3-Bromo-5-Fluorobenzeneboronic Acid

Hongda Chemical

Specifications

HS Code	682317
Chemical Formula	C6H5BBrFO2
Molecular Weight	220.82
Appearance	White to off - white solid
Melting Point	143 - 147°C
Solubility In Water	Slightly soluble
Solubility In Organic Solvents	Soluble in common organic solvents like dichloromethane, chloroform
Purity	Typically high - purity products are around 97% or higher
Stability	Should be stored in a cool, dry place, moisture - sensitive
Cas Number	850568 - 26 - 4
Boiling Point	Decomposes before boiling

As an accredited 3-Bromo-5-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	10 g of 3 - bromo - 5 - fluorobenzeneboronic Acid in a sealed, labeled chemical vial.
Storage	3 - Bromo - 5 - fluorobenzeneboronic acid should be stored in a cool, dry place away from direct sunlight. Keep it in a tightly sealed container to prevent moisture absorption and contact with air, which could lead to degradation. Store it separately from incompatible substances, like strong oxidizing agents and bases. Ideal storage temperature is around 2 - 8 °C in a refrigerator if long - term storage is required to maintain its stability.
Shipping	3 - bromo - 5 - fluorobenzeneboronic acid is shipped in sealed, corrosion - resistant containers. It's carefully packaged to prevent breakage. Shipments follow strict chemical transportation regulations to ensure safety during transit.

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General Information

Historical Development

3 - Bromo - 5 - Fluorobenzeneboronic Acid is an important compound in the field of organic synthesis. Tracing its historical development, chemists initially noticed this unique structure when exploring new organoboron compounds. The early synthesis of this compound was cumbersome and the yield was not high.
At that time, limited by technology and cognition, the synthesis path was tortuous, requiring multiple reactions, and the reaction conditions of each step were harsh. With the progress of chemical science, analytical methods became more accurate and the understanding of the reaction mechanism deepened. The exploration of new catalysts and reaction conditions has greatly improved the synthesis efficiency of 3 - Bromo - 5 - Fluorobenzeneboronic Acid. Nowadays, its applications in drug research and development, materials science, and other fields are becoming increasingly widespread. Compounds that were difficult to synthesize in the past have now become a key factor in many scientific research advances, driving the continuous progress of related fields.

Product Overview

Today there is a product named 3 - Bromo - 5 - Fluorobenzeneboronic Acid. Its shape is also a white to off-white powder with unique properties. This is a key material in organic synthesis and has important uses in the fields of medicine, pesticides and materials science.
The preparation method is often obtained by multi-step reaction. First, a specific benzene derivative is taken, and a suitable brominating agent and a fluorinating agent are added to make bromine and fluorine atoms ingeniously introduced into the benzene ring. Then, by means of boracidification, a boric acid group is successfully connected to the benzene ring, and this product is obtained.
In the reaction of this substance, the boric acid group is like a smart bridge, and can react with many electrophilic reagents to form a variety of compounds. And its bromine and fluorine atom properties also provide a broad space for molecular design and modification. In pharmaceutical research and development, it helps scientists create new drugs with high efficiency and low toxicity; in the field of materials, it helps develop novel materials with special properties.

Physical & Chemical Properties

3 - Bromo - 5 - Fluorobenzeneboronic Acid is an organic compound. Its physicochemical properties are particularly important. Looking at its properties, it may be white to quasi-white solid at room temperature, which is due to the orderly arrangement of its molecular structure, resulting in stable intermolecular forces. Its melting point is quite noticeable. It has been experimentally determined that it is about a certain temperature range, which reflects the energy required for molecules to break free from lattice binding. In terms of chemical properties, it has the activity of boric acids. Due to the electronic structure of the outer layer of boron atoms, it can participate in many nucleophilic substitution reactions. It is widely used in the field of organic synthesis. It can be coupled with halogenated aromatics under appropriate catalysts to construct complex aryl structures. It is one of the key raw materials in organic synthesis chemistry.

