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3-Chioro-4-Fluoronitrobenzene

3-Chioro-4-Fluoronitrobenzene

Hongda Chemical

    Specifications

    HS Code

    398061

    Chemical Formula C6H3ClFNO2
    Molar Mass 177.545 g/mol
    Appearance Yellow - brown solid
    Boiling Point 245 - 246 °C
    Melting Point 39 - 41 °C
    Density 1.479 g/cm³ (calculated)
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in many organic solvents like ethanol, ether
    Flash Point 106 °C
    Vapor Pressure Low vapor pressure at room temperature
    Stability Stable under normal conditions, but may react with strong oxidizing agents

    As an accredited 3-Chioro-4-Fluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 25 - kg drum packaging for 3 - chloro - 4 - fluoronitrobenzene chemical.
    Storage 3 - chloro - 4 - fluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat, sparks, and open flames as it is potentially flammable. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents, reducing agents, and other incompatible substances to avoid chemical reactions.
    Shipping 3 - Chloro - 4 - fluoronitrobenzene is a chemical. For shipping, it must be in proper, sealed containers. It should be classified and labeled correctly according to hazardous materials regulations, transported by approved carriers.
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    3-Chioro-4-Fluoronitrobenzene 3-Chioro-4-Fluoronitrobenzene
    General Information
    Historical Development
    I have heard of the chemical industry, and there are many categories. There is one thing called 3-Chloro-4-Fluoronitrobenzene. The beginning of this thing was the research of many wise men. At that time, everyone was diligently exploring the field of chemistry, wanting to find new things to meet the needs of various industries.
    At the beginning, this 3-Chloro-4-Fluoronitrobenzene was made, but the process was not refined, the quantity of production was small, and the quality was not high. However, the researchers were reluctant to give up and moved forward. After years of research and improvement of techniques, the reaction and the agents used were all carefully studied.
    Years have passed, and the process has advanced. The amount of 3-Chloro-4-Fluoronitrobenzene produced is increasing, and the quality is also getting better. It has a wide range of benefits in medicine, pesticides and other industries. In the past, it was difficult to find it, but now it is gradually able to meet the requirements of various industries. This is the work of researchers, so that the development of 3-Chloro-4-Fluoronitrobenzene has flourished since the end.
    Product Overview
    3-Chloro-4-fluoronitrobenzene is an important raw material for organic synthesis. Its color is light yellow, the shape is crystalline, and it has a special smell. This substance has a suitable melting point and is widely used in the field of chemical synthesis.
    The method of preparation often starts with a specific aromatic hydrocarbon and is obtained by halogenation and nitrification. The reaction conditions need to be precisely controlled, such as temperature, pressure, and the amount of catalyst, which are all related to the purity and yield of the product.
    It is widely used and can be used as an intermediate in the synthesis of medicines, pesticides, dyes, etc. In the development of medicine, it helps to build the molecular structure of new drugs; in the creation of pesticides, it contributes to the synthesis of high-efficiency and low-toxicity pesticides; in the production of dyes, it promotes the production of dyes with bright colors and excellent performance.
    However, this material has certain toxicity and irritation. When operating, it is necessary to strictly abide by safety procedures and take protective measures to avoid endangering human health, and properly dispose of its waste and prevent pollution of the environment.
    Physical & Chemical Properties
    3-Chloro-4-fluoronitrobenzene is an organic compound. Its physical and chemical properties are quite specific. Looking at its shape, at room temperature, it is mostly in a crystalline state, with a certain luster. Its melting point is unique, about [X] ° C. At this temperature, the state of matter is converted from solid to liquid, and phase changes occur.
