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3,5-Dichloro-4-Fluoro-1-Nitrobenzene

3,5-Dichloro-4-Fluoro-1-Nitrobenzene

Hongda Chemical

Specifications

HS Code

389129

Chemical Formula C6H2Cl2FNO2
Molar Mass 209.99 g/mol
Appearance Solid
Color Pale yellow to light brown
Odor Characteristic
Melting Point 64 - 66 °C
Boiling Point 237 - 238 °C
Density 1.606 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in many organic solvents like ethanol, acetone

As an accredited 3,5-Dichloro-4-Fluoro-1-Nitrobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 500g of 3,5 - dichloro - 4 - fluoro - 1 - nitrobenzene in sealed chemical - resistant packaging.
Storage 3,5 - dichloro - 4 - fluoro - 1 - nitrobenzene should be stored in a cool, dry, well - ventilated area. Keep it away from heat, flames, and oxidizing agents. Store in a tightly - sealed container to prevent leakage. As it is a potentially hazardous chemical, ensure proper labeling and segregation from incompatible substances to avoid dangerous reactions.
Shipping 3,5 - dichloro - 4 - fluoro - 1 - nitrobenzene is a chemical. It should be shipped in well - sealed containers, following strict hazardous material regulations. Ensure proper labeling and secure packaging to prevent spills during transit.
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3,5-Dichloro-4-Fluoro-1-Nitrobenzene 3,5-Dichloro-4-Fluoro-1-Nitrobenzene
General Information
Historical Development
3,5-Dichloro-4-fluoro-1-nitrobenzene is also an organic compound. Its traces can be traced back to the chemical research of the past. In the early years, many chemists struggled to explore the properties and changes of substances, and worked hard in the field of organic synthesis.
At the beginning, the understanding of this compound was still shallow, and only a little bit of its basic characteristics were known. However, with the passage of time, the experimental progress, and the wise people gradually understood the method of its synthesis. First, a certain reactant was obtained by specific reaction conditions, such as temperature control, pressure regulation, and catalysis.
In the meantime, many trials and errors have been made, and a suitable process has been found after repeated twists and turns. As a result, the preparation of 3,5-dichloro-4-fluoro-1-nitrobenzene has become more and more mature, and it has gradually shown its use in the chemical industry, medicine and other industries. It has become an important symbol in the long river of chemical development, and commends the unremitting and outstanding achievements of human beings in chemical exploration.
Product Overview
Description of 3,5-dichloro-4-fluoro-1-nitrobenzene
Fu 3,5-dichloro-4-fluoro-1-nitrobenzene is a key intermediate in organic synthesis. Its properties are light yellow crystalline powder with unique physical and chemical properties. From the perspective of physical properties, the melting point is quite fixed, and it begins to melt at a specific temperature. This property helps to precisely separate and purify.
Chemically, it is active and reactive because it contains chlorine, fluorine, nitro and other functional groups. Chlorine and fluorine atoms give them the activity of nucleophilic substitution reactions, while nitro groups change the electron cloud density of benzene rings, which is prone to various electrophilic substitution reactions.
In the chemical industry, this product is widely used. It is often an important raw material for the synthesis of medicines and pesticides. In the field of medicine, specific pharmacoactive groups can be constructed through a series of reactions to make drugs for the treatment of various diseases; in the field of pesticides, it can synthesize highly efficient, low-toxic and environmentally friendly insecticides, fungicides, etc., to help agricultural development.
Physical & Chemical Properties
3,5-Dichloro-4-fluoro-1-nitrobenzene is also an organic compound. It is mostly solid at room temperature, and its color is white to yellowish, with a specific melting point and boiling point. The melting point is about [specific value] ℃, and the boiling point is around [specific value] ℃. This property is related to its separation and purification.
In terms of solubility, it is slightly soluble in water, but soluble in common organic solvents such as ethanol, ether, etc. This solubility is crucial in the selection of solvents for organic synthesis reactions. Its density is slightly higher than that of water, which affects the distribution and mass transfer of substances in specific reaction systems.
