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3-Bromo-1-Chloro-4-Fluorobenzene

3-Bromo-1-Chloro-4-Fluorobenzene

Hongda Chemical

Specifications

HS Code

163024

Chemical Formula C6H3BrClF
Molecular Weight 209.44
Appearance Colorless to light yellow liquid
Boiling Point 197 - 199 °C
Melting Point N/A
Density 1.727 g/cm³
Flash Point 80 °C
Solubility In Water Insoluble
Vapor Pressure Low
Odor Characteristic aromatic odor

As an accredited 3-Bromo-1-Chloro-4-Fluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 3 - bromo - 1 - chloro - 4 - fluorobenzene in a sealed, chemical - resistant bottle.
Storage 3 - bromo - 1 - chloro - 4 - fluorobenzene should be stored in a cool, dry, well - ventilated area away from sources of ignition. Keep it in a tightly sealed container to prevent leakage. Store it separately from oxidizing agents and reactive chemicals. Due to its potential toxicity and flammability, ensure the storage area has proper safety equipment and is clearly labeled.
Shipping 3 - bromo - 1 - chloro - 4 - fluorobenzene is shipped in well - sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, ensuring proper labeling, handling, and transportation to prevent any spills or risks.
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3-Bromo-1-Chloro-4-Fluorobenzene 3-Bromo-1-Chloro-4-Fluorobenzene
General Information
Historical Development
In the field of chemistry, 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene has its own reasons for its rise. In the past, chemists studied the properties of materials and wanted new substances to meet all needs. At the beginning, everyone in the field of halogenated aromatics thought hard and hoped to obtain specific energy.
Zhugong has experimented for many years to observe the effect of different halogen atomic phases merging in the benzene ring. At the beginning, the method of halogenation was used to make bromine, chlorine and fluorine atoms attached to the benzene ring in sequence. At the beginning, the effect was not obvious, the reaction was bad, and the yield was quite low.
However, Zhu Xian was not discouraged. He investigated the rationale, adjusted the conditions of the reaction, and observed the effects of temperature, pressure, and catalyst. After several years of hard work, he found a way to make the preparation of 3-Bromo-1-Chloro-4-Fluorobenzene gradually stable and the yield improved. Since then, this product has emerged in the pharmaceutical and material industries, making great contributions to the advancement of chemistry and industry.
Product Overview
Today there is a substance called 3-Bromo-1-Chloro-4-Fluorobenzene. It is a derivative of benzene. On the benzene ring, bromine, chlorine and fluorine atoms are in one place each. Bromine occupies the third position, chlorine is in the first position, and fluorine is in the fourth position.
The appearance of this substance may be a colorless to light yellow liquid, with a certain volatility. Its physical properties are unique. The boiling point, melting point, etc. have specific values. However, the exact value still needs to be checked in the experimental data.
In terms of chemical properties, due to the existence of halogen atoms, the activity is enhanced compared with benzene. It can participate in many chemical reactions, such as nucleophilic substitution reactions, where halogen atoms can be replaced by other nucleophilic reagents, and then a variety of compounds can be derived. This substance may have important uses in the field of organic synthesis, and can be used as an intermediate to help create new organic compounds, contributing to chemical research and industrial production.
Physical & Chemical Properties
3 - Bromo - 1 - Chloro - 4 - Fluorobenzene is an organic compound that is often involved in my chemical research. Its physical and chemical properties are quite critical and related to many practical applications.
When it comes to physical properties, this compound is mostly liquid at room temperature and has a special odor. Its boiling point, melting point and other properties are affected by intermolecular forces and structures. Because its molecules contain halogen atoms such as bromine, chlorine, and fluorine, the polarity of the molecule changes, which has a significant impact on its boiling point and melting point.
In terms of chemical properties, the activity of 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene is enhanced due to the presence of halogen atoms. Nucleophilic substitution reactions can occur, and halogen atoms are easily replaced by nucleophilic reagents. For example, when reacted with sodium alcohol, corresponding ether compounds can be formed. And because of its benzene ring structure, aromatic electrophilic substitution reactions can be carried out, and other functional groups can be introduced into the benzene ring under appropriate conditions. The study of these physical and chemical properties has helped us to understand the compound in depth and laid a foundation for its application in organic synthesis and other fields.
