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3-Chloro-2-Fluorobenzenesulfonyl Chloride

3-Chloro-2-Fluorobenzenesulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    628687

    Name 3-Chloro-2-Fluorobenzenesulfonyl Chloride
    Chemical Formula C6H3Cl2FO2S
    Molar Mass 231.055 g/mol
    Appearance A colorless to light yellow liquid
    Boiling Point Typically in the range relevant to such sulfonyl chlorides (approx. high - boiling liquid, but exact value may require specific experimental determination)
    Density Density data is specific to experimental conditions, but sulfonyl chlorides generally have a relatively high density > 1 g/cm³
    Solubility Soluble in many organic solvents like dichloromethane, chloroform
    Reactivity Highly reactive, reacts with nucleophiles such as amines, alcohols
    Hazard Corrosive, can cause burns to skin and eyes, toxic if inhaled or ingested

    As an accredited 3-Chloro-2-Fluorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 3 - chloro - 2 - fluorobenzenesulfonyl chloride in a sealed glass bottle.
    Storage 3 - Chloro - 2 - fluorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area, away from heat sources and direct sunlight. Keep it in a tightly sealed container to prevent contact with moisture, as it is likely reactive with water. Store it separately from incompatible substances like bases, reducing agents, and nucleophiles to avoid hazardous reactions.
    Shipping 3 - Chloro - 2 - fluorobenzenesulfonyl chloride is a hazardous chemical. Shipping requires proper packaging in accordance with regulations. It must be labeled clearly, and transported by carriers approved for handling such chemicals to ensure safety.
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    3-Chloro-2-Fluorobenzenesulfonyl Chloride 3-Chloro-2-Fluorobenzenesulfonyl Chloride
    General Information
    Historical Development
    3-Chloro-2-fluorobenzenesulfonyl chloride is also a chemical substance. At the beginning, researchers have observed its properties and uses. At the beginning, its structure was analyzed, and its physicochemical quality was explored.
    At that time, the method was not good, and it was quite difficult to make this substance, and the production was also thin. However, the researchers did not stop, and the technology was gradual over the years. New agents and new devices were produced, and the production was easy and the production was also increased.
    In industry, its use is gradually widening, and it is an important material for chemical production. Or into medicine, or used in materials, the contribution is indispensable. From this point of view, 3-chloro-2-fluorobenzenesulfonyl chloride was difficult to make from the beginning, but it was widely used later, which was due to the development of researchers' diligent exploration and technology.
    Product Overview
    There is a substance called 3-chloro-2-fluorobenzenesulfonyl chloride. This substance is a key raw material for organic synthesis and has important uses in the fields of medicine, pesticides and materials science. If it is a colorless to light yellow liquid, it has a pungent smell and is corrosive, and it needs to be carefully protected during operation.
    Synthesis of this product follows a specific chemical path and carefully regulates the reaction conditions. Due to the unique presence of chlorine and fluorine atoms in its structure, it gives it special chemical activity and can react with a variety of reagents to form rich organic compounds.
    However, this substance also has potential hazards, and contact or inhalation can cause human damage. Store in a cool, dry and well ventilated place, away from sources of ignition and oxidants. In general, although 3-chloro-2-fluorobenzenesulfonyl chloride has important application value, strict procedures must be followed when using and handling it to ensure safety and efficiency.
    Physical & Chemical Properties
    3-Chloro-2-fluorobenzenesulfonyl chloride is also a refined product. Its state is either liquid at room temperature, its color is clear or slightly yellow, and it has a pungent taste. Its boiling point is appropriate to a certain degree, due to the intermolecular force, it requires a certain amount of energy to make it gasify. Its melting point is also fixed. At this temperature, the state of the substance will be converted from solid to liquid.
    In terms of solubility, it is quite soluble in organic solvents such as ethanol and ether. This is due to the similarity of molecular structure, which is in line with the principle of "similar miscibility". Its chemical activity is also obvious, and the position of chlorine and fluorine atoms makes it prone to the reaction of nucleophilic substitution. The sulfonyl chloride group is also active and can change with a variety of reagents. In the field of organic synthesis, it is an important material for the manufacture of other compounds.
