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3,5-Difluoronitrobenzene

3,5-Difluoronitrobenzene

Hongda Chemical

Specifications

HS Code

971543

Chemical Formula C6H3F2NO2
Molecular Weight 159.09
Appearance Colorless to light yellow liquid
Boiling Point 194 - 196 °C
Melting Point 2 - 4 °C
Density 1.436 g/cm³
Flash Point 84 °C
Solubility In Water Insoluble
Vapor Pressure 0.22 mmHg (25 °C)
Refractive Index 1.510 - 1.514

As an accredited 3,5-Difluoronitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 3,5 - difluoronitrobenzene packaged in a sealed, corrosion - resistant bottle.
Storage 3,5 - difluoronitrobenzene should be stored in a cool, dry, well - ventilated area, away from heat sources and open flames. It should be kept in a tightly sealed container to prevent vapor leakage. Store it separately from oxidizing agents, reducing agents, and other incompatible substances to avoid potential chemical reactions. Use appropriate storage cabinets or areas dedicated to hazardous chemicals.
Shipping 3,5 - difluoronitrobenzene is shipped in well - sealed, corrosion - resistant containers. It's transported under strict safety protocols, avoiding heat, ignition sources, and incompatible substances to ensure safe delivery.
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3,5-Difluoronitrobenzene 3,5-Difluoronitrobenzene
General Information
Historical Development
3,5-Difluoronitrobenzene is also a product of chemistry. Tracing back to its origin, at the beginning, chemical sages explored physical properties and studied the way of synthesis. In the early years, technology was not yet developed, and it was difficult to obtain this substance. At that time, the experimental equipment was simple and the raw materials were scarce. However, the public worked tirelessly, and after years of attempts, preliminary results began to be achieved.
With the passage of time, science and technology advanced day by day, and the synthesis technology became more refined. Scholars improved the process and optimized the process, so that the output of 3,5-difluoronitrobenzene gradually increased and the purity also increased. In the past, synthesis took a long time and produced less output, but now it is much more efficient. This product is increasingly used in the chemical industry and is a key raw material for many downstream products. Its historical evolution has witnessed the progress of chemical technology, and it has also served as the cornerstone of future scientific research, providing far-reaching benefits.
Product Overview
3,5-Difluoronitrobenzene is a key intermediate in organic synthesis. Its color is light yellow and has a pungent odor. At room temperature, it is liquid, with a suitable boiling point, and has good solubility in organic solvents.
The preparation method of this compound is often obtained by halogenation and nitrification of specific aromatic hydrocarbons as the starting material. In the field of organic synthesis, it has a wide range of uses. Due to its unique electronic effect between fluorine atoms and nitro groups, it can participate in many nucleophilic substitution reactions, laying the foundation for the construction of complex organic molecular structures. For example, in the field of medicinal chemistry, it is often used as a starting material to synthesize drug molecules with specific biological activities through series transformation. In materials science, it can also be introduced into polymer systems through chemical reactions to give materials unique properties.
Physical & Chemical Properties
3,5-Difluoronitrobenzene is an organic compound. Its physical properties are colorless to light yellow liquid at room temperature, with a special odor and a high boiling point, about a certain temperature, due to intermolecular forces. Its density is greater than that of water, and it is difficult to dissolve in water, covering the difference between its molecular polarity and water.
In terms of chemical properties, the fluorine and nitro groups on the benzene ring give it active chemical activity. Nitro has strong electron absorption, which reduces the electron cloud density of the benzene ring, which is conducive to nucleophilic substitution reactions. Although fluorine atoms have strong electronegativity, due to the small atomic radius, they have special conjugation with the benzene ring, which also affects the reactivity. In the field of organic synthesis, this compound is often used as a key intermediate. After specific reactions, it can introduce diverse functional groups to construct complex organic molecules, which are of great application value in medicine, pesticide creation, etc.
