.
    This product has a unique chemical structure, and its chlorine, fluorine and sulfonyl chloride groups coexist. After many experiments, it may have a significant impact on the biological system. Contact with the skin can cause burning, redness and swelling, and its active groups react quickly with the skin tissue. If inhaled inadvertently, it may hurt the respiratory tract, cause coughing, asthma, and even endanger life.
    To clarify the details, I set up various experiments to observe its effect on different biological samples. From the cellular level, it is seen that it interferes with normal metabolism; in animal experiments, corresponding lesions are also found. It can be seen that the toxicity of this substance must be carefully investigated to ensure the safety of the survivors and avoid chemical damage.
    Future Prospects
    Wuguanfu 3-chloro-4-fluorobenzenesulfonyl chloride is unique and has extraordinary potential in the field of chemical industry. Although it may not be extremely prosperous today, the future development can be looked forward to.
    Due to the increasing innovation of science and technology, the need for fine chemicals in various industries is gradually increasing. 3-chloro-4-fluorobenzenesulfonyl chloride, as a key intermediate, can emerge in the pharmaceutical, pesticide, material and other industries. In medicine, it can help create new drugs and overcome difficult diseases; in the field of pesticides, it may lead to new products with high efficiency and low toxicity, protecting agricultural mulberry; on top of materials, it is expected to develop novel materials, leading the forefront.
    Over time, with the depth of research and the advancement of technology, it will be able to expand the boundaries of application, create a new situation, and shine in the unfinished business, bringing many benefits to the world and becoming a bright star in the future chemical industry.
    Where to Buy 3-Chloro-4-Fluorobenzenesulfonyl Chloride in China?
    As a trusted 3-Chloro-4-Fluorobenzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3-Chloro-4-Fluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 3-Chloro-4-Fluorobenzenesulfonyl Chloride?
    3-Chloro-4-fluorobenzenesulfonyl chloride is a crucial reagent in organic synthesis. It has a wide range of uses and has significant applications in many fields such as medicine, pesticides and material science.
    In the field of medicine, this compound is often a key intermediate for the synthesis of new drugs. Due to the unique reactivity of benzenesulfonyl chloride groups, it can undergo nucleophilic substitution reactions with many nucleophiles containing nitrogen and oxygen, and then construct a variety of drug molecular structures. For example, when reacted with amine compounds, sulfonamide structures can be formed. Many biologically active drugs contain this structural unit, which is of great significance for the development of antibacterial, anti-inflammatory and anti-tumor drugs.
    In the field of pesticides, 3-chloro-4-fluorobenzenesulfonyl chloride also plays an important role. After a series of chemical reactions, it can be converted into pesticide components with high insecticidal, weeding or bactericidal properties. Its unique chemical structure can enhance the interaction between pesticides and specific receptors or enzymes in target organisms, improve the selectivity and activity of pesticides, and because it contains chlorine, fluorine and other elements, it helps to enhance the stability and environmental adaptability of pesticides.
    In the field of materials science, this compound can be used to synthesize polymer materials with special functions. By polymerizing with monomers containing unsaturated bonds, benzenesulfonyl chloride groups are introduced into the main or side chains of polymers to endow materials with unique properties, such as improved solubility, thermal stability and surface properties of materials. It can be used to prepare high-performance coatings, plastics and fibers to meet the needs of different industrial fields for special properties of materials.
    3-Chloro-4-fluorobenzenesulfonyl chloride has become an indispensable organic synthesis reagent in many fields due to its unique chemical structure and reactivity, promoting technological development and innovation in various fields.
    What are the physical properties of 3-Chloro-4-Fluorobenzenesulfonyl Chloride?
    3-Chloro-4-fluorobenzenesulfonyl chloride is an important compound in organic chemistry. Its physical properties are particularly critical and are related to many chemical applications.
    Looking at its appearance, it often takes the form of a colorless to light yellow liquid, which is easy to operate and mix in many reaction systems. It has a specific odor, but the description of this odor is difficult to achieve accurately in quaint words, and it generally has a stimulating and unique smell.
    When it comes to melting point, there is no exact ancient book to test the corresponding accurate data. However, in today's chemical research, its melting point information is crucial for the identification of substances and the control of reaction conditions. The boiling point is also an important physical property. Knowing its boiling point, it can set suitable temperature conditions in distillation, separation and other operations, so that the compound can be effectively purified or separated.
    The density of 3-chloro-4-fluorobenzenesulfonyl chloride is also a key physical property. Its density affects its distribution and behavior in the mixed system. If liquid-liquid reaction or extraction is performed, the density difference can be used to achieve the purpose of separation or promotion of the reaction.
    In terms of solubility, it has good solubility in organic solvents, such as common ether and dichloromethane. This property makes it possible to choose a suitable solvent in organic synthesis to create a good reaction environment and help the reaction proceed smoothly. In water, its solubility is not good, and this property also affects its reaction pathways and application scenarios in different media.
