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3,4,5-Trifluorobenzeneboronic Acid

3,4,5-Trifluorobenzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    643454

    Name 3,4,5-Trifluorobenzeneboronic Acid
    Molecular Formula C6H4BF3O2
    Molecular Weight 175.90
    Appearance White to off-white solid
    Melting Point 148 - 152 °C
    Solubility Soluble in common organic solvents like ethanol, dichloromethane
    Purity Typically high purity available, e.g., 97%+
    Cas Number 1212194-31-2
    Storage Condition Store in a cool, dry place, protected from moisture
    Acidity Weakly acidic due to the boronic acid group

    As an accredited 3,4,5-Trifluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 3,4,5 - trifluorobenzeneboronic acid packaged in a sealed, chemical - resistant vial.
    Storage 3,4,5 - trifluorobenzeneboronic acid should be stored in a cool, dry place, away from heat and sources of ignition. Keep it in a tightly - sealed container to prevent contact with moisture, as boronic acids can react with water. Store it separately from oxidizing agents and incompatible substances to avoid potential chemical reactions.
    Shipping 3,4,5 - trifluorobenzeneboronic acid is shipped in well - sealed containers, compliant with chemical transport regulations. It's carefully packaged to prevent breakage and exposure, transported via approved carriers handling hazardous chemicals.
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    3,4,5-Trifluorobenzeneboronic Acid 3,4,5-Trifluorobenzeneboronic Acid
    General Information
    Historical Development
    I have tried to study chemical products, and now I say 3,4,5 - Trifluorobenzeneboronic Acid this product. At the beginning, the sages did not know this product, and the road to research was difficult. However, the scholars are determined, and they have studied it for a long time, and its nature is gradually becoming clear. At first, the method of preparation was not good, and it was not easy to obtain. After being improved by the craftsmen, its yield has gradually increased and it is widely used. In the fields of medicine and materials, it has shown its ability. Since its inception, this product has been evolving with the progress of science and technology, from little known to important, witnessing the rise of chemical industry, and it is also a fan for future generations to research new products.
    Product Overview
    "On the Product Description of 3,4,5-Trifluorophenylboronic Acid"
    Fu 3,4,5-trifluorophenylboronic acid is an important agent in organic synthesis. Its shape is often white crystalline powder with relatively stable properties. Looking at its structure, fluorine atoms are arranged in an orderly manner on the benzene ring, and boron atoms are connected to it, giving this product unique chemical activity.
    In the field of organic synthesis, this product has a wide range of uses. It can participate in the coupling reaction of Suzuki-Miyaura, and couple with halogenated aromatics or olefins to form carbon-carbon bonds to form complex organic molecules. Because of its strong electronegativity of fluorine atoms, it can affect the electron cloud density at the check point of the reaction, so that the reaction selectivity is good and the product purity is also high.
    The preparation method often uses 3,4,5-trifluorobromobenzene as the starting material and is obtained by lithiation, boration and other steps. However, when preparing, it is necessary to pay attention to the control of the reaction conditions, such as temperature, reagent ratio, etc., if there is a little carelessness, or the yield is low and the quality is not up to.
    In summary, 3,4,5-trifluorobenzene boronic acid plays an important role in the synthesis of organic chemistry. It is a treasure of organic synthesis and helps chemists produce a variety of novel organic products.
    Physical & Chemical Properties
    3,4,5-Trifluorophenylboronic acid This substance has unique physical and chemical properties. Looking at its physical state, at room temperature, it is usually white and crystalline, with a fine and pure texture. Its melting point is moderate, and it quietly changes its physical state at a specific temperature. The value of this temperature is one of the characteristics for accurately measuring its physical stability.
    Talking about chemical properties, 3,4,5-trifluorophenylboronic acid has the activity of typical boric acid. It can react ingeniously with a variety of organic compounds and is often a key reagent in the field of organic synthesis. The unique electronic structure of boron atoms gives it the ability to combine with nucleophiles, thus opening a series of chemical reactions and providing an important way to prepare complex organic molecules. And because it contains fluorine atoms, it also adds a different chemical activity, which shows unique advantages in specific reactions and provides many possibilities for chemical research and production applications.
