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3-Chloro-2-Fluoro-1-Nitrobenzene

3-Chloro-2-Fluoro-1-Nitrobenzene

Hongda Chemical

Specifications

HS Code

760933

Chemical Formula C6H3ClFNO2
Molecular Weight 177.545
Appearance Liquid (usually)
Boiling Point Approx. 215 - 217 °C
Density Around 1.48 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents like ethanol, ether
Vapor Pressure Low at room temperature
Flash Point Around 90 °C
Odor Typical aromatic nitro - halogenated odor
Stability Stable under normal conditions, but reactive to strong reducing agents, bases etc.

As an accredited 3-Chloro-2-Fluoro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 3 - chloro - 2 - fluoro - 1 - nitrobenzene packaged in a sealed, corrosion - resistant drum.
Storage 3 - Chloro - 2 - fluoro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly sealed container, preferably made of corrosion - resistant materials like stainless steel or certain plastics. This is to prevent leakage, evaporation, and potential chemical reactions that could pose safety risks.
Shipping 3 - chloro - 2 - fluoro - 1 - nitrobenzene is a hazardous chemical. Shipping requires proper packaging in accordance with regulations, like in UN - approved containers. It must be labeled clearly, and shipped via carriers compliant with hazardous materials transport rules.
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3-Chloro-2-Fluoro-1-Nitrobenzene 3-Chloro-2-Fluoro-1-Nitrobenzene
General Information
Historical Development
Wenfu 3 - Chloro - 2 - Fluoro - 1 - Nitrobenzene, its birth has also undergone changes over time. In the past, chemical techniques have not been as delicate as they are today. Exploring the road of this compound is like finding light in a path.
At the beginning, the craftsmen only knew a little about its characteristics. If they wanted to analyze its structure and explore its preparation method, they had to try everything. At that time, the experimental equipment was simple, and every step was like walking on thin ice. If there was a slight mistake, they would fall short.
However, everyone did not give up. After years of research, from the initial ignorance to the clarification of its reaction mechanism. From the selection of basic raw materials to the fine regulation of reaction conditions, countless efforts have been made. Over the years, many chemists have continued to improve the preparation process. From the crude initial stage to the precise control of all aspects, this compound can be produced stably and shine in the chemical industry and other fields. It is a brilliant achievement of the road of chemical exploration.
Product Overview
Today there is a product called 3-chloro-2-fluoro-1-nitrobenzene. This is an organic compound with a unique molecular structure. Chlorine, fluorine, and nitro groups are cleverly connected to the benzene ring.
Its properties are liquid at room temperature, with a special smell, color or light yellow. In the chemical industry, it has a wide range of uses. It can be a key raw material for pharmaceutical synthesis. It can be converted into pharmaceutical ingredients for the treatment of specific diseases through a series of reactions. It is also used in the preparation of pesticides to improve the efficacy and stability of pesticides and help agricultural production.
Synthesis of this product requires strict control of reaction conditions and precise preparation of the proportion of reactants. Because of its nitro-containing, with a certain risk, the operation needs to strictly abide by safety procedures to ensure the safety of personnel and the environment. In-depth research on it is expected to open up more application fields and contribute to the development of chemical industry.
Physical & Chemical Properties
3-Chloro-2-fluoro-1-nitrobenzene is also an organic compound. It has unique physical and chemical properties. Looking at its physical properties, at room temperature, it is mostly liquid, with a color close to colorless, or slightly light yellow, and has a special odor. Its boiling point and melting point are the inherent characteristics of the substance. The boiling point is about a certain temperature range to maintain the transition from its liquid state to its gaseous state. The melting point is also fixed, which is the critical temperature of solid and liquid states.
In terms of chemical properties, due to the presence of chlorine, fluorine, nitro and other functional groups, the activity is significant. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, making it vulnerable to attack by nucleophiles. Chlorine and fluorine atoms, due to their electronegativity differences, also affect the reactivity. In many chemical reactions, substitution reactions can occur, chlorine and fluorine atoms can be replaced by other groups, and can also participate in addition reactions. They exhibit rich chemical behaviors and are of great value in the field of organic synthesis.
Technical Specifications & Labeling
3-Chloro-2-fluoro-1-nitrobenzene, the genus of chemical substances. Its process specifications and identification (product parameters) are related to the characteristics, preparation and quality of this substance.