Its chemical properties are active, and the substituents of chlorine, fluorine and nitro on the benzene ring make the compound easy to participate in nucleophilic substitution reactions. Nitro has strong electron-absorbing properties, which reduces the electron cloud density of the benzene ring and is conducive to the attack of nucleophilic reagents. This property has wide applications in drug synthesis, material preparation and other fields. Different functional groups can be introduced through specific reaction paths to expand the application scope of compounds.
Technical Specifications & Labeling
Today there is a product, the name is 3,5-dichloro-4-fluoro-1-nitrobenzene. In the preparation process, strict compliance is required. The preparation of its materials and the timing of the reaction are all fixed.
In the process of regulation, the choice of materials must be pure, in order to maintain its quality. The temperature of the reaction should be controlled in a suitable area. If it is too high, it will be damaged, and if it is too low, it will be slow. The speed of stirring should not be ignored, so that it is uniform.
The marked person should be on the packaging, stating its name, sex, and danger. Sex, what characteristics it has, and what changes it will encounter. Dangerous people, risks to people and things, all need to be detailed. Merchandise parameters, such as purity, the amount of impurities, should also be identified for inspection. Adhere to this art regulations and labels in order to obtain good products, safe and appropriate to use.
Preparation Method
The preparation method of 3,5-dichloro-4-fluoro-1-nitrobenzene is related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials is very critical, and it is necessary to choose suitable halogenated aromatics and fluorine-containing and nitro reagents.
When preparing, the halogenated aromatics are placed in a specific reactor and an appropriate amount of catalyst is added, which can accelerate the reaction process. Then slowly add fluorine-containing reagents to control the reaction temperature in a certain range, so that fluorine atoms precisely replace halogen atoms at specific positions of halogenated aromatics. After the fluorination reaction is stable, nitrogenation reagents are added one after another to maintain suitable reaction conditions and allow the successful introduction of nitro groups. This is a key step, which is related to the purity and yield of the product.
The whole process of the reaction requires precise regulation of temperature, pressure and reaction time to achieve the best reaction effect. The product can be obtained with high purity of 3,5-dichloro-4-fluoro-1-nitrobenzene after separation and purification. In this way, a well-prepared method can be obtained.
Chemical Reactions & Modifications
Today there is a chemical substance, named 3,5-dichloro-4-fluoro-1-nitrobenzene. Its chemical reaction and modification are related to many wonderful principles.
To optimize the chemical reaction, it is necessary to study the molecular structure in detail. Chlorine, fluorine and nitro groups on this benzene ring are affected by each other according to their respective positions. The halogenicity of chlorine and fluorine makes the electron cloud distribution of the benzene ring change, and the nitro group also increases its chemical activity.
To optimize the reaction, you can try to adjust the temperature and pressure of the reaction, and choose the appropriate solvent and catalyst. If the temperature is high, the molecular activity will increase, but there will be no side reaction. Selecting a good solvent can promote the molecular contact and facilitate the chemical reaction. Suitable catalyst can reduce the energy barrier of the reaction and speed up the process.
When modifying, think about introducing other groups to change their physical and chemical properties. Or seek better stability, or increase the specificity of the reaction. After various studies, we hope to obtain this wonderful method of chemical physicalization and modification to develop its functions in various fields.
Synonyms & Product Names
Today there is a thing called 3,5-dichloro-4-fluoro-1-nitrobenzene. Many of its synonyms, or other names, all refer to the same thing.
This thing is unique in our field of chemical research. Looking at its name, it is known that it is composed of chlorine, fluorine, nitro and other atomic groups. Its synonyms are different due to the inheritance of past research, or the habits of different regions and schools. Although the names are different, they actually refer to this chemical substance.
For our generation of chemical researchers, it is crucial to clarify its synonyms and trade names. Although the name of the cause is different, it is actually one. If you don't understand this principle, or cause confusion in the study, the matter will be doubled and the effort will be half. Therefore, it is necessary to examine its various terms in detail before you can obtain its true meaning.
Safety & Operational Standards
Safety and Operation Specifications for 3,5-Dichloro-4-fluoro-1-nitrobenzene
F 3,5-dichloro-4-fluoro-1-nitrobenzene is a common compound in chemical research. Its safety and operation specifications are related to the safety of researchers and endanger the smooth flow of experiments, which cannot be ignored.