    Technical Specifications & Labeling
    Today there is a product called 3,4,5-trifluorophenylboronic acid (3,4,5-Trifluorobenzeneboronic Acid). The preparation method of this product depends on the fine process regulations. Parameters such as the ratio of materials, the temperature and duration of the reaction are all key.
    At the beginning of preparation, select raw materials to ensure purity and no impurities. In a special vessel, put the reactants in precise proportions. Control the temperature in a suitable range, or water bath, or oil bath, so that the reaction can proceed smoothly. When reacting, pay close attention to the phenomenon and adjust the parameters in a timely manner.
    As for the identification of this product, in addition to clearly indicating the name and chemical formula, it is also necessary to indicate the purity, batch and other commercial parameters. On the packaging, warning labels are also indispensable to clarify its physical and chemical characteristics and precautions, and to ensure the safety of its transportation and storage. In this way, the standardized products can be used in all kinds of scientific research and production.
    Preparation Method
    The preparation method of 3.4.5-trifluorophenylboronic acid is very important related to the raw materials and production process, reaction steps and catalytic mechanism. The selection of raw materials needs to be carefully selected, and high-quality raw materials are the foundation for the purity of the product. The production process is like a delicate brocade, and all links are interlocked.
    The first starting conditions of the reaction step are precise temperature control and pressure regulation, so that the reaction can proceed in sequence. The catalytic mechanism is like a golden hand, and the clever catalyst accelerates the reaction process and improves the yield. First take a specific proportion of fluorobenzene derivatives and place them in the reactor with the boron source. Protect it with inert gas to prevent impurities from disturbing it. Slowly heat up to a specific range, add a catalyst, observe the reaction like a star, and fine-tune the conditions in a timely manner. After the reaction is completed, through multiple separation and purification processes, impurities are removed and pure products are retained, and 3,4,5-trifluorophenylboronic acid is finally obtained.
    Chemical Reactions & Modifications
    In the field of chemistry, its reaction and modification are crucial.
    The reaction of this compound often depends on the characteristics of fluorine atoms and boron atoms in its structure. Fluorine atoms have strong electronegativity, which can affect the reactivity and selectivity. Boron atoms can participate in a variety of reactions, such as nucleophilic substitution, coupling reactions, etc.
    As for modification, it is designed to optimize its properties. Or to improve its stability, or to enhance its solubility, to suit different scenarios. By chemical means, adjusting its structure, increasing or decreasing functional groups, can cause its properties to be very different. In this way, this compound can play a greater role in the fields of materials science, drug research and development, and contribute to the progress of chemistry.
    Synonyms & Product Names
    Today there is a product called 3,4,5-trifluorophenylboronic acid (3,4,5-Trifluorobenzeneboronic Acid). This product is used in the field of chemical industry and has a wide range of uses. There are also many different names, all of which vary depending on the industry and region.
    In the path of organic synthesis, or it is called by another name, but in its essence, they all refer to the same thing. Or because of different preparation methods, or for the convenience of application, many synonymous names are born. As for the name of the product, the merchant also ordered it according to their own considerations, hoping to highlight the characteristics and catch people's eyes.
    Although the names are different, their properties are the same. On the stage of chemical reactions, it is essential to participate in various changes, contribute to the chemical industry, and promote the progress of science and technology.
    Safety & Operational Standards
    "3,4,5-Trifluorophenylboronic Acid Product Safety and Operation Specifications"
    Fu 3,4,5-trifluorophenylboronic acid is a commonly used material in chemical research. If you want to make good use of this material, you must first clarify its safety and operation specifications.
    Its properties are different, and it is related to safety. For storage, it should be placed in a cool, dry and well-ventilated place, away from fires and heat sources. Do not store with oxidants, acids, etc., to prevent unexpected reactions.
    When taking it, you must wear appropriate protective equipment. For example, wear protective gloves to avoid touching your hands; wear protective glasses to protect your eyes from damage; also need protective clothing to protect your whole body. When the operation room is well ventilated, if there is volatile gas, it can be quickly discharged to avoid aggregation and risk.
    When using, the action should be steady and careful. Weigh accurately, do not spill. If it is accidentally spilled, it should be disposed of according to the specifications. Small amounts of sprinklers can be absorbed by inert materials such as sand and vermiculite, and properly collected and disposed of. If a large number of spills are spilled, it is necessary to evacuate personnel, seal the scene, and professionally dispose of them.