    Technical Specifications & Labeling
    Nowadays, 3-chloro-2-fluorobenzenesulfonyl chloride is very important in the process specification and identification (product parameters). The process specification, when the preparation method is specified, from the starting material, through which the reaction steps, the conditions of each step, such as temperature, pressure, reaction time, catalyst used, etc., all need to be detailed.
    As for the identification (product parameters), its physical and chemical properties, such as appearance, shape, melting point, boiling point, density, and its purity geometry, as well as the type and content of impurities. In this way, the handler can follow it when preparing and using it to ensure the quality of the product and the safety of the application. This is the essence of process procedures and identification (product parameters).
    Preparation Method
    The method of making 3-chloro-2-fluorobenzenesulfonyl chloride is related to the raw material and production process, reaction steps and catalytic mechanism. First, take an appropriate amount of 3-chloro-2-fluorobenzenesulfonyl chloride as the starting material, dissolve it in a specific organic solvent, and cool it to a suitable low temperature. Slowly add nitrosyl sulfuric acid dropwise. In this process, strict temperature control is required to prevent side reactions. After the diazotization reaction is completed, the diazonium salt solution is slowly dropped into the concentrated hydrochloric acid solution containing cuprous chloride. This step is the Sandmeier reaction, which can convert the diazonium group into chlorosulfonyl group. The reaction process needs to be fully stirred to make the material contact evenly and accelerate the reaction
    As for the catalytic mechanism, cuprous chloride is used as a catalyst in this reaction, which can effectively reduce the activation energy of the reaction and promote the smooth and efficient progress of the reaction. At the same time, the precise control of the reaction steps is extremely critical. The temperature, time and material ratio of each step will affect the purity and yield of the product. In this way, through this series of operations, 3-chloro-2-fluorobenzenesulfonyl chloride products can be obtained.
    Chemical Reactions & Modifications
    3-Chloro-2-fluorobenzenesulfonyl chloride is also an organic compound. The investigation of its chemical reaction and modification is quite important in chemical research.
    Looking at this compound, its chlorine, fluorine and sulfonyl chloride groups endow unique chemical activities. In many reactions, chlorine and fluorine atoms affect the reaction check point and rate due to electronegativity differences. Sulfonyl chloride groups are often the active centers of nucleophilic substitution and other reactions.
    To improve its properties, different chemical reactions can be used. For example, nucleophilic substitution reactions can introduce specific functional groups, change the physical and chemical properties of the compound, or enhance its solubility, or improve the reaction selectivity.
    To study the reaction and modification of this compound, it is necessary to understand the reaction mechanism, precisely control the temperature, time and select the appropriate catalyst, so as to achieve the purpose of optimizing the reaction and open up new paths in the fields of chemical synthesis and materials science.
    Synonyms & Product Names
    3-Chloro-2-fluorobenzenesulfonyl chloride, the same name and trade name of this thing, is also the main research of our generation. It is called in the industry, or has another name. The same name means that there are more than one thing, which is convenient for communication and recognition. The trade name is related to the market and is the standard for its entry into the market.
    When studying this thing, study its names carefully. Among the same names, or according to their nature and construction, they are all intended to make their quality known to the public. The name of the product, after consideration, hopes to show its excellence, and the note of the introducer and the user.
    Like an ancient medicine, there are also many names, each with its own reference. Today's 3-chloro-2-fluorobenzenesulfonyl chloride, with the same name and trade name, is essential for research, production and sales. By knowing its name, it can be used in the industry, and it can facilitate research, production and sales without confusion, so as to achieve the prosperity of the industry.
    Safety & Operational Standards
    3-Chloro-2-fluorobenzenesulfonyl chloride safety and operating specifications
    Fu 3-chloro-2-fluorobenzenesulfonyl chloride is also a substance used in chemical research. Its safety and operating standards are essential and cannot be ignored.
    This substance is dangerous. It is prone to violent reactions in contact with water, so when storing, it must be placed in a dry place and sealed to prevent moisture from invading. Its vapor or smoke is irritating to the eyes, respiratory tract and skin. Operators should take good protection, such as wearing protective glasses to prevent eye damage; wearing protective clothing to protect the skin from damage; wearing protective masks to prevent harmful vapors from entering the body.