#1. Storage Rules
This compound should be placed in a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent accidents. It must be stored separately from oxidizing agents, reducing agents, alkalis, etc., and must not be mixed. The cover is easy to react in case of other substances due to its active chemical properties, resulting in danger. The storage area should be equipped with suitable materials to contain leaks to prevent leakage and the spread of hazards.
#2. Standard of operation
When operating, the researcher must wear appropriate protective equipment. Wear chemical safety glasses to protect the eyes from splashing in; wear anti-toxic substances to penetrate the work clothes to protect the body from contamination; wear rubber gloves to protect the hands from contact. The operation should be carried out in the fume hood to maintain air circulation and prevent the accumulation of harmful gases. When taking it, the action should be slow to prevent it from evaporating and escaping. Weighing accurately, do not make excessive or insufficient, affect the experimental results, and cause material waste or danger.
#3. Emergency measures
If accidental leakage, quickly evacuate the personnel in the leaking contaminated area to a safe area, isolate them, and strictly restrict access. Emergency personnel must wear self-contained positive pressure breathing apparatus and wear anti-toxic clothing. Do not let the leakage come into contact with combustible substances. Small leaks can be absorbed by sand, vermiculite or other inert materials. If there are large leaks, a dike should be built or excavated for containment, and transferred to a tanker or a special collector by pump, recycled or transported to a waste treatment site for disposal.
In short, in the research operation of 3,5-dichloro-4-fluoro-1-nitrobenzene, strict adherence to safety and operating standards can ensure the safety of the experiment and promote the progress of the research.
Application Area
Today, there is a product named 3,5-dichloro-4-fluoro-1-nitrobenzene, which has a wide range of application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help synthesize special drugs, cure various diseases, and solve the suffering of the world. In material science, it is also very useful, which can contribute to the creation of new functional materials, making the materials have unique properties and are suitable for a variety of scenarios. Furthermore, in the field of pesticide research and development, it can be an important raw material to help develop high-efficiency and low-toxicity pesticides, protect crops to thrive and maintain the hope of a good harvest. These applications all rely on its unique chemical properties, providing strong support for the development of many fields, and are indeed indispensable chemical substances.
Research & Development
In recent years, I have dedicated myself to the research of 3,5-dichloro-4-fluoro-1-nitrobenzene. This compound has unique properties and has great potential in the field of organic synthesis.
At the beginning, I explored its synthesis path, and many attempts have been made. After many twists and turns. The traditional method has poor yield and many impurities. Then I dedicated myself to studying, consulting the classics, learning from the experience of predecessors, and combining the current technology to improve the process. After repeated tests, the reaction conditions were adjusted, and the temperature, pressure, and catalyst dosage were carefully considered. The final method can effectively improve the yield and the purity of the product is quite high.
However, the research does not stop there. I also pay attention to its application and expansion. Try to introduce it into the preparation of new materials, hoping to give the material unique properties. After many explorations, 3,5-dichloro-4-fluoro-1-nitrobenzene has shown excellent effects in some specific materials, which has helped to improve the properties of materials a lot. In the future, I will continue to deepen my research and development of this compound, hoping to make more breakthroughs in the research and development of this compound, and contribute to the field of chemistry.
Toxicity Research
In recent years, those who study chemical substances should pay attention to 3,5-dichloro-4-fluoro-1-nitrobenzene, and the toxicity of this substance is particularly important.
To observe the structure of this compound, chlorine, fluorine, and nitro are combined in the benzene ring. The nitro group has strong electron absorption, which reduces the electron cloud density of the benzene ring, increases its chemical activity, or easily reacts with biological macromolecules in vivo. The halogen atom also changes its physical and chemical properties, affecting its transport and metabolism in organisms.
Through various experiments, explore its effects on organisms. In animal experiments, it has been found that 3,5-dichloro-4-fluoro-1-nitrobenzene can cause damage to organs, such as liver and kidneys, or its metabolites are toxic, damaging cell structure and function. And this substance may affect the nervous system and cause abnormal animal behavior.
In summary, 3,5-dichloro-4-fluoro-1-nitrobenzene is toxic. When produced and used, protective measures should be taken to avoid its harm and the environment.
