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What are the main uses of 3,3,3-trifluorobenzenesulfonamide?
3,3,3-triethylaminopropionitrile is alkaline and its main uses are as follows:
This compound has important applications in many fields. In the field of organic synthesis, it is often used as a key intermediate. For example, when preparing specific nitrogen-containing heterocyclic compounds, with its unique structure, it can build a complex ring structure through a series of chemical reactions, laying the foundation for the synthesis of many biologically active drugs and natural products.
In the field of materials science, it can participate in the synthesis of some functional polymers. Due to its basic properties, it can react with acidic monomers to change the properties of the polymer, such as solubility, thermal stability and mechanical properties, to meet the special needs of materials in different scenarios.
In the field of catalysis, it also shows a certain role. Because its basic check point can interact with the reactant molecules, it affects the activity and selectivity of the reaction, thereby improving the efficiency of specific chemical reactions and helping to achieve more efficient and targeted chemical conversion processes.
In summary, 3,3,3-triethylaminopropionitrile plays an indispensable role in many fields such as organic synthesis, materials science and catalysis, and is of great significance to promote the development of related fields.
What are the physical properties of 3,3,3-trifluorobenzenesulfonamide?
3,3,3-Trifluoroacrylonitrile benzamide is a strange and delicate compound with unique physical properties.
Its properties are often white to off-white crystalline powders with fine texture. This appearance characteristic is crucial in many practical applications, such as in the field of pharmaceutical preparations. This appearance is conducive to the accurate preparation and preparation of pharmaceutical dosage forms.
Melting point is also an important physical property. It is about 150-155 ° C in a specific temperature range. This melting point characteristic can assist in the identification of this compound. In the synthesis and purification process, the melting point is a key indicator for quality control. If the melting point deviates from the normal range, it may suggest that the compound is not pure or contains impurities.
In terms of solubility, it is slightly soluble in water, but soluble in some organic solvents, such as dichloromethane, N, N-dimethylformamide, etc. Such solubility characteristics are conducive to the selection of suitable reaction solvents during chemical synthesis to promote the smooth progress of the reaction; in drug development, the solubility of organic solvents provides ideas for the design of drug delivery systems, which can improve the bioavailability of drugs with the help of suitable solvents.
In terms of stability, it is quite stable under conventional conditions, but it needs to avoid high temperature, open flame and strong oxidants. Because its structure contains special functional groups, when exposed to high temperature or strong oxidants, it may cause chemical reactions, resulting in structural changes and performance damage. During storage and transportation, strict conditions must be followed to ensure its quality and performance.
The density is about a certain value. Although the exact density data varies depending on the measurement conditions, this physical property plays an important role in the process of mass and volume conversion, such as the accurate calculation of material quantity in large-scale production.
3,3,3-trifluoroacrylonitrile benzamide These physical properties are of great significance in many fields such as chemical synthesis, drug development, and materials science, and have a profound impact on its application efficiency and prospects.
Is the chemical properties of 3,3,3-trifluorobenzenesulfonamide stable?
3,3,3-trifluoroacrylonitrile, the chemical properties of this substance are relatively stable.
Looking at its structure, the introduction of trifluoromethyl gives it unique properties. The fluorine atom has high electronegativity, which makes the C-F bond energy very high. To break this bond requires a lot of energy, which is one of the sources of its chemical stability. And the existence of trifluoromethyl changes the distribution of molecular electron clouds, causing changes in molecular polarity, but the overall structure still has certain stability.
Furthermore, the nitrile group (-CN) also has its own characteristics. The carbon-nitrogen triple bond in the nitrile group is quite stable, and its electron cloud distribution is concentrated between carbon and nitrogen atoms, which has a certain resistance to the attack of external reagents. Under common chemical reaction conditions, specific catalysts or more violent reaction conditions are required to make the nitrile group react, such as hydrolysis to form carboxylic acids, reduction to form amines, etc., all of which require specific conditions to proceed smoothly.
And because the bonding mode and spatial arrangement of the atoms in the molecule are relatively stable, without suitable initiators, the molecular structure is not easy to change spontaneously. Therefore, in general, the chemical properties of 3,3,3-trifluoroacrylonitrile are relatively stable.
What are the synthesis methods of 3,3,3-trifluorobenzenesulfonamide?
The synthesis of 3,3,3-trifluoroacrylonitrile has been known for a long time.
To make 3,3,3-trifluoroacrylonitrile, one of the methods can be started with fluorohalogenated hydrocarbons. Take an appropriate amount of fluorohalogenated hydrocarbons, such as 1,1,1-trifluoro-2-chloropropane, and cyanide reagents, such as potassium cyanide (KCN), in a suitable solvent, such as N, N-dimethylformamide (DMF), under certain temperature and catalytic conditions. This reaction needs to be protected by inert gases, such as nitrogen, to avoid impurities. Temperature control is critical and usually needs to be maintained in a moderate range, such as 60 to 80 degrees Celsius. During the reaction, the halogen atom is substituted with the cyanyl group, and the crude product of 3,3,3-trifluoroacrylonitrile is obtained. The crude product can be purified by distillation, extraction, etc.
Another way can be started from fluoroolefins. For example, 3,3,3-trifluoropropylene is used as raw material to react with halogenated cyanides, such as cyanogen bromide (BrCN), under the action of a catalyst. The catalyst used may be a transition metal compound, such as palladium chloride (PdCl ²). The pH and temperature of the reaction system need to be precisely regulated. At a suitable temperature, such as 40 to 60 degrees Celsius, and when the pH is suitable, the addition reaction of olefins and halogenated cyanide occurs to generate an intermediate product of 3,3,3-trifluoroacrylonitrile, and then subsequent treatment to remove impurities to obtain the desired product.
These two methods have their own advantages and disadvantages. The former raw materials are easy to obtain, but the cyanide reagent is quite toxic, and the operation needs to be extremely cautious; the latter reaction conditions are mild, but the catalyst price may be high, and some raw materials are rare.
What is the price range of 3,3,3-trifluorobenzenesulfonamide in the market?
The price of 3-triallyl cyanurate varies from market to market due to changes in quality, supply and demand. Generally speaking, its price fluctuates between tens of yuan and hundreds of yuan per kilogram. If the quality is high and the market demand is strong, and the supply is slightly tight, the price may rise, up to two or three hundred yuan per kilogram, or even higher.
However, if the quality is slightly inferior, or the market supply is sufficient, and the demand is not strong, the price may be slightly lower, or in the tens to hundreds of yuan per kilogram. The reason for this is that because quality is related to its use, the superior is suitable for the fine industry, and the natural price is high; and the state of supply and demand also affects the price. If the supply exceeds the demand, the price will fall, and if the supply exceeds the demand, the price will rise.
Merchants are in the market, often weighing quality and price in order to maximize profit. And buyers also choose the right one according to their own needs. It is at the price of 3-triallyl cyanurate, which is indeterminate in the market and often varies with various factors.