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3-Chloro-4-Fluorobenzene-1-Thiol

3-Chloro-4-Fluorobenzene-1-Thiol

Hongda Chemical

Specifications

HS Code

317172

Name 3-Chloro-4-Fluorobenzene-1-Thiol
Molecular Formula C6H4ClFS
Molecular Weight 162.61
Appearance Solid
Boiling Point 213 - 215 °C
Melting Point 33 - 37 °C
Density 1.382 g/cm³
Flash Point 82.8 °C
Solubility In Water Insoluble
Pungent Odor Yes

As an accredited 3-Chloro-4-Fluorobenzene-1-Thiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 3 - chloro - 4 - fluorobenzene - 1 - thiol in a sealed, corrosion - resistant container.
Storage Store 3 - chloro - 4 - fluorobenzene - 1 - thiol in a cool, dry, well - ventilated area, away from heat, flames, and oxidizing agents. Keep it in a tightly sealed container, preferably made of corrosion - resistant materials due to its potentially reactive nature. Store it separately from incompatible substances to prevent hazardous reactions. Label the storage clearly for easy identification and safety.
Shipping 3 - chloro - 4 - fluorobenzene - 1 - thiol is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous material shipping regulations, ensuring proper labeling and handling to prevent spills and ensure safety during transit.
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3-Chloro-4-Fluorobenzene-1-Thiol 3-Chloro-4-Fluorobenzene-1-Thiol
General Information
Historical Development
The historical evolution of 3-chloro-4-fluorobenzene-1-mercaptan is worth exploring. Ancient chemical research only briefly involved the appearance of matter. And science gradually developed, and various compounds began to be deeply studied.
As the field of organic chemistry expanded, researchers gradually focused on this special mercaptan. At first, the understanding was still shallow, and only some of its properties could be roughly distinguished. After repeated experiments by countless scholars, its structure and characteristics were analyzed, and its role in the reaction was gradually understood.
From the simple understanding of the past to the extensive exploration of its synthesis methods and application fields today, the research process of 3-chloro-4-fluorobenzene-1-thiol is just like an important tributary in the long river of chemical development. Witness the great changes of chemical science from ignorance to clarity, from shallow to profound, and lay the foundation for subsequent progress in many fields.
Product Overview
Today there is a substance called 3-chloro-4-fluorobenzene-1-mercaptan. Its shape may be colorless to light yellow liquid with a special odor. This substance is widely used in the field of chemistry.
In the process of organic synthesis, it is often used as a key intermediate. With its unique chemical structure, it can react with many compounds to derive a wide variety of organic products. And because it contains chlorine, fluorine and thiol groups, it gives the substance special chemical activity and physical properties.
Preparation of this product may require multiple delicate steps, and the reaction conditions are extremely strict. Temperature, pressure, and the proportion of reactants all have a significant impact on the purity and yield of the product. When storing, pay attention to environmental factors to avoid unnecessary reactions with air and moisture to maintain the stability of its chemical properties.
Physical & Chemical Properties
The physicochemical properties of 3-chloro-4-fluorobenzene-1-mercaptan are particularly important. Looking at its shape, at room temperature, or as a colorless to slightly yellow liquid, it has a special mercaptan odor. Its boiling point is about a certain temperature range, which is determined by the intermolecular force. As for the melting point, it is also in a specific range, which depends on the degree of close arrangement of molecules.
When it comes to solubility, it has good solubility in organic solvents such as ethanol and ether, because it is similar to each other. In water, the solubility is relatively limited, due to the difference between its molecular polarity and water. Its chemical properties are active, and thiol groups are easily involved in many chemical reactions, or complexed with metal ions, or transformed in an oxidizing environment. These physicochemical properties are crucial in the fields of organic synthesis and materials science, and are related to their application efficiency and prospects.
Technical Specifications & Labeling
For 3-chloro-4-fluorobenzene-1-thiol, its technical specifications and identification (commodity parameters) are the key. This compound is an important object of chemical research. Technical specifications require clear preparation methods, from the selection of raw materials to the control of reaction conditions. Reaction temperature, duration, and ratio of reactants are all the keys to the success or failure of the preparation.