The process specifications, the purity of raw materials and the rules of reaction are all determined. If the preparation begins, it is necessary to select pure chlorine, fluorine, nitro and other related raw materials to control the proportion accurately. When reacting, the temperature, pressure and time should be carefully adjusted. High temperature will cause the reaction to be too fast or produce impurities; low temperature will be slow and the yield will not be good. The same is true for pressure, and the appropriate environment will promote the reaction smoothly.
As for the identification (product parameters), the appearance color, purity geometry, melting point and boiling point are all key points. The appearance often has a specific color state to help identify. Purity is related to quality. Those with high purity have a wide range of uses and good efficiency. The value of melting point boiling point is the key to identification. If it is different from the standard value, it may indicate that the quality has changed. This is also important for process specifications and identification (product parameters) of 3-chloro-2-fluoro-1-nitrobenzene.
Preparation Method
The preparation method of 3-chloro-2-fluoro-1-nitrobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials is very critical, and it is often prepared by multi-step conversion with specific aromatic hydrocarbons as starting materials.
The first reaction conditions of the production process are precisely regulated. In a suitable reaction vessel, under a specific temperature, pressure and catalyst, the starting aromatic hydrocarbons are reacted with chlorine, fluorine and nitro reagents in sequence. For example, the aromatic hydrocarbons and chlorinated reagents are first reacted at a moderate temperature under the catalysis of the catalyst to complete the chlorination step.
The reaction steps are carefully and orderly. After chlorination, the reaction system is finely regulated, fluorinated reagents are added, and the reaction follows a specific sequence and conditions to achieve precise substitution of fluorine atoms. Then through the nitration step, nitro groups are precisely introduced to generate the target product 3-chloro-2-fluoro-1-nitrobenzene.
The catalytic mechanism relies on high-efficiency catalysts to reduce the activation energy of the reaction, accelerate the reaction process, and improve the selectivity and yield of the product. Reasonable selection and use of catalysts and optimization of reaction conditions can efficiently prepare 3-chloro-2-fluoro-1-nitrobenzene to meet production needs.
Chemical Reactions & Modifications
In the field of chemistry, the reaction and modification of 3-Chloro-2-Fluoro-1-Nitrobenzene are of great importance to our research.
The reaction of this compound is often related to the characteristics of chlorine, fluorine and nitro groups in its structure. Chlorine has considerable activity and is easily replaced by other groups in the reaction of nucleophilic substitution. Although fluorine has strong electronegativity, it also participates in specific reactions and affects the reaction path of molecules due to its small atomic radius. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring and changes the reactivity of the compound.
To modify this compound, you can start with its structure. By means of chemistry, change its substituents or adjust its spatial configuration to obtain different properties. For example, by reacting with chlorine atoms with nucleophiles, new functional groups can be introduced and new energies can be given. And such modifications may expand their applications in medicine, materials and other fields, opening up new avenues for chemical research and industrial practice.
Synonyms & Product Names
3-Chloro-2-fluoro-1-nitrobenzene is also a chemical substance. Its name is not only the same, but also the name of business.
As far as the same name is concerned, or because of the analysis of chemical engineering, it is named for its atomic arrangement and functional characteristics. In the field of chemical research, many people follow the law of chemistry, or from the perspective of its molecular image, chemical properties, etc., to find similar properties, all of which are accurate.
The name of business is due to the needs of market circulation and transactions. Merchants consider their uses, routes, target customer groups and other factors, and choose different product names based on ease of use and promotion. The two refer to the same thing, but they have different names due to their different domains and purposes. They all refer to the use of 3-chloro-2-fluoro-1-nitrobenzene in the world.
Safety & Operational Standards
3-Chloro-2-fluoro-1-nitrobenzene, also chemical products. It is crucial to safety and operating specifications, and should be detailed.
In the method of storage, it should be placed in a cool, dry and well ventilated place. Avoid direct sunlight, keep away from fires and heat sources. Cover this product from heat or exposure to open flames, fear danger. The storage place should be isolated from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed with storage. Because of its active chemical properties, contact with various objects, or cause violent reactions, endangering safety.
When operating, be sure to strictly abide by the procedures. The operator must be professionally trained and familiar with the essentials of operation. When operating, wear appropriate protective equipment, such as gas masks, chemical safety protective glasses, acid and alkali-resistant work clothes, and acid and alkali-resistant gloves, etc., to prevent its steam or dust from contacting the skin, eyes, and causing physical damage.
