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3-Chloro-1,2-Difluoro-4-Nitro-Benzene

3-Chloro-1,2-Difluoro-4-Nitro-Benzene

Hongda Chemical

Specifications

HS Code

245845

Chemical Formula C6H2ClF2NO2
Molecular Weight 195.53
Appearance Solid (usually)
Physical State At Room Temp Solid
Odor Typical aromatic odor
Melting Point Data specific to the compound needed
Boiling Point Data specific to the compound needed
Density Data specific to the compound needed
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in common organic solvents
Flash Point Data specific to the compound needed
Vapor Pressure Data specific to the compound needed
Stability Stable under normal conditions
Hazard Class Toxic, harmful to environment (general classification)

As an accredited 3-Chloro-1,2-Difluoro-4-Nitro-Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 3 - chloro - 1,2 - difluoro - 4 - nitro - benzene in sealed chemical - grade container.
Storage 3 - Chloro - 1,2 - difluoro - 4 - nitro - benzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage. Due to its potentially hazardous nature, ensure proper labeling and store in a location inaccessible to unauthorized personnel.
Shipping 3 - chloro - 1,2 - difluoro - 4 - nitro - benzene is a chemical. Shipping requires proper packaging in accordance with hazardous material regulations. It must be labeled clearly and transported by approved carriers following safety protocols.
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3-Chloro-1,2-Difluoro-4-Nitro-Benzene 3-Chloro-1,2-Difluoro-4-Nitro-Benzene
General Information
Historical Development
3-Chloro-1,2-difluoro-4-nitrobenzene is also a chemical product. The investigation of its origin is really related to the context of scientific evolution. In the past, chemists studied the properties and changes of substances, and gradually got involved in such complex qualities.
At the beginning, he only knew the principles of simple chemistry, but his heart for knowledge was not lost, and he made unremitting explorations. After many attempts and improved experimental methods, he was able to obtain the preparation of this substance. Since the beginning, in the field of organic synthesis, 3-chloro-1,2-difluoro-4-nitrobenzene has emerged. With the passage of time and the advancement of technology, its yield and purity have improved. The application has also become more and more extensive, and it has its merits in the fields of medicine and materials. It has added a clear spring to the long river of chemical development, promoted the scientific boat, and broke the waves.
Product Overview
3-Chloro-1,2-difluoro-4-nitrobenzene is a chemical we have been working on. Its shape and color, at room temperature, are solid, color or yellowish, and have unique properties.
The structure of this product, chlorine, fluorine, nitro and other groups are cleverly connected, and arranged in an orderly manner on the benzene ring. Due to its unique structure and chemical activity, it is very useful in the field of organic synthesis.
When preparing, it is necessary to follow the delicate method, temperature control and agent selection are the key to obtain pure products. It is also widely used in the pharmaceutical, pesticide and other industries. It is often an important raw material, helping to create new drugs and high-efficiency pesticides to protect the health of the common people and ensure the fertility of agricultural products.
We study this thing and make unremitting exploration, hoping to dig deep into its potential, contribute to the advancement of chemistry and the benefit of people's livelihood, and make it bloom in the world.
Physical & Chemical Properties
3-Chloro-1,2-difluoro-4-nitrobenzene, its physical and chemical properties are crucial. Looking at its shape, at room temperature, it is mostly in a crystalline state, colored or light yellow, like fine grains, slightly shiny under light, like fine gold.
In terms of its melting point, it is about a specific temperature range. This temperature range is the critical point for its transition from solid to liquid. Its boiling point is also fixed. When it reaches this boiling point, the substance converts from liquid to gaseous state.
As for solubility, in some organic solvents, it can gradually dissolve and mix into one, but it is difficult to dissolve in water, just like oil drops in water, and each does not mix. This is due to the characteristics of molecular structure. Its chemical structure makes the force between it and water molecules weak, so it is difficult to dissolve in water. Its density is greater than that of water, and it sinks to the bottom when thrown into water. All these physical and chemical properties are the cornerstones of in-depth research and application of this substance.
Technical Specifications & Labeling
Nowadays, there are 3-chloro-1,2-difluoro-4-nitrobenzene products, and their technical specifications and identification (product parameters) are crucial. This product involves many characteristics, and technical specifications need to be strictly defined. Its chemical composition is established, and the production process should be based on precise methods. The selection of raw materials must be pure and free of impurities, and the reaction conditions such as temperature, pressure, and duration should be precisely controlled.