    After the experiment is completed, the remaining items should not be discarded at will. Store or dispose of properly according to regulations to prevent pollution of the environment and disaster.
    In short, in the use of 3,4,5-trifluorophenylboronic acid, safety is the top priority, and the operation is in accordance with regulations, so as to ensure the smooth experiment, personnel safety, and the environment is worry-free.
    Application Area
    3,4,5-Trifluorophenylboronic acid is also useful for chemical compounds. Its use is not limited, and it has its own work in all kinds of fields.
    In the field of synthesis, it can be used to improve the activity and performance of important materials. With its unique characteristics, it can create a variety of reactions, assist in the production of compounds, improve the activity and performance of substances, or improve their performance.
    In the field of materials, it also has wonderful uses. It can be used to synthesize photogenic materials, semi-transparent materials, etc. By its reaction, it can repair the molecular properties of materials, improve the performance and light properties of materials, etc., so that materials are more suitable for different applications.
    In addition, in the catalytic reverse domain, 3,4,5-trifluorophenylboronic acid can be used as a catalyst to enhance its catalytic efficiency, improve the reaction rate, performance, and high-efficiency synthesis. Therefore, this compound has important value in the multi-purpose domain, and the technological progress of each domain is promoted.
    Research & Development
    In recent years, Yu devoted himself to the research of 3,4,5 - Trifluorobenzeneboronic Acid. This compound has a wide range of properties and applications, and has attracted much attention in the field of organic synthesis.
    At the beginning, the preparation method was not good, the yield was low, and the impurities were difficult to remove. Yu and his colleagues studied day and night, consulting countless classics, imitating the methods of predecessors and improving it. After months of trial and error, they finally came up with a strategy. Using a reagent as a medium, temperature control and timing, the yield gradually increased, and the purity was also good.
    Then, explore its reaction mechanism. With precise instruments, observe the changes of its molecules, and analyze the reasons for its bonding. Explain the key role it plays in a specific reaction.
    Looking to the future, we hope to expand its application based on this. It can be used to create new drugs, or to help the research and development of high-performance materials. Make this compound shine in the world of scientific research and industry, and it is also the vision of our generation of researchers.
    Toxicity Research
    Nowadays, there are chemical substances called 3, 4, 5 - Trifluorobenzeneboronic Acid, and we must study its toxicity. This substance is new, and its impact on the world is unknown. Toxicity research is urgent.
    Look at its structure, fluorine, boron and other elements are in between. Fluoride is mostly active, or can easily react with other things, entering the body to fear the process of biochemistry. Although boron is needed in living organisms, there are also hidden dangers in the amount of boride or abnormal states.
    If you want to study its toxicity, first look at its impact on microbial bodies. Test it with the genus of bacteria and algae to observe its growth and metabolism changes. Test it with animals again, and observe the differences in organs and behavior after ingestion. And explore its fate in the environment, considering that it is scattered in water, soil and air, and is harmful to all kinds of ecology. Expect to know the toxicity of this substance in detail, so as to use it for safety and ecological protection.
    Future Prospects
    The future prospect concerns 3,4,5-trifluorophenylboronic acid. It is an important product in the chemical industry and has great potential in scientific research and industry.
    Looking at the world today, science and technology are changing with each passing day, and pharmaceutical research and development is advancing by leaps and bounds. 3,4,5-trifluorophenylboronic acid is used in the creation of new drugs, which can be a key building block and assist in the synthesis of compounds to treat various diseases and benefit the common people.
    Furthermore, the field of materials is also booming. This product may optimize material properties, make electronic devices more efficient and optical materials more excellent, and open up new paths for the industry.
    The industrial system will also be changed accordingly, and greener and more efficient methods may emerge as the times require, reducing costs and increasing efficiency, which is in line with the grand purpose of sustainable development.
    Although there may be thorns ahead, our generation of chemical researchers should have the determination to explore the unknown. With unremitting efforts, we hope to uncover more of its potential, draw a bright new future for 3,4,5-trifluorobenzene boronic acid, and do our best for the prosperity of the industry and the well-being of mankind.
    Where to Buy 3,4,5-Trifluorobenzeneboronic Acid in China?