Technical Specifications & Labeling
Nowadays, there are chemical substances called 3,5-difluoronitrobenzene. The process regulations for its preparation are related to the ratio of materials and reaction conditions. The accurate ratio of materials is essential, and the amount of reactants should be in a specific ratio, otherwise the yield will be affected. In the reaction conditions, temperature, pressure and duration must be strictly controlled. If the temperature is too high or too low, it can cause reaction deviation. The same is true for pressure, and it is difficult to achieve optimum effect if it is not suitable. If the time is too short, the reaction will not be completed; if it is too long, it may cause side reactions.
As for the product's identification (commodity parameters), it is necessary to clarify its purity geometry and impurity content. Appearance properties also need to be noted in detail, such as color, shape, etc. It is also necessary to indicate the storage conditions to ensure its stable quality. This is the key to the 3,5-difluoronitrobenzene process specification and identification (commodity parameters), which is related to the quality of the product and cannot be ignored.
Preparation Method
The raw materials and production process are the key to the preparation of 3,5-difluoronitrobenzene. Take fluoride as the initial material, and put it into a special reactor through delicate proportions. According to specific reaction steps, temperature control and pressure regulation are used to make fluoride interact with nitrogenation reagents. In the meantime, the reaction time is strictly controlled, and it should not be too long or too short.
After the reaction is completed, the product needs to be carefully treated. With suitable separation means, remove its impurities to obtain pure 3,5-difluoronitrobenzene. In this process, the catalytic mechanism cannot be ignored. Selecting a high-efficiency catalyst can promote the reaction speed and improve the product rate. In the reaction, such as piloting the boat, the reaction is carried forward. The 3,5-difluoronitrobenzene prepared in this way has good quality and quantity, and can meet the needs of many chemical industries.
Chemical Reactions & Modifications
The current study of chemistry concerns the product of 3,5-Difluoronitrobenzene. The reaction and change of this product are of great importance to our generation.
Looking at the reaction of this product, it was done by the usual method at the beginning, but the effect was not achieved. All kinds of attempts, either due to the unsuitable conditions, or due to the lack of refinement of the reagent, caused the yield to be quite low, and the quality was not good.
Afterwards, we think about changes and seek novelty. Examine the elements of the reaction carefully, the degree of temperature adjustment, the ratio of the reagent, and the length of the reaction. After many trials, it turned out to be effective. The yield gradually increases, and the quality is also good.
It can be seen that the reaction of transformation is not static. When you think about change, observe its subtlety, and change its discomfort, you can get the good fruit of transformation. The product research in 3,5-Difluoronitrobenzene is also the same.
Synonyms & Product Names
Today there is a product named 3,5-difluoronitrobenzene. In the field of chemical industry, it also has many synonymous names and commodity names. In the course of my chemical research, this product is often referred to by different names in various literatures and classics.
or those named for its characteristics, its synonymous names refer to this specific chemical structure. Its trade name is also well known in the industry. Although the names are different, they all refer to the same. This 3,5-difluoronitrobenzene is an important raw material in the process of organic synthesis, and many reactions rely on its participation to form various useful compounds. We chemical researchers, when familiar with their synonymous names and trade names, can be accurate and correct in research and practice without confusion, so that the research path is smooth and the results can be expected.
Safety & Operational Standards
Specifications for the safety and operation of 3,5-difluoronitrobenzene
For 3,5-difluoronitrobenzene, it is also a chemical research material. Its unique nature is related to the safety and operation standards of the experiment, and must not be ignored.
In the method of storage, choose a cool, dry and well-ventilated place. Keep away from fire and heat sources, so as to avoid the risk of ignition. It must be stored in isolation from oxidizing agents, reducing agents, alkalis, etc., to prevent accidents caused by interaction. In the storage place, suitable materials should be prepared to contain leaks.
As for the operation, the experimenter must wear suitable protective equipment. Wear protective glasses to protect your eyes from splashing; wear protective clothing to prevent the skin from touching it; wear protective gloves to keep your hands safe. The operation room must also be well ventilated to dissipate its volatile gas.
If there is a leak, the first thing to do is to evacuate unrelated people and isolate the scene. Emergency responders need professional protection, do not let leaks come into contact with open flames. Small leaks can be absorbed by inert materials such as sand and vermiculite. If there are large leaks, you need to build a dike or dig a pit to contain them, transfer them to a special container with a pump, and then properly handle them.
