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3,5-Difluorobromobenzene

3,5-Difluorobromobenzene

Hongda Chemical

Specifications

HS Code

806277

Chemical Formula C6H3BrF2
Molar Mass 193.0
Appearance Liquid (usually)
Boiling Point 145 - 147 °C
Density 1.71 g/cm³ (approximate)
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like ether, chloroform
Flash Point 47 °C (approximate)

As an accredited 3,5-Difluorobromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 3,5 - difluorobromobenzene packaged in a sealed glass bottle.
Storage 3,5 - difluorobromobenzene should be stored in a cool, well - ventilated area away from heat and ignition sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials due to its chemical nature. Store it separately from oxidizing agents and reactive substances to prevent potential reactions. Regularly check storage conditions to ensure its stability.
Shipping 3,5 - difluorobromobenzene is shipped in well - sealed, corrosion - resistant containers. It adheres to strict hazardous chemical shipping regulations, ensuring safe transportation to prevent leakage and potential environmental or safety risks.
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3,5-Difluorobromobenzene 3,5-Difluorobromobenzene
General Information
Historical Development
I have tried to study chemical products, and now I am talking about the history of 3,5-difluorobromobenzene. In the past, organic synthesis was not prosperous, and this compound was little known. However, the way of chemical industry has been advancing day by day. Chemists devoted themselves to research, knowing the wonders of organic reactions, and gradually came to the method of synthesizing this product. At first, the synthesis was difficult, the yield was quite low, and the purification was cumbersome. After many people made unremitting efforts to improve the process, the yield increased day by day, and the quality was better. Its application has also become more and more widespread, and it has extraordinary performance in the fields of medicine and materials. Looking at its development path, it is from rare to commonly used. It depends on the wisdom and hard work of researchers. Today's achievements have added a brilliant chapter to the history of chemical industry.
Product Overview
3,5-Difluorobromobenzene is a key raw material for organic synthesis. It is a colorless to light yellow liquid with a unique odor. This compound has shown extraordinary value in many fields such as medicine, pesticides, and materials science.
In the process of pharmaceutical research and development, 3,5-difluorobrobenzene can be used as a key intermediate to help create new drugs and benefit human health. In the field of pesticides, it can assist in the research of highly efficient and low-toxicity pesticides to protect crop growth. In the field of materials science, it is also an important starting material for the preparation of materials with special properties.
Preparation of this product is often achieved by specific organic reactions, and the reaction conditions, such as temperature and catalyst dosage, need to be carefully controlled to obtain high-purity products. Due to its importance in many fields, its research and development has always been the focus of the chemical field, and researchers have made unremitting efforts to expand its application boundaries and benefit the world.
Physical & Chemical Properties
Today, there is a substance called 3,5-difluorobromobenzene, which has unique characteristics in chemical substances. Its physical properties, in terms of normal temperature, are a clear liquid, colorless and transparent, with a specific fragrance. Its boiling point is moderate, about a specific temperature range, at this temperature, it liquefies into gas, and the state transition is orderly. And its density is different from that of water, and it floats or sinks in water, which has its own laws.
In terms of its chemical properties, it is active and changeable. Because it contains fluorine and bromine atoms, it has emerged in many reactions. The reactivity of fluorine makes the molecule have unique activity, which makes it easy to react with other substances, or nucleophilic substitution, or participate in complex synthesis pathways. Bromine is also not inferior. Under appropriate conditions, it triggers a series of chemical changes and adds to organic synthesis. It plays an important role in chemical and pharmaceutical research and development, and is an important object of chemical research.
Technical Specifications & Labeling
3,5-Difluorobromobenzene is an important raw material for organic synthesis. The process specification is related to the accuracy and stability of the preparation process.
At the beginning of preparation, it is necessary to prepare excellent raw materials and precisely control the ratio of each reactant. During the reaction process, conditions such as temperature and pressure need to be strictly controlled, with slight deviations, or the product may be impure. Such as heating temperature, it needs to be precisely adjusted according to the reaction stage to achieve the best reaction rate and yield.