    As for its chemical properties, it is very active due to the presence of chlorine, fluorine, nitro and other groups. Nitro has strong electron absorption, causing the electron cloud density of the benzene ring to decrease, making nucleophilic substitution reactions easy to occur. Although chlorine and fluorine atoms have different electronegativity, they both have a great impact on the reactivity of the benzene ring. In the case of nucleophiles, chlorine and fluorine atoms can be replaced to generate a variety of derivatives, which are widely used in the field of organic synthesis. They can be used to produce drugs and pesticides. They are important in the chemical industry and are valued by chemical researchers. Exploring their properties can provide a basis for the creation of new substances, process improvement, and help a lot.
    Technical Specifications & Labeling
    Nowadays, there is a chemical substance called 3-Chloro-4-Fluoronitrobenzene. Its process specifications and identification (product parameters) are the key.
    When it comes to process specifications, the preparation of this product requires a precise method. From the selection of raw materials, it is necessary to be pure and free of impurities to ensure a smooth reaction. The reaction conditions, such as temperature, pressure, and the amount of catalyst, must be carefully controlled. If the temperature is too high or too low, it can cause the reaction to be biased, affecting the purity and yield of the product. The same is true for pressure. Improper pressure may make the reaction difficult or cause side reactions to breed. If the amount of catalyst is small, the reaction will be delayed, and if it is more, it may lead to other changes.
    As for the identification (product parameters), the appearance, color, smell, etc. of this product are all elements of the identification. It is also necessary to specify the purity geometry, the type and content of impurities. Because the purity is related to its effectiveness in subsequent applications, too many impurities, or cause various problems during application. In this way, the gist of the 3 - Chloro - 4 - Fluoronitrobenzene process specifications and identification (product parameters) is also.
    Preparation Method
    The method of making 3-chloro-4-fluoronitrobenzene is very important, which is related to the raw materials and production process, reaction steps and catalytic mechanism.
    Preliminary raw materials need to be based on specific chlorine substitutes and fluorine substitutes. The two are placed in a special reactor in an appropriate ratio. The kettle needs to be temperature and pressure resistant and has good sealing.
    Initially, the reaction is slowly heated to a specific temperature, about [X] degrees Celsius, to initiate a preliminary reaction. This process requires strict temperature control, and the fluctuation must not exceed [X] degrees Celsius to ensure a smooth reaction.
    Add a special catalyst, this agent can accelerate the reaction process, optimize the reaction path, and make the molecules combine accurately. Its catalytic mechanism is to reduce the activation energy of the reaction, so that the reaction is more likely to occur.
    According to the established steps, the reaction is gradually advanced. During this period, the degree of reaction is closely monitored, and its composition changes are detected by modern analytical methods, such as chromatography. When the reaction reaches the expected level, the temperature is lowered to stop the reaction.
    After separation and purification, pure 3-chloro-4-fluoronitrobenzene is obtained. The whole preparation process, all links are closely linked, and there is no room for error, so that high-quality products can be prepared.
    Chemical Reactions & Modifications
    Nowadays, there is a chemical thing called 3-Chloro-4-Fluoronitrobenzene. In the process of chemical change, its reaction and denaturation can lead to our deep research.
    Looking at its reaction, this compound has different changes when it encounters different reagents. Or when it encounters nucleophiles, halogen atoms are easily replaced. Because the halogen on the benzene ring is affected by nitro and fluorine atoms, its activity is special. And the different reaction conditions, such as temperature and solvent, also affect the rate and product of the reaction.
    In terms of its denaturation, the positions of chlorine, fluorine and nitro in the molecular structure make the distribution of electron clouds different, resulting in its unique physical and chemical properties. The number of melting points and boiling points has characteristics compared with similar ones. And because it contains nitro groups and has certain oxidation properties, it can be used as a raw material for key steps in organic synthesis. After reduction and other methods, it can become other useful compounds.
    The study of the reaction and denaturation of this chemical substance 3 - Chloro - 4 - Fluoronitrobenzene can add new knowledge and promote its progress in various fields such as organic synthesis and material chemistry.
    Synonyms & Product Names
    The style of "Mengxi Bi Tan" focuses on explaining the truth of things in concise and clear language. Today, in this way, in ancient classical style, the synonym and trade name of "3-Chioro-4-Fluoronitrobenzene" are mentioned.
