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3,5-Difluorobenzenethiol

3,5-Difluorobenzenethiol

Hongda Chemical

    Specifications

    HS Code

    996648

    Chemical Formula C6H4F2S
    Molecular Weight 146.16
    Appearance Colorless to light yellow liquid
    Boiling Point 180 - 182 °C
    Melting Point N/A
    Density 1.31 g/cm³
    Flash Point 64 °C
    Solubility In Water Insoluble
    Vapor Pressure N/A
    Odor Pungent sulfur - like odor

    As an accredited 3,5-Difluorobenzenethiol factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 3,5 - difluorobenzenethiol packaged in a sealed, corrosion - resistant bottle.
    Storage 3,5 - difluorobenzenethiol should be stored in a cool, dry, well - ventilated area away from heat sources and ignition sources. It should be kept in a tightly sealed container, preferably made of a material resistant to corrosion by this chemical. Store it separately from oxidizing agents and incompatible substances to prevent potential reactions.
    Shipping 3,5 - difluorobenzenethiol is a chemical. It should be shipped in accordance with hazardous material regulations. Packed in well - sealed containers, transported by carriers authorized for such chemicals, ensuring proper handling to prevent spills and exposure.
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    3,5-Difluorobenzenethiol 3,5-Difluorobenzenethiol
    General Information
    Historical Development
    The technology of chemical industry is changing with each passing day, and the research of substances is gradually becoming more and more subtle. Today there are 3,5 - Difluorobenzenethiol of this material, which originated from the research of various scholars. At the beginning, scholars explored in the complex chemical system, wanting to obtain unique compounds. After years of study, with various techniques, reconciling the elements, and gradually the embryonic form of this substance.
    At the beginning, it was only a rare product in the laboratory, and few people knew it. Later, because of its characteristics, it emerged in the fields of medicine and materials, so it was gathered by the eyes of the public. The researchers worked tirelessly to improve the production method, improve the purity, and make its output gradually increase and its application gradually wider. The rarity of the past has now become a commonly used thing in the chemical industry. Its historical evolution is like a pearl gradually shining, leaving a profound impression on the path of chemistry, paving the way for future generations to research new things and explore new frontiers.
    Product Overview
    3,5-Difluorothiophenol is a key raw material for organic synthesis. It is active and has unique effects in many chemical reactions. Looking at its shape, it is a colorless to light yellow liquid at room temperature, and it has a special smell.
    This compound contains difluorophenyl and thiol groups, and its unique structure gives it excellent chemical properties. With the substitution of difluoride, the distribution of electron clouds changes, resulting in different reactivity and selectivity from normal substances. The existence of thiol groups allows it to participate in various reactions such as thioetherization and oxidation.
    In the field of pharmaceutical synthesis, 3,5-difluorothiophenol is often used as an intermediate to help develop new specific drugs. In the field of materials science, it is also an important starting material for the preparation of special functional materials. Due to its unique structure and properties, 3,5-difluorothiophenol occupies an important place in the cutting-edge research of chemical industry, and has broad application prospects in the future.
    Physical & Chemical Properties
    3,5-Difluorothiophenol is an organic compound. Its physical and chemical properties are quite specific. Looking at its physical properties, at room temperature, it is mostly liquid and has a special smell. This smell may be irritating because of sulfur. Its boiling point and melting point are fixed. The boiling point is related to the temperature of gasification, and the melting point is the critical point of solidification. In terms of chemical properties, thiophenol groups are highly active and easily react with other substances. In case of oxidants, oxidation reactions can occur, causing structural changes. And the fluorine atoms on the benzene ring also affect its chemical activity. Due to the high electronegativity of fluorine, the electron cloud density of the benzene ring changes, and it exhibits unique reactivity and selectivity in electrophilic substitution reactions. This compound is widely used in the field of organic synthesis and is also an important intermediate for the preparation of special structural organic materials.
    Technical Specifications & Labeling
    There are 3,5 - Difluorobenzenethiol products today, and their process specifications and identification (product parameters) are the key. The process specification is the method of making this product, from the selection of raw materials, the accuracy of the ratio, to the reaction conditions, such as temperature, pressure, time, etc., must be in accordance with the regulations. The reaction equipment should also be well-made to ensure the smooth process.