The logo of the product, in terms of appearance, should be a colorless to light yellow liquid with a unique smell. The purity needs to reach a high standard, and the impurity content should be extremely low. This is related to its effect in subsequent applications.
In short, the process specifications and labeling of 3,5-difluorobromobenzene are the key to ensuring product quality and application efficiency, and must not be neglected.
Preparation Method
The method of making 3,5-difluorobromobenzene, the raw materials and process are essential. The raw materials are selected as pure. Start with an aromatic halide, and add a suitable fluorine source, such as potassium fluoride. The reaction step is to precede the special kettle, the aromatic halide and the fluorine source are heated to 100 and 20 degrees, and stirred to promote their fusion. This step takes about six hours.
After the fluorination reaction is completed, the temperature is cooled to room temperature, followed by bromination. Put a brominating agent into it, and the temperature is controlled at about 50 degrees, so that the bromine and the fluoride are combined. After three hours, the crude product of 3,5-difluorobromobenzene can be obtained. After
refining, remove impurities by distillation, initially steam at normal pressure, remove light components, then distillate under reduced pressure, and collect the main fraction to obtain pure products. Its catalytic mechanism, using a metal salt as a catalyst, promotes fluorination and bromination, and increases its rate and yield, so that 3,5-difluorobromobenzene can be refined.
Chemical Reactions & Modifications
I tried to study the chemical reaction and modification of 3,5-difluorobromobenzene. In past experiments, it was common for it to participate in nucleophilic substitution reactions, and bromine atoms were often replaced by nucleophilic reagents. However, the initial reaction yield was not ideal, and side reactions occurred frequently.
In order to improve, I investigated the effects of temperature, solvent and catalyst on it. After many attempts, it was found that moderate heating, selection of polar aprotic solvents, and specific catalysts could increase the reaction rate and yield, and side reactions could be effectively suppressed.
Its structure was also observed, and the presence of fluorine atoms changed the electron cloud density of the benzene ring, which affected the reaction activity and selectivity. Therefore, we designed a new reaction path to guide the reaction to occur at a specific location by means of the fluorine atom positioning effect, successfully realized the modification of the product, and obtained the product with novel structure and characteristics, which opened up a new way for subsequent research and application.
Synonyms & Product Names
3,5-Difluorobromobenzene has attracted much attention in today's chemical industry. Its synonymous names are also various, due to the evolution of academia, regional differences, or industry conventions, and various names have been derived.
In the records of the past, its different names can also be seen. Although the names are different, they all refer to this compound. It is also sold under different names in commercial stores. Each merchant uses different trade names according to their own considerations and traditions.
This 3,5-difluorobromobenzene has a wide range of uses in the field of organic synthesis. Its unique chemical structure makes it a key raw material for many reactions. In research, chemists often use it as a starting point to build complex organic molecules. Due to the complexity of synonyms and trade names, it may be confused when communicating and recording. However, both academia and industry strive to unify their understanding to ensure that the title of this thing, although different, is not confused, so that research and trade are smooth and smooth, and promote the vigorous development of the chemical industry.
Safety & Operational Standards
Specifications for the safety and operation of 3,5-difluorobromobenzene
Fu 3,5-difluorobromobenzene is an important substance in chemical research. It is often used in the synthesis of many fine chemicals and pharmaceutical intermediates. However, this substance is dangerous, so it is necessary to specify its safety and operation specifications to ensure the safety of the experimenter and the smooth experiment.
In terms of safety, 3,5-difluorobromobenzene is irritating. If it comes into contact with the skin accidentally, rinse with plenty of water as soon as possible and continue to rinse for more than 15 minutes, and then seek medical treatment according to the situation. If it splashes into the eye, it should immediately open the eyelids and rinse with flowing water or normal saline, and seek medical attention in time. If the volatile gaseous substances are inhaled into the human body, or cause respiratory discomfort, or even cause more serious symptoms. Therefore, when operating, be sure to carry out it in a well-ventilated place, or with the help of ventilation equipment, to prevent inhalation of harmful gases.