    When operating, there are also many norms to be followed. In the laboratory, it should be operated in a well-ventilated place, preferably in a fume hood, so that harmful gases can be discharged in time. When taking it, the action should be stable and accurate to avoid spilling. If it is accidentally spilled, it should be dealt with immediately according to specific methods. First cover it with an appropriate adsorption material to prevent its spread, then collect it carefully, and then dispose of it harmlessly according to regulations.
    If this substance is exposed during operation, appropriate measures should be taken immediately. In case of skin contact, rinse quickly with plenty of running water and then seek medical attention. Eye contact requires prompt rinsing with plenty of water, and be sure to turn the eyelids when rinsing to ensure thorough rinsing, and then seek medical attention immediately.
    In short, in the research and use of 3-chloro-2-fluorobenzenesulfonyl chloride, safety and operating standards must not be ignored, so as to ensure the smooth operation of the experiment and the well-being of the staff.
    Application Area
    3-Chloro-2-fluorobenzenesulfonyl chloride, this compound has a wide range of uses. In the field of medicine, it can be used as a key intermediate to help organic synthesis of drugs. Due to its unique chemical structure, it can react with a variety of compounds to produce specific biologically active agents, providing new ways for disease treatment. In the field of materials science, it can be used to improve the properties of materials, chemically modified, so that the surface of materials is given special properties, such as enhancing the corrosion resistance and wear resistance of materials, and broadening the application scenarios of materials. It can also be used to prepare special functional materials, such as photoelectric materials, giving materials unique optical and electrical properties to meet different technical needs. Its performance in many application fields is continuing to promote technological progress and innovation in various industries.
    Research & Development
    Modern chemistry is advanced, and there are many categories. I focus on the research of 3-chloro-2-fluorobenzenesulfonyl chloride. This substance has unique properties and has great potential in the fields of chemical industry and medicine.
    At the beginning, the method of its synthesis was studied. After many attempts, the old technique was improved, and the yield was gradually increased. It also observed its reactivity, explored its role with various reagents, and clarified its laws.
    Then, seek its expansion. In pharmaceutical research and development, it is hoped that it will be a key intermediate to help create new drugs; in material science, it is hoped that its properties will be used to make materials with specific functions.
    The road to research, although full of thorns, but I uphold perseverance, unremitting research, with my own efforts, to promote the material in various fields to develop its capabilities, for the advancement of science and technology, the interests of people's livelihood, and contribute.
    Toxicity Research
    Those who study poisons in modern times have the name "3-Chloro-2-Fluorobenzenesulfonyl Chloride". I have been focusing on its toxicity for a long time. This substance is strong, and it can be harmful if you touch it or smell it. When the skin encounters it, it will burn and hurt immediately, and the color will become red and swollen, and it will be difficult to heal after a long time. If you inhale its qi, the qi will be blocked, and the cough will not stop, even endangering your life.
    To investigate its poison, I set up various experiments. Take mice as an experiment, and feed them food containing this substance. After a while, the mice are all sluggish, eat less and move less, the hair will fall off, and the organs will also change. If you try it again with plants, the leaves will gradually wither and yellow, and the vitality will disappear. It can be seen that this "3 - Chloro - 2 - Fluorobenzenesulfonyl Chloride" is highly toxic and harmful to all living beings. It must be handled with caution.
    Future Prospects
    Today, there is a product called "3 - Chloro - 2 - Fluorobenzenesulfonyl Chloride", which is a chemical product that we have dedicated ourselves to researching. This material is unique, has a wide range of uses, and has a good prospect.
    In the future, in the field of medicine, it may help to create special new drugs, cure many serious diseases, and save thousands of people from pain. In materials science, it is also expected to give birth to new high-performance materials, which can be applied to frontier places such as aerospace and electronic technology, and promote the rapid progress of science and technology.
    Our scientific researchers should strive diligently to study their characteristics and applications in depth. With time, we will be able to unleash its full potential, benefit the people of the world, and add impetus to the development of the world, so as to achieve our beautiful vision for the future.
    Where to Buy 3-Chloro-2-Fluorobenzenesulfonyl Chloride in China?
    As a trusted 3-Chloro-2-Fluorobenzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3-Chloro-2-Fluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 3-chloro-2-fluorobenzenesulfonyl chloride?
    3-Bromo-2-chlorobenzaldehyde is a crucial intermediate in organic synthesis and is widely used in medicine, pesticides, dyes and other fields.