    As a trusted 3,4,5-Trifluorobenzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 3,4,5-Trifluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the chemical properties of 3,4,5-trifluorophenylboronic acid?
    3,4,5-Trihydroxybenzoic acid is an organic compound. It has the following chemical properties:
    1. ** Acidic **: Because of the carboxyl group (-COOH), this is an acidic functional group, which can dissociate hydrogen ions (H 🥰) in water, showing acidity. It can neutralize with bases, such as with sodium hydroxide (NaOH). The hydrogen ion in the carboxyl group combines with hydroxyl ion (OH) to form water to form the corresponding carboxylate and water. This reaction is similar to the reaction of common organic acids and bases, such as the reaction between acetic acid and sodium hydroxide.
    2. ** Properties of phenolic hydroxyl groups **: This compound contains three phenolic hydroxyl groups (-OH is directly connected to the benzene ring). The phenolic hydroxyl group has a certain acidity. Although its acidity is weaker than that of the carboxyl group, it can react with strong bases such as sodium hydroxide to form phenolic salts. At the same time, the phenolic hydroxyl group is easily oxidized and can be gradually oxidized in the air to change color. And the phenolic hydroxyl group can react with ferric trichloride (FeCl 🥰) solution and usually appear purple. This is a characteristic reaction of phenolic compounds, which can be used to identify the existence of phenolic hydroxyl groups in the substance.
    3. ** Esterification reaction **: The carboxyl group can react with alcohol under the catalysis of concentrated sulfuric acid and heating conditions to form esters and water. For example, it reacts with ethanol to form corresponding esters and water. This reaction is a reversible reaction and follows the general law of esterification reaction.
    4. ** Benzene ring reaction **: The benzene ring, as an important structural part of the compound, has the typical reaction of the benzene ring. If under appropriate conditions, a halogenation reaction can occur, and the hydrogen atom on the benzene ring is replaced by a halogen atom; a nitration reaction can also occur, and the benzene ring is introduced into the nitro group (-NO 2); a sulfonation reaction can also occur, and a sulfonic acid group (-SO 🥰 H) is introduced. These reactions require specific catalysts and reaction conditions to promote the reaction in the desired direction.
    What are the main uses of 3,4,5-trifluorophenylboronic acid?
    3,4,5-Trihydroxybenzoic acid, also known as gallic acid, its main uses are as follows:
    First, in the field of medicine, has many effects. It can be used as an antibacterial drug, inhibiting common bacteria such as Escherichia coli, Staphylococcus aureus, etc., and can help prevent and treat infectious diseases. It can also resist oxidation, reduce the damage of free radicals in the body to cells, help prevent aging and cardiovascular diseases, etc. It can also assist in stopping bleeding, play an astringent role in wounds, and speed up the coagulation process.
    Second, in the food industry, it is a high-quality antioxidant. It can prevent oxidative deterioration of foods such as oils, meats, fruits and vegetables, and prolong the shelf life. Like adding gallic acid to oils, it can inhibit the automatic oxidation of oils, avoid rancidity, and ensure the flavor and quality of food. It can also be used as a food preservative to delay food spoilage, maintain freshness, and is used in the preservation of fruits and vegetables to reduce rot losses.
    Third, in the chemical industry, it is an important organic synthetic raw material. It is used to prepare a variety of chemical products, such as gallate esters, which are used as antioxidants in plastics, rubber, and coatings to enhance material stability and durability. Gallic acid can also participate in the synthesis of dyes, providing specific colors and properties for dyes.
    Fourth, in agriculture, it can enhance plant disease resistance. By regulating plant physiological metabolism, activating defense mechanisms, plants can resist pathogenic bacteria and reduce the use of pesticides. It can also be used as a plant growth regulator to promote seed germination, root growth and plant development at appropriate concentrations, and improve crop yield and quality.
    What is the synthesis method of 3,4,5-trifluorophenylboronic acid?
    3,4,5-Trihydroxybenzoic acid, also known as gallic acid, its preparation methods have been used throughout the ages.