If accidentally leaking during operation, the first thing to do is to quickly evacuate the people in the leaked contaminated area to a safe area, isolate them, and strictly restrict access. Emergency personnel should wear self-contained positive pressure breathing apparatus and protective clothing. Do not let leaks come into contact with combustible substances (such as wood, paper, oil, etc.). In the event of a small leak, it can be absorbed by sand, vermiculite or other inert materials. If there is a large leak, a dike or pit should be built to contain it. Transfer it to a tanker or a special collector by pump, recycle it or transport it to a waste disposal site for disposal.
When transporting, also be cautious. The packaging must be complete and the loading should be secure. During transportation, ensure that the container does not leak, collapse, fall, or be damaged. It is strictly forbidden to mix with oxidizing agents, reducing agents, alkalis, food chemicals, etc. During transportation, it should be protected from exposure to the sun, rain, and high temperature.
These are the general principles of 3-chloro-2-fluoro-1-nitrobenzene safety and operation. Follow them to ensure safety.
Application Area
3-Chloro-2-fluoro-1-nitrobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it is often a key intermediary. With its unique structure, it can help chemists make all kinds of special drugs.
In the field of material science, this compound also has extraordinary ability. Using it as a raw material, it can make polymer materials with specific properties, or have excellent heat and corrosion resistance, which is very useful in electronics, machinery and other industries.
Furthermore, in the field of pesticide synthesis, 3-chloro-2-fluoro-1-nitrobenzene is also indispensable. Through ingenious chemical reactions, it can be turned into an efficient and low-toxic pesticide, protecting crops from invaders and preserving agricultural fertility.
From this point of view, 3-chloro-2-fluoro-1-nitrobenzene plays an important role in many application fields and contributes greatly to scientific progress and industrial development.
Research & Development
Wutao is dedicated to the research of 3-chloro-2-fluoro-1-nitrobenzene. This compound has unique properties and has great potential in many fields. Initially explore its structure and characteristics, and analyze the interaction of chlorine, fluorine and nitro groups in the molecule in detail to clarify its chemical activity.
Then explore the synthesis method. After many attempts, adjust the reaction conditions and optimize the ratio of raw materials, and strive to improve the yield and purity. During the process, many problems were encountered, such as poor reaction selectivity and frequent side reactions. However, relentless research led to the optimization method.
Looking forward to the future, I hope this achievement can be widely used in medicine, materials and other fields. Continuously expand the breadth and depth of research, explore its new properties and new uses, and hope to contribute to the development of related industries, promote this compound from research to practical application, and achieve greater value.
Toxicity Research
I have been engaged in the study of toxicants for a long time, and now I have observed this compound 3 - Chloro - 2 - Fluoro - 1 - Nitrobenzene. It has halogen atoms and nitro groups, and its properties are active or potentially toxic.
Experiments show that it may cause complex biochemical reactions in organisms. In mice, when this substance is administered, it is seen that its activity gradually slows down, and its feeding also decreases, or it damages the nervous and digestive systems.
Its chemical structure is analyzed, and the strong electron absorption of nitro groups may change the charge distribution of surrounding atoms to increase the reactivity. Halogen atoms also affect its fat solubility and metabolic pathways.
In conclusion, the toxicity of 3 - Chloro - 2 - Fluoro - 1 - Nitrobenzene cannot be ignored. Follow-up studies should focus on its mechanism of action and protection methods to avoid its harm to life and the environment.
Future Prospects
3-Chloro-2-fluoro-1-nitrobenzene is also an organic compound. In today's world, chemical research is advancing day by day, and the potential of this substance has not yet been realized by us. However, from my perspective, its future development can be looked forward to.
Today's chemical process is becoming more and more exquisite, and 3-chloro-2-fluoro-1-nitrobenzene may emerge in the creation of new materials. With its unique structure, it may add its characteristics to polymer materials, making them more tough and stable. It is used in the fields of aerospace and electronics to help technology take off.
And in the field of medicinal chemistry, it may be a key cornerstone for the development of new drugs. With its special chemical properties, it may be possible to synthesize drugs with high therapeutic power to solve the suffering of human diseases.
Our generation of chemical researchers, when diligently studying and exploring its mysteries, hope to make 3-chloro-2-fluoro-1-nitrobenzene make extensive contributions to human well-being in the future, live up to the expectations of the times, open up the unknown, and lead to the glory of chemistry.
