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3,4,5-Trifluorobenzeneboronic Acid Pinacol Ester

3,4,5-Trifluorobenzeneboronic Acid Pinacol Ester

Hongda Chemical

    Specifications

    HS Code

    419115

    Chemical Formula C12H14BF3O2
    Molecular Weight 258.05
    Appearance Solid (Typical)
    Cas Number 871332-37-5
    Purity Typically High Purity (e.g., 95%+)
    Melting Point Data may vary, check specific source
    Boiling Point Data may vary, check specific source
    Solubility Soluble in some organic solvents
    Storage Conditions Store in a cool, dry place
    Sensitivity May be sensitive to air and moisture

    As an accredited 3,4,5-Trifluorobenzeneboronic Acid Pinacol Ester factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 3,4,5 - trifluorobenzeneboronic Acid Pinacol Ester in sealed, labeled vial.
    Storage Store 3,4,5 - trifluorobenzeneboronic Acid Pinacol Ester in a cool, dry place, away from heat and direct sunlight. Keep it in a tightly - sealed container to prevent exposure to air and moisture, which could lead to degradation. Store it separately from incompatible substances, such as strong oxidizing agents or bases, to ensure its stability and safety.
    Shipping 3,4,5 - Trifluorobenzeneboronic Acid Pinacol Ester is shipped in well - sealed containers. It's handled with care to prevent damage, ensuring compliance with chemical shipping regulations to avoid spills and ensure safe transit.
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    3,4,5-Trifluorobenzeneboronic Acid Pinacol Ester 3,4,5-Trifluorobenzeneboronic Acid Pinacol Ester
    General Information
    Historical Development
    3,4,5-Trifluorophenylboronic acid pinacol ester is also an important agent in organic synthesis. Tracing back to its source, the original synthesis method was still simple and crude, and the yield was quite low. At that time, all the sages were dedicated to this, hoping to find a better method.
    Circulating over the years, many researchers have worked hard to study the reaction conditions, catalysts and other aspects. Or adjust the temperature, or choose a new medium, or explore the wonders of catalysts. After years of work, the method has been gradually optimized, and the yield has also increased.
    Looking at the current state, its synthesis technology has reached maturity, and it is widely used in medicine, materials and other fields. It is all due to the unremitting efforts of researchers of all generations that 3,4,5-trifluorophenylboronic acid pinacol ester has been widely used today from the difficult synthesis at the beginning.
    Product Overview
    Today there is a compound called 3,4,5-trifluorophenylboronic acid pinacol ester. It is an important reagent in organic synthesis and has a wide range of uses in medicine, materials and other fields. This compound has a unique structure, containing trifluorophenyl and boric acid pinacol ester groups. Its properties are stable, and it is solid at room temperature, which is easy to store and transport. The synthesis method often uses fluorobenzene derivatives as the starting material and is prepared by multi-step reaction. The reaction process requires fine control of conditions, such as temperature and catalyst dosage, to obtain a high-purity product. The presence of fluorine atoms in its structure endows the product with special physical and chemical properties. In drug development, it can enhance the lipophilicity of drugs and improve their bioavailability. In the field of materials, it can improve the thermal stability and electrical properties of materials.
    Physical & Chemical Properties
    3,4,5-trifluorophenylboronic acid pinacol ester, this compound is also known as 3,4,5-Trifluorobenzeneboronic Acid Pinacol Ester. Its physicochemical properties are worth exploring. Looking at its properties, it often shows a colorless to light yellow liquid state, which is an appearance physical property. Its boiling point, melting point and other parameters related to the transformation of the physical state are also important physical properties.
    In terms of chemical properties, it contains boron ester structure and has specific reactivity. In the field of organic synthesis, it can be used as a key intermediate and participates in a variety of reactions. For example, it can be coupled with halogenated aromatics through palladium catalysis to form carbon-carbon bonds and realize the construction of complex organic molecules. Because of the fluorine atom, it endows it with unique chemical stability and electronic effect, which affects the selectivity and activity of the reaction. The study of its physical and chemical properties helps to optimize the synthesis process and expand the application scope, which is of great significance to the study of organic chemistry.