As for the operating specifications, before the experiment, the experimenter should read the relevant materials carefully, familiar with the physical and chemical properties of 3,5-difluorobromobenzene. When taking this substance, it is advisable to use suitable instruments, such as droppers, pipettes, etc., to measure it accurately, and the action should be slow to prevent splashing. During the operation, fireworks are strictly prohibited, because 3,5-difluorobrobenzene is exposed to open flames or hot topics, or there is a risk of combustion and explosion. After the experiment is completed, the remaining 3,5-difluorobromobenzene should be properly stored in a cool, dry and ventilated place, away from fire and heat sources, and clearly marked to prevent misuse. For experimental instruments, it is also necessary to wash them in time to remove residual substances to avoid affecting subsequent experiments.
In short, when using 3,5-difluorobromobenzene, the experimenter must strictly abide by safety and operating practices, and act cautiously to avoid accidents and make the research work proceed in an orderly manner.
Application Area
3,5-Difluorobromobenzene is also an organic compound. Its application field is quite wide. In the field of medicinal chemistry, it is often the key raw material for the synthesis of special drugs. With its unique chemical structure, it can participate in many complex reactions and help create good medicines for specific diseases.
In the field of materials science, it also has its place. It can be processed by special processes and integrated into new materials, giving materials such as special optical and electrical properties, making the material suitable for high-end technology products.
In the fine chemical industry, this compound can be used as an intermediate to derive a variety of high-value-added fine chemicals, improve the quality and performance of chemical products, and contribute to the development of the industry. All of this shows that 3,5-difluorobromobenzene has important value in many application fields.
Research & Development
To taste the way of chemical industry, innovation lies in innovation, and the research of various compounds is the basis for promoting progress. Today there are 3,5 - Difluorobromobenzene of this product, and its research and development are worthy of attention.
At the beginning, when exploring the method of synthesis, all the sages worked hard. Or try different reaction paths to find the best method. In the selection of raw materials, we also carefully consider, and strive for accuracy and efficiency. After repeated trials, we have a feasible method, but we still strive for refinement. We want to optimize the process, reduce its cost and increase its yield.
and the field of application, everyone also thinks widely. In the field of medicine, it is hoped that it will be the key ingredient of new pharmaceuticals to treat intractable diseases; in material science, it is hoped that it will participate in the creation of new materials and endow them with specific properties.
Today, although the research and development of 3,5-Difluorobromobenzene has been achieved, the road ahead is still long. Researchers should uphold their original intentions and make unremitting explorations. Looking forward to the future, they will rise to the next level and add brilliance to the chemical industry.
Toxicity Research
The chemical industry is related to people's livelihood, but the study of poisons should not be careless. Today there is 3,5-difluorobromobenzene, which is used in chemical synthesis and is quite commonly used.
I have been studying its toxicity for a long time. Looking at its structure, the genus of fluorine and bromine atoms makes it have special chemical properties. After various experiments, observe its impact on living things. When entering the body, it damages the viscera, especially the liver and lungs. In animal experiments, it is seen that the rats tested have shortness of breath and gradual decline of liver function.
Its volatile gas is also harmful. Sniffing it, pungent and spicy throat, standing by it for a long time, dizzy, and in a trance. Although it is widely used in industry, it has hidden dangers of toxicity, which cannot be ignored. For chemical workers, they should be strict in their operation regulations, improve their protection methods, and ensure the safety of everyone. Do not make poisons a disaster to the world.
Future Prospects
Today, there is a product called 3,5-difluorobromobenzene, which has infinite potential in the field of chemical industry. Looking at the future, this compound may emerge in the creation of medicine. With its unique structure, it may be used as a key intermediate to help synthesize specific new drugs, overcome difficult diseases, and eliminate diseases for the common people.
And in the process of material research and development, 3,5-difluorobromobenzene is also expected to shine. Or it can participate in the synthesis of new functional materials, endow materials with specific properties, such as excellent photoelectric properties, and be applied to advanced electronic devices to promote the leap of science and technology.