    In addition, its volatility cannot be ignored. Although there is no exact ancient book to compare the details of its volatilization rate, in the actual operating environment, the volatilization characteristics are related to the safety protection of the experimenter and the stability of the reaction system. Volatilization is too fast, or it may cause material loss, or form harmful gases in the environment; volatilization is too slow, or it may affect the escape and separation of substances in the reaction process.
    All these physical properties are of great significance in many fields such as organic synthesis and drug development, and are the basis for chemists to operate and study this compound.
    What is the synthesis method of 3-Chloro-4-Fluorobenzenesulfonyl Chloride?
    The synthesis of 3-chloro-4-fluorobenzenesulfonyl chloride is related to the key of chemical preparation. The method usually begins with the corresponding aromatic hydrocarbon, based on benzene compounds, by halogenation reaction, chlorine and fluorine atoms are introduced into the benzene ring one after another to obtain 3-chloro-4-fluorobenzene. This halogenation method requires appropriate temperature and pressure, and is accompanied by a suitable catalyst to promote the smooth reaction.
    When 3-chloro-4-fluorobenzene is obtained, it is a step of sulfonation. It is co-placed with strong sulfonating reagents, such as fuming sulfuric acid, so that the benzene ring is connected with a sulfonyl group to form 3-chloro-4-fluorobenzenesulfonic acid. This step requires temperature control and time control to prevent side reactions from occurring and causing impure products.
    Finally, 3-chloro-4-fluorobenzenesulfonic acid is converted into 3-chloro-4-fluorobenzenesulfonyl chloride by chlorination. Thionyl chloride and phosphorus trichloride are often used as chlorination agents, and the two are co-heated with 3-chloro-4-fluorobenzenesulfonic acid. The hydroxyl group of the sulfonic acid group is replaced by a chlorine atom, so as to obtain the target product 3-chloro-4-fluorobenzenesulfonyl chloride. After the reaction, it is purified by distillation, extraction, recrystallization, etc., to extract the purity of the product and obtain high-purity 3-chloro-4-fluorobenzenesulfonyl chloride. This synthesis method, each step is interconnected, and all need to be carefully handled to obtain satisfactory results.
    What are the precautions for 3-Chloro-4-Fluorobenzenesulfonyl Chloride in storage and transportation?
    3-Chloro-4-fluorobenzenesulfonyl chloride is also a chemical substance. During storage and transportation, many matters need to be paid attention to.
    First word storage. This substance is corrosive and reactive, and must be stored in a dry, cool and well-ventilated place. Avoid high temperatures, fire sources and strong oxidizing agents to prevent unexpected reactions. Use a sealed container to avoid contact with air and water vapor, and cover it with harmful hydrogen chloride gas because it or reacts violently with water. And it should be separated from flammable and combustible materials to prevent the spread of fire and harm to the surrounding area.
    Times and transportation. When transporting, be sure to use suitable packaging materials in accordance with relevant laws and regulations. The packaging must be solid and reliable, capable of resisting vibration, collision and leakage. Transportation personnel should also be familiar with its characteristics and emergency response methods. Transportation vehicles should be equipped with fire extinguishers and equipment for emergency treatment of leaks. Beware of sun exposure and rain on the way, and the driving route should also avoid densely populated areas. In case of leakage, the harm can be minimized.
    In short, the storage and transportation of 3-chloro-4-fluorobenzenesulfonyl chloride is related to safety. It must not be slack at all. It must strictly follow the regulations to ensure the safety of personnel and the environment.
    What is the market price range for 3-Chloro-4-Fluorobenzenesulfonyl Chloride?
    3-Chloro-4-fluorobenzenesulfonyl chloride is an important raw material for organic synthesis and is widely used in medicine, pesticides, materials and other fields. Its market price range is difficult to generalize, because it is affected by many factors.
    The first to bear the brunt is the cost of raw materials. The synthesis of this compound requires specific starting materials. If its supply is tight or the price fluctuates, the cost of 3-chloro-4-fluorobenzenesulfonyl chloride will also change. For example, if the production of key starting materials is suddenly reduced due to natural disasters in the place of origin, its price will rise, and the price of this compound will also rise.
    Furthermore, the difficulty of the preparation process is closely related to the production cost. If the preparation process is complicated, multi-step reactions are required, and the reaction conditions are strictly controlled, such as precise temperature, pressure, and catalyst use, all of which will increase the production cost, which in turn will affect the market price.
    The market supply and demand relationship is also a major factor in determining the price. If the pharmaceutical industry has a large increase in demand for intermediates containing this structure and the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price will be under downward pressure.
    In addition, the scale of production also has an impact. In large-scale production, the unit production cost may be reduced due to the scale effect, and the price may be more competitive; in small-scale production, the cost is higher and the price is relatively high.
    According to past market conditions and relevant data, the price per kilogram may range from a few hundred to several thousand yuan. However, this is only a rough estimate. The actual price may fluctuate widely in the market due to the dynamic changes of the above factors, and it is difficult to give a fixed price range.