In terms of identification, commodity parameters should be accurate. The characterization of its chemical structure needs to be analyzed by professional instruments, such as NMR, IR, etc., to ensure that the structure is conclusive. The identification of purity cannot be ignored, and high purity can ensure the effect of its application in various fields. In addition, storage conditions, safety precautions, and other labels are also related to the safety of the user and the stability of the product.
Preparation and labeling complement each other to build the quality assurance of this compound, which is of great significance in chemical research and related applications.
Preparation Method
The method of making 3-chloro-4-fluorobenzene-1-mercaptan is very important, which is related to the raw material and production process, reaction steps and catalytic mechanism. First, take an appropriate amount of 3-chloro-4-fluorobromobenzene as the starting material, which is the key thing. Mix it with potassium thioacetate in an organic solvent and control the reaction conditions at an appropriate temperature. The two go through a nucleophilic substitution reaction, and the bromine atom is replaced by a thioacetyl group to obtain an intermediate product.
Then, a hydrolysis step is applied to the intermediate product. 3-Chloro-4-fluorobenzene-1-thiol is obtained by hydrolyzing thioacetyl groups into sulfhydryl groups in an alkaline solution. During the reaction process, it is crucial to precisely control the temperature, reaction time and proportion of reactants. The organic solvent used needs to be selected which is favorable for the reaction, has good solubility and is convenient for subsequent separation. The catalytic mechanism, with appropriate catalysts, accelerates the reaction rate and increases the yield. In this way, 3-chloro-4-fluorobenzene-1-thiol can be effectively prepared.
Chemical Reactions & Modifications
The reaction of 3-Chloro-4-Fluorobenzene-1-Thiol is related to the interaction of chlorine, fluorine and thiol groups in its molecular structure.
Its chlorine atom has certain electronegativity, and can be used as a leaving group in nucleophilic substitution reactions, causing nucleophilic reagents to attack specific positions in the benzene ring. Although fluorine atoms have strong electronegativity, they have unique effects on the distribution of electron clouds in the benzene ring, or change the reactivity and selectivity.
As for thiol groups, they have high reactivity and can participate in oxidation, condensation and other reactions. By adjusting the reaction conditions, such as temperature, solvent and catalyst, the reaction path can be optimized, and the yield and purity of the product can be improved.
Furthermore, structural modification or introduction of other functional groups into the benzene ring are expected to endow this compound with new physicochemical properties and application potential. Studying the chemical and variable properties can pave the way for its application in organic synthesis, materials science and other fields.
Synonyms & Product Names
Today there is a thing called 3 - Chloro - 4 - Fluorobenzene - 1 - Thiol. It is used in the field of chemical industry and has a wide range of uses. The synonyms and trade names of this thing are also our investigation.
Looking at various classics, there are some synonyms similar to this. Covering chemical things, the names may vary from region to region and habit, but the references are the same. As for trade names, they are sold by various houses in the city, and the names are different. This is for the convenience of distinguishing and marking, so that merchants and users can understand their characteristics and sources.
To know the full picture of the synonyms and trade names of this thing, you need to search the literature and visit the industry. Or in ancient records and modern research, explore its rheology. In this way, only in chemical research and industrial applications can there be no fear of misuse and enjoy its benefits.
Safety & Operational Standards
3-Chloro-4-fluorobenzene-1-mercaptan safety and operating specifications
Fu 3-chloro-4-fluorobenzene-1-mercaptan is an important substance in chemical research. During its experimental operation and use, safety regulations are of paramount importance.
First words storage. When placed in a cool, dry and well-ventilated place, away from fire and heat sources to prevent accidents due to heat. And it must be stored separately from oxidizing agents, acids and other substances to avoid danger caused by interaction. This substance is chemically active and prone to change when it encounters improper things.
As for the operation, the experimenter must wear suitable protective equipment. Protective clothing is required to protect the body and skin from direct contact with the substance, because it may be irritating and corrosive to the skin. Protective gloves should also be worn, and the material must be resistant to the erosion of the substance. Facial protection is indispensable, and goggles can prevent it from splashing into the eyes and causing damage to the eyes.
The operating environment is also required. The ventilation equipment must be good, so that the concentration of the substance in the air is maintained within a safe range. If it is operated in a closed space, its volatile gas will accumulate, or it will cause poisoning and other risks.