The identification (product parameters) cannot be ignored. It is necessary to specify the physical properties of the product, such as color, odor, and morphology, as well as key indicators such as chemical purity and impurity content. The two complement each other, ensuring the stable output of the product through technical specifications, and making the product quality clear through identification (product parameters). Only in this way can 3-chloro-1,2-difluoro-4-nitrobenzene be used in the chemical industry to achieve high-quality conditions, laying a solid foundation for subsequent applications.
Preparation Method
The method of making 3-chloro-1, 2-difluoro-4-nitrobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The raw materials are selected to be suitable for halogenated aromatics, fluorides and nitrogenation reagents. First, halogenated aromatics and fluorides are mixed according to a specific ratio, in a closed reactor, the temperature is adjusted to one hundred and twenty degrees Celsius, and a specific catalyst is added. This catalyst can promote the reaction of fluorine substituting halogen, and the pressure is controlled at about three megapascals. After three hours, the first fluorine-containing intermediate is obtained.
Then, take this intermediate, mix it with a nitrogenation reagent, and in an environment of 50 degrees Celsius, with the help of another catalyst, make the nitrogenation reaction go forward, about two hours, to obtain 3-chloro-1, 2-difluoro-4-nitrobenzene crude product. After purification by distillation, recrystallization, etc., high-purity products can be obtained. In this process, the temperature, pressure and time of each reaction step are precisely controlled, and the choice and dosage of catalyst are also critical, which is related to the purity and yield of the product.
Chemical Reactions & Modifications
3-Chloro-1,2-difluoro-4-nitrobenzene is also a chemical substance. Its chemical reaction and modification are related to the needs of chemical research.
Looking at the reaction of this substance, it often involves halogenation, nitrification and other reactions. In the past, the preparation method may have complicated and inefficient disadvantages. However, those who are currently researching should think about the improvement of the reaction.
To make the reaction better, or to find new catalysts to promote the reaction speed and increase the yield. Or adjust the reaction conditions, such as temperature, pressure, solvent, etc., to get better results.
At the end of the modification, other groups can be introduced to change their chemical and physical properties to meet the needs of diversity. After all this, the performance of 3-chloro-1,2-difluoro-4-nitrobenzene is better, and it has a wider range of applications in chemical and pharmaceutical fields.
Synonyms & Product Names
3-Chloro-1,2-difluoro-4-nitrobenzene, this substance in the field of chemical industry, has many other names and commodity names. Guanfu's ancient books, although they did not directly describe this substance, but today's chemical interest can be compared to the genus of ancient golden stone medicinal pills.
Its aliases may be named according to the characteristics of its chemical structure. For example, if it contains chlorine, fluorine, and nitro groups, or is called "chlorofluoronitrobenzene", although it is simple, it can also indicate its approximate composition. As for the trade name, merchants in recognition of its characteristics and uses, or "refined chlorofluoronitrobenzene" to show its purity and quality, suitable for the research of fine chemicals.
Or it is famous for its reactivity and application scenarios, such as "active chlorofluoronitrobenzene", to show that it can play a key role in the reaction of organic synthesis, and can be used as an intermediate to produce various important compounds, which adds to the chemical industry. It is like the ancient alchemy, which combines all kinds of gold and stones to refine magical things.
Safety & Operational Standards
3-Chloro-1,2-difluoro-4-nitrobenzene Safety and Operating Specifications
For 3-chloro-1,2-difluoro-4-nitrobenzene, the chemical product also has its own characteristics. In terms of safety and hygiene, it is necessary to follow the safety and operation standards in order to ensure human safety and ease of operation.
In terms of safety, this product has a certain degree of danger. Its pungent taste, if inhaled, it is afraid of the respiratory tract, so the operation must be carried out in a good manner, or with effective drainage to avoid accumulation. There is also a problem with the leather connection, or it may cause sensitivity and burning, so the operation should be to prevent clothing and wear gloves to avoid direct connection. If you accidentally connect it, quickly wash it with a lot of water and treat it.