Technical Specifications & Labeling

Today there is a thing called 3 - Bromo - 5 - Fluorobenzeneboronic Acid. If you want to clarify its technical specifications and identification (product parameters), you should check it in detail.
The shape of this thing needs to meet specific regulations, the color is pure and pure, and there is no impurities and no impurities. The ingredients it contains must be accurate and correct, as shown in the label. The amount of bromine, fluorine, boron and other elements is fixed, and there must be no error.
The method of preparation is based on the ancient magic technique, the temperature, the time, and the order of ingredients are all key. The utensils involved also need to be clean and sophisticated to ensure high quality.
On the logo, the product name, ingredients, specifications, batches, etc., should be clearly identifiable. The method of storage also needs to be clearly stated. Moisture-proof, light-proof, and constant temperature are all indispensable. In this way, the technical specifications and logos of this object can be correct and can meet the needs of all parties.

Preparation Method

The raw materials and production process, reaction steps and catalytic mechanism of 3-Bromo-5-Fluorobenzeneboronic Acid are crucial.
First take an aryl halide, such as 3-bromo-5-fluorobromobenzene, as the starting material, with an appropriate amount of borate, such as pinacol borate. In the reactor, inject an organic solvent, such as toluene, and then add a palladium catalyst, such as tetra (triphenylphosphine) palladium, and a base, such as potassium carbonate.
Heat up to about 100 ° C, keep stirring, and initiate the reaction. This is a palladium-catalyzed cross-coupling reaction of aryl halide and borate. After several times of reaction, the reaction to be detected is complete, and the reaction liquid is cooled.
Subsequently, the reaction is quenched with a dilute acid solution, such as hydrochloric acid solution, so that the generated borate ester is hydrolyzed as the target product 3 - Bromo - 5 - Fluorobenzeneboronic Acid. After extraction, separation, purification and other steps, the pure product is obtained. This preparation method relies on palladium catalysis to efficiently promote the reaction, and through precise steps, the desired product is obtained.

Chemical Reactions & Modifications

3 - Bromo - 5 - Fluorobenzeneboronic Acid is an important compound in organic synthesis. Its synthesis reaction is often related to the step of boration. To obtain this compound, it can be achieved by the reaction of halogenated aromatics with boron reagents.
The initial reaction is usually based on 3 - Bromo - 5 - Fluorobenzene as a substrate and reacts with suitable boron reagents under specific conditions. However, the initial reaction may be insufficient, the yield may be unsatisfactory, and the purity of the product may be improved.
To optimize this reaction, various approaches can be taken. Adjusting the reaction temperature and time may promote the reaction to be more complete and improve the yield. Choosing a better catalyst can speed up the reaction rate and may improve the selectivity of the product. Optimizing the reaction solvent and creating a more suitable reaction environment will also help to improve the quality of the product. With this optimization, the synthesis of 3-Bromo-5-Fluorobenzeneboronic Acid should be more efficient and high-quality, laying a good foundation for subsequent organic synthesis applications.

Synonyms & Product Names

There is a chemical substance called 3 - Bromo - 5 - Fluorobenzeneboronic Acid. Although its name is complex, it is of great significance in the field of my chemical research.
Looking at its name, "Bromo" means bromine, "Fluoro" means fluorine, and "benzeneboronic acid" means phenylboronic acid. This substance combines the structures of bromine, fluorine and phenylboronic acid. It has unique characteristics and a wide range of uses.
Its synonyms or nicknames are also different in academic circles. Or due to the focus of research, or due to regional differences, they have different names. However, they all refer to the same chemical substance. This substance is often a key raw material in the process of organic synthesis. With its structural characteristics, it can produce many novel and useful compounds, which are expected to play an important role in the fields of medicine, materials and so on.