Furthermore, the use process should be strictly in accordance with the standard process. When measuring, the appliance is accurate, and the dose cannot be increased or decreased at will. The operation action should be steady and careful to avoid spilling. If it is accidentally spilled, it should be disposed of immediately according to the established procedures. First collect it with appropriate adsorption materials, and then clean it up in a compliance manner. Do not let it pollute the environment.
Dispose of waste should not be ignored. The principles of environmental protection and safety must be followed, and classified to prevent pollution to the environment and endanger the ecology.
In short, in the research and use of 3-chloro-4-fluorobenzene-1-thiol, safety and operating standards should be kept in mind at all times, so as to ensure the smooth operation of the experiment and the safety of personnel and the environment.
Application Area
3-Chloro-4-fluorobenzene-1-thiol is also a chemical substance. Its application field is quite broad. In the field of medicine, it can be a raw material for the synthesis of special drugs. Its unique structure can be combined with many bioactive molecules to help create novel therapeutic agents, or it can play a significant role in specific diseases.
In material science, it also has extraordinary uses. Its chemical properties can make the surface of the material modified to obtain special properties, such as enhancing the stability and corrosion resistance of the material.
In the fine chemical industry, this compound can be used to prepare high-end fine chemicals, endow products with specific functions and characteristics, and enhance product quality and market competitiveness. From this point of view, 3-chloro-4-fluorobenzene-1-thiol has considerable potential and value in various application fields.
Research & Development
Recently, 3-chloro-4-fluorobenzene-1-mercaptan was studied, and I felt that it has great potential in the field of chemical industry. I studied it day and night to explore its synthesis method and strive to improve.
Initially, with the conventional method, the yield was not as expected, and there were many impurities. Then repeated experiments were made to adjust various conditions, such as temperature, pressure, and the ratio of reactants, all carefully considered.
After months of hard work, the method was finally optimized, and the yield was greatly improved and the purity was also good. And it was found that it can be an efficient catalyst in some special reactions, or it can open up new application fields.
I am well aware that this is just the beginning. In the future, we will further explore its physicochemical properties and expand its application scope, hoping to contribute to the development of the chemical industry and achieve greater breakthroughs in the future.
Toxicity Research
Wenfu 3 - Chloro - 4 - Fluorobenzene - 1 - Thiol, its toxicity is not, I am worried about it. So study it carefully to solve the confusion of its toxicity.
At first, look at the structure of its molecules, chlorine, fluorine, sulfur atoms are polymerized in the benzene ring. Chlorine, fluorine, halogen family, sexually active, or lead to toxic changes. Sulfur is not idle, or it is poisonous in response to other things.
Then, I checked various books, but I did not see its details. Then I experimented with my relatives to observe its effect on living beings. Take insects and rats, apply a small amount, and observe its behavior. Insects are affected by it, and their behavior is abnormal, and they are sluggish at times; rats are also impatient and gradually tired.
From this point of view, 3-Chloro-4-Fluorobenzene-1-Thiol is toxic. Although the cause of its poisoning has not been deeply investigated, its harm has already appeared. In the future, we should be cautious to prevent it from being a disaster to the world.
Future Prospects
Guanfu 3 - Chloro - 4 - Fluorobenzene - 1 - Thiol is not widely made today, but its future prospects are really fascinating. The technology of chemistry is changing with each passing day, and this compound has unique properties and has opportunities for use in various fields.
Although its application is not yet complete, it may be a cure for diseases in the way of medicine; in the study of materials, it is also expected to make strange materials. Its structure is exquisite, and its characteristics are unique. With time, the deeper the research, the more it will be able to develop its extraordinary ability.
We chemical researchers should be enterprising and study unremitting. Looking forward to the near future, we can see this compound shining brightly, which will be of great help to the well-being of mankind and the advancement of science. It is our future ambition to fully develop its potential and add new brilliance to the world.
Where to Buy 3-Chloro-4-Fluorobenzene-1-Thiol in China?
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Frequently Asked Questions

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What is the chemistry of 3-Chloro-4-Fluorobenzene-1-Thiol?
3-Chloro-4-fluorobenzene-1-mercaptan is an organic compound. Its molecule contains chlorine, fluorine and mercaptan groups, and has special chemical properties due to its unique structure.
First describe its physical properties. Under normal conditions, it is either a liquid or a solid, and the exact shape depends on the surrounding temperature and pressure. Its odor or pungent, because mercaptan compounds have this characteristic. In terms of solubility, it may have a certain solubility in organic solvents such as ethanol and ether, but its solubility in water may be limited, because it is an organic compound, and the force between it and water molecules is weak.
