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What is the chemical structure of (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, 4-methylbenzenesulfonate?
(The structure of this compound is quite complex, let me go through it in detail.) This compound is named after it ((2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) butene, 4-methylbenzenesulfonate), and its structure can be gradually analyzed.
First, the main chain is a butene structure containing double bonds, with specific substituents at the 2nd and 3rd positions, respectively, and the configurations are R and S. The substituent at the 2nd position is ethoxy, and the ethoxy group is connected with a structure, namely (1R) -L- [3,5-bis (trifluoromethyl) phenyl]. This benzene is based on trifluoromethyl at the 3rd and 5th positions, and the structure has a specific R configuration. The 3rd position is connected with 4-fluorophenyl. The 4th position of the butene structure is connected with 4-methylbenzene sulfonate group.
In this way, the chemical structure of this compound can be outlined by connecting the structure of each part according to the position and configuration shown in the name. In this structure, each atom and group are connected to each other to form a specific spatial arrangement to meet its stereochemical requirements and overall structural characteristics.
What are the physical properties of (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, 4-methylbenzene sulfonate?
(This is an extremely complex organic compound, which is (2R, 3S) -2- [ (1R) -L - [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) pentene, 4-methylbenzenesulfonate. Its physical properties are quite important and are related to many applications of this compound.)
The physical properties of this compound, the first is the melting point. The melting point is the temperature at which a substance changes from a solid state to a liquid state. However, due to the extremely complex structure involved, the spatial resistance and intermolecular forces are intertwined, so the determination of its melting point requires fine operation. Or because of the high electronegativity of fluorine atoms, coupled with the influence of the benzene ring conjugation system, the intermolecular force is enhanced, and the melting point may be in a higher range. However, the exact value needs to be accurately determined by experiments.
Second words boiling point. The boiling point is restricted by the intermolecular force and the relative molecular weight. This compound contains many functional groups and a large benzene ring structure, and has a relatively large molecular weight. In addition to van der Waals force, there may be special interactions such as hydrogen bonds between molecules. Therefore, its boiling point may be considerable. Due to the complex structure, more energy is required for molecular separation, but the specific boiling point also depends on experimental investigation.
In terms of solubility, because it contains hydrophobic phenyl groups and trifluoromethyl groups, it may have good solubility in non-polar organic solvents such as toluene and dichloromethane. In polar solvents such as water, the solubility may be poor due to the relatively small proportion of polar functional groups in the structure. However, factors such as solvent polarity and temperature