    Those who "3-Chioro-4-Fluoronitrobenzene" are chemical things. Its synonyms are, but with today's knowledge, it is difficult to find a suitable ancient word to replace it. In today's academic circles, its name is established, and there is no confusion between other names. As for the name of the product, it may vary depending on the merchant. However, they are all named according to their chemical nature to distinguish them from other things. Although this substance has not existed in ancient times, today's chemists have studied it to understand its nature and use it. Its synonyms and trade names are also valued by the academic and business circles to understand it and facilitate its use. Although there is no name of the same thing in ancient times, today's research is also a lesson for future generations, and those who come will know more about it.
    Safety & Operational Standards
    3-Chloro-4-fluoronitrobenzene is an important chemical compound in chemical research. In the process of experiment and production, safety and operation standards are of paramount importance, which are related to the safety of researchers and endanger the smooth operation of experiments.
    #1. Storage Safety
    This compound should be stored in a cool and ventilated warehouse. Keep away from fire and heat sources, and avoid direct sunlight. Because of its certain chemical activity, it should be stored separately from oxidants, reducing agents, alkalis, etc., and should not be mixed. The warehouse should be equipped with suitable materials to contain leaks to prevent accidental leakage from causing harm.
    #2. Operating Specifications
    When operating, researchers must wear appropriate protective equipment. Wear chemical safety glasses to prevent liquid from splashing into the eyes; wear anti-toxic substances to penetrate work clothes to avoid skin contact; wear rubber gloves to enhance protection. The operation should be carried out in a well-ventilated environment, preferably in a fume hood, to ensure that harmful gases are discharged in time.
    When taking 3-chloro-4-fluoronitrobenzene, the action should be stable and accurate, and the container should be sealed after use to prevent volatilization and leakage. During the experiment, strictly control the reaction conditions, such as temperature, pressure, proportion of reactants, etc. Because of the reaction involved or dangerous, a little carelessness can cause accidents.
    #3. Emergency treatment
    If a leak unfortunately occurs, personnel from the contaminated area of the leak should be quickly evacuated to the safe area, and quarantined, and access should be strictly restricted. Emergency personnel must wear self-contained positive pressure breathing apparatus and anti-toxic clothing. Do not let the leak come into contact with combustible substances. In the event of a small leak, mix sand, dry lime or soda ash and collect it in a dry, clean and covered container. If a large leak occurs, build an embankment or dig a pit for containment, and transfer it to a tanker or special collector by pump for recycling or transportation to a waste disposal site for disposal.
    If someone comes into contact with this compound, skin contacts should immediately take off the contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and seek medical attention; for eye contacts, lift the eyelids, rinse with flowing water or normal saline, and seek medical attention; inhalers, quickly leave the scene to a fresh place of air, keep the respiratory tract unobstructed, such as breathing difficulties, give oxygen, if breathing stops, immediately perform artificial respiration, and seek medical attention.
    In short, in the research and use of 3-chloro-4-fluoronitrobenzene, strictly abide by safety and operating practices to ensure that everything goes smoothly and protect people's safety.
    Application Area
    Today there is a substance called 3 - Chloro - 4 - Fluoronitrobenzene. This substance has a wide range of uses and has its presence in many fields.
    In the field of pharmaceutical synthesis, it can be used as a key intermediate. Through delicate chemical reactions, it can help synthesize special drugs to treat various diseases and contribute to the development of medicine.
    In the field of materials science, it also has important functions. It can participate in the preparation of new materials to give materials special properties, or increase their stability, or give them unique optical properties, helping materials to continuously innovate.
    In agricultural chemistry, it can be used to create high-efficiency pesticides. With its chemical properties, it can precisely kill pests, protect the growth of crops, ensure the harvest of agricultural products, and have many benefits to farming.
    It can be seen that 3 - Chloro - 4 - Fluoronitrobenzene plays an indispensable role in the application fields of medicine, materials, agriculture, etc. It is an important chemical substance.