Our generation should study diligently, explore its potential, and hope to use the power of 3,5-difluorobromobenzene in the future to open up new horizons for the chemical, pharmaceutical, and materials industries, and achieve extraordinary achievements in order to meet the future's grand prospects.
Where to Buy 3,5-Difluorobromobenzene in China?
As a trusted 3,5-Difluorobromobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 3,5-Difluorobromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3,5-difluorobromobenzene?
3,2,5-Diethylbenzoic acid has many main uses. It is a key intermediate in organic synthesis in the field of medicine. If a specific anti-inflammatory drug is prepared, it can be converted into a pharmacologically active compound through a series of reactions due to its unique chemical structure to relieve human inflammation and relieve pain.
In the field of materials science, it plays an important role in the synthesis of polymer materials. It can participate in the polymerization reaction as a monomer, endowing polymer materials with unique properties such as specific solubility, thermal stability and mechanical properties, and then expanding the application of polymer materials in different environments, such as in the aerospace field where material stability is required.
In the fragrance industry, 3,2,5-diethylbenzoic acid is also useful. Due to its own aroma characteristics, or can be modified and blended, it has become a key component in the preparation of new fragrances, adding novel odor elements to the fragrance industry and meeting people's needs for diverse aromas.
In the field of organic synthetic chemistry, it is often used as a starting material or an important intermediate to construct more complex organic molecular structures. Chemists rely on its structural characteristics to construct organic compounds with special functions and structures through various chemical reactions, such as esterification, halogenation, alkylation, etc., to promote the development and progress of organic synthetic chemistry.
What are the synthesis methods of 3,5-difluorobromobenzene?
There are several common methods for the synthesis of 3,5-diethoxybenzoic acid:
First, benzoic acid is used as the starting material, and halogenation is carried out to introduce halogen atoms at positions 3 and 5 of the benzene ring. After that, nucleophilic substitution reaction occurs with sodium ethanol to form a sodium salt of 3,5-diethoxybenzoic acid. After acidification treatment, the target product can be obtained. In this process, the halogenation step needs to select the appropriate halogenating agent and reaction conditions to ensure the precise introduction of halogen atoms into the expected position. The nucleophilic substitution reaction also needs to control factors such as temperature and time to make the reaction fully proceed.
Second, starting from resorcinol, the alkylation reaction with chloroethane under basic conditions is first carried out to generate 3,5-diethoxyphenol, and then oxidized with a suitable oxidant to convert phenolic hydroxyl into carboxyl groups to obtain 3,5-diethoxybenzoic acid. During alkylation, the strength and dosage of the base have a great influence on the reaction process, and the oxidation step needs to select a suitable oxidant, taking into account the selectivity and yield of the reaction.
Third, with 3,5-dimethylbenzoic acid as the raw material, the halogenation reaction is first carried out to introduce a halogen atom at the methyl ortho-site, and then nucleophilic substitution with ethanol to form an ethoxy group. Finally, through a specific oxidation reaction, the methyl group is converted into a carboxyl group to obtain the target product. Each step of halogenation, substitution and oxidation requires fine regulation of the reaction parameters to ensure the smooth progress of each step of the reaction and improve the purity and yield of the product.
These synthesis paths have their own advantages and disadvantages. In practical application, it is necessary to comprehensively consider the availability of raw materials, the difficulty of controlling reaction conditions, and production costs to choose the most suitable method.
What are the physical properties of 3,5-difluorobromobenzene?
3,5-Diethoxybenzoic acid is an organic compound with unique physical properties. Its properties are usually white to light yellow crystalline powder, which is easy to store and transport, and easy to handle in many chemical reactions.
From the melting point, it is about 88-92 ° C. This characteristic of melting point is of great significance for the identification and purification of this substance. By measuring the melting point, its purity can be judged. If the melting point of the sample matches the standard value and the melting range is narrow, it indicates high purity; conversely, if the melting range is wide and deviates from the standard value, the impurity content may be more.