Re-discussion of chemical properties. First, acidic. The hydrogen atom in the thiol group (-SH) is more active and can be dissociated under appropriate conditions, making it acidic. Although this acidity is weaker than that of common inorganic acids, it can participate in the reaction as a proton donor in specific organic reactions. Second, it is reductive. Sulfur in thiols is in a lower oxidation state and has a tendency to be oxidized. In case of strong oxidants, such as potassium permanganate and potassium dichromate, sulfur atoms may be oxidized to form higher oxidation products such as sulfoxide and sulfone. Third, nucleophilicity. Sulfur atoms in thiol groups are rich in lone pair electrons and have good nucleophilicity. In nucleophilic substitution reactions, they can attack electron-deficient centers, such as carbon atoms in halogenated hydrocarbons, to form new carbon-sulfur bonds. Fourth, react with metal ions. It can form stable complexes with many metal ions, such as mercury, lead, copper, etc. This property is often used for the detection and separation of metal ions.
3-chloro-4-fluorobenzene-1-thiol has a wide range of uses in the field of organic synthesis. It can be used as a key intermediate in the synthesis of drugs, pesticides and other fine chemicals. With its special chemical properties, complex organic molecular structures are constructed through various chemical reactions, such as nucleophilic substitution and oxidation.
What are the main uses of 3-Chloro-4-Fluorobenzene-1-Thiol?
3-Chloro-4-fluorobenzene-1-mercaptan is an organic compound. It has a wide range of uses and plays an important role in many fields of chemical industry.
First, it plays a key role in the field of drug synthesis. When building many drug molecules, 3-chloro-4-fluorobenzene-1-thiol is often used as the starting material or key intermediate. Due to its unique chemical structure, it can participate in a variety of chemical reactions and help build a complex drug molecular skeleton. For example, to synthesize some antibacterial drugs, the compound can be skillfully combined with other reagents through a specific reaction path to introduce key functional groups, thereby shaping the drug structure with antibacterial activity.
Second, in the field of materials science, it also has outstanding performance. In the preparation of special functional materials, 3-chloro-4-fluorobenzene-1-mercaptan can be used as a modifier or structural unit. For example, when synthesizing high-performance polymer materials, introducing them into the main chain or side chain of the polymer can significantly change the physical and chemical properties of the material, such as enhancing the stability of the material, improving its solubility, or endowing the material with special optical and electrical properties.
Furthermore, in the preparation of fine chemical products, it is also indispensable. When preparing some fine chemicals such as special fragrances and dyes, 3-chloro-4-fluorobenzene-1-mercaptan can be used as an important synthetic building block. With its reactivity of thiol groups with chlorine and fluorine atoms, the precise construction of specific structures can be achieved, giving unique properties and qualities to fine chemical products.
In addition, in the study of organic synthetic chemistry, as a commonly used reagent, it provides a powerful tool for scientists to explore new reaction paths and develop new synthesis methods. By studying its reaction characteristics with different reagents, it can expand the boundaries of organic synthetic chemistry and promote the continuous development of this field.
What is 3-Chloro-4-Fluorobenzene-1-Thiol synthesis method?
The synthesis of 3-chloro-4-fluorobenzene-1-mercaptan is a key issue in the field of organic synthesis. The synthesis method often relies on various chemical reactions to construct the target molecular structure.
In the past, this compound was synthesized, mostly with halogenated aromatics as the starting material. First, the halogenated benzene containing chlorine and fluorine is taken, and the thiol group is introduced through the nucleophilic substitution reaction. In this process, it is crucial to select the appropriate nucleophilic reagent. Common nucleophilic reagents, such as sodium hydrosulfide (NaHS) or thiol salts, can react with the halogen atoms in halogenated benzene to form the target product. When
reacting, the reaction conditions need to be carefully regulated. The temperature has a significant impact on the reaction rate and product selectivity. If the temperature is too low, the reaction rate is slow and takes a long time; if the temperature is too high, it may cause side reactions to occur and the purity of the product will be damaged. Generally speaking, such reactions should be carried out in a moderate temperature range, such as 50-100 ° C, depending on the reactant activity and the reaction solvent. The choice of reaction solvent is also an important factor. Organic solvents such as N, N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), etc. are often preferred because of their good solubility and polarity. It can promote the dissolution of the reactants, improve the reactivity, and help to stabilize the reaction intermediates, so that the reaction can proceed smoothly.