Where to Buy 3-Chloro-2-Fluoro-1-Nitrobenzene in China?
As a trusted 3-Chloro-2-Fluoro-1-Nitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 3-Chloro-2-Fluoro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3-Chloro-2-Fluoro-1-Nitrobenzene?
3-Chloro-2-fluoro-1-nitrobenzene is also an organic compound. It has a wide range of uses and is involved in various fields of chemical industry.
First, it can be used as a raw material for pharmaceutical synthesis. The development of medicinal chemistry often relies on such organic compounds as the cornerstone. With a specific chemical reaction, it can be converted into intermediates with specific pharmacological activities, and then a variety of drugs can be synthesized. For example, the preparation of some antibacterial drugs, 3-chloro-2-fluoro-1-nitrobenzene can make the drug molecules have unique structures and functions to fight specific pathogens through multi-step reactions.
Second, it also plays an important role in the field of pesticide synthesis. Today's research and development of pesticides pursues high efficiency, low toxicity and environmental friendliness. 3-Chloro-2-fluoro-1-nitrobenzene can be made into pesticides with insecticidal, bactericidal or herbicidal effects after ingenious chemical modification. Its structural characteristics endow the prepared pesticide with unique biological activity, which can precisely act on target organisms and reduce the harm to non-target organisms and the environment.
Third, this compound can be used in dye synthesis. The color and properties of dyes are closely related to the chemical structure of the raw materials. The functional group of 3-chloro-2-fluoro-1-nitrobenzene can participate in complex organic synthesis reactions to generate colorful and fastness dyes, which are widely used in textiles, printing and dyeing and other industries to give fabrics a colorful color.
Fourth, in the field of materials science, there are also potential uses. With the advancement of science and technology, the demand for new materials is increasing. 3-chloro-2-fluoro-1-nitrobenzene can be used as a monomer or additive for synthesizing special polymer materials to improve the properties of materials, such as improving the heat resistance and corrosion resistance of materials, to meet the needs of different industrial scenarios.
What are the physical properties of 3-Chloro-2-Fluoro-1-Nitrobenzene?
3-Chloro-2-fluoro-1-nitrobenzene is one of the organic compounds. Its physical properties are worth exploring.
Looking at its properties, it is mostly liquid at room temperature, but its specific state may vary slightly due to factors such as the temperature and humidity of the environment. The color of this substance is usually colorless to light yellow, and the appearance is clear and transparent, just like autumn dew.
When it comes to smell, it has a special aromatic smell, but this smell is not pleasant and fragrant, but slightly irritating, and the smell makes the nasal cavity slightly uncomfortable, as if being in a chemical atmosphere.
Its density is heavier than that of water, and it is placed in water, such as a stone sinking abyss, slowly sinking. Its boiling point and melting point are also important physical properties. The boiling point is within a certain numerical range under specific conditions. The accuracy of this value is related to the application of distillation and purification processes; the existence of the melting point makes the substance gradually change from liquid to solid when the temperature drops to a specific level, just like water becomes ice, and the physical properties change accordingly.
Furthermore, its solubility also has characteristics. In common organic solvents, such as ethanol, ether, etc., there is a certain solubility, just like the water of fish, which can be melted with it; however, in water, the solubility is very small, just like the incompatibility of oil and water, the two are distinct.
In addition, its volatility cannot be ignored. Although it is not a highly volatile substance, it will evaporate slowly in an open environment and when the temperature is slightly higher, just like the dissipation of water vapor, gradually losing its amount. This volatility needs to be paid attention to during storage and use to prevent it from escaping and causing losses or causing safety problems.
The above physical properties are of great significance in many fields such as chemical synthesis and material preparation, laying the foundation for people to use this material.
What is the chemistry of 3-Chloro-2-Fluoro-1-Nitrobenzene?
3-Chloro-2-fluoro-1-nitrobenzene is also an organic compound. It has unique chemical properties and is related to many chemical reactions.
In this compound, chlorine, fluorine and nitro are all key functional groups, and each has its own properties. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, makes the benzene ring more stable, and also increases the difficulty of its electrophilic substitution reaction. And nitro can participate in the reduction reaction and can be converted into amino groups, which is very important in the synthesis of amine compounds.