    Research & Development
    In the field of chemical industry, there is a name 3 - Chloro - 4 - Fluoronitrobenzene. We have dedicated ourselves to studying, wanting to clarify its properties and expand its uses, in order to achieve the development environment.
    At the beginning, analyze its structure and explore its physicochemical properties. This substance has a unique structure. Chlorine, fluorine and nitro co-attach to the benzene ring and interact with each other, causing it to have unique properties. Its reactivity and stability are all important for research.
    Then, study the method of its preparation. Find ways to be efficient and environmentally friendly. Or improve the old method to increase the yield and reduce its energy consumption; or innovate the process to avoid cumbersome steps and reduce the generation of waste.
    Furthermore, look for its application. In the fields of medicine, pesticides, and materials, explore its possibilities. Hope that based on this substance, innovative drugs can be used to cure diseases, good agents can be used to protect farmers, and good materials can be developed to meet the needs of the world.
    We persevere, hoping to make some achievements in the research and development of 3 - Chloro - 4 - Fluoronitrobenzene, and do our best to make a contribution to the prosperity of the chemical industry.
    Toxicity Research
    Since modern times, chemical refinement has led to the emergence of various compounds in an endless stream. Today, there is 3-Chioro-4-Fluoronitrobenzene, and the study of its toxicity is crucial.
    Examine this compound in detail. Its molecular structure is unique, and chlorine, fluorine and nitro coexist. Nitro is highly oxidizing, and chlorine and fluorine atoms also affect its chemical activity and toxicity. In terms of organisms, it may interfere with the normal metabolism of cells. After its entry into the body, it may interact with biological macromolecules such as proteins and nucleic acids, causing cell dysfunction or even causing lesions.
    However, the investigation of toxicity is not achieved overnight. When rigorous methods are used, multiple experiments are conducted, and different doses, time of action, and objects of action are considered, the full picture of its toxicity can be explored, providing a solid basis for the world to avoid its harm and take advantage of it when using this substance.
    Future Prospects
    I have dedicated myself to the field of chemical products, and now I am focusing on 3 - Chloro - 4 - Fluoronitrobenzene. The properties of this substance have unique chemical activity. It is often a key raw material in organic synthesis and has a wide range of uses.
    Looking at its future prospects, technology is new, and the method of organic synthesis should also be refined. 3 - Chloro - 4 - Fluoronitrobenzene may be used in the development of new drugs and the creation of fine chemical materials. In drug development, it may be the cornerstone of building a specific molecular structure to help medicine overcome difficult diseases; in the field of fine chemical materials, it may endow materials with specific properties, such as higher stability and unique optical properties.
    Although the road ahead is uncertain, with the current trend, 3-Chloro-4-Fluoronitrobenzene will play an important role in the future chemical arena, contributing to the progress of science and technology and the prosperity of the industry.
    Where to Buy 3-Chioro-4-Fluoronitrobenzene in China?
    As a trusted 3-Chioro-4-Fluoronitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3-Chioro-4-Fluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 3-Chioro-4-Fluoronitrobenzene?
    3-Chloro-4-fluoronitrobenzene is a crucial intermediate in the field of organic synthesis and plays a key role in the preparation of many fine chemicals.
    First, in the field of pharmaceutical synthesis, this compound has a wide range of uses. It can be used as an important raw material for the synthesis of antibacterial drugs, anti-inflammatory drugs, etc. Due to its unique chemical structure, it can endow the synthesized drugs with specific biological activities and pharmacological properties. For example, through a specific chemical reaction, it is converted into a substance with antibacterial efficacy, which can inhibit or kill bacteria by interfering with the metabolic process of bacteria, providing a powerful weapon for human beings to resist diseases.
    Second, in the manufacture of pesticides, 3-chloro-4-fluoronitrobenzene also plays an important role. It can be used as a key intermediate for the synthesis of high-efficiency and low-toxicity pesticides. Based on it, pesticide molecules with high selectivity and high activity to pests can be constructed. Such pesticides can effectively kill crop pests, reduce the harm to the environment and non-target organisms, help the sustainable development of agriculture, ensure the harvest of crops, and ensure food security.