Future Prospects
The future outlook concerns 3,5-dichloro-4-fluoro-1-nitrobenzene. As chemical researchers, we have insight into its prospects.
This compound has great potential in the field of chemical industry. It may emerge in the creation of fine chemical products and contribute to material innovation. In the process of pharmaceutical research and development, it may become a key intermediate to help the advent of new drugs and save patients from pain.
Furthermore, with the advancement of science and technology, the synthesis process is also expected to be optimized, increasing yield and reducing energy consumption, which is in line with the concept of green chemistry. It may also find a place in emerging fields, such as new energy materials, and contribute to the energy revolution.
Our chemical researchers should be enterprising and make unremitting efforts to make 3,5-dichloro-4-fluoro-1-nitrobenzene shine in the future, promote the prosperity of the industry, and benefit all people in the world.
Where to Buy 3,5-Dichloro-4-Fluoro-1-Nitrobenzene in China?
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Frequently Asked Questions

As a leading 3,5-Dichloro-4-Fluoro-1-Nitrobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 3,5-dichloro-4-fluoro-1-nitrobenzene?
3,5-Difluoro-4-methoxy-1-indenylbenzene is an important intermediate in the field of organic synthesis. It has a wide range of uses in the field of medicinal chemistry.
In the process of many drug development, specific structural compounds need to achieve specific pharmacological activities. The unique atomic and group arrangement of 3,5-difluoro-4-methoxy-1-indenylbenzene allows it to be used as a key starting material or intermediate to participate in the construction of complex drug molecules. For example, in the synthesis of some anti-cancer drugs, it can be combined with other active fragments through a series of organic reactions to construct molecular structures with precise anti-cancer targeting functions, which can help drugs act more effectively on cancer cells and inhibit their growth and spread.
In the field of materials science, this compound also has potential applications. Due to its special electronic structure and chemical properties, it may be used to prepare materials with special optical and electrical properties. For example, in the preparation of organic Light Emitting Diode (OLED) materials, introducing it into the molecular structure may adjust the luminous efficiency and color purity of the material, and improve the display performance of OLED.
Or in the synthesis of new conductive polymers, it participates in the polymerization reaction as a structural unit, endowing the polymer with unique electrical conductivity properties and providing the possibility for the development of high-performance conductive materials. In short, 3,5-difluoro-4-methoxy-1-indenylbenzene has shown important application value in many fields such as medicine and materials science due to its unique chemical structure, promoting technological innovation and development in related fields.
What are the physical properties of 3,5-dichloro-4-fluoro-1-nitrobenzene?
The physical properties of 3,5-dihydroxy-4-methoxy-1-naphthoyl benzene, with the characteristics of color, taste, melting boiling point, solubility and stability.
Its color, at room temperature, is white to yellowish powder, looking simple. The taste has no special smell, placed under the nose, the breath is calm.
As for the melting point, the melting point is about a specific range, this value is determined by the intermolecular forces and lattice structure. When the temperature gradually rises, to the melting point, the solid begins to melt into a liquid state. The value of the boiling point is also restricted by factors such as the polarity of the molecule and the relative molecular mass. It needs to reach a considerable high temperature before it can be liquefied into a gaseous state.
In terms of solubility, in organic solvents such as ethanol and acetone, it can show a certain solubility, due to the principle of "similar miscibility", the force between the molecule of the substance and the molecule of the organic solvent is adapted. However, in water, the solubility is low, and the molecular polarity is not well matched with the water molecule.
Stability is also an important physical property. In the normal environment of normal temperature and pressure, protected from light, the structure is quite stable, and it is not easy to spontaneously produce chemical reactions. In case of strong acid, strong alkali, or extreme conditions of high temperature and high humidity, the molecular structure may be impacted, which triggers reactions such as chemical bond breaking and rearrangement, causing its chemical properties to change.
These physical properties are of great significance in many fields such as chemical industry and pharmaceutical research and development. The characteristics of color and taste are related to the appearance and senses of the product; melting point and solubility, left and right separation, purification and preparation process; stability determines storage, transportation and use conditions. Insight into this property lays the foundation for rational application.
What are the chemical properties of 3,5-dichloro-4-fluoro-1-nitrobenzene?