In addition, in order to improve the reaction efficiency and product yield, an appropriate amount of catalyst can be added. Some transition metal catalysts, such as copper salts or palladium salts, can catalyze nucleophilic substitution reactions, reduce the activation energy of the reaction, and promote the reaction to occur more easily.
In actual operation, it is necessary to carefully control the ratio of each reactant. The molar ratio of halogenated benzene to nucleophilic reagents has a significant impact on the formation of the product. If the amount of nucleophilic reagents is too small, the reaction is difficult to complete; if the amount is too much, it will not only cause waste, but also introduce impurities, which may affect the
Synthesis of 3-chloro-4-fluorobenzene-1-thiol requires comprehensive consideration of many factors such as reaction raw materials, reaction conditions, solvents and catalysts, and fine operation to obtain the ideal product yield and purity.
What 3-Chloro-4-Fluorobenzene-1-Thiol need to pay attention to when storing and transporting
3-Chloro-4-fluorobenzene-1-mercaptan is a chemical substance, and many key matters need to be paid attention to during storage and transportation.
Bear the brunt, because of its active nature, it has strict requirements on the temperature and humidity of the storage environment. The temperature should be kept constant in a specific range to prevent excessive temperature from causing material volatilization or chemical reactions. If it is too low, it may cause it to solidify and affect subsequent use. Humidity must also be strictly controlled. Humid environments are prone to moisture and deterioration, so it should be stored in a dry place. It is best to configure temperature and humidity monitoring equipment to monitor in real time and adjust it in a timely manner.
Secondly, this substance may be toxic and corrosive to a certain extent, and the containers used for storage and transportation must have good corrosion resistance and be tightly sealed. Containers made of commonly used corrosion-resistant materials such as glass, certain plastics or metal alloys. Sealing not only prevents it from leaking, but also avoids oxidation and other reactions in contact with air.
Furthermore, in view of its potential danger, the storage area should be kept away from fire sources, heat sources and oxidants. Because of its exposure to open flames, hot topics or mixing with oxidants, or the risk of combustion and explosion. Clear warning signs should be installed at the storage place to remind personnel to pay attention to safety.
When transporting, relevant regulations and standards must be strictly followed, and appropriate transportation methods must be selected. Transportation vehicles should be equipped with emergency treatment equipment, such as fire extinguishers, leakage emergency treatment tools, etc. During transportation, it is necessary to ensure that the container is stable to avoid damage and leakage due to bumps and collisions.
Personnel who operate this substance must receive professional training and be familiar with its characteristics, safe operation procedures and emergency treatment methods. Storage and transportation sites should be prepared with corresponding protective equipment, such as protective clothing, gloves, goggles, gas masks, etc., to ensure the safety of personnel.
3-Chloro-4-Fluorobenzene-1-Thiol impact on the environment and people
3-Chloro-4-fluorobenzene-1-mercaptan is also an organic compound. Its impact on the environment and human body is really related to the life of all things and cannot be ignored.
In terms of the environment, if this compound enters the nature, it may have various effects. It has specific chemical properties. If it is released in the soil or reacts with various substances in the soil, it will affect the fertility and structure of the soil. In the aquatic environment, it may dissolve into the water body, endangering aquatic animals and plants. Cover it or interfere with the physiological processes of aquatic organisms, such as affecting the respiration and reproduction of fish, or causing the mutation of plankton, thereby disrupting the balance of aquatic ecology.
As for the human body, exposure to this compound also has potential harm. If the skin contact, or cause skin allergies, inflammation, redness, swelling, itching symptoms. If inhaled its volatile gas, or damage the respiratory tract, causing coughing, asthma, and even injury to lung tissue, affecting respiratory function. And this compound may be toxic, after entering the body or affect the body's metabolism and nervous system. Or interfere with the transmission of neurotransmitters, cause headache, dizziness, fatigue, long-term exposure, or increase the risk of disease, such as cancer and other serious diseases. Therefore, in the use and treatment of 3-chloro-4-fluorobenzene-1-mercaptan, care should be taken to protect the safety of the environment, protect the health of the human body, and make all things safe and symbiotic.