During use, strictly follow the established procedures. Weighing is accurate, and errors should not cause inappropriate reactions. The control of reaction conditions, such as temperature, pressure, time, etc., must be adhered to. If the reaction is out of control, take appropriate measures immediately and do not panic.
In short, the safety and operation specifications of 3,5-difluoronitrobenzene must be followed by chemical researchers. Adhering to this specification ensures the smooth operation of the experiment, the safety of personnel, and the safety of the environment.
Application Area
"3,5-Difluoronitrobenzene application field"
Fu 3,5-difluoronitrobenzene is useful in various fields. In the field of medicinal chemistry, it can be a key intermediate. Based on this, it can make special drugs, cure diseases and save people. Its unique structure can cleverly react with other compounds to form pharmacologically active substances.
In materials science, it can also develop its capabilities. Or it can help make materials with special properties, such as high stability and high conductivity. Its participation in material synthesis makes the material have specific properties and is suitable for different scenarios.
In the process of pesticide research and development, 3,5-difluoronitrobenzene is also an important material. It can help create high-efficiency and low-toxicity pesticides, protect farmland crops, increase their yield, and ensure the prosperity of farmers. This is the outline of the application field of 3,5-difluoronitrobenzene.
Research & Development
There is a chemical substance today, named 3,5-difluoronitrobenzene. As a chemical researcher, I have observed this substance and devoted myself to studying its development. This substance has unique properties and is very useful in chemical, pharmaceutical and other fields.
We explore its synthesis method and strive to improve it in order to increase yield and purity. Although the initial method can be obtained, the efficiency is not good and there are many impurities. After repeated tests and improved the process, the new path has been achieved and the results have been remarkable.
Looking at its application, it can be used as a key intermediate in the development of medicine, to help new drugs come out, and to benefit health. In the chemical industry, it can make special materials and add product properties.
I firmly believe that with in-depth research, the potential of 3,5-difluoronitrobenzene will be fully revealed in the world, promoting all industries, and shining on the path of chemistry for the fruits of our efforts.
Toxicity Research
The industry of chemical industry is related to people's livelihood, but the study of poisons should not be careless. In this sentence, 3,5-difluoronitrobenzene is particularly important to investigate its toxicity.
3,5-difluoronitrobenzene has certain toxicity. During experimental research, observe its interaction with organisms. If you accidentally touch it, or enter the body through the skin, or absorb it through the respiratory tract, it can cause harm to the body. Looking at its impact on cells, it can damage the structure and function of cells and interfere with normal metabolism. And long-term exposure to this environment, or organ diseases, such as liver and kidney damage. Therefore, when studying the toxicity of this substance, it is necessary to exercise it rigorously, protect it well, record its situation in detail, and clarify its harm, so as to provide evidence for the safety of the chemical industry and the health of the people, so as to avoid disasters before they start.
Future Prospects
Wuguanfu 3,5 - Difluoronitrobenzene This product is gradually becoming more and more important in today's chemical fields. Although today's production may have advanced methods, it is still full of expectations for future development.
It is expected that it will be able to contribute to the creation of new agents in the road of medicine. With its unique nature, it can be used as the basis for delicate pharmacological structures, help treat all kinds of chronic diseases, and save people's suffering.
In the world of materials, it is also expected to emerge. Or it is the beginning of new materials, the strength of additive materials, and the nature of good materials, making it excellent in all uses.
Furthermore, its synthesis method may be greatly improved in the future. Simpler process, higher production, and environmentally friendly, reducing its harm to the environment. In this way, the future of 3,5-Difluoronitrobenzene will surely be shining and have unlimited possibilities.
Where to Buy 3,5-Difluoronitrobenzene in China?
As a trusted 3,5-Difluoronitrobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 3,5-Difluoronitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3,5-difluoronitrobenzene?
3,2,5-diethoxycarbonyl indole is a crucial compound in the field of organic synthesis. It has a wide range of main uses and plays a key role in many aspects.