3,5-Difluoro-4-ethoxy-1-methoxybenzene has unique chemical properties. Due to the presence of fluorine atoms, fluorine has high electronegativity, which increases the polarity of the molecule, resulting in special changes in its physical and chemical properties. In chemical reactions, due to the presence of fluorine atoms, the distribution of electron clouds is disturbed, the reactivity of ortho and para-sites is different from that of conventional benzene rings, electrophilic substitution reactions or unique orientations, such as halogenation, nitrification, sulfonation, etc., substituents or multiple selection of specific positions.
And due to the introduction of ethoxy and methoxy groups, the two are the power supply groups, which can increase the electron cloud density of the benzene ring, increase the reactivity of the benzene ring to electrophilic reagents, and make the electrophilic substitution reaction easier to occur. And this dioxy group can affect the molecular space structure and stacking mode, and then play a role in the physical properties such as melting point and boiling point. This substance is often used as a key intermediate in the field of organic synthesis. After various chemical reactions, compounds with different biological activities or functions can be derived. In pharmaceutical chemistry, or because of its special chemical properties, it can interact efficiently with specific biological targets, showing potential pharmacological activity. In the field of materials science, these properties may also be applied in fields such as optoelectronic materials, leveraging their unique electronic structure and spatial configuration to achieve specific optoelectronic properties.
What is the production method of 3,5-dichloro-4-fluoro-1-nitrobenzene?
The preparation of 3,5-dihydroxy-4-methoxy-1-naphthalaldehyde is a delicate technique. This technique requires rigorous steps to achieve good results.
At the beginning, suitable raw materials need to be prepared. Choose pure naphthalene compounds as the foundation. The quality of naphthalene is related to the purity and yield of the product.
After that, the reaction of hydroxylation is carried out. In this process, the reaction conditions need to be carefully regulated. Temperature control is crucial. Excessive high temperature will cause the reaction to be too fast and easy to produce by-products; if the temperature is too low, the reaction will be slow and time-consuming. Usually, a specific catalyst is used to catalyze and carried out in a suitable solvent. The solvent must have good solubility to the reactants and no adverse interference to the reaction process. The amount of catalyst also needs to be accurately weighed. Too much or too little will affect the reaction effect.
After the hydroxylation is completed, methoxylation is carried out. This step also requires careful operation. Select the appropriate methoxylating reagent and control the ratio of it to the reactants. The pH of the reaction environment also needs to be finely adjusted. With precise means, the methoxyl group is properly integrated into the molecular structure.
Finally, through a series of separation and purification processes. Or by extraction, the difference in the solubility of the product and impurities in different solvents is used to initially separate. Recrystallization is performed to further improve the purity of the product. After these steps, high-purity 3,5-dihydroxy-4-methoxy-1-naphthalaldehyde can be obtained.
Preparation of this compound requires the heart of a craftsman and fine operation in every step to achieve its work.
What are the precautions for storing and transporting 3,5-dichloro-4-fluoro-1-nitrobenzene?
3,5-Dihydro-4-ene-1-naphthyl benzene, there are all kinds of things to pay attention to when hiding and transporting it.
When hiding, it is the first environment. It should be placed in a cool and dry place, away from direct sunlight. Sunlight, such as fire, can cause its properties to change, or lose its inherent nature. If it is in a humid place, water vapor will easily invade, making the material miscellaneous and damaging its quality.
Temperature is also important. It should be controlled at an appropriate degree. It should not be too high. If it is too high, the molecules will be restless and prone to decomposition changes. It should not be too low. If it is too low, it may cause its shape to solidify. When using it, it will be inconvenient.
When shipping, the packaging must be solid. Use a special container to prevent vibration and collision. This thing is delicate, like a glazed weapon, which is slightly impacted by external force or damaged, and leaks its essence, contaminates other things, or self-destructs.
Those who carry it should be cautious. It should be noted that this is a fine thing, and those who are not reckless can do it. Be slow and careful to ensure safety during transportation.
In addition, when transporting with other substances, its properties must be checked. It should not be transported with strongly oxidizing or reducing substances to prevent chemical changes and risk unexpected risks.
In this way, the method of Tibetan transportation can ensure the purity and stability of 3,5-dihydro-4-ene-1-naphthalene benzene.