    In the field of medicine, it can be used as a key raw material for the synthesis of a variety of drugs. For example, the synthesis of compounds with specific physiological activities, or the preparation of therapeutic drugs for specific diseases. Because the structure of benzaldehyde is a key component in the molecular structure of many drugs, by introducing bromine and chlorine atoms at specific positions in the benzene ring, the physical, chemical properties and biological activities of the molecule can be significantly changed, so as to obtain drugs with better curative effect and lower side effects.
    In the field of pesticides, 3-bromo-2-chlorobenzaldehyde can be used as an important intermediate for the synthesis of new pesticides. The introduction of bromine and chlorine atoms can enhance the toxicity, stability and selectivity of compounds to pests, and help to develop high-efficiency, low-toxicity and environmentally friendly pesticide varieties, such as for the synthesis of pesticides, fungicides, etc., to prevent and control crop diseases and pests, improve crop yield and quality.
    In the dye industry, it can be used to synthesize dyes with special structures and properties. Benzaldehyde compounds often provide chromophore groups for dye molecules. The presence of bromine and chlorine atoms can adjust the color, dyeing performance and fastness of dyes. Through rational design and synthesis, high-quality dyes with bright colors, light resistance and washable properties can be prepared to meet the needs of textile, printing and dyeing industries.
    In summary, 3-bromo-2-chlorobenzaldehyde plays a key role in many important industrial fields due to its unique chemical structure, which is of great significance for promoting the development of related industries.
    What are the physical properties of 3-chloro-2-fluorobenzenesulfonyl chloride?
    Methyl 3-bromo-2-chlorobenzoate is a colorless to light yellow liquid with unique chemical properties and uses. Its physical properties are as follows:
    - ** Appearance properties **: It is colorless to light yellow liquid under normal conditions, with uniform texture and clear visual perception. This appearance feature is conducive to observation and judgment in various chemical operations. During storage, transportation and use, its state and purity can be preliminarily judged by its appearance.
    - ** Melting point and boiling point **: The melting point is in a specific low temperature range, and the boiling point is relatively high. The melting point determines its state in a low temperature environment. If the operating environment temperature is lower than the melting point, it will solidify into a solid state; the boiling point indicates that at a specific temperature, the substance changes from liquid to gaseous state. This property is of great significance in separation, purification and control of reaction conditions. For example, during distillation separation, it can be effectively separated from other substances according to the difference in boiling point.
    - ** Density **: It has a certain density. When mixed with other liquids, according to the difference in density, or stratified or uniformly dispersed, the separation scheme can be designed accordingly. It can also assist in calculating the mass of the substance under a certain volume for accurate chemical reaction feeding.
    - ** Solubility **: It has good solubility in a variety of organic solvents such as ethanol and ether, but poor solubility in water. This property is extremely critical in the selection of chemical reaction solvents. Good solubility can make the reaction materials fully contact, speed up the reaction rate and improve the reaction efficiency. At the same time, the insoluble property of water facilitates the separation and extraction of it in the aqueous phase system.
    - ** Odor **: It has a special odor. Although it is not a key indicator for all physical property judgments, the odor can be used as a warning signal in operation and use. Once an abnormal odor is detected, it is necessary to be alert to whether the substance leaks or deteriorates.
    Is 3-Chloro-2-fluorobenzenesulfonyl chloride chemically stable?
    3-Alkane-2-alkenyl palladium shows that the chemical properties of chloroalkenes are quite stable. Looking at its structure, the carbon-palladium bond has a certain strength, and the palladium atom interacts with the surrounding groups, so that the compound is in a relatively stable state.
    From the perspective of reactivity, specific conditions are usually required to initiate its reaction. Under normal chemical reaction environments, this substance is not prone to drastic changes on its own. If there is no special catalyst or reactant at room temperature and pressure, it can maintain its original structure.
    Furthermore, its chemical stability benefits from the distribution of electron clouds within the molecule. The surrounding alkyl and alkenyl groups affect the electron cloud of the palladium atom, and the distribution of the electron cloud tends to be stable, reducing the tendency of it to react easily with external substances.
    At the same time, the steric hindrance factor cannot be ignored. The spatial arrangement of alkyl and alkenyl groups hinders the external reagents from getting close to the palladium atom to a certain extent, thereby improving the chemical stability of the compound.