    One of them can be extracted from natural substances. Many plants, such as gallnut, tea leaves, oak bowls, etc., contain this acid. Take gallnut as an example, take gallnut first, wash it, add an appropriate amount of water, and use acid or enzyme as a catalyst to promote hydrolysis. The method of acidification, commonly used strong acids such as sulfuric acid, under heating conditions, the tannins in gallnut are hydrolyzed to obtain gallic acid. However, this way, sulfuric acid is corrosive, demanding equipment, and subsequent separation and purification are complicated. Although the method of enzymatic hydrolysis has mild conditions and good selectivity, the cost of enzymes is high, which is also inconvenient.
    Second, the way of chemical synthesis. Gallic acid can be formed from gallic as a raw material through a series of steps such as acetylation, oxidation, and hydrolysis. Gallic and acetic anhydride are first reacted under an appropriate catalyst to obtain acetylated products. This step can protect phenolic hydroxyl groups. Then a suitable oxidant, such as potassium permanganate, oxidizes the side chain and introduces carboxyl groups. Finally, hydrolysis under alkaline conditions removes the acetyl group to obtain the target product. Although the reaction can be precisely controlled in this way, there are many steps, the raw materials are rare and the cost is quite high.
    Third, microbial fermentation method. Choose suitable microorganisms, such as certain fungi, bacteria, etc., and cultivate them in a medium containing carbon sources and nitrogen sources. In the process of growth and metabolism, microorganisms can convert substrates into gallic acid. This way is green and environmentally friendly, and the conditions are mild. However, the fermentation cycle may be long, and the yield may need to be improved. The screening and culture of strains also need to be carefully controlled.
    In summary, the raw materials of the natural extraction method are naturally easy to obtain, but the separation is complicated; the chemical synthesis method is accurate but cumbersome and expensive; the microbial fermentation method is green and mild, and still needs to be refined. The advantages and disadvantages of each method coexist. According to the actual needs and conditions, choose the best one to prepare gallic acid.
    What is the market price of 3,4,5-trifluorophenylboronic acid?
    At present, the price of 3,4,5-trihydroxybenzoic acid in the market varies depending on the quality, quantity, source and market conditions. If the quality is good and the quantity is wide, the price may be higher; if the quality is small, the price may be inferior.
    It is derived from natural extraction or chemical synthesis. Natural ones, due to the difficulty of extraction and consumption, are often higher than synthesizers. And the distance of origin, supply and demand are also variables of price. If the origin is remote, the cost of transportation increases, and the price will rise; if the market demand is strong, the supply is not enough, and the price will also increase.
    Looking at various cities, the price of 3,4,5-trihydroxybenzoic acid synthesized varies from a few yuan to tens of yuan per gram. However, the price of natural extracts may be doubled, or even several times. And the price of block trade and retail is also different. Bulk buyers, because of the huge quantity, often get preferential prices; retail is convenient, the price may be slightly higher.
    Therefore, if you want to know the exact price, you need to check the market situation carefully, and it is better than everyone's report.
    What are the precautions for storing and transporting 3,4,5-trifluorophenylboronic acid?
    When storing and transporting 3,4,5-trihydroxybenzoic acid, pay attention to many matters. Its nature may be more sensitive, and it may be damaged by changes in the environment such as heat, light, and humidity.
    When storing, be sure to find a cool, dry and well-ventilated place. Heat can easily cause it to decompose or deteriorate, so it should be avoided in a high temperature place, away from heat sources and fire sources. Light may also cause its chemical reactions, so it should be stored in an opaque container or placed in a dark place. Humid environment can cause moisture, cause it to agglomerate, mildew, and affect quality, so it is necessary to keep the environment dry.
    During transportation, make sure that the packaging is intact. Packaging should be sufficiently protected to resist vibration and collision, so as to avoid leakage caused by damage to the container. If it is long-distance transportation, it is even more necessary to pay attention to temperature control and humidity control. High temperature in summer, or need to use refrigeration equipment to maintain a suitable temperature; humid areas or seasons, desiccant can be placed in the package to prevent moisture.
    Furthermore, this substance may be dangerous and must be carried out in accordance with relevant regulations and standards during transportation. Transport personnel should be familiar with its characteristics and emergency treatment methods. In the event of leakage and other accidents, they can respond quickly and properly to reduce losses and avoid hazards. In this way, the quality and safety of 3,4,5-trihydroxybenzoic acid can be guaranteed during storage and transportation.