    In terms of identification, the product parameters should be detailed. Its purity geometry, impurity content, should be clearly marked. The appearance of the state, the smell of the state, also can not be ignored. This is the key to recognizing this thing, related to its application in various fields. Only the process fit and the identification of accurate, can get high-quality 3,5 - Difluorobenzenethiol, to meet the needs of all parties.
    Preparation Method
    This product is made of 3,5-Difluorobenzenethiol, and the first raw material is selected. When fluorobenzene is used as the base, supplemented by a sulfur source, such as sodium hydrosulfide. The preparation process follows in sequence. First halogenate fluorobenzene to obtain halogenated fluorobenzene. This step requires temperature control and reaction time to ensure the accurate halogenation site.
    Then react with the sulfur source. This reaction is carried out in an appropriate solvent, such as an alcohol solvent, by heating to promote its reaction. The reaction process must be monitored frequently, and chromatography can be used. To increase the purity of the product, a purification mechanism should be set up. After the reaction is completed, the impurities are removed by distillation, extraction and other methods to keep the purity. The final result is 3,5 - Difluorobenzenethiol, which is of good quality and ready for subsequent use.
    Chemical Reactions & Modifications
    To taste the wonders of chemical industry, it is related to the change of substances, and it should be combined with the technology of transformation. It is the key to explore. The chemical reaction and properties of 3,5-Difluorobenzenethiol are worth investigating.
    If you want to make 3,5-Difluorobenzenethiol, or you can introduce thio groups by nucleophilic substitution of the corresponding halogenated aromatics. However, this reaction is often subject to the structure of the substrate and the activity of the reagents. The activity of halogen atoms in halogenated aromatics affects the difficulty of attacking nucleophilic reagents. If there are strong electron-absorbing groups in the ortho or para-position of the halogen atom, the reaction is easy; otherwise, it is difficult.
    Furthermore, its properties can also be investigated. The fluorine-containing group gives the molecule unique physical and chemical properties. The fluorine atom has strong electronegativity, which affects the polarity and boiling point of the molecule. The existence of thiol groups gives it special reactivity, easy oxidation, and can form disulfide bonds. This property is used in organic synthesis or is the key to building complex structures.
    We should carefully consider its reaction conditions, optimize the path, and clarify the rules of its property changes. In order to make good use of this substance in the field of chemical industry, it will open up a new path for the research and development of new materials and drug creation.
    Synonyms & Product Names
    3,5-Difluorothiophenol is also a chemical. It is the same as the product name, and it is also the main point of our research. This chemical, its characteristics, and its uses. In the process of synthesis, it is often an important raw material. Due to its characteristics, it can be used to create multiple and reverse effects, and other useful things can be obtained.
    and the same name, or the same name, all refer to this thing. Trade names are used in the market circulation to identify its products. However, they are not the same or the trade name, and they all refer to this 3,5-difluorothiophenol. We study to clarify the similarity of its names, due to different names, or in different contexts, such as research, industrial and industrial production, market sales, etc. And each name has a back, or hides different reasons and histories, which are all studied by our chemical researchers.
    Safety & Operational Standards
    3.5-Difluorothiophenol is an important substance in chemical research, and its safety and operation standards are of paramount importance.
    At the beginning of preparation, all raw materials and reagents used should be carefully checked to ensure purity and qualified quality. The instruments used must be clean and dry to prevent impurities from mixing. And the connections of each instrument must be tight to prevent air leakage and other conditions.
    During operation, the experimenter should be fully armed, wearing protective clothing, protective gloves and goggles, which is a necessary measure to protect his own safety. Because 3,5-difluorothiophenol may be corrosive and irritating, if accidentally touched, it may damage the skin and eyes.
    During the reaction process, temperature, pressure, reaction time and other factors must be strictly controlled. Accurately follow the established reaction conditions and must not be changed without authorization. Close observation of reaction phenomena, such as temperature changes, color changes, gas escape, etc. If there is any abnormality, immediately suspend the operation to find out the cause.
