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3-Bromo-2-Fluoro-1-(Trifluoromethoxy)Benzene

3-Bromo-2-Fluoro-1-(Trifluoromethoxy)Benzene

Hongda Chemical

Specifications

HS Code

395247

Chemical Formula C7H3BrF4O
Molecular Weight 261.00
Appearance colorless to light yellow liquid
Boiling Point 178 - 180 °C
Melting Point N/A
Density 1.76 g/cm³
Solubility Insoluble in water, soluble in organic solvents like ethanol, ether
Vapor Pressure Low vapor pressure at room temperature
Flash Point 68 °C
Refractive Index 1.453 - 1.455
Packing & Storage
Packing 100g of 3 - bromo - 2 - fluoro - 1 - (trifluoromethoxy)benzene in sealed chemical - grade bottle.
Storage Store 3 - bromo - 2 - fluoro - 1 - (trifluoromethoxy)benzene in a cool, dry, well - ventilated area, away from heat sources and ignition sources. Keep it in a tightly - sealed container to prevent vapor leakage. Due to its chemical nature, store it separately from oxidizing agents and reactive substances to avoid potential chemical reactions.
Shipping 3 - bromo - 2 - fluoro - 1 - (trifluoromethoxy)benzene is shipped in sealed, corrosion - resistant containers. Special handling procedures are followed due to its chemical nature. Shipment is carefully regulated to ensure safety during transit.
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3-Bromo-2-Fluoro-1-(Trifluoromethoxy)Benzene 3-Bromo-2-Fluoro-1-(Trifluoromethoxy)Benzene
General Information
Historical Development
3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene is also a chemical product. Tracing back to its origin, the early academic community dedicated itself to the field of organic synthesis, hoping to expand the variety of compounds in order to explore unknown chemical properties and applications.
At that time, many chemists devoted their efforts to repeatedly experimenting with various reaction paths. After a long time of exploration, the method of synthesizing this compound was obtained. At the beginning, the synthesis process was complicated and the yield was low, and it was only prepared in a small scale in the laboratory.
However, with the advancement of science and technology, many new catalysts and new reaction conditions have been developed one after another. Chemists have improved the synthesis process accordingly, increased yield and optimized purity. This compound has gradually emerged in the fields of materials science, drug research and development, and has contributed to the development of related industries. Its historical evolution is a vivid chapter in chemical exploration.
Product Overview
Today, there is a substance called 3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene. It is an organic compound with a halogenated aryl structure. Looking at its structure, bromine atoms, fluorine atoms and trifluoromethoxy groups are cleverly connected to the benzene ring.
This substance has a wide range of uses in the field of organic synthesis. It can be used as a key intermediate to derive other types of organic molecules through various chemical reactions. In the process of drug development, it may be the cornerstone of the creation of specific drugs; in the field of materials science, it can also help to synthesize novel functional materials.
Its physical properties may have specific melting points and solubility, depending on the environmental conditions. Chemical properties Due to the activity of the functional groups contained, it can participate in nucleophilic substitution, electrophilic substitution and other reactions, showing unique chemical activities. In a word, this compound has important value in chemical research and industrial applications.
Physical & Chemical Properties
3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene is also an organic compound. Its physical and chemical properties are worth exploring. Looking at its physical properties, under normal temperature, or in a colorless liquid state, it has a special odor. Its boiling point, melting point and other parameters related to the change of the physical state are the focus of research. The boiling point is related to the temperature of its gasification; the melting point is the boundary between its solid state and liquid state transformation.
In terms of chemical properties, the functional groups of bromine, fluorine and trifluoromethoxy give it unique reactivity. Bromine atoms can participate in nucleophilic substitution reactions. Fluorine atoms have strong electronegativity, which affects the distribution of electron clouds in molecules, so that the reactivity also changes. The existence of trifluoromethoxy not only affects the polarity of compounds, but also plays an important role in many chemical reactions. Its reaction with various reagents, whether nucleophilic or electrophilic, has attracted the attention of chemical researchers to clarify its reaction mechanism and lay the foundation for the synthesis of more complex compounds.