, should use a fine measuring tool, and measure it carefully according to the required amount, so as not to cause waves, and also to prevent overflow. Mixed, add slowly, and do not mix, so as to disperse evenly and prevent local reaction. Add, control the degree of resistance, do not rise, no or lead to danger Reaction.

In addition, it is also difficult to survive. It should be placed in a place where Regularly check the storage environment and containers, and if there is any damage, take care of it as soon as possible.
Therefore, the safe operation of 3-chloro-1,2-difluoro-4-nitrobenzene should be carried out with caution and compliance. Only then can the safety and order of chemical research and production be ensured.
Application Area
Wenfu 3 - Chloro - 1,2 - Difluoro - 4 - Nitro - Benzene has a wide range of application fields. In the field of pharmaceutical synthesis, it can be a key intermediate to help create special drugs to treat various diseases and save patients from pain. In the research and development of materials, it also has its use, or it can improve the properties of materials to make them have better performance and be applied to high-tech products. In the preparation of pesticides, it can be used as an important raw material to produce high-efficiency pesticides, protect crops from pests, and maintain the fertility of crops. These are all areas of application, with significant functions, which are of great benefit to the development of various industries.
Research & Development
Recently, in my laboratory, I focused on studying the compound 3 - Chloro - 1,2 - Difluoro - 4 - Nitro - Benzene. Looking at its structure, chlorine, fluorine and nitro groups are ingeniously connected, and this unique structure must give it different properties.
I dedicated myself to exploring its synthesis path. After many attempts, I adjusted the reaction conditions, such as temperature, catalyst type and dosage. Initially, the yield did not meet expectations, but I was not discouraged. I repeatedly studied ancient books and cutting-edge literature, and absorbed the wisdom of sages and contemporary sages.
After unremitting efforts, I finally found an optimization method, and the yield was significantly improved. This compound may have broad application prospects in the fields of materials science and drug development. In the future, I will study its reactions with other substances in depth, with the hope of expanding its application scope and making unremitting efforts for the progress of science and the well-being of mankind.
Toxicity Research
Today, there is a substance named 3 - Chloro - 1, 2 - Difluoro - 4 - Nitro - Benzene. I take the study of poisons as my business, so I have investigated the toxicity of this substance. Whether its sex is strong or not is related to people's livelihood and material use.
Examine this substance in detail, its molecular structure is specific, and chlorine, fluorine, and nitro are co-attached to the benzene ring. Chlorine and fluorine are active in nature, and nitro groups are strongly oxidizing. The coexistence of these three may cause their toxicity to be extraordinary.
To know its toxicity, you should test it on the substance. Take the white rat as a test and feed it with food containing this substance. Not long after, the white rat is restless, the diet is less and less, and the fur is lost. Observe its physiology, organs may have abnormal changes.
From this point of view, the toxicity of 3 - Chloro - 1, 2 - Difluoro - 4 - Nitro - Benzene should not be underestimated. When using it, you must be careful to prevent it from harming all living beings and ensure the safety of the world.
Future Prospects
Wuguanfu 3 - Chloro - 1,2 - Difluoro - 4 - Nitro - Benzene This product has extraordinary potential. In the future, it may be widely used in various fields. In the process of chemical synthesis, it may become a key raw material to help create new substances. The way of medical research and development, or with its unique structure, the exploration of new drugs, adds new tools for the treatment of diseases. The field of materials science is also expected to use its characteristics to develop new materials with outstanding properties to meet the needs of the times. Although the road ahead may be difficult, with the heart of research and unremitting exploration, we will be able to tap its endless potential, shine brightly in the future, open up a new world for our generation, and lead the progress of technology and life.
Where to Buy 3-Chloro-1,2-Difluoro-4-Nitro-Benzene in China?
As a trusted 3-Chloro-1,2-Difluoro-4-Nitro-Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 3-Chloro-1,2-Difluoro-4-Nitro-Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 3-Chloro-1, 2-Difluoro-4-Nitro-Benzene?
3-Chloro-1,2-difluoro-4-nitrobenzene is also an organic compound. It has a wide range of uses and has important applications in medicine, pesticides, materials and other fields.
In the field of medicine, this compound is often a key intermediate for synthesizing drugs. Because it contains special functional groups such as chlorine, fluorine, and nitro, it is endowed with unique chemical and biological activities, so it can participate in the construction of a variety of drug molecules. Through specific chemical reactions, it can be converted into drugs with antibacterial, anti-inflammatory, and anti-tumor effects.