    Third, in the dye industry, this compound also occupies a place. It can be used to synthesize dyes with bright color and good stability. Due to the specific interaction between its structure and fibers and other substrates, the dye adheres firmly, and the dyed fabric has a lasting and bright color, which meets people's needs for textile aesthetics and plays an important role in the textile printing and dyeing industry.
    Fourth, in the field of electronic chemicals, 3-chloro-4-fluoronitrobenzene also shows unique value. It can be used as a raw material for synthesizing some electronic materials, providing assistance for the development of the electronics industry. With the rapid development of electronic technology, the demand for special performance electronic chemicals is increasing, and it is expected to be more widely used in this field.
    In conclusion, 3-chloro-4-fluoronitrobenzene has important uses in many fields such as medicine, pesticides, dyes, and electronic chemicals, and is of great significance for promoting the progress of related industries.
    What are the physical properties of 3-Chioro-4-Fluoronitrobenzene?
    3-Chloro-4-fluoronitrobenzene is one of the organic compounds. Its physical properties are worth exploring.
    First of all, its appearance is mostly white to light yellow crystalline powder at room temperature. This state is convenient for observation and preliminary identification.
    The melting point is about 32-35 ° C. The characteristics of the melting point are crucial in the identification and separation of substances. At this temperature, its state changes from solid to liquid, and this change provides a key basis for many chemical operations.
    The boiling point is about 242 ° C. The boiling point represents the temperature at which the substance changes from liquid to gas under a specific pressure. Knowing the boiling point allows for precise temperature control in separation processes such as distillation to achieve effective separation of substances.
    As for the density, it is about 1.579g/cm ³. The density reflects the mass of the substance per unit volume and is indispensable in chemical processes such as material balance and mixing and blending. Based on this, the dosage of the substance can be accurately calculated to ensure the accurate progress of the reaction.
    In terms of solubility, it is slightly soluble in water. Water is a common solvent, and this property indicates that the affinity of the substance with water is weak. However, it is soluble in most organic solvents, such as ethanol, ether, acetone, etc. This solubility characteristic provides various possibilities for the selection of solvents in organic synthesis reactions. In a specific reaction, selecting a suitable organic solvent according to the reaction requirements can promote the smooth development of the reaction.
    The physical properties of 3-chloro-4-fluoronitrobenzene are of various uses, and are of key significance in many fields such as chemical production, organic synthesis and analysis and testing, laying a solid foundation for related operations and research.
    What are the chemical properties of 3-Chioro-4-Fluoronitrobenzene?
    3-Chloro-4-fluoronitrobenzene is a crucial raw material in organic synthesis. It has unique chemical properties and is widely used in many fields.
    This compound has significant chemical activity, among which the nitro group is particularly active. Nitro groups have strong electron absorption, causing a significant reduction in the electron cloud density of the benzene ring, making the benzene ring more vulnerable to attack by nucleophiles. For example, under certain conditions, nucleophiles can replace chlorine or fluorine atoms on the benzene ring, which is an important reaction path for the construction of new carbon-heteroatomic bonds.
    Furthermore, chlorine and fluorine atoms also play key roles in molecules. Chlorine atoms are relatively large, which has a great impact on the spatial structure and reactivity of molecules. Although fluorine atoms are small, they are highly electronegative, and their presence changes the electron distribution of molecules, which affects the physical and chemical properties of compounds. Both can participate in nucleophilic substitution reactions. Among them, fluorine atoms usually require more severe conditions due to their high C-F bond energy, while chlorine atoms are relatively easy to replace, but the specific conditions and reagents are also affected.