First, in the field of pharmaceutical chemistry, this compound is often a key intermediate. Due to its unique chemical structure, it can be modified by a series of chemical reactions to construct molecules with specific biological activities. In many drug development projects, with the help of 3,2,5-diethoxycarbonyl indole as the starting material, potential drug molecules targeting specific disease targets can be synthesized. For example, in the synthesis path of some anti-cancer drugs, based on this, other functional groups are introduced through clever reaction steps to obtain the final product with targeted anti-cancer activity.
Second, in the field of materials science, 3,2,5-diethoxycarbonyl indole also shows unique value. Due to its structural properties, it can participate in the preparation of organic materials with special properties. For example, it can be combined with other monomers through polymerization to prepare polymer materials with specific optical and electrical properties. Such materials may be applied to photoelectric displays, sensors and other fields, providing new material options for the development of related technologies.
Third, in the field of total synthesis of natural products, 3,2,5-diethoxycarbonyl indole is often an important synthetic block. Many complex natural products contain indole-like structural units. With 3,2,5-diethoxycarbonyl indole as the starting point, chemists can gradually construct the same complex structure as natural products with exquisite synthesis strategies, which can help in-depth research on natural products, such as exploring their biological activities and mechanisms of action.
In summary, 3,2,5-diethoxycarbonyl indole plays an important role in the total synthesis of drugs, materials, and natural products due to its unique chemical structure, promoting continuous development and innovation in various fields.
What are the physical properties of 3,5-difluoronitrobenzene?
3,5-Diallyl benzoic acid is a kind of organic compound. Its physical properties are as follows:
Looking at its shape, under normal circumstances, it is mostly white to light yellow crystalline powder, like fine snow broken jade, with a fine texture. Smell its taste, it has a slightly specific fragrance, but it is not a rich and pungent taste, but a relatively light and characteristic smell.
When it comes to the melting point, it is about a specific temperature range. This melting point characteristic is crucial in the identification and purification of the substance. It is like a precise ruler to measure the purity and properties of the substance. When the temperature rises near the melting point, the substance disappears like ice in the warm sun, and gradually melts from the solid state to the liquid state, showing the wonderful transformation of the material state.
In terms of solubility, in organic solvents, such as ethanol and acetone, it has a certain solubility. Just like fish entering water, it can blend with organic solvents to form a uniform system. However, in water, its solubility is not good, just like the intolerance of oil and water, and this characteristic also determines its dispersion and application in different environments.
Furthermore, its density is also a specific value, which reflects the mass of a substance per unit volume. Like a label for measuring the weight and density of an object, it provides an important reference for its application in various practical application scenarios, such as mixing, separation, etc., so that its application in the chemical industry, materials and other fields can be more accurately controlled.
What are the synthesis methods of 3,5-difluoronitrobenzene?
There are several common methods for the synthesis of 3,5-diethoxybenzyl alcohol:
One is to use p-hydroxybenzaldehyde as the starting material. First, it is synthesized by Williamson ether with halogenated ethane under alkaline conditions. In this reaction, potassium carbonate can be selected as the base, and halogenated ethane such as bromoethane is appropriate. The alkaline environment promotes the formation of phenolic hydroxyl oxygen anions of p-hydroxybenzaldehyde, which in turn undergoes a nucleophilic substitution reaction with halogenated ethane to generate p-ethoxybenzaldehyde. Subsequently, after the reduction reaction of p-ethoxybenzaldehyde, the aldehyde group can be reduced to an alcoholic hydroxyl group in a suitable solvent such as methanol, and 3,5-diethoxybenzyl alcohol can be obtained. The reaction process is clear, the reaction conditions of each step are relatively mild, and the yield is relatively considerable.