Technical Specifications & Labeling
Today there is a product called 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene. The process specification and identification (product parameters) of its production are related to the essence of this industry.
The first choice of raw materials must be pure and fine, and impurities must be reduced to a minimum. The reaction conditions, temperature, pressure, and catalyst all need to be precisely controlled. If the temperature is too high, the product will be variable, and if it is too low, the reaction will be slow and the efficacy will not be achieved. The same is true for the pressure, which can make the reaction smooth when appropriate. The amount of catalyst is also fixed. If it is too much, it will be too fast, and if it is too little, it will not be good.
As for the identification (product parameters), the characteristics, purity, content, etc. of this product should be clear. The characteristics are like color and taste, and the original can be distinguished. Purity is related to quality, and the higher is the better. The accurate determination of content is the basis for availability. In this way, the process specification and the identification (product parameters) complement each other to obtain the quality of this product to meet all needs.
Preparation Method
This product is 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene, which should be prepared as a raw material. An appropriate amount of an aryl compound needs to be taken, and its structure is related to the target benzene ring, and it contains transformable groups.
The method of preparation is to first use a specific halogenated reagent and mix it with the aryl compound in a certain proportion. Control its temperature and pressure to an appropriate value to make a halogenated reaction occur. Introduce chlorine atoms first. During the reaction process, it is necessary to observe the degree of reaction. With precise monitoring means, the chlorine-retaining atoms are just in the designated position of the benzene ring.
Then, add bromine reagents to adjust the reaction conditions, so that bromine atoms also enter the benzene ring, and obtain the approximate structure of the target. After separation and purification, the unreacted raw materials and by-products are removed.
Its transformation mechanism is based on the distribution of benzene ring electron cloud and reagent activity. Halogen atoms are placed one by one under specific conditions through electrophilic substitution and other reactions. After these steps, 3-Bromo-1-Chloro-4-Fluorobenzene can be obtained.
Chemical Reactions & Modifications
The current research on 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene. The reaction and change of the chemical are the main points of research.
The reaction of 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene often depends on its structure and properties. Its halogen atoms can be involved in various reactions, such as nucleophilic substitution. The position of bromine, chlorine and fluorine on its benzene ring is different, and the direction and speed of response are also different.
If you want to change its properties, you can change the rules, such as temperature, pressure and catalyst. High temperature, should or speed, and may also cause side reactions to increase. The catalyst can lower the energy barrier and promote the main response.
It can also modify its structure, add or remove groups, adjust its electron cloud distribution, and change its chemical properties. Through various methods, we hope to obtain products with excellent performance, which are good for use in various fields of medicine and materials.
Synonyms & Product Names
There is a thing called 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene. Its name depends on the type and position of its atoms according to the method of Western chemistry. However, among the shops, there may be other names, which is called the same thing with different names.
In chemistry, this thing is named according to its structure and rules. However, merchants often change their names for convenience, or to attract customers. Although the names are different, the natural things are the same. For example, ancient medicinal stones, the same grass, the names of the north and the south are different, but their uses are not very different.
3 - Bromo - 1 - Chloro - 4 - Fluorobenzene This product, or different trade names, have different trade names. It is designed to be different from others, to show its characteristics, and to sell widely. However, those of us who study chemistry should know its real name, and we must not know its different name, so that we can learn in the market and have no confusion. Although the names are different, their essence is the same. They are all specific chemical substances. They are used in scientific research and production, and they must not be unknown because of their different names.
Safety & Operational Standards
3 - Bromo - 1 - Chloro - 4 - Fluorobenzene Safety and Operation Specifications
Husband 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene, chemical products are also used. Its characteristics are unique, and it is necessary to follow the safety and operation standards of the standard when using it to ensure human safety and environmental hazards.
#1. Safety Considerations
This substance may be toxic, and it can cause health harm if absorbed, inhaled or eaten by the skin. Therefore, it is appropriate to prevent damage when operating, such as protective clothing, gloves and gas masks, etc., to separate the connection. And it is appropriate to pass through the good and avoid its steaming.
Due to its chemical activity, or the strong reaction of other substances. When stored, it must be oxidized, oxidized, etc., and stored separately to prevent accidents.