    In addition, the chemical properties of 3-chloro-4-fluoronitrobenzene make it possible to participate in reduction reactions. Nitro groups can be reduced to amino groups, and many important intermediates can be derived. It is of great significance in the fields of drug synthesis and dye preparation. Due to its unique chemical properties, in the field of organic synthesis, chemists can skillfully design reactions and use their properties to build complex organic molecular structures to meet different industrial and scientific needs.
    What is the preparation method of 3-Chioro-4-Fluoronitrobenzene?
    3-Chloro-4-fluoronitrobenzene is also an important intermediate commonly used in organic synthesis. Its preparation method is more elegant.
    One method is to use 3-chloro-4-fluoroaniline as the starting material. First, 3-chloro-4-fluoroaniline is co-diazotized with sodium nitrite and hydrochloric acid. Under low temperature and careful temperature control, slowly add an aqueous solution of sodium nitrite dropwise in a mixture of 3-chloro-4-fluoroaniline and hydrochloric acid. In this process, it is necessary to closely observe the temperature of the reaction system to prevent the sudden rise of temperature from causing the decomposition of diazonium salts, to ensure that the diazotization reaction proceeds smoothly, and to obtain 3-chloro-4-fluorobenzene diazonium salts. Then, the diazonium salt is co-heated with sodium nitrite and copper powder, or treated with other suitable reducing agents to promote the conversion of diazonium groups to nitro groups, and then 3-chloro-4-fluoronitrobenzene is obtained.
    Another method is to use 3-chloro-4-fluorobenzene as the starting material. First, the benzene ring is nitrified, and mixed acid (a mixture of concentrated sulfuric acid and concentrated nitric acid) can be used as the nitrifying agent. Under specific temperature and reaction conditions, the nitro positive ion in the mixed acid attacks the benzene ring and introduces the nitro group at a specific position of 3-chloro-4-fluorobenzene. However, this reaction requires attention to regioselectivity, because the localization effect of chlorine and fluorine will affect the position of nitro introduction. After the reaction, the pure 3-chloro-4-fluoro nitrobenzene is obtained through separation and purification steps, such as extraction, distillation, recrystallization, etc. When preparing
    , many factors must be considered in detail. Reaction temperature, ratio of reactants, reaction time, type and amount of catalyst, etc., all have a significant impact on the yield of the reaction and the purity of the product. Only by precisely controlling various conditions can the preparation process be efficient and the product quality be excellent.
    What 3-Chioro-4-Fluoronitrobenzene need to pay attention to when storing and transporting
    3-Chloro-4-fluoronitrobenzene is an important raw material in organic synthesis. During storage and transportation, there are many matters that need to be paid more attention.
    First, the storage environment is very important. This substance must be stored in a cool, dry and well-ventilated place. Because the compound is easily decomposed by heat, if the ambient temperature is too high, it may cause danger. Furthermore, humid air may affect it or cause quality changes, so it is extremely important to keep it dry. In addition, good ventilation can disperse steam that may leak and avoid dangerous accumulation.
    Second, the packaging must be strong and tight. Appropriate packaging materials should be used to prevent product leakage or external factors. The packaging container must be able to withstand a certain pressure, and can resist vibration, collision and other conditions during transportation to ensure product safety.
    Furthermore, it should be properly isolated from other chemicals during transportation. 3-Chloro-4-fluoronitrobenzene may react with certain substances, causing danger, so it cannot be mixed with oxidants, reducing agents, acids, alkalis, etc. Transportation vehicles should also have corresponding fire and explosion-proof measures to ensure safety.
    At the same time, storage and transportation places should be strictly prohibited from fire. This substance has certain flammability, and in case of open flames, hot topics or cause combustion and explosion, fireworks are strictly prohibited, and appropriate fire equipment must be equipped.
    In addition, when handling this substance, operators should wear protective equipment, such as protective gloves, goggles, gas masks, etc., to avoid skin contact and inhalation of steam to prevent damage to the body.
    When storing and transporting 3-chloro-4-fluoronitrobenzene, it is necessary to consider all factors and strictly follow relevant norms and requirements to ensure the safety of the whole process.