    The separation and purification of the product should not be underestimated. Appropriate methods such as distillation, extraction, recrystallization, etc. should be used, and the operation process should be cautious to prevent product loss or the introduction of new impurities.
    When storing, 3,5-difluorothiophenol should be placed in a cool, dry and well-ventilated place, away from fire sources and oxidants. Contain in a sealed container to avoid deterioration due to contact with air and moisture.
    In addition, the experimental site should be equipped with complete safety facilities, such as fire extinguishers, eye washers, emergency sprinklers, etc. The experimenter should also be familiar with the use of various safety equipment to prevent accidents.
    Only by strictly observing safety and operating standards can we ensure the smooth progress of the research and production of 3,5-difluorothiophenol to ensure the safety of personnel and the environment.
    Application Area
    Today there is a product named 3,5-difluorothiophenol. Its application field is quite wide. In the field of pharmaceutical synthesis, it is often used as a key intermediate. Based on it, it can be used to make special drugs, treat various diseases in the world, and relieve the suffering of patients.
    In the field of material science, it is also of extraordinary use. It can add unique properties to new materials, making them tough and durable, suitable for many special places.
    In chemical production, it helps the reaction to proceed smoothly and increases the quality and quantity of the product. Although this substance is small, its function in various fields cannot be underestimated. It is like a star. Although it is small, it can illuminate the world and contribute greatly to the progress of science and technology and the improvement of people's livelihood.
    Research & Development
    In recent years, Yu has dedicated himself to the research and development of 3,5 - Difluorobenzenethiol. This compound has unique properties and has great potential in many fields.
    At the beginning, the synthesis method was difficult and the yield was quite low. However, Yu and colleagues worked tirelessly and tried repeatedly, and finally obtained the optimization method. The new technique significantly improved the yield and better product purity.
    At the same time, the reaction characteristics were investigated in detail, and the changes under different conditions were observed. It is clear that it can react efficiently with a variety of reagents in a specific catalytic system to derive a series of valuable derivatives.
    Looking to the future, we hope to use this as a basis to expand the scope of application. Or used to create new drugs, or to help the progress of materials science. We should uphold the spirit of research and make unremitting efforts to promote the research and development of 3,5-Difluorobenzenethiol to a new level, and contribute to the academic and industry.
    Toxicity Research
    The nature of taste and smell is related to the use and danger. This study 3,5 - Difluorobenzenethiol This substance, the study of its toxicity is very important.
    View its chemical structure, containing fluorine and sulfur base. Fluoride is active and highly electronegative; thiol sulfur is also the active site of the reaction. The two are compatible, or the toxicity is different.
    After various experiments, observe its effect on living things. In cell culture, it can disturb the metabolism of cells and gradually decline the vitality. In animal tests, the behavior is slightly different at the beginning, but over time the organs are damaged, especially the liver and kidneys.
    It can be seen that 3,5 - Difluorobenzenethiol is toxic, and its potential harm to the environment and organisms should not be ignored. The mechanism of its action should be further studied in order to protect and use it.
    Future Prospects
    Wuguanfu 3,5 - Difluorobenzenethiol Although this product is not widely used today, its potential is like a hidden dragon in the abyss, and the future development can be looked forward to.
    In today's world, science and technology are changing, and all kinds of chemicals are seeking unique properties. 3,5 - Difluorobenzenethiol has a unique chemical structure, which makes it useful in materials science, drug research and development and other fields. In materials science, it may help to develop new types of conductive materials and high-performance polymers to meet the needs of lightweight and efficient electronic devices. In drug research and development, its unique chemical activity may be the key to creating new drugs with special effects, for human health and well-being.
    Our chemical researchers should study diligently, with scientific method and rigorous heart, to explore more characteristics and applications of this thing. With time, we will be able to make 3,5-Difluorobenzenethiol shine, and in the future of science and technology, medicine and other fields, develop their talents, and benefit the world. This is our vision for the future.
    Where to Buy 3,5-Difluorobenzenethiol in China?
    As a trusted 3,5-Difluorobenzenethiol manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3,5-Difluorobenzenethiol supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 3,5-difluorothiophenol?