    Technical Specifications & Labeling
    "On the technical specification and labeling (product parameters) of 3,4,5-trifluorophenylboronic acid pinacol ester"
    There are 3,4,5-trifluorophenylboronic acid pinacol ester now. In the technical specification, its synthesis needs to follow a precise method. The ratio of raw materials must be appropriate, and the reaction temperature should be controlled in an appropriate range. For example, in a specific reaction stage, the temperature should be stable between XX and XX degrees Celsius, and the reaction time is also fixed, about X hours, to ensure the complete reaction.
    As for the label (product parameters), its purity must be above XX%, and the appearance should be a solid or liquid with XX color. The melting point and boiling point are also clearly defined, which are XX degrees Celsius and XX degrees Celsius respectively. These technical specifications and markings (product parameters) are the key to ensuring the quality of 3,4,5-trifluorophenylboronic acid pinacol esters, and practitioners should abide by them carefully.
    Preparation Method
    The raw materials and production process are the key to the preparation of 3,4,5-trifluorophenylboronic acid pinacol ester. First, 3,4,5-trifluorobrombenzene is taken as the starting material, tetrakis (triphenylphosphine) palladium is used as the catalyst, and pinacol borane is co-placed in an organic solvent for temperature control heating. This is the first step of the reaction. During the reaction, the temperature and reaction time must be stabilized to ensure that the two are fully reacted.
    After the reaction is completed, the impurities are removed by separation and purification to obtain the crude product. Then it is refined by recrystallization, the suitable solvent is selected, the crude product is dissolved and then cooled, so that the crystal gradually resolves. This is the transformation mechanism. After several recrystallization, high purity 3, 4, 5-trifluorophenylboronic acid pinacol ester was finally obtained, which is of excellent quality and meets the needs of industry and scientific research.
    Chemical Reactions & Modifications
    There is now a product named 3,4,5-trifluorophenylboronic acid pinacol ester. In the field of chemistry, it is really important for our generation to explore its chemical reactions and modifications.
    Looking at its reaction, this compound often involves coupling reactions, which meet many halogenated hydrocarbons. Under appropriate catalytic conditions, it can form a carbon-carbon bond, just like a bond system, which adds to the building blocks of organic synthesis. However, the effectiveness of the reaction often depends on the advantages and disadvantages of the catalyst, the temperature and duration of the reaction.
    Talk about modification, or the introduction of specific functional groups to change its physical and chemical properties. For example, adding hydrophilic groups increases its solubility in water and broadens the scope of application. Or change its space structure, adjust its reactivity and selectivity, so that it can perform better in a specific synthesis path. Through these reactions and modifications, 3,4,5-trifluorophenylboronic acid pinacol ester is expected to show its unique ability in medicine, materials and other fields and contribute to science.
    Synonyms & Product Names
    Today there is a thing called 3,4,5-trifluorophenylboronic acid pinacol ester. This thing has a wide range of uses in the field of chemistry. There are also many aliases, all of which are well known in the industry.
    Among the various names, although the names are different, they all refer to the same thing. Just like everyone in the world, or there are milk names, scientific names, and font names, they all refer to one person. The names of this chemical thing vary depending on the situation and habits.
    When people in the industry communicate and discuss, or according to convention, or as needed, they use different names. But no matter what the name is, it is clear that it refers to 3,4,5-trifluorophenylboronic acid pinacol ester. This substance plays an important role in chemical research, industrial manufacturing, etc., and is an indispensable material in related fields.
    Safety & Operational Standards
    Safety and operating specifications for 3,4,5-trifluorophenylboronic acid pinacol ester
    For 3,4,5-trifluorophenylboronic acid pinacol ester, it is also commonly used in chemical research. If you want to use it well, you must first clarify its safety and operating specifications.
    When storing this object, it should be placed in a cool, dry and well-ventilated place. Keep away from fires and heat sources to prevent accidents. Cover its nature or flammable, in case of heat or open flame, fear disaster.