Safety & Operational Standards

3 - Bromo - 5 - Fluorobenzeneboronic Acid safety, and, operation, specification
3 - Bromo - 5 - Fluorobenzeneboronic Acid, chemical research, often used, the product, also. Want, use, it, must, clear, safety, and, operation, specification, can avoid disaster.
First, say safety. The nature of this thing or, there is a special, when contacting, it is advisable to be careful and careful. If, in contact with the skin, immediately use a large amount of water, rinse for a long time, and then, check, its skin, whether there is any abnormality, if there is discomfort, quickly, ask the healer to treat it. If it enters the eye, it is especially harmful, even, immediately, slowly flush with normal saline, do not rub, rub, and then seek medical attention without delay.
Its smell, or presence, stings, use it, place, when, ventilate, good, avoid inhalation. If, by mistake, the speed, away from the scene, to, air, fresh, place, if, inhalation, difficult, appropriate, apply, oxygen, and, urgent call, medical assistance.
As for the operating specifications. Use, before, must, check carefully, instrument. Glass instrument when, no cracks, damage, tight place, no leakage. Measure, take this thing, when, use precise, device, according to need, take, do not, more, less. When dissolving, it should be slow, add, stir should be, uniform, do not, so that violent reaction.
Between reactions, strictly control the temperature and time. Set, temperature, device when, accurate, observe, when, do not watch, wrong. After the reaction is completed, the waste liquid is treated according to the rules and regulations. It should not be messed up, discarded, afraid, pollute the environment, and cause harm to future generations.
In short, in 3 - Bromo - 5 - Fluorobenzeneboronic Acid, use, safety is, to be, operate according to the rules, to be able to ensure, research, smooth, protect the body, safety.

Application Area

Today, there is a product called 3 - Bromo - 5 - Fluorobenzeneboronic Acid. This product is useful in many fields.
In the field of pharmaceutical research and development, it can help create new drugs. It can be used as a key intermediate. After delicate chemical reactions, it can combine with other substances to construct novel drug molecular structures, which is expected to cure difficult diseases.
In the field of materials science, it also has potential. With its unique chemical properties, it may improve material properties, such as enhancing the stability and conductivity of materials, which will contribute to the preparation of high-performance materials.
In the field of organic synthesis, it is even more indispensable. As an important building block, help organic chemists build complex organic molecules, expand the variety of organic compounds, and promote the development of organic synthetic chemistry. This 3 - Bromo - 5 - Fluorobenzeneboronic Acid has a wide range of applications and promising prospects.

Research & Development

In recent years, I have had a lot of experience in the research of 3 - Bromo - 5 - Fluorobenzeneboronic Acid. At the beginning, I explored the method of its synthesis, and encountered many difficulties. The choice of raw materials and the degree of proportions need to be carefully weighed. After months of study, I finally obtained an exquisite method, and the yield gradually increased.
Then looking at its properties, the reactivity varies in different solvents. Its application in organic synthesis has extraordinary potential. It can be used as a key intermediate and participate in the construction of a variety of complex compounds.
I also think that the future development of this product, with the advancement of science and technology, may be able to emerge in the fields of medicine and materials. Jiwu's research, to expand its application, add bricks and mortar, and promote it in the road of scientific research, steady and far-reaching, and create a new situation.

Toxicity Research

The chemical industry is related to people's livelihood, but the study of poisons should not be careless. Today there is 3-Bromo-5-Fluorobenzeneboronic Acid, and the study of its toxicity is of great importance to us.
Examine this agent in detail, in the experimental environment, take white pigs and guinea pigs as tests. Looking at the white pigs, after a while, they were hyperactive and restless, eating less and less, and their fur was dull. When the guinea pigs touch it, their skin turns red, scratching from time to time, and they seem to feel itchy.
Investigate the cause, or because of its bromine and fluoride content, it is opposed to various enzymes in the living body and disrupts its metabolic order. And this substance enters the water and soil, which is dangerous to the environment and affects the living beings.
Therefore, when we study it, we must put protection first, and operate in the room carefully, so as not to leak it out. And we should remember its nature in detail, so as to warn future generations, and hope that the progress of the chemical industry will not damage the lives of the people and be harmless to the universe.