    3,2,5-diethoxybenzoic anhydride is an important compound in organic chemistry. Its main uses are complex and critical, and are described as follows:
    First, in the field of organic synthesis, it is often used as an acylating agent. Because of its active anhydride group, it can acylate with many compounds such as alcohols and amines to generate corresponding esters and amides. This reaction is widely used in drug synthesis, fragrance preparation, etc. For example, when preparing drug molecules with specific structures, 3,2,5-diethoxybenzoic anhydride can be reacted with hydroxyl-containing drug intermediates to introduce specific acyl groups to change the activity and properties of the drug.
    Second, in the field of materials science, it can be used to prepare functional polymer materials. By reacting with polymer monomers containing active groups, its structure is introduced into the polymer chain, giving the material special properties. For example, reacting with some polymers containing hydroxyl groups can improve the water resistance and thermal stability of the material, and has potential application value in coatings, plastics and other fields.
    Third, in the fragrance industry, its reaction products or some of its own derivatives can be used as fragrance components. Due to its unique molecular structure, it can produce a specific aroma. After proper synthesis and transformation, unique fragrances can be prepared, adding the richness of fragrance categories.
    Fourth, in scientific research, as an organic reagent with a specific structure, it provides an important tool for chemical mechanism research. Researchers can use the reactions they participate in to deeply explore basic chemical problems such as reaction process and kinetics, and promote the development of organic chemistry theory.
    What are the physical properties of 3,5-difluorothiophenol?
    3,5-Diethoxybenzoic acid is an organic compound. It has the following physical properties:
    Viewed at room temperature, it is a white to light yellow crystalline powder, resembling finely crushed jade chips, with a fine texture.
    Smell it, it has no special and obvious smell, just like the tranquility of the forest, and it is not stained with odors.
    When it comes to the melting point, it is about 82-84 ° C. When the temperature gradually rises, it is like ice and snow meeting the warm sun, and the substance melts from the solid state to the liquid state, showing the wonder of the phase transition.
    Its solubility also has characteristics. It is slightly soluble in water, just like a light boat on the surface of a vast river, and it is difficult to blend with water; but it is easily soluble in organic solvents such as ethanol and ether, like a fish in water, in which it can quickly disperse and dissolve, just like salt in soup, invisible.
    In addition, the chemical properties of this substance are quite stable at room temperature and pressure. However, when encountering specific chemical reagents such as strong acids and alkalis, it will be like a calm lake thrown into a boulder, which will cause chemical reactions, and the structure and properties will change. The balance of its stability and reactivity is like the way of yin and yang, which are mutually restricted and interdependent, laying the foundation for many reactions and applications in the field of chemistry.
    Is the chemical properties of 3,5-difluorothiophenol stable?
    Is the chemical properties of 3% 2C5-diethylbenzoic anhydride stable? This is an exploration of chemical properties. Today, in ancient Chinese, it is the analysis of Jun.
    3% 2C5-diethylbenzoic anhydride, a genus of chemistry, is an organic compound or the like. Its molecular structure contains groups of diethyl and benzoic anhydride. This kind of structure has a great influence on its chemical properties.
    The stability of organic compounds often depends on the strength of chemical bonds in the molecule and the arrangement of spatial structures. In 3% 2C5-diethylbenzoic anhydride, the benzene ring has a conjugated system, which can endow the molecule with certain stability. However, the introduction of diethyl groups may change the electron cloud distribution and spatial steric resistance of the molecule.
    Under normal conditions, 3% 2C5-diethylbenzoic anhydride can be relatively stable. Its chemical bonds are not easily broken. At room temperature and pressure, it is difficult to undergo chemical reactions without specific chemical reagents or external conditions.
    However, under special conditions such as high temperature, strong acid-base or strong oxidant, its stability may be challenged. Under high temperature, the thermal motion of the molecule intensifies, the chemical bond energy increases, or the bond breaks, triggering reactions such as decomposition. Strong acid-base can react with specific functional groups in the molecule, such as acid-base neutralization or nucleophilic substitution, thereby changing its chemical structure. Strong oxidants can also cause molecules to oxidize and destroy their original structures and properties.
    3% 2C5 -diethylbenzoic anhydride is chemically stable under conventional conditions; however, under special chemical environments or external conditions, its stability will also change, and corresponding chemical changes will occur.