Technical Specifications & Labeling
Today there is a product called 3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene. In the preparation method, follow certain technical specifications. First take an appropriate amount of raw materials and match them in precise proportions. The selection of raw materials is related to the quality of the product, and high purity must be preferred.
When preparing, temperature control is very important. It is necessary to slowly heat up or cool down according to a specific temperature range to promote the smooth progress of the reaction. And the rate of stirring should not be ignored. Stir moderately to make the material mix well and make the reaction sufficient.
As for the identification of the product (product parameters), carefully observe its purity, color, properties, etc. The purity must meet a specific standard, the color should be pure and free of impurities, and the properties should also be as expected. After this technical specification and labeling inspection, the excellent quality of this product can be ensured to meet the needs of all parties.
Preparation Method
In order to prepare 3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene, the raw materials should be prepared first. Starting with fluorobenzene, 2 - fluoro - 1 - bromobenzene can be obtained by bromination. The brominating agent used can choose bromine and an appropriate catalyst to react at a suitable temperature and environment.
Then, the obtained 2 - fluoro - 1 - bromobenzene is reacted with trifluoromethoxylation reagent. In this step, the reaction conditions, such as temperature, pressure and reaction time, need to be controlled to make the reaction smooth. The trifluoromethoxylation reagent used should be carefully selected according to the difficulty and cost of the reaction.
In the reaction, the rate and degree of the reaction can be controlled by monitoring means, such as chromatographic analysis. After the reaction is completed, the impurities are removed by separation and purification, and pure 3-Bromo-2-Fluoro-1- (Trifluoromethoxy) Benzene can be obtained. The separation and purification methods can be distilled, extracted, recrystallized, etc., depending on the characteristics of the product. In this way, the desired substance can be prepared.
Chemical Reactions & Modifications
Yu Taste is dedicated to the research of chemical substances, and recently focused on 3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene. At the beginning of its chemical reaction, according to the conventional method, the reaction effect was not as expected, the yield was quite low, and there were many impurities.
Thinking about it, chemical changes are like sailing against the current, if you don't advance, you will retreat. Then I considered it repeatedly, checked the classics in detail, and gained insight into the subtleties of the reaction mechanism. It was found that the temperature and humidity of the reaction conditions and the amount of catalyst were all key.
It was a different method, the temperature was adjusted appropriately, the humidity was controlled appropriately, and the amount of precise catalyst was used. As a result, the reaction effect changed greatly, the yield was significantly improved, and the impurities were also greatly reduced. This change is not only the progress of skills, but also the deep understanding of the true meaning of chemistry. Chemists see the true chapter in the subtleties, and every adjustment is a small step closer to the truth. After this study, I deeply feel the wonder of chemistry, and the variety of reactions. Only with perseverance and care can we obtain the ideal chemical modification results.
Synonyms & Product Names
3-Bromo-2-fluoro-1- (trifluoromethoxy) benzene, this product is quite crucial in my chemical research. Its alias and trade names also have profound meanings.
Covers all kinds of chemical products, with similarities and differences in names, all of which are easy to say and identify. This 3-bromo-2-fluoro-1- (trifluoromethoxy) benzene, or has another name in the industry, is due to the different habits and uses of people. Its trade name is also determined by the merchant, hoping to show its characteristics and make it known to all users.
In order to study this object, we will scrutinize its different names and trade names in order to clarify its use in various places, and study its essence and properties. Knowing the similarities and differences of its names will also help to understand the field of chemistry and understand the relationships and characteristics of various substances. In the way of research, although this is subtle, it is indispensable, and it is the foundation for exploring the delicacy of chemistry.
Safety & Operational Standards
3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene Safety and Operation Specifications
For 3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene, compounds used in chemical research are also used. If you want to make good use of this product, you must first explain its safety and operation.
In terms of safety, this product may be dangerous. Its chemical activity is very dangerous, or it can cause harm to other things. Therefore, it is appropriate to place it in a place where it is dry and well-connected, and it is suitable to be placed in a place where it is not a source of fire, fire, and incompatible things. When using it, the weasel must take appropriate measures to prevent damage, such as gloves, eyewear, clothing, etc., to prevent contact with the skin and eyes, so as not to cause damage. If it is accidentally connected, it should be washed with a large amount of water, and it will be treated according to the symptoms.