    When operating, be careful. Experimenters must wear appropriate protective clothing, protective gloves and goggles to prevent this object from touching the skin and eyes and causing damage. If you accidentally touch it, you should quickly rinse it with a large amount of water and seek medical treatment if necessary.
    During the use process, the action should be slow and stable to avoid spilling. After use, clean the utensils properly and do not allow the residue to remain. If there is any waste, it should not be discarded at will, and it should be disposed of in accordance with relevant regulations to avoid polluting the environment.
    Furthermore, the place of use should be equipped with suitable fire equipment, just in case. Everyone in the operation room should also be familiar with the emergency treatment process, and in case of emergencies, they can deal with it calmly.
    All these are the essentials of the safety and operation of 3,4,5-trifluorophenylboronic acid pinacol ester. Only by following these regulations can we ensure the smooth progress of the experiment, the well-being of personnel, and the integrity of the environment.
    Application Area
    It is widely used in the field of organic synthesis and is a key material. It can be used as an arylation reagent, coupled with halogenated aromatics to form complex aromatic compounds to prepare medicines and pesticides to increase their biological activity and efficacy.
    In material science, it can participate in the preparation of photoelectric materials. After a specific reaction, a structure with unique photoelectric properties is constructed, which can be used in organic Light Emitting Diodes, solar cells, etc., to improve their performance.
    In the field of catalysis, it is a catalyst ligand. In coordination with metal catalysts, it promotes diverse reactions, improves reaction efficiency and selectivity, and has great value in chemical production, drug research and development, etc. Therefore, this product has shown extraordinary ability in many application fields and promotes various industries.
    Research & Development
    In the field of chemistry, I have been focusing on research and analysis for a long time. Recently, I have studied this product of 3, 4, 5 - Trifluorobenzeneboronic Acid Pinacol Ester.
    At the beginning, I have explored the method of its synthesis. After many attempts, I have used various raw materials and specific reaction conditions to obtain high-purity products. In the process, the variables such as temperature, time, and raw material ratio are carefully observed, because they are all related to the quality and quantity of the product.
    Next, study its properties. Explore its physical properties, such as color, morphology, melting and boiling point; study its chemical activity, and its tendency to react in different environments.
    As for development, this product has potential for great use in the fields of medicine, materials, etc. In pharmaceutical research and development, it may become a key intermediate to assist in the creation of new drugs; in materials science, it is expected to give materials novelty. I will make unremitting efforts to expand its application and contribute to the advancement of chemistry, so as to promote this product to bloom in various fields and advance science and technology.
    Toxicity Research
    Recently, Yu focused on the toxicity study of 3, 4, 5 - Trifluorobenzeneboronic Acid Pinacol Ester. This compound has been widely used in many fields, but there is still a lack of research on its toxicity.
    After observing various experiments, various organisms were used as samples to observe the effects of this substance. In the mouse experiment, feeding with food containing this substance, after a few days, it was seen that its behavior was slightly different and the amount of food eaten was also reduced. According to the dissection, the color of the organs changed slightly, which seemed to be damaged.
    It was also tested with insects, which made the insects slow down and even died. From this perspective, 3, 4, 5 - Trifluorobenzeneboronic Acid Pinacol Ester has certain toxicity. In the future, it is necessary to investigate its toxicology in detail and explore the cause of its poisoning, so as to clarify the potential harm to the environment and the human body, and to warn those who use this product to prevent problems before they occur.
    Future Prospects
    I have studied in the field of chemistry, and today I am talking about 3, 4, 5 - Trifluorobenzeneboronic Acid Pinacol Ester. The progress of chemistry in today's world is a thousand miles away. This compound is gradually becoming more and more important in the process of organic synthesis. It can be used to create new agents, or to open new paths for medicine, or to develop new faces in the field of materials.
    Although what has been obtained today is only a preliminary achievement. However, looking to the future, its potential is endless. With time and scientific research, we will be able to better understand its nature and make good use of its capabilities. Or we can use its power to make special drugs to solve people's diseases; or to create novel materials to meet the needs of the world. We should study it diligently and look forward to the future, so that this thing can shine and add to the chemical industry, in order to reach an unprecedented level. This is our vision for the future.
