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What is the chemical structure of (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine 4-methylbenzenesulfonate?
There are (2R, 3S) - 2 - ((R) - 1 - (3,5 - bis (trifluoromethyl) phenyl) ethoxy) - 3 - (4 - fluorophenyl) furan - 4 - methylbenzenesulfonate lactone. To know its chemical structure. This is a study of the structure of specific compounds in organic chemistry.
The structure of this compound needs to be analyzed one by one according to its naming rules. (2R, 3S) Specifies the configuration of specific chiral carbons in the molecule. " 2 - ((R) - 1 - (3,5 - bis (trifluoromethyl) phenyl) ethoxy) ", indicating that an ethoxy group is connected at position 2, the carbon at position 1 of this ethoxy group is of the R configuration, and the ethoxy group is connected to 3,5 - bis (trifluoromethyl) phenyl." 3 - (4 - fluorophenyl) "shows that there is 4 - fluorophenyl at position 3." Furan - 4 - methylbenzenesulfonolactone "is clearly the main structure of furan, and there is a methylbenzenesulfonactone attached at position 4.
The specific structure is described as follows: the furan ring is used as the core skeleton, and an ethoxy-containing branched chain is extended at position 2. The carbon configuration at position 1 on the ethoxy group is R, and this ethoxy group is connected to 3,5-bis (trifluoromethyl) phenyl; position 3 is connected to 4-fluorophenyl; position 4 is connected to methylbenzenesulfonide. In this way, the complete chemical structure of this compound can be obtained.
What are the main uses of (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate?
(2R, 3S) 2- ((R) -1- (3,5-Bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) butene 4-methylbenzenesulfonate, which has a wide range of uses. In the field of pharmaceutical chemistry, it is often an intermediate in organic synthesis. Its structure is unique, or it can be reacted through specific chemical reactions to construct more complex compounds, laying the foundation for the creation of new drugs.
In the field of materials science, or because of its special chemical structure and properties, it participates in the preparation of materials with special properties. For example, it can be combined with other materials, or it can change the electrical and optical properties of materials, and is used in electronic devices, optical materials and other fields.
Furthermore, in organic catalytic reactions, it can be used as a catalyst or ligand. With its spatial structure and electronic effect, it can affect the selectivity and activity of the reaction, promote the efficient and accurate progress of organic synthesis, and assist the synthesis of complex organic molecules. In short, due to its special structure, this compound shows potential and important application value in many fields, providing many possibilities for scientific research and industrial production.
What are the synthesis methods of (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate?
To prepare\ ((2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine-4-methylbenzoic anhydride, there are many methods.
First, start with a phenyl compound containing a specific substituent. For example, a benzene derivative with corresponding fluorine and trifluoromethyl substitutions is used as a raw material, and it is delicately transformed in multiple steps to form key fragments of the target molecule. First, by the method of nucleophilic substitution, a suitable halogen is reacted with a hydroxy-containing compound to construct an ether bond structure to introduce the\ ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy\) part. In this process, it is necessary to choose a suitable base and solvent to promote the smooth reaction, and pay attention to the control of reaction temperature and time to avoid side reactions.
Then, the construction of the morpholine ring structure is also the key. The structure of the morpholine ring can be shaped by multi-step reaction, such as condensation and cyclization of suitable amines and carbonyl compounds. And in the reaction process, pay attention to the control of stereochemistry, and obtain the desired\ ((2R, 3S) \) configuration by chiral catalysts or chiral auxiliaries.
As for the access of the benzoic anhydride part, it can be formed by acylation after the main structure is initially formed. Select the appropriate active acylating reagent, such as acyl chloride or acid anhydride, and react with the host molecule under the catalysis of an organic base to obtain the target\ (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine-4-methylbenzoic anhydride.
Each step of the reaction requires fine control of the reaction conditions, and the product also needs to be purified and refined, such as chromatography, recrystallization, etc., to achieve high purity and obtain the desired target product.
What are the physicochemical properties of (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate?
(2R, 3S) - 2 - ((R) - 1 - (3,5 - bis (trifluoromethyl) phenyl) ethoxy) - 3 - (4 - fluorophenyl) pentanitrile 4 - methylbenzenesulfonate, this is a complex organic compound. Its physical and chemical properties are quite important, related to its performance in various chemical processes and practical applications.
First of all, the appearance properties are often white to white solid powder. This form is easy to store and use, and it is easy to disperse in many reaction systems, which is conducive to the full occurrence of reactions. Looking at its solubility, it has good solubility in common organic solvents such as dichloromethane, N, N-dimethylformamide (DMF). This property makes it possible to build a homogeneous reaction environment with suitable solvents in a variety of organic synthesis scenarios, thereby promoting the smooth progress of the reaction.
Besides the melting point, the melting point of this compound is about [X] ° C. As a key physical property, the melting point can be used to determine the purity. If the purity is extremely high, the melting point range is narrow and close to the theoretical value; if it contains impurities, the melting point is reduced and the melting range is widened.
In terms of chemical stability, it is relatively stable under conventional environmental conditions. When it encounters strong oxidants, strong acids and bases, some chemical bonds in the structure are vulnerable to attack, triggering chemical reactions and causing structural changes. Its molecules have specific functional groups, such as nitrile groups and sulfonate groups, which endow it with unique chemical activities. Nitrile groups can participate in various reactions such as hydrolysis and reduction, while sulfonate groups are often used as excellent leaving groups. They play a key role in nucleophilic substitution reactions, helping to construct novel carbon-carbon bonds or carbon-heteroatomic bonds, and then derive more organic compounds with unique properties and functions.
What are the relevant pharmaceutical applications of (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate?
(2R, 3S) - 2 - ((R) - 1 - (3,5 - bis (trifluoromethyl) phenyl) ethoxy) - 3 - (4 - fluorophenyl) butene - 4 - methylbenzenesulfonate This compound is widely used in related drugs.
In the field of antihypertensive, this compound can precisely act on angiotensin-converting enzyme by virtue of its unique chemical structure, effectively inhibit angiotensin ⅱ production, promote vasodilation, reduce peripheral vascular resistance, and achieve a stable drop in blood pressure, with a significant and lasting antihypertensive effect.
In the treatment of cardiovascular diseases, it can improve myocardial remodeling, improve cardiac function, and reduce cardiac load by regulating the level of certain physiologically active substances in the body. It has good therapeutic and preventive effects on myocardial infarction, heart failure and other diseases.
In addition, it has also emerged in the field of neurological disease treatment. Because of its specific fat solubility and molecular configuration, it can penetrate the blood-brain barrier and act on specific targets of the nervous system, which may have potential value in the treatment of neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease, or can regulate neurotransmitter metabolism, protect nerve cells, and delay disease progression.
At the same time, in the treatment of some inflammation-related diseases, the compound may inhibit specific inflammatory signaling pathways, reduce the release of inflammatory mediators, and exhibit certain anti-inflammatory properties, providing new ideas for the treatment of related inflammatory diseases.
In summary, (2R, 3S) -2- ((R) -1- (3,5-bis (trifluoromethyl) phenyl) ethoxy) -3- (4-fluorophenyl) butene-4-methylbenzenesulfonate has broad application prospects and in-depth research value in the field of medicine.