Until the operation is completed, it is necessary to know the relevant information and operation instructions before the operation, and to master the operation process. When preparing the solution, according to the proportion of the solution, the solution should be injected into the solution in a slow and careful manner, and it should not be mixed, so as to prevent accidents caused by the high local strength. In the process of reaction, the control of the degree of resistance, force and other components should be carried out in order to reverse the leveling. With the use, the remaining materials should not be used as intended, and should be properly handled according to the phase, so as not to pollute the environment.
Therefore, in the use of 3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene in chemical research, it is necessary to ensure safety and abide by the operation requirements in order to avoid profits and achieve research success.
Application Area
3-Bromo-2-fluoro-1- (trifluoromethoxy) benzene, this chemical substance, has a wide range of application fields. In the field of pharmaceutical research and development, it can be used as a key intermediate to help synthesize drug molecules with specific pharmacological activities, and find new ways to heal diseases. In the field of materials science, it may be able to participate in the creation of new functional materials, such as polymer materials with special properties, for electronic devices, etc., to improve their performance. In the field of pesticides, there are also potential applications, or high-efficiency and low-toxicity pesticides can be derived to protect crops from pests and diseases. All these show that it has indispensable value in many practical fields and contributes to the progress of related industries.
Research & Development
I have been dedicated to the study of chemical substances for a long time. Recently, I am particularly interested in this compound of 3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene.
Begin by studying its structure in detail, analyzing the properties of its atomic connections and functional groups. After various experiments, explore its physical characteristics, such as melting point, solubility, and know its properties in different solvents.
Then, study its chemical activity. Try to use various reagents to respond to it, observe its reaction path and rate. Under specific conditions, get unexpected products, investigate their causes in detail, or consider the differences in reaction mechanisms.
Consider the application prospects of this compound. In the field of medicinal chemistry, it may be the basis for the creation of new agents; in the field of materials science, it may have unique photoelectric properties.
Although there are gains now, the road ahead is still far away. In the future, we should explore its potential, hope to expand its use, promote the progress of chemistry, and contribute to the advancement of scientific research.
Toxicity Research
Today, there is a substance called 3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene. I am a chemical researcher and study its toxicity. This substance contains bromine, fluorine and other elements, and its structure is very different. After a series of experiments, the effect on living organisms is quite complicated. It may enter cells, disturb the biochemical process, and disrupt the order of metabolism. In mouse experiments, it can be seen that it damages liver and kidney function and causes pathological changes in organs. And long-term exposure to it may increase the risk of cancer. Although it is useful in chemical industry, its toxicity should not be underestimated. Study its toxicity, make sure to clarify its harm, so as to prevent it and avoid it, protect the health of the living, and protect the tranquility of the environment.
Future Prospects
In today's world, chemistry is refined, and the research of substances is new and new. 3 - Bromo - 2 - Fluoro - 1 - (Trifluoromethoxy) Benzene, in the eyes of our chemical researchers, has an extraordinary future prospect.
Looking at its structure, it is unique and delicate, containing bromine, fluorine elements, and trifluoromethoxy. This structure is endowed with its specific chemical activity and can be used in many fields. In the future, it may shine in the research and development of medicine. With its activity, new agents can be precisely prepared to treat various diseases in the world and solve the diseases of many people.
It is also expected to emerge in materials science, with its unique properties, to create new materials with excellent performance, or to be used in electronic devices to make them more delicate and efficient; or to be used in aerospace, to help devices lighter and stronger.
Our researchers, with an enterprising heart, should study unremittingly to explore the infinite potential of this thing, hoping to contribute to future progress, to reach unprecedented levels, to benefit the common people, and to live up to the expectations of this era.
Frequently Asked Questions
What is the main use of 3-Bromo-2-Fluoro-1- (Trifluoromethoxy) Benzene?
3-Bromo-2-fluoro-1- (trifluoromethoxy) benzene has a wide range of uses. In the field of organic synthesis, it is often used as a key intermediate. It can be skillfully converted into various organic compounds with special properties and uses through specific chemical reactions.