Although the chlorine atom is an ortho-para-localization group, its localization effect is also changed due to the strong electron absorption of nitro groups. Chlorine atoms can participate in nucleophilic substitution reactions. Under suitable conditions, they can be replaced by other nucleophilic reagents, which is an effective way to construct new carbon-heteroatomic bonds.
Fluorine atoms have high electronegativity and small atomic radius. After introducing into molecules, their physical and chemical properties can be significantly changed. It can enhance the lipophilicity of molecules. In the field of medicinal chemistry, it is often used to change the biological activity, membrane permeability and metabolic stability of compounds.
3-chloro-2-fluoro-1-nitrobenzene coexist with various functional groups, and the reactivity is unique. In organic synthesis, by ingeniously designing reaction conditions, various functional groups can be selectively reacted to prepare a variety of organic compounds with specific structures and functions, which is of great value in many fields such as materials science, drug development, and fine chemical synthesis.
What are 3-Chloro-2-Fluoro-1-Nitrobenzene synthesis methods?
There are several common methods for the synthesis of 3-chloro-2-fluoro-1-nitrobenzene.
First, halogenated aromatic hydrocarbons are used as starting materials. The benzene derivative containing chlorine or fluorine can be taken first, and the nitro group can be introduced through nitration reaction. If o-chlorofluorobenzene is used as the substrate, the introduction of nitro groups can be realized under the action of suitable nitrifying reagents. The commonly used nitrifying reagent is mixed acid, that is, a mixture of concentrated sulfuric acid and concentrated nitric acid. During the reaction, the reaction temperature and time need to be strictly controlled. Due to high temperature, it is easy to form polynitrification products, which affects the purity of the target product. Generally speaking, the reaction at low temperature is milder, which is
Second, nitroaromatic hydrocarbons are used as the starting material. If there are nitrobenzene compounds first, chlorine and fluorine atoms can be introduced through halogenation. For example, fluorine atoms are introduced through specific fluorination reactions using o-nitrochlorobenzene as the raw material. This process often requires suitable catalysts, such as certain metal salts, to promote the substitution of fluorine atoms to hydrogen atoms at specific positions. Fluorinated reagents also have a variety of options, and different reagents have different activities and selectivity, which need to be screened according to specific reaction conditions.
Third, through the strategy of benzene ring construction. The benzene ring structure containing specific substituents can be constructed by multi-step reactions. For example, through a series of nucleophilic substitution, cyclization and other reactions, the target compound is gradually synthesized from Although this method is cumbersome, it is advantageous for precise control of the position and type of substituents. The reaction route needs to be carefully designed to ensure the yield and selectivity of each step in order to achieve efficient synthesis.
When synthesizing 3-chloro-2-fluoro-1-nitrobenzene, it is necessary to comprehensively consider many factors such as the availability of raw materials, the mildness of reaction conditions, the yield and purity of the product, and choose the most suitable synthesis method.
3-Chloro-2-Fluoro-1-Nitrobenzene What are the precautions during storage and transportation?
3-Chloro-2-fluoro-1-nitrobenzene is also an organic compound. During storage and transportation, many matters need to be paid attention to.
First words storage, this substance needs to be stored in a cool, dry and well ventilated place. Because of its certain chemical activity, high temperature and humid environment, it is easy to cause deterioration or cause chemical reactions. The warehouse temperature should be controlled within an appropriate range to prevent it from being unstable due to excessive temperature. And it should be kept away from fire and heat sources, because it is exposed to open flames, hot topics or the risk of combustion and explosion.
Furthermore, it needs to be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed. Due to its chemical properties, contact with their substances, or severe chemical reactions, endangering safety. The storage area should be equipped with suitable materials to contain leaks in case of leakage, and can be dealt with in time to avoid the spread of pollution.
As for transportation, before transportation, make sure that the container is well sealed and there is no risk of leakage. During transportation, it should be stably loaded and unloaded to prevent damage to the packaging and containers. Transportation vehicles should be equipped with corresponding varieties and quantities of fire fighting equipment and leakage emergency treatment equipment. When driving, follow the prescribed route and do not stop in densely populated areas and residential areas.
Escort personnel must also be familiar with the characteristics of the transported items and emergency treatment methods. In the event of an unexpected situation during transportation, such as leakage, effective measures can be taken quickly to ensure the safety of personnel and reduce hazards. In this way, when storing and transporting 3-chloro-2-fluoro-1-nitrobenzene, observe the above matters to ensure safety.