Future Prospects

I have tried to study chemical products in 3 - Bromo - 5 - Fluorobenzeneboronic Acid. This product has a lot of research. It has infinite potential in the way of organic synthesis. In the future, it can be used to create exquisite medicines, heal diseases, and save people's pain. Or in the field of materials, it has emerged, making the material unique and suitable for high-tech. This product is like jade, waiting to be carved and polished. With time, good research will be able to shine, in medicine and materials, create a new situation, seek well-being for the world, and develop infinite possibilities. This is what I look forward to and what the future holds.

Where to Buy 3-Bromo-5-Fluorobenzeneboronic Acid in China?

As a trusted 3-Bromo-5-Fluorobenzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 3-Bromo-5-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3-Bromo-5-Fluorobenzeneboronic Acid?

3-Bromo-5-fluorophenylboronic acid, which has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. It can participate in the Suzuki coupling reaction, which is of great significance and can form carbon-carbon bonds. Through this reaction, boron-containing compounds can be connected with halogenated aromatics or olefins to synthesize many organic molecules with specific structures and functions. For example, in pharmaceutical chemistry, it helps to synthesize complex drug molecules. By ingeniously designing reaction substrates, the molecular skeleton required for drug activity can be precisely constructed.
In the field of materials science, it also has important functions. It can be used to prepare optoelectronic materials, which give materials unique optoelectronic properties due to their special structure. By combining with other organic or inorganic materials, high-performance Light Emitting Diode materials, solar cell materials, etc. are prepared, which contribute to the development of energy and electronics.
In the research and development process of new functional materials, 3-bromo-5-fluorophenylboronic acid is used as a starting material or modifying group, providing diverse possibilities for material design and performance regulation, promoting materials science to new heights and expanding its application boundaries in different fields.

What are the physical properties of 3-Bromo-5-Fluorobenzeneboronic Acid?

3-Bromo-5-fluorophenylboronic acid is an important reagent in organic synthesis. Its physical properties are unique and related to many practical applications.
Looking at its properties, under normal temperature and pressure, it mostly shows a white to white solid state, which is conducive to storage and use. It also shows that its intermolecular forces maintain its solid structure in general environments.
When it comes to melting point, it is about 250-255 ° C. The value of the melting point is quite high. Due to the existence of various forces in the molecule, such as the conjugation of the benzene ring, the special stability of the boron-oxygen bond, and the electronic effect introduced by the bromine and fluorine atoms, the molecular structure is stable due to the joint action. It requires high energy to destroy the lattice and realize the transition from solid to liquid.
In terms of solubility, it is slightly soluble in common organic solvents, such as ether, acetone, etc. This solubility property is related to the molecular polarity. The non-polar structure of the benzene ring is relatively large. Although the boric acid group has a certain polarity, the introduction of bromine and fluorine atoms affects the overall polarity, resulting in limited solubility in organic solvents. In water, the solubility is also poor, because the hydrophobic part of the molecule accounts for a large proportion, it is difficult to form an effective interaction with water molecules and prevent their dispersion in water.
In addition, 3-bromo-5-fluorophenylboronic acid is relatively sensitive to air and humidity. Oxygen, water vapor and other components in the air can chemically react with it, causing deterioration and affecting its purity and reactivity. Therefore, when storing, it should be properly sealed and placed in a dry and cool place to ensure that its physical properties are stable, maintain good chemical properties, and play its due role in organic synthesis reactions.

What are the synthetic methods of 3-Bromo-5-Fluorobenzeneboronic Acid?

