3-Chloro-4-fluorobenzenesulfonyl chloride is a crucial reagent in organic synthesis. It has a wide range of uses and has significant applications in many fields such as medicine, pesticides and material science.
In the field of medicine, this compound is often a key intermediate for the synthesis of new drugs. Due to the unique reactivity of benzenesulfonyl chloride groups, it can undergo nucleophilic substitution reactions with many nucleophiles containing nitrogen and oxygen, and then construct a variety of drug molecular structures. For example, when reacted with amine compounds, sulfonamide structures can be formed. Many biologically active drugs contain this structural unit, which is of great significance for the development of antibacterial, anti-inflammatory and anti-tumor drugs.
In the field of pesticides, 3-chloro-4-fluorobenzenesulfonyl chloride also plays an important role. After a series of chemical reactions, it can be converted into pesticide components with high insecticidal, weeding or bactericidal properties. Its unique chemical structure can enhance the interaction between pesticides and specific receptors or enzymes in target organisms, improve the selectivity and activity of pesticides, and because it contains chlorine, fluorine and other elements, it helps to enhance the stability and environmental adaptability of pesticides.
In the field of materials science, this compound can be used to synthesize polymer materials with special functions. By polymerizing with monomers containing unsaturated bonds, benzenesulfonyl chloride groups are introduced into the main or side chains of polymers to endow materials with unique properties, such as improved solubility, thermal stability and surface properties of materials. It can be used to prepare high-performance coatings, plastics and fibers to meet the needs of different industrial fields for special properties of materials.
3-Chloro-4-fluorobenzenesulfonyl chloride has become an indispensable organic synthesis reagent in many fields due to its unique chemical structure and reactivity, promoting technological development and innovation in various fields.

3-Chloro-4-fluorobenzenesulfonyl chloride is an important compound in organic chemistry. Its physical properties are particularly critical and are related to many chemical applications.
Looking at its appearance, it often takes the form of a colorless to light yellow liquid, which is easy to operate and mix in many reaction systems. It has a specific odor, but the description of this odor is difficult to achieve accurately in quaint words, and it generally has a stimulating and unique smell.
When it comes to melting point, there is no exact ancient book to test the corresponding accurate data. However, in today's chemical research, its melting point information is crucial for the identification of substances and the control of reaction conditions. The boiling point is also an important physical property. Knowing its boiling point, it can set suitable temperature conditions in distillation, separation and other operations, so that the compound can be effectively purified or separated.
The density of 3-chloro-4-fluorobenzenesulfonyl chloride is also a key physical property. Its density affects its distribution and behavior in the mixed system. If liquid-liquid reaction or extraction is performed, the density difference can be used to achieve the purpose of separation or promotion of the reaction.
In terms of solubility, it has good solubility in organic solvents, such as common ether and dichloromethane. This property makes it possible to choose a suitable solvent in organic synthesis to create a good reaction environment and help the reaction proceed smoothly. In water, its solubility is not good, and this property also affects its reaction pathways and application scenarios in different media.
In addition, its volatility cannot be ignored. Although there is no exact ancient book to compare the details of its volatilization rate, in the actual operating environment, the volatilization characteristics are related to the safety protection of the experimenter and the stability of the reaction system. Volatilization is too fast, or it may cause material loss, or form harmful gases in the environment; volatilization is too slow, or it may affect the escape and separation of substances in the reaction process.
All these physical properties are of great significance in many fields such as organic synthesis and drug development, and are the basis for chemists to operate and study this compound.