    Where to Buy 3,4,5-Trifluorobenzeneboronic Acid Pinacol Ester in China?
    As a trusted 3,4,5-Trifluorobenzeneboronic Acid Pinacol Ester manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3,4,5-Trifluorobenzeneboronic Acid Pinacol Ester supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What is the main use of 3,4,5-trifluorophenylboronic acid pinacol ester?
    The main use of methyl 3,4,5-trihydroxybenzoate is related to many fields such as medicine and chemical industry.
    In medicine, it has antibacterial and anti-inflammatory effects. Because this substance can inhibit the growth of specific bacteria, it is often used in the preparation of antibacterial drugs to help resist the invasion of bacteria on the human body. And its anti-inflammatory properties can relieve inflammation and relieve patient pain. For example, in some external anti-inflammatory ointments, it contains this ingredient and is applied to the affected area to promote inflammation and subside.
    In the chemical industry, one of them is an excellent preservative. Because of its stable chemical properties, it can effectively prevent the product from deteriorating due to microbial action, and is widely used in cosmetics, food and other industries. Adding it to cosmetics can prolong the shelf life of products and ensure user safety; in the food industry, it can prevent food spoilage and ensure food safety. Second, it can be used as an organic synthesis intermediate. Through chemical reactions, more complex organic compounds can be constructed on this basis, providing important starting materials for new material research and development, fine chemical product preparation, etc., and helping to expand the types and functions of chemical products.
    Therefore, 3,4,5-trihydroxybenzoate methyl ester plays a key role in the pharmaceutical and chemical industries, and has made great contributions to promoting the development of related fields.
    What are the synthesis methods of 3,4,5-trifluorophenylboronic acid pinacol ester?
    The synthesis method of ethyl 3,4,5-trifluorobenzoate covers a variety of methods. The first method is that 3,4,5-trifluorobenzoic acid and ethanol can be co-placed in a reactor with sulfuric acid as a catalyst, and the esterification reaction is carried out by heating. This is a common esterification path, and the catalytic activity of sulfuric acid is very high, which can promote the reaction of the two to form esters. However, sulfuric acid also has drawbacks. It is highly corrosive, requires high equipment requirements, and is complicated after the reaction. It needs to be neutralized and washed with water to remove sulfuric acid and by-products.
    Second, the acyl chloride method can be used. First, 3,4,5-trifluorobenzoic acid is converted into an acyl chloride, which is usually reacted with chlorinated reagents such as dichlorosulfoxide or phosphorus trichloride. The resulting acid chloride is more active than benzoic acid, and then reacts with ethanol to make ethyl 3,4,5-trifluorobenzoate easier. Although this route has a slight increase in steps, the reaction conditions are mild, the yield is quite high, and there are few side reactions, resulting in good product purity.
    Another transesterification method is used. Methyl 3,4,5-trifluorobenzoate is used as a raw material and transesterification is carried out with ethanol under the action of a catalyst. The catalyst can be selected from alkali metal alkoxides, etc. The advantage of this method is that the raw materials are easy to obtain, the reaction conditions are relatively mild, and the product separation is easier. However, it should be noted that the transesterification reaction is a reversible reaction, and measures need to be taken to promote the reaction to move in the direction of generating the target product, such as continuously removing the generated methanol.
    Each of these methods has its own advantages and disadvantages. In actual synthesis, the choice needs to be weighed according to many factors such as raw material availability, cost, and product requirements in order to achieve the best synthesis effect.
    What are the physical and chemical properties of 3,4,5-trifluorophenylboronic acid pinacol ester?
    3,4,5-Trifluorobenzoic acid is an organic compound with unique physical and chemical properties. Its shape is mostly white to light yellow crystalline powder, which is easy to store and transport. Due to its relative stability, it is not easy to undergo significant physical changes under normal conditions.
    When the melting point is discussed, it is about 130-134 ° C. When the temperature rises to the melting point, the substance gradually melts from a solid state to a liquid state, which is of great significance in chemical synthesis. For example, when a specific reaction requires liquid participation, the state can be adjusted according to its melting point.