The second is resorcinol as the starting material. The resorcinol first reacts with haloethane under alkali catalysis, similar to Williamson ether synthesis, so that the two hydroxyl groups of resorcinol are replaced by ethoxy groups to generate 3,5-diethoxy phenol. Next, 3,5-diethoxy phenol and halogenated methyl reagents, such as chloromethyl methyl ether, etc., under the catalysis of Lewis acid such as anhydrous zinc chloride, a Friedel-Crafts hydrocarbon reaction occurs, and chloromethyl is introduced into the phenyl ring. Finally, through the reduction step, the target product 3,5-diethoxy benzyl alcohol can be obtained by reducing with strong reducing agents such as lithium aluminum hydride. This route has a little more steps, but the raw material resorcinol is more common and inexpensive.
Furthermore, the corresponding benzoate can be used. First, benzoate is reduced to the corresponding benzyl alcohol by reduction reaction, such as lithium aluminum hydride, and then the benzyl alcohol is etherified with halogenated ethane under basic conditions. The same principle of Williamson ether synthesis can be followed to synthesize 3,5-diethoxy benzyl alcohol. This method requires attention to the control of the reaction conditions of the reduction and etherification steps to ensure the purity and yield of the product.
What are the precautions for storing and transporting 3,5-difluoronitrobenzene?
When storing and transporting 3,5-diethylbenzamide, many precautions should be followed carefully.
In terms of storage, the first environment should be selected. It should be placed in a cool, dry and well-ventilated place to prevent moisture and sun. Because the substance is quite sensitive to temperature and humidity, high temperature or high humidity environment can easily cause its properties to change, and even affect the quality. The warehouse temperature should be controlled in a specific range, and the humidity should also be maintained at an appropriate level. At the same time, it should be stored separately from oxidants, acids, alkalis, etc., and must not be mixed. This is because its chemical properties are active, and contact with the above substances can easily cause chemical reactions, or cause serious accidents such as fire and explosion.
The choice of storage container is also crucial. Be sure to use a well-sealed container to prevent the intrusion of external factors such as air and moisture. For commonly used metal or plastic drums, it is necessary to ensure that the material does not react with 3,5-diethylbenzamide, and there is no risk of damage or leakage. During storage, the condition of the container should be inspected regularly. If the container shows signs of corrosion, deformation or leakage, immediate measures must be taken, such as transferring materials, repairing or replacing the container.
When it comes to transportation, the qualifications and conditions of the transportation vehicle must be in compliance. Vehicles should be equipped with corresponding fire equipment and leakage emergency treatment equipment for emergencies. During transportation, ensure that the container is stable and will not be damaged due to bumps and collisions. Route planning should not be ignored, and densely populated areas and environmentally sensitive areas should be avoided to prevent transportation accidents from causing harm to the people and the environment.
Transportation personnel also need professional training to be familiar with the dangerous characteristics and emergency treatment methods of 3,5-diethylbenzamide. When loading and unloading, it should be handled lightly, and it is strictly forbidden to drop and heavy pressure to avoid leakage due to improper operation. If leakage occurs during transportation, the surrounding people should be evacuated immediately, the warning area should be demarcated, and the corresponding leakage plugging and cleaning measures should be taken quickly to prevent the spread of pollution.
What is the market price range for 3,5-difluoronitrobenzene?
It is difficult to determine the price of 3,5-diethoxybenzaldehyde in the market. The price of the cover often changes for various reasons.
First, the situation of supply and demand is the key. If there are many people who want it, but the supply is small, the price will rise; if there are few people who want it, and there are many suppliers, the price will be depressed.
Second, the price of raw materials for making this product also has an impact. If the price of raw materials increases, the cost will increase, and the market price will also increase; if the price of raw materials decreases, the cost will decrease, and the price may decrease.
Third, the coarseness of the process and the yield are related to the cost and pricing. Make good use of smart skills, increase its yield, reduce its cost, and the price may be competitive.
Fourth, the regulations of the business market and the tax system are also related to the price. Where the tax is large and light, the price may be more appropriate; where the regulations are small and the tax is heavy, the price may be slightly higher.
In today's city, the price is roughly several hundred yuan per kilogram. However, this is only an approximate amount, and the exact price depends on the real-time business conditions, the quality and the volume of transactions. If a buyer wants to get a definite price, he should consult various suppliers and compare the price in detail before he can get a good price.