The synthesis of 3-chloro-4-fluorobenzenesulfonyl chloride is related to the key of chemical preparation. The method usually begins with the corresponding aromatic hydrocarbon, based on benzene compounds, by halogenation reaction, chlorine and fluorine atoms are introduced into the benzene ring one after another to obtain 3-chloro-4-fluorobenzene. This halogenation method requires appropriate temperature and pressure, and is accompanied by a suitable catalyst to promote the smooth reaction.
When 3-chloro-4-fluorobenzene is obtained, it is a step of sulfonation. It is co-placed with strong sulfonating reagents, such as fuming sulfuric acid, so that the benzene ring is connected with a sulfonyl group to form 3-chloro-4-fluorobenzenesulfonic acid. This step requires temperature control and time control to prevent side reactions from occurring and causing impure products.
Finally, 3-chloro-4-fluorobenzenesulfonic acid is converted into 3-chloro-4-fluorobenzenesulfonyl chloride by chlorination. Thionyl chloride and phosphorus trichloride are often used as chlorination agents, and the two are co-heated with 3-chloro-4-fluorobenzenesulfonic acid. The hydroxyl group of the sulfonic acid group is replaced by a chlorine atom, so as to obtain the target product 3-chloro-4-fluorobenzenesulfonyl chloride. After the reaction, it is purified by distillation, extraction, recrystallization, etc., to extract the purity of the product and obtain high-purity 3-chloro-4-fluorobenzenesulfonyl chloride. This synthesis method, each step is interconnected, and all need to be carefully handled to obtain satisfactory results.

3-Chloro-4-fluorobenzenesulfonyl chloride is also a chemical substance. During storage and transportation, many matters need to be paid attention to.
First word storage. This substance is corrosive and reactive, and must be stored in a dry, cool and well-ventilated place. Avoid high temperatures, fire sources and strong oxidizing agents to prevent unexpected reactions. Use a sealed container to avoid contact with air and water vapor, and cover it with harmful hydrogen chloride gas because it or reacts violently with water. And it should be separated from flammable and combustible materials to prevent the spread of fire and harm to the surrounding area.
Times and transportation. When transporting, be sure to use suitable packaging materials in accordance with relevant laws and regulations. The packaging must be solid and reliable, capable of resisting vibration, collision and leakage. Transportation personnel should also be familiar with its characteristics and emergency response methods. Transportation vehicles should be equipped with fire extinguishers and equipment for emergency treatment of leaks. Beware of sun exposure and rain on the way, and the driving route should also avoid densely populated areas. In case of leakage, the harm can be minimized.
In short, the storage and transportation of 3-chloro-4-fluorobenzenesulfonyl chloride is related to safety. It must not be slack at all. It must strictly follow the regulations to ensure the safety of personnel and the environment.

3-Chloro-4-fluorobenzenesulfonyl chloride is an important raw material for organic synthesis and is widely used in medicine, pesticides, materials and other fields. Its market price range is difficult to generalize, because it is affected by many factors.
The first to bear the brunt is the cost of raw materials. The synthesis of this compound requires specific starting materials. If its supply is tight or the price fluctuates, the cost of 3-chloro-4-fluorobenzenesulfonyl chloride will also change. For example, if the production of key starting materials is suddenly reduced due to natural disasters in the place of origin, its price will rise, and the price of this compound will also rise.
Furthermore, the difficulty of the preparation process is closely related to the production cost. If the preparation process is complicated, multi-step reactions are required, and the reaction conditions are strictly controlled, such as precise temperature, pressure, and catalyst use, all of which will increase the production cost, which in turn will affect the market price.
The market supply and demand relationship is also a major factor in determining the price. If the pharmaceutical industry has a large increase in demand for intermediates containing this structure and the supply is limited, the price will rise; conversely, if the supply exceeds the demand, the price will be under downward pressure.
In addition, the scale of production also has an impact. In large-scale production, the unit production cost may be reduced due to the scale effect, and the price may be more competitive; in small-scale production, the cost is higher and the price is relatively high.
According to past market conditions and relevant data, the price per kilogram may range from a few hundred to several thousand yuan. However, this is only a rough estimate. The actual price may fluctuate widely in the market due to the dynamic changes of the above factors, and it is difficult to give a fixed price range.