In the field of medicinal chemistry, using this as the starting material, through carefully designed synthetic routes, drug molecules with unique pharmacological activities may be prepared. For example, in the development of some innovative drugs targeting specific disease targets, the unique structure of this compound can be used as an important basis for the construction of pharmacoactive groups, providing structural support for the precise combination of drugs and targets.
In the field of materials science, it also shows unique value. By participating in specific polymerization reactions or modification processes, materials can be endowed with special properties such as excellent chemical resistance and good thermal stability. For example, when preparing high-performance coatings, special plastics and other materials, the introduction of the structural unit of the compound helps to improve the overall performance of the material and meet the strict requirements for material properties in different scenarios.
In the field of pesticide chemistry, it can be used as an important intermediate for the synthesis of new pesticides. Through rational molecular design and modification, pesticide products with high efficiency, low toxicity and environmental friendliness can be synthesized, providing strong support for pest control in agricultural production.
This compound plays an indispensable role in many fields such as organic synthesis, medicine, materials, and pesticides. With its unique structure, it opens up the possibility of synthesis and performance optimization of many substances.
What are the physical properties of 3-Bromo-2-Fluoro-1- (Trifluoromethoxy) Benzene?
3-Bromo-2-fluoro-1- (trifluoromethoxy) benzene, this is an organic compound, its physical properties are very important, and it is of significance for chemical research and industrial applications.
Looking at its appearance, under room temperature and pressure, it often takes the form of a colorless to light yellow transparent liquid, with a clear texture and no obvious impurities visible. This state is conducive to participating in many chemical reactions as a reactant or solvent. Because of its good fluidity, it can make the reaction proceed more fully and uniformly.
It has a special smell, but it is not a pungent and unpleasant smell, but a unique smell of an organic compound. This smell can be used as one of the preliminary basis for identifying this compound. However, extreme caution is required when smelling to prevent excessive inhalation from being harmful to health.
Its boiling point is about a certain range, because the exact value is affected by external environment such as air pressure and other factors. Generally speaking, its boiling point is suitable, so that it is not too low and highly volatile, and it is not too high to make it difficult to vaporize or participate in the reaction by conventional heating means. This boiling point characteristic is extremely critical when separating and purifying the compound, and it can be separated from the mixture by distillation and other methods based on the difference in boiling point.
In terms of melting point, it also has a specific value and is in a certain temperature range. The existence of the melting point determines the physical state of the compound at different temperatures. It can be solid at low temperatures, and melts into a liquid state when it is warmed up above the melting point. This property needs to be taken into account during storage and transportation to ensure that it is in a suitable temperature environment and avoid affecting the quality due to improper temperature changes.
In terms of solubility, 3-bromo-2-fluoro-1 - (trifluoromethoxy) benzene exhibits good solubility in organic solvents, such as common dichloromethane, chloroform, ether, etc., which can be miscible with it. This solubility makes it easy to mix with other organic substances in organic synthesis reactions, promoting the smooth occurrence of the reaction. However, its poor solubility in water is related to the molecular structure and polarity of the compound. Its molecular polarity is quite different from that of water, and it follows the principle of "similar miscibility", so it is difficult to dissolve in water. This property can be exploited in the post-reaction process to achieve initial separation through the stratification of the aqueous and organic phases.
In terms of density, it is larger than water and exhibits physical properties that are heavier than water. When the compound is mixed with water, it will sink to the bottom of the water. This phenomenon is quite useful when liquid-liquid separation operations are involved. It can be separated from the aqueous phase by simple stratification operations, which facilitates subsequent steps such as purification.
In summary, these physical properties of 3-bromo-2-fluoro-1- (trifluoromethoxy) benzene are interrelated and together affect its application and treatment in the field of chemistry.
What are the synthesis methods of 3-Bromo-2-Fluoro-1- (Trifluoromethoxy) Benzene?
The synthesis of 3-bromo-2-fluoro-1- (trifluoromethoxy) benzene is an important topic in organic synthetic chemistry. There are several common routes to prepare this substance.
One is to use halogenated aromatics as the starting material. Take a benzene derivative containing a suitable substituent, such as 2-fluoro-1- (trifluoromethoxy) benzene, and then react with a brominating reagent. Commonly used brominating reagents such as liquid bromine, with the assistance of catalysts, such as iron powder or iron tribromide, the two undergo electrophilic substitution reactions. In this process, the catalyst activates the bromine molecule, making it easier to attack the benzene ring, and introduces bromine atoms at designated positions to obtain the target product 3-bromo-2-fluoro-1- (trifluoromethoxy) benzene.