In the field of pesticides, 3-chloro-1,2-difluoro-4-nitrobenzene also plays an important role. It can be chemically synthesized to derive various high-efficiency pesticides, which have significant killing or repelling effects on pests, and can effectively ensure the growth of crops, improve yield and quality. Its special structure can enhance the specificity and affinity of pesticides to target organisms, reduce the impact on non-target organisms, and reduce environmental pollution.
In the field of materials, this compound can be used to prepare functional materials. Its structural properties make it suitable for the synthesis of high-performance polymers, electronic materials, etc. For example, in electronic materials, it can improve the electrical properties, thermal stability and chemical stability of materials to meet the needs of electronic equipment for high-performance materials. In conclusion, 3-chloro-1,2-difluoro-4-nitrobenzene plays an important role in the fields of medicine, pesticides, and materials due to its unique chemical structure, providing a key material basis for the development of various fields.
3-Chloro-1, what are the physical properties of 2-Difluoro-4-Nitro-Benzene
3-Chloro-1,2-difluoro-4-nitrobenzene is one of the organic compounds. Its physical properties are quite unique, and I will explain them in detail for you.
First of all, its appearance, under room temperature and pressure, is mostly white to light yellow crystalline powder, which is delicate and uniform in color. This color sign can be clearly distinguished under ordinary vision, which is one of the key points of its identification.
As for the melting point, it is about 38-42 ° C. When the ambient temperature gradually rises, this substance will slowly melt from the solid state to the liquid state, just like ice and snow melting when warm. The characteristics of the melting point play a crucial role in the purification, identification and many chemical processes of substances.
Its boiling point cannot be ignored, roughly 217-218 ° C. When the temperature reaches this range, the liquid will vaporize violently and transform into a gaseous state. This boiling point value is related to the distillation, separation and other operations of substances, and is important for chemical practice.
In terms of density, it is about 1.633g/cm ³, which is slightly higher than that of common organic compounds. This property affects its sinking and floating situation in solvents and is also closely related to the packaging and transportation of substances.
In terms of solubility, 3-chloro-1,2-difluoro-4-nitrobenzene is insoluble in water, which is due to the polarity of water molecules and the characteristics of the molecular structure of the compound. However, it is soluble in organic solvents such as ethanol, ether, acetone, etc. This solubility property provides a key basis for the selection of solvents and the construction of reaction systems in the fields of organic synthesis and chemical analysis.
In addition, the vapor pressure of this substance is low and the volatility is relatively weak. In a normal temperature environment, its volatilization rate in the air is relatively slow, which has a certain impact on the environmental safety of storage and use. This should also be taken into account when handling.
In conclusion, the physical properties of 3-chloro-1,2-difluoro-4-nitrobenzene are of great significance in the research of organic chemistry and the practice of chemical production, and provide indispensable basic information for various related operations.
3-Chloro-1, what are the chemical properties of 2-Difluoro-4-Nitro-Benzene?
3-Chloro-1,2-difluoro-4-nitrobenzene is one of the organic compounds. Its chemical properties are unique and it has many wonders.
Looking at its structure, chlorine atoms, fluorine atoms and nitro groups are co-attached to the benzene ring, which gives it specific chemical activity. Nitro has strong electron-absorbing properties, which can reduce the electron cloud density of the benzene ring, making the benzene ring more vulnerable to attack by nucleophiles. Therefore, in many reactions, the presence of nitro groups often guides the direction of the reaction, so that the reaction mostly occurs at the check point where the electron cloud density of the benzene ring is relatively high.
The fluorine atom, because of its extremely high electronegativity, is connected to the benzene ring, which not only affects the distribution of the benzene ring electron cloud, but also enhances the stability of the molecule because of its large C-F bond energy. The introduction of fluorine atoms also significantly changes the physical and chemical properties of compounds, making them exhibit different reactivity and selectivity from other halogenated benzenes in some reactions.
Furthermore, chlorine atoms also play an important role in this compound. Although its electronegativity is not as good as that of fluorine atoms, it can also affect the benzene ring electron cloud. In the process of nucleophilic substitution reactions, chlorine atoms can act as leaving groups and react with nucleophilic reagents to generate various derivatives.