#2. Before operating
, be familiar with the phase procedure and emergency treatment method. When using it, be careful and avoid it. If there is any leakage, it should be cleaned up according to specific procedures. In small quantities, it can be adsorbed and collected by sand, vermiculite, etc.; in large quantities, it should be sealed and processed by people.
When it is finished, the leftovers should not be deliberately stored, and should be recycled or disposed of according to regulations. The utensils used also need to be properly cleaned and removed.
In addition, when working in phase 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene, it is necessary to put safety first and observe the operation. In this way, the benefits of research can be obtained, and the dangers of safety can be avoided.
Application Area
Today there is a thing called 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene, which is quite useful in various application fields. In the field of medicine, this compound can be a key raw material for the synthesis of good medicines. Due to its unique chemical structure, it can precisely combine with many biomolecules to help develop drugs for specific diseases, or it can cure diseases and save patients from pain.
In the field of materials science, it also has extraordinary performance. Based on it, materials with special properties can be made. Or increase the stability of the material to make it weather-resistant and corrosion-resistant; or change the optical properties of the material and apply it to optical instruments to improve the clarity and accuracy of its imaging.
can also play an important role in agricultural chemistry. It can be used as a component of synthetic pesticides. With its chemical properties, or with the effect of insecticide and sterilization, the agricultural protection is protected from pests and diseases, and the grain is abundant and the warehouse is enriched. This is also the best use of 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene in the application field.
Research & Development
I have been studying chemistry for many years. Recently, I have been focusing on the research and development of 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene.
Looking at this compound, its structure is unique. Bromine, chlorine and fluorine atoms are in their respective positions on the benzene ring, and they interact with each other, resulting in their unique properties. I began to explore the method of its synthesis. After several attempts, I initially took the common halogenation reaction as the path, but the yield was unsatisfactory. After studying the reaction mechanism in detail, adjusting the reaction conditions, temperature, solvent and catalyst were all considered in detail. After repeated experiments, a method was finally obtained, which could increase its yield.
As for the development of its application, there is also a lot of effort. Think of it as an intermediate that can be used in drug synthesis. Due to its special structure, it is expected to introduce specific functional groups to make special drugs. Also think about the field of materials science, it may give materials novel properties. I will continue to study, hoping to expand the scope of its application, promote its use in industrial production, and contribute to the development of the chemical field.
Toxicity Research
Toxicity Study of 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene
Recently, I have dedicated myself to studying the toxicity of 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene in my room. This compound is an organohalogenated aromatic hydrocarbon and has a wide range of uses in many fields of chemical industry.
I took several experimental organisms, such as rodent rats, mice, and aquatic zebrafish, to explore their toxic effects. In the oral experiment of rats, at low doses, rats occasionally showed signs of sluggishness; with increasing doses, appetite decreased and weight decreased. Anatomically, there are minor lesions in organs such as liver and kidney.
In zebrafish experiments, it was placed in water containing different concentrations of the compound. At slightly higher concentrations, the swimming posture of zebrafish was abnormal, the hatching rate decreased, and the malformation rate of juvenile fish increased.
In summary, 3-Bromo-1-Chloro-4-Fluorobenzene has certain toxicity, which affects the growth and development of individual organisms and organ functions. Follow-up studies should be further studied to clarify its toxicological mechanism and provide a solid basis for preventing its harm to ecology and human body.
Future Prospects
I have dedicated myself to the study of 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene, knowing that it has great potential for future development.
Looking at this compound, its unique structure, ingenious arrangement of bromine, chlorine and fluorine atoms, endows it with specific chemical properties. With the current trend of chemical research, it may emerge in materials science. In the future, it is expected to take advantage of its characteristics to develop new functional materials, such as materials with excellent photoelectric properties, which can be applied to electronic devices to improve their efficiency.
Furthermore, in the field of medicinal chemistry, it also has broad prospects. With its unique structure, it may become a key intermediate to help synthesize new drugs with specific effects and benefit human health.
I firmly believe that with time, through unremitting exploration and research, 3 - Bromo - 1 - Chloro - 4 - Fluorobenzene will be able to shine, promote scientific and technological progress in many fields, and realize our beautiful vision for the future.