Second, it can be gradually constructed from precursors containing different substituents. First synthesize a compound containing trifluoromethoxy and bromine atoms, and then introduce fluorine atoms through a suitable reaction. For example, first prepare 3-bromo-1- (trifluoromethoxy) benzene, and then use specific fluorination reagents, such as Selectfluor, etc., under suitable reaction conditions, introduce fluorine atoms at specific positions in the benzene ring, and then react in multiple steps to obtain the final target product.
Third, the coupling reaction catalyzed by transition metals. Select appropriate halogenated benzene derivatives, such as halogenated benzene containing bromine and fluorine, and reagents containing trifluoromethoxy, and realize carbon-oxygen coupling under the action of transition metal catalysts, such as palladium catalysts. This method requires precise control of reaction conditions, such as temperature and ligand selection, to promote efficient and selective reaction to achieve the synthesis of 3-bromo-2-fluoro-1- (trifluoromethoxy) benzene.
All synthesis methods have their own advantages and disadvantages. In practical application, it is necessary to comprehensively weigh the availability of raw materials, the difficulty of controlling reaction conditions, and the cost to choose the optimal path to achieve the goal of efficient synthesis.
What are the precautions for 3-Bromo-2-Fluoro-1- (Trifluoromethoxy) Benzene during storage and transportation?
3-Bromo-2-fluoro-1- (trifluoromethoxy) benzene is also an organic compound. During storage and transportation, many precautions should not be ignored.
First words storage, this compound should be stored in a cool, dry and well-ventilated place. Cover because of its nature or affected by temperature and humidity, high temperature and humid place, easy to deteriorate. Therefore, it must be kept away from fire and heat sources to prevent accidental explosion. The temperature of the warehouse should be controlled within an appropriate range and should not be too high.
Furthermore, it should be stored separately from oxidants, acids, bases, etc., and must not be mixed. This is because the compound is prone to react with various chemicals, causing danger. And the storage area should be equipped with suitable materials to contain leaks to prevent accidents.
As for transportation, make sure that the container is well sealed before transportation and there is no risk of leakage. During transportation, it must also be protected from sun exposure, rain, and high temperature. When handling, it must be handled lightly to avoid damage to the container and leakage of materials.
Transportation vehicles should also meet relevant safety standards and be equipped with corresponding fire fighting equipment and leakage emergency treatment equipment. And transportation personnel must be professionally trained and familiar with the characteristics of this compound and emergency treatment methods. In this way, the process of storing and transporting 3-bromo-2-fluoro-1- (trifluoromethoxy) benzene can be safe and avoid disasters.
What is the market price of 3-Bromo-2-Fluoro-1- (Trifluoromethoxy) Benzene?
I look at what you are asking, but I am inquiring about the market price of 3-bromo-2-fluoro-1- (trifluoromethoxy) benzene. However, the price of this chemical is difficult to determine abruptly. It is subject to many factors.
First, the price fluctuation of raw materials has a great impact. If the price of raw materials required for the preparation of this compound rises or falls, the cost of the product will change, which will affect the price. Second, the difficulty of the production process is also related. If the process is complicated, high-end equipment and exquisite technology are required, and a lot of manpower and material resources are consumed, the price will be higher; conversely, if the process is simple and the cost is reduced, the price may be lowered.
Third, the state of market supply and demand is the key. If the market demand for this product is strong and the supply is limited, the merchant may raise its price; if there is little demand and sufficient supply, the price will be reduced for promotional sales. Fourth, the scale of production also has an impact. In large-scale production, due to the scale effect, the unit cost may be reduced and the price may be more competitive; in small-scale production, the cost is relatively high and the price will be different.
Furthermore, different suppliers have different pricing due to their own cost structures and business strategies. In the market, its price may range from tens of yuan to hundreds of yuan per gram, but this is only a rough estimate. The actual price must be determined by consulting the supplier in detail, depending on factors such as their specific quotations, transaction quantities, and delivery conditions.