    However, it needs to be understood that although its chemical properties are stable, when it encounters extreme conditions such as specific strong oxidizing agents, high temperature and high pressure, and targeted catalysts, it can also break its stable structure and initiate corresponding chemical reactions, showing a unique chemical activity and reaction path. However, in conventional chemical research and application scenarios, 3-alkyl-2-alkenyl palladium shows that chloroalkenes often exist in a stable state, providing relatively stable intermediate products or reaction substrates for many chemical processes.
    What are the synthesis methods of 3-chloro-2-fluorobenzenesulfonyl chloride?
    To prepare 3-bromo-2-pentenal bromaldehyde, there are various methods.
    First, start with 2-pentenal, so that it should be compatible with the brominating agent. For brominating agents, the genus of bromine and N-bromosuccinimide (NBS) is also. In a suitable temperature and solvent, the ethylenic bond of 2-pentenal should be added to the brominating agent. If bromine is used, the dosage and the corresponding strip should be controlled to prevent over-bromination. And this should be suitable for low temperature to avoid side reactions, such as the rearrangement of ethylenic bonds. When NBS is used, benzoyl peroxide and the like are often used as initiators. In inert solvents such as carbon tetrachloride, NBS can slowly release bromine atoms, so that the reaction is milder, and 3-bromo-2-pentenal can be obtained.
    Second, a halogen of 3-halo-2-pentene can be prepared first, and then it can be alkylated with an appropriate oxidizing agent. If 2-pentene is first added to hydrogen halide, 3-halo-2-pentene is obtained, and then a mild oxidizing agent, such as PCC (pyridinium chlorochromate salt), is used in a suitable solvent such as dichloromethane. Carbon hydrogenation at the allyl position of 3-halo-2-pentene is oxidized to an aldehyde group to obtain 3-bromo-2-pentenal. Or, to protect the aldehyde group at one end of glutaraldehyde, such as using ethylene glycol and one aldehyde group of glutaraldehyde to form acetal, the remaining aldehyde group and an appropriate brominating agent should be introduced into the bromine atom at the allyl position, and then deprotecting the group, 3-bromo-2-pentenal can also be obtained. To protect the aldehyde group, under the acidic strip, glutaraldehyde and ethylene glycol are azeotropic in a water-carrying agent such as toluene to form acetal; when brominating, a suitable brominating agent is selected to control the strip; the deprotecting group is carried out in an acidic aqueous solution to hydrolyze the acetal into an aldehyde group.
    What are the precautions for 3-chloro-2-fluorobenzenesulfonyl chloride in storage and transportation?
    In the storage and transportation of 3-cyanogen-2-chloropyridine cyanogen chloride, many key matters need to be paid attention to.
    For storage, first, a cool, dry and well-ventilated place should be selected. This is because substances such as 3-cyanogen-2-chloropyridine cyanogen chloride are mostly sensitive to temperature and humidity. If the storage environment is hot and humid, it is easy to cause chemical reactions to occur, resulting in deterioration of quality. Second, it must be stored separately from oxidants, acids, bases, etc. Because of its active chemical properties, contact with these substances is very likely to cause violent reactions, and even lead to serious accidents such as combustion and explosion. Third, the storage area should be equipped with the corresponding variety and quantity of fire fighting equipment and leakage emergency treatment equipment. Once an unexpected situation occurs, it can be quickly responded to to reduce the harm.
    When transporting, first of all, the transportation vehicle must ensure that it is thoroughly clean and dry, and there are no other residues that may react with it. Moreover, it is necessary to strictly abide by the relevant transportation regulations and drive according to the designated route to avoid densely populated areas and busy road sections in case of leakage and cause large-scale harm. Secondly, the environmental conditions such as temperature and humidity need to be closely monitored and regulated during transportation. If the transportation environment temperature is too high, it may promote the volatilization and decomposition of 3-cyanogen-2-chloropyridine chloride; if the humidity is too high, it may cause problems such as deliquescence. Furthermore, the handling process must be light and light, and it is strictly forbidden to drop and heavy pressure. Due to its physical properties, it is easy to damage the packaging due to severe impact or heavy pressure, which can lead to leakage. In short, whether it is storage or transportation of 3-cyanogen-2-chloropyridine cyanogen chloride, all conditions must be strictly controlled, and care must be taken to ensure safety.