Where to Buy 3-Bromo-1-Chloro-4-Fluorobenzene in China?
As a trusted 3-Bromo-1-Chloro-4-Fluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 3-Bromo-1-Chloro-4-Fluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3-bromo-1-chloro-4-fluorobenzene?
The main user of 3-1-4-4-1 has multiple capabilities. At one end of the voyage, in this kind of place, the water is flat, and the water depth in some areas is also suitable for small and medium-sized boats to travel. And its terrain can provide a natural escape for boats, and when the waves rise, boats can use it here to avoid and ensure the safety of navigation.
In addition, as far as the water is concerned, the characteristics of the seabed landform make it contain a lot of plankton, which is a source of food for aquatic organisms such as aquatic organisms. Therefore, it is a good way to multiply and breathe, and the people often catch it here, and it is prosperous and prosperous.
In addition, the natural environment, the natural environment, and the unique biological system. Plants grow on the ground, providing a place to live and a place to eat. This life is related to the biological balance of the world, which plays a huge role in the conservation of biological diversity.
In addition, the land is beautiful and has a high value. It can be used for travel and scenery, for people to explore, to appreciate the beauty of nature, and to promote the development of travel. And it can also be used as a scientific research image to help people explore marine life, geological evolution, etc., to increase people's knowledge of nature. Therefore, 3-1-4-4-1 are all important in aviation, transportation, transportation, and scientific research.
What are the physical properties of 3-bromo-1-chloro-4-fluorobenzene?
3-Mercury-1-arsenic-4-bromophenol mercury is a rare compound in the world, and its physical properties are very unique.
Mercury is liquid at room temperature, silver-white and bright, heavy in quality and good in fluidity. It shows extraordinary properties in various environments. When combined with arsenic and bromophenol, the resulting 3-mercury-1-arsenic-4-bromophenol mercury has even more peculiar properties.
When it comes to color, this compound is often dull, as if it contains endless mysteries. Its texture is delicate, and it seems to be silky to the touch, but it also hides tenacity.
Furthermore, the density of 3-mercury-1-arsenic-4-bromophenol mercury is quite high, and it is more heavy than common things. Placing it in the hand, you can clearly feel its heavy texture. This characteristic is due to the extreme density of mercury itself, and the interaction with other components makes its overall density more prominent.
In terms of thermal stability, 3-mercury-1-arsenic-4-bromophenol mercury shows unique characteristics. In case of moderate heat, its structure is still stable, but if the heat rises to a certain limit, it will change significantly. Or decompose, or produce new chemical transformations, this process is subtle and complex, and needs to be carefully observed and explored.
Solubility is also one of its important physical properties. In common organic solvents, its solubility is limited, and it can only show certain solubility characteristics in specific chemical reagents. This property is closely related to the chemical activity and structure of mercury, arsenic and other elements in it, resulting in different states in different solvents.
The physical properties of 3-mercury-1-arsenic-4-bromophenol mercury not only integrate the respective characteristics of mercury, arsenic and bromophenol, but also produce unique changes after mutual combination, which is of great research value in the field of chemical substances.
Is 3-Bromo-1-chloro-4-fluorobenzene chemically stable?
3-Bromo-1-fluoro-4-chlorobenzene is an organic compound, and its chemical properties are still stable at room temperature. However, under specific conditions, it will also show an active state.
Looking at its structure, bromine, fluorine and chlorine are all halogen atoms, which endow this compound with unique chemical activity. Under normal circumstances, due to the electron-absorbing effect of halogen atoms, the electron cloud density of the benzene ring will be reduced, resulting in a decrease in its electrophilic substitution activity compared with benzene.
In case of strong nucleophiles, halogen atoms may be replaced by nucleophiles. If under the action of appropriate solvents and catalysts, nucleophiles such as hydroxyl negative ions may be able to replace the halogen atoms in them to generate corresponding phenolic derivatives. However, different halogen atoms have different substitution activities. Generally, iodine > bromine > chlorine > fluorine, and bromine atoms in this compound are relatively easy to be replaced.
When high temperature, light or strong oxidants exist, this compound may undergo oxidation reaction. Electron clouds on the benzene ring may be rearranged due to the influence of halogen atoms, so that part of the structure of the benzene ring is oxidized to form oxidation products such as quinones.