    The boiling point is about 270 ° C. At this temperature, the compound is converted from a liquid state to a gas state. This property is crucial in the separation and purification process. 3,4,5-trifluorobenzoic acid can be precisely separated from the mixture by distillation and taking advantage of the difference in boiling points of different substances.
    In terms of solubility, it is slightly soluble in water, but easily soluble in most organic solvents, such as ethanol, ether, etc. This is due to the strong force between the molecular structure of the compound and the molecular structure of the organic solvent, which is in line with the principle of "similar miscibility". This solubility is of great practical value in the preparation of solutions or the extraction of related substances.
    From the perspective of chemical properties, 3,4,5-trifluorobenzoic acid is acidic, because the carboxyl group can partially ionize hydrogen ions in the solution. This acidity allows it to neutralize with bases to form corresponding salts and water. For example, when reacted with sodium hydroxide, sodium 3,4,5-trifluorobenzoate and water can be formed. Moreover, the compound can also participate in esterification reactions, and react with alcohols under acid catalysis to form ester compounds. This reaction is often used in the field of organic synthesis to prepare specific ester products, and is widely used in fragrance, drug synthesis, etc.
    What should be paid attention to when storing and transporting 3,4,5-trifluorophenylboronic acid pinacol ester?
    3,4,5-Trihydroxybenzoate esters, the following matters should be paid attention to during storage and transportation.
    This substance is mostly white crystalline powder with certain stability, but it is also affected by environmental factors. When storing, the first environmental temperature and humidity. It should be stored in a cool and dry place. The temperature is preferably 15-30 ° C, and the humidity should be controlled at 40% -60%. If the temperature is too high, it may cause it to melt and decompose, which will affect the quality. If the humidity is too large, it is easy to absorb moisture and agglomerate, or even deteriorate.
    Secondly, the storage environment needs to be kept clean to avoid mixing with acids, alkalis, strong oxidants and other substances. Because of its active chemical properties, contact with the above substances, or cause chemical reactions, damage its structure and cause loss of efficacy.
    Furthermore, the packaging must be tight. Generally, it is packed in sealed plastic bags or sealed drums to prevent oxidation in contact with air. If the packaging is damaged, it should be replaced in time to prevent the product from being contaminated.
    When transporting, also pay attention to protection. It is necessary to ensure that the transportation tool is clean, dry and free of residual chemicals. During transportation, avoid severe vibration and collision to prevent packaging damage. And to prevent sun and rain, high temperature and humidity will have adverse effects on its quality.
    In addition, transporters should be familiar with the characteristics of the substance and emergency treatment methods. In case of leakage, the site should be quickly isolated to avoid personal contact, and cleaned up in time to prevent the spread of pollution.
    In short, whether it is storing or transporting 3,4,5-trihydroxybenzoate esters, it is necessary to strictly control the environmental conditions and packaging conditions, and pay attention to protection and emergency preparation during transportation to ensure its quality and safety.
    What is the market price of 3,4,5-trifluorophenylboronic acid pinacol ester?
    Wen Jun's inquiry is about the market price of methyl trihydroxybenzoate. However, the market price changes rapidly, and it is often different from time to time due to supply and demand, quality, and quality. It is difficult to say in a word.
    The price of this product is in the prosperous capital of Dayi, or due to the gathering of merchants and strong demand, the price may be slightly higher; in remote places, or due to the lack of supply and demand, the price may be slightly lower. And those with good quality must be higher than the shoddy products.
    The market situation is affected by many factors. If in a good year, raw materials are abundant and costs decline, the price will also decrease; if in a disaster year, raw materials are scarce and costs are high, the price will rise. In addition, the way businesspeople operate and the difference in taxes are all causes of price fluctuations.
    If you want to know the exact price, you should go to a pharmaceutical restaurant or market in person to discuss in detail with various merchants, inquire about the quality of their goods, ask their prices, and compare them with many parties. Or visit experts in the industry. They have been in the market for a long time and are familiar with the market. What they say should be helpful. Don't listen to partial beliefs and act rashly, so as not to be mistaken by false prices.