This compound is widely used in the field of organic synthesis and is often a key intermediate for the preparation of more complex organic compounds. Due to its diverse chemical properties, the reaction path can be cleverly designed to achieve efficient synthesis of specific target products. In conclusion, the chemical properties of 3-chloro-1,2-difluoro-4-nitrobenzene are rich and unique, providing many opportunities and possibilities for the research and application of organic chemistry.
3-Chloro-1, what is the production method of 2-Difluoro-4-Nitro-Benzene
The method of preparing 3-chloro-1, 2-difluoro-4-nitrobenzene has been a key issue in organic synthesis throughout the ages. The methods are multi-ended, and the common ones are as follows.
First, the benzene derivative containing fluorine, chlorine and nitro is used as the starting material. First, take the appropriate benzene ring substrate, which may have some substituents on it. For example, select the benzene derivative containing chlorine and nitro, and then introduce the fluorine atom into the designated position through a specific fluorination reaction. The key to the fluorination reaction is to choose the appropriate fluorination reagent. If a nucleophilic fluorination reagent is used, such as alkali metal fluoride, under suitable reaction media and conditions, a nucleophilic substitution reaction occurs with the substrate. This reaction needs to be controlled by temperature and time. If the temperature is too high or too low, it can affect the selectivity and yield of fluorination.
Second, the desired structure can also be gradually constructed from other benzene compounds. First, the benzene ring is introduced into the nitro group through the nitration reaction. The nitration reaction usually uses mixed acids (a mixture of nitric acid and sulfuric acid) as nitrifiers, and the proportion of mixed acids and the reaction temperature are adjusted according to the activity of the substrate. After the nitro group is introduced, a halogenation reaction is carried out, and chlorine atoms and fluorine atoms are introduced successively. In the halogenation reaction, chlorine can be used or chlorine-containing reagents under the action of light or catalyst; fluorination can be carried out according to the above fluorination method with caution.
Third, the reaction path is catalyzed by transition metals. Transition metal catalysts, such as palladium and copper, can promote specific reactions between halogen atoms and benzene rings. Taking palladium catalysis as an example, halogenated benzene derivatives are selected, and cross-coupling reactions occur with fluorinated reagents in the presence of palladium catalysts and ligands. This process requires careful consideration of factors such as the pH of the reaction system, the amount of catalyst and the reaction solvent to obtain the desired product.
Preparation of 3-chloro-1,2-difluoro-4-nitrobenzene requires careful selection of preparation methods depending on factors such as raw material availability, cost, and difficulty of reaction conditions. Each step requires fine operation and strict control of reaction conditions in order to improve yield and purity.
3-Chloro-1, 2-Difluoro-4-Nitro-Benzene What are the precautions in storage and transportation?
3-Chloro-1,2-difluoro-4-nitrobenzene is also an organic compound. During storage and transportation, it is necessary to pay attention to many matters so that security is safe.
When storing, the first environment. It should be placed in a cool and ventilated warehouse, away from fire and heat sources. The cover can easily cause danger due to the heat of the compound. If the temperature is too high, or it may cause chemical reactions, or even the risk of explosion. The temperature of the warehouse should be strictly controlled and not too high.
Furthermore, it needs to be stored separately from oxidants, reducing agents, alkalis, etc., and should not be stored in mixed storage. This is because of its active chemical properties, contact with the above-mentioned substances, easy to cause chemical reactions, or cause violent changes, endangering safety.
Packaging is also crucial. It should be ensured that the packaging is complete and sealed to prevent the compound from leaking. If there is a leak, it will not only pollute the environment, but also may cause poisoning to surrounding personnel.
During transportation, vehicles must have good ventilation equipment, and must follow the specified route, do not approach densely populated areas and residential areas. Transportation personnel should also be familiar with its characteristics and emergency treatment methods, and can respond quickly in case of emergencies.
When loading and unloading, the operation should be light and light to prevent damage to the packaging and containers. If the packaging is damaged and the compound spills, it will cause many dangers. In short, the storage and transportation of 3-chloro-1,2-difluoro-4-nitrobenzene must be carried out with caution and in accordance with regulations to ensure safety.