    What are the preparation methods of 3,5-difluorothiophenol?
    The preparation method of 3,2,5-diethoxybenzoic anhydride has been known for a long time. The first method is to use 2,5-diethoxybenzoic acid as the base, supplemented by acetic anhydride. First take an appropriate amount of 2,5-diethoxybenzoic acid, place it in a clean reactor, and slowly add acetic anhydride. The ratio of the two should be carefully considered by experiment to ensure that the reaction is smooth. Next, heat up to a suitable degree, usually between 100 and 120 degrees Celsius, maintain this temperature, and stir to fully blend the material for reaction. In the meantime, it is necessary to closely monitor the progress of the reaction, or to analyze it by means of instruments. After the reaction is completed, it is cooled, crystallized, and filtered to obtain a crude product of 3,2,5-diethoxybenzoic anhydride. After recrystallization, a pure product can be obtained.
    Second, use 2,5-diethoxybenzoyl chloride and anhydrous sodium acetate as materials. First pour 2,5-diethoxybenzoyl chloride into the reaction vessel. The container should be dry and anhydrous to prevent side reactions. Then, slowly add anhydrous sodium acetate, and the ratio of the two needs to be accurately weighed. After adding it, at a moderate temperature, about 60 to 80 degrees Celsius, let it react. In this process, it is also necessary to stir to help it to complete the reaction. After the reaction is completed, the organic phase is extracted with a suitable solvent, and then the impurities are removed through various steps such as distillation and drying, and the final product is 3,2,5-diethoxybenzoic anhydride.
    Furthermore, 2,5-diethoxybenzoic acid is co-reacted with phosphorus oxychloride. First put 2,5-diethoxybenzoic acid into the reaction bottle, and then inject an appropriate amount of phosphorus oxychloride, and mix the two evenly. Heat up and control the temperature between 80 and 100 degrees Celsius. When the reaction is completed, cool down, pour into ice water, precipitate, filter and collect. After washing and drying, 3,2,5-diethoxybenzoic anhydride can also be obtained. Each of these methods has its own advantages and disadvantages, depending on the actual needs, the ease of access to materials, and the level of cost.
    What are the precautions for the storage and transportation of 3,5-difluorothiophenol?
    3,5-Diethylbenzoic anhydride is an important raw material for fine chemicals. During storage and transportation, many matters must be paid attention to.
    First, when storing, it should be placed in a cool, dry and well-ventilated place. This substance is quite sensitive to temperature and humidity. In a high temperature and humid environment, it is easy to cause chemical reactions and cause quality damage. As "Tiangong Kaiwu" says, "things have their own characteristics, and they can be stored if they follow their characteristics, and destroyed if they are reversed." 3,5-Diethylbenzoic anhydride likes dryness and coolness, so it should be protected from direct sunlight and rain infiltration. The warehouse temperature should be controlled below 20 ° C and the humidity should not exceed 60%.
    Second, because of its corrosive nature, storage containers must be selected carefully. Corrosion-resistant materials, such as glass, ceramics or containers made of specific plastics, should be used. Metal containers should not be used to prevent corrosion and perforation, and the risk of leakage. Just as "Tiangong Kaiwu" said, "If you want to do a good job, you must first sharpen your tools". Choosing the right storage container is the foundation for ensuring safety and quality.
    Third, during transportation, it is necessary to ensure that the packaging is firm. Shockproof and collision-proof packaging materials should be used to stabilize the packaging to avoid damage to the container due to transportation bumps. And the transportation vehicle needs to be well ventilated, and it is strictly forbidden to mix with flammable, explosive and strong oxidizing agents to prevent accidents. This is as "Tiangong Kaiwu" said, act carefully and meticulously to prevent problems before they occur.
    Fourth, whether it is storage or transportation, it is necessary to strictly follow the relevant safety regulations and operating procedures. Operators should be professionally trained to be familiar with its characteristics and emergency treatment methods. In the event of an accident such as a leak, it can be handled quickly and correctly to minimize the harm. This is in line with the rigorous craftsmanship advocated in "Tiangong Kaiwu".