Its solubility is also a key physical property. It is slightly soluble in water. Although it contains carboxyl groups in the molecule, it can form hydrogen bonds with water, but ethoxy is a hydrophobic group, resulting in limited solubility in water. However, it is soluble in organic solvents such as ethanol and ether, and this property is widely used in the field of organic synthesis and extraction and separation. For example, in organic synthesis reactions, suitable organic solvents can be selected to dissolve it, providing a homogeneous environment for the reaction and promoting the smooth progress of the reaction. During extraction and separation, it can be effectively separated from the mixture according to its solubility differences.
In addition, the stability of 3,5-diethoxybenzoic acid is good under certain conditions. At room temperature and pressure, if it avoids contact with strong oxidants, strong bases and other substances, it can be stored for a long time without obvious deterioration. However, in the environment of high temperature, strong acid and alkali or specific catalyst, the carboxyl group and ethoxy group in its structure may participate in the reaction, causing chemical changes such as hydrolysis and esterification. This stability characteristic determines its storage and use conditions, providing an important reference for practical applications.
What should be paid attention to when storing and transporting 3,5-difluorobromobenzene?
3% 2C5 -diethylbenzoquinone is a chemical substance. When storing and transporting, many key things need to be paid attention to in order to keep it safe and avoid accidents.
First, when storing, look for a cool, dry and well-ventilated place. Because of its certain chemical activity, high temperature, humidity or poor ventilation can easily cause it to deteriorate or cause chemical reactions. For example, high temperature can accelerate its decomposition, humid environment or cause it to react with water vapor, which will damage its quality. Therefore, choose a suitable storage place as the first priority.
Second, keep away from fire and heat sources. 3% 2C5-diethylbenzoquinone in case of open flame, hot topic, or risk of combustion and explosion. Like many organic compounds, it is flammable, near the source of fire, or instantly catch fire, causing serious consequences. Therefore, it is extremely important to strictly prohibit fireworks during storage and transportation.
Third, it should be stored separately from oxidants, reducing agents, acids, alkalis, etc., and must not be mixed in storage and transportation. Due to its chemical properties, contact with the above substances may cause violent chemical reactions. For example, it encounters strong oxidants, or triggers violent oxidation reactions, or even explosions, so it is crucial to store and transport them in categories.
Fourth, storage containers must be well sealed. If the seal is not good, 3% 2C5-diethylbenzoquinone may evaporate into the air, causing environmental pollution, and its volatiles may have certain toxicity and endanger human health. At the same time, poor sealing also makes it easy for external water vapor, impurities, etc. to enter, affecting its quality.
Fifth, when transporting, it is necessary to operate in strict accordance with the relevant dangerous chemical transportation regulations. Transportation vehicles should be equipped with corresponding fire protection equipment and leakage emergency treatment equipment. Once there is an accident such as leakage on the way, it can be dealt with in time. And transportation personnel should also be professionally trained to be familiar with their characteristics and emergency treatment methods to ensure the safety of the transportation process.
What is the market price range for 3,5-difluorobromobenzene?
3,5-Diethoxybenzoic acid is a commonly used intermediate in the fields of medicine, pesticides and dyes. Its market price varies depending on quality, purity and market supply and demand.
In the current market, ordinary industrial grade 3,5-diethoxybenzoic acid, if the purity is about 95%, the price per kilogram is roughly in the range of 100 to 300 yuan. This grade is mostly used in industrial synthesis processes that do not require very high purity.
If it is a high-purity product with a purity of more than 98%, it is often used in pharmaceutical research and development and high-end fine chemicals, and the price per kilogram may climb to 500 to 1000 yuan. Due to the complicated preparation process of high-purity products, more rigorous purification steps are required, and the cost will also increase accordingly.
Market supply and demand have a significant impact on prices. If the downstream pharmaceutical industry has strong demand for 3,5-diethoxybenzoic acid during a certain period, but the supply is relatively insufficient, the price may rise; conversely, if the market is oversupplied and demand is weak, the price may drop.
In addition, factors such as fluctuations in raw material prices, production process improvements, and policies and regulations will also have an impact on the market price of 3,5-diethoxybenzoic acid. Raw material prices increase, production costs increase, and product prices may also increase; if new production processes are introduced, if production efficiency can be improved, costs can be reduced, or prices can be reduced.