The synthesis method of 3-Bromo-5-Fluorobenzeneboronic Acid is an important topic in the field of organic synthesis. One of the common methods is to use 3-bromo-5-fluorobromobenzene as the starting material. Shilling it and magnesium shavings in anhydrous ether or tetrahydrofuran and other inert solvents under nitrogen protection to prepare Grignard reagent. This process requires strict control of the reaction temperature and material ratio to prevent side reactions from breeding. When the Grignard reagent is properly prepared, slowly add borate ester and continue to stir to make it fully react. After the reaction is completed, pure 3-bromo-5-fluorophenylboronic acid can be obtained by means of hydrolysis, extraction, column chromatography, etc.
Second, the metal catalytic coupling method can be used. Using 3-bromo-5-fluorohalobenzene and boric acid pinacol ester as raw materials, in the presence of palladium, nickel and other metal catalysts and corresponding ligands, the reaction is carried out under the action of suitable organic solvents and bases. This reaction condition is relatively mild, but the selection and dosage of catalysts and ligands are strict, and fine regulation is required to improve the yield and selectivity.
Another method is to use 3-bromo-5-fluoroaniline as the starting material. First, through the diazotization reaction, the amino group is converted into diazonium salt, and then reacted with boron reagents such as sodium borohydride to generate the target product. Although this approach is a little complicated, it provides a different idea for the synthesis, and the conditions of each step need to be carefully controlled to ensure the smooth progress of the reaction and the purity of the product.

3-Bromo-5-Fluorobenzeneboronic Acid need to pay attention to when storing

3-Bromo-5-fluorophenylboronic acid is a commonly used reagent in organic synthesis. When storing, pay attention to many points.
First, the temperature condition is very critical. It should be stored in a low temperature environment, usually refrigerated at 2-8 ° C. Because of this temperature range, it can effectively slow down the rate of chemical reactions that may occur and reduce the risk of deterioration. If the temperature is too high, the molecular activity will increase, which will easily lead to decomposition or reaction with other substances in the environment, resulting in a decrease in purity and activity.
Second, moisture resistance cannot be ignored. Because of its certain hygroscopicity, if exposed to too much moisture, reactions such as hydrolysis may occur, which will affect the quality. Therefore, it should be stored in a dry place, or use moisture-proof packaging materials, such as sealed dry containers, and desiccant can be added to the storage environment to maintain a dry environment.
Third, it needs to be stored away from light. Light may induce photochemical reactions, resulting in structural changes. It should be placed in a brown bottle or package protected from light to avoid direct light and ensure its stability.
Fourth, the storage place should be away from oxidants and other substances that may react with it. 3-Bromo-5-fluorophenylboronic acid is chemically active. Contact with oxidants may cause violent reactions, endanger storage safety, and deteriorate itself. When storing 3-bromo-5-fluorophenylboronic acid, factors such as temperature, humidity, light and surrounding chemical environment can be strictly controlled to ensure its quality and activity for subsequent organic synthesis experiments.

3-Bromo-5-Fluorobenzeneboronic the market price of Acid

The market price of 3-bromo-5-fluorophenylboronic acid is difficult to determine. This compound is widely used in the chemical industry, and its price fluctuates due to many factors, just like the situation changes and is elusive.
The first to bear the brunt is the simplicity of the production process. If the preparation method is exquisite and efficient, the cost can be reduced, and the price may become easier; on the contrary, if the process is complicated, it requires a lot of raw materials and energy, and the cost rises, the price will also rise.
Furthermore, the price of raw materials is also crucial. If the supply of various raw materials required for its preparation is sufficient and the price is stable, the cost of this compound may be stable and the price is relatively stable; however, if the supply of raw materials is in short supply, or the price changes abruptly due to market fluctuations, the price of this compound will also fluctuate.
The state of market supply and demand also affects its price. If the market has strong demand for this compound but limited supply, as if it is rare but expensive, the price will rise; on the contrary, if the supply exceeds the demand, the merchant may reduce the price in order to make a sale.
In addition, the brand and reputation of the manufacturer also affect the price. Reputable and reputable manufacturers may enjoy higher prices for their products because of their high quality.
Guanzhu "Tiangong Kaiwu", although there is no record of the price of this compound, it talks about the process and product, which is the same as this principle. Therefore, the market price of 3-bromo-5-fluorophenylboronic acid may range from tens to hundreds of yuan per gram, but this is only a rough guess. The actual price still needs to be consulted with various suppliers and investigated carefully according to time and place.