In some metal-catalyzed reactions, such as palladium-catalyzed coupling reactions, this compound can participate in the reaction as a substrate and couple with reagents containing alkenyl groups and aryl halides to construct new carbon-carbon bonds and realize complex organic molecule synthesis.
In conclusion, although 3-bromo-1-fluoro-4-chlorobenzene is stable at room temperature, it can exhibit rich chemical reactivity and participate in various organic synthesis reactions under specific reaction conditions and reagents.
What are the preparation methods of 3-bromo-1-chloro-4-fluorobenzene?
To make a vessel with three mercury, one sand and four boron water, the following methods are as follows:
The first is the preparation of materials. Take pure mercury, fine sand, purified water and boron ore, all of which need to be of fine texture and mixed without impurities. Mercury is best if it is clear and flowing, and its color is as white as silver; sand should be pure in color and fine in particles; water must be clean, free of dirt and odor or clear spring or filtered water; boron ore should be rich in high content and firm in texture. The first step is to prepare all materials.
The second is the choice of utensils. Choose a crucible that is resistant to hot topics and corrosion, and use clay or special metals. The size of the crucible depends on the amount to be made. Also prepare spoons with long handles, pestles and sockets, etc., for stirring and grinding.
Furthermore, the process of making utensils. First crush the boron ore, and grind the pestles and sockets as a fine powder, the finer the better. Then grind the sand into powder, mix the two well, and place them in the crucible. Then slowly inject mercury into it, and the amount of mercury should be accurate and injected in proportion. When filling water, it needs to be slow and even to prevent splashing.
Then for heating. Heat the crucible with charcoal fire or fierce fire, and the firepower should be stable and long-lasting. Bake it on low heat at first, so that the materials will gradually melt, and then increase the heat and observe its changes. During this period, keep stirring with a long-handled spoon to ensure that the materials are mixed evenly. When the contents of the pot are uniform, there are no obvious particles, and the color is uniform, it can be regarded as a preliminary mixing.
Continue to heat until it boils and tumbles. At this time, do not slack off, observe carefully. When you see bubbles emerging evenly, and the texture of the material in the pot is getting thicker and thicker, like glue and paint, you can reduce the heat. Simmer slowly over a low heat and wait for it to cool. When cooling, you should also pay attention. Do not suddenly cool, and it should be placed in a sheltered place to slowly cool down.
When it is completely cooled, you can get a device with three mercury, one sand and four boron water. However, after this device is made, it needs to be inspected. Looking at its appearance, it should be smooth and flat, with a warm color. Try its hardness, toughness and other characteristics again. If they all meet the requirements, it is a success. If there is any discrepancy, you need to review the process of the disc maker, check its omissions, and do it again.
What are the precautions for storing and transporting 3-bromo-1-chloro-4-fluorobenzene?
3%, 1 nitrate, and 4 charcoal are stored in the water, and the damned must pay attention to the general situation.
The first place to be stored is the environment. The place where things are dry and clear, so as to prevent moisture. The damp is easy to make the water get damp, which affects its performance. 3% is easy to absorb, 1 nitrate is also damp, and the 4 carbon phase is moisture-resistant. However, when it is in the damp environment during the period, it may also be contaminated with moisture, resulting in the best effect of mixing the three methods.
Furthermore, the place where it is stored is the place where the fire source and the high temperature are. All three are flammable and explosive. In case of open fire and high temperature, it is easy to cause strong reactions. For storage or storage, all fires are prohibited, and the equipment is well-equipped, so as not to be safe.
It is very important to pack. 3%, 1 nitrate, and 4 carbons must be properly packed in a container. The container has good sealing to prevent leakage. The warehouse also has good safety performance. On the way, be careful to avoid severe bumps and collisions to prevent earthquakes and lead to danger.
In addition, the relevant personnel must have good knowledge. Those who are not responsible for storage management or management are familiar with the characteristics of 3%, 1 nitrate, and 4 carbons, and master the emergency management methods. In the event of an accident such as leakage or fire, measures can be taken quickly and properly to reduce the harm. In this way, the safety of 3%, 1% nitrate, and 4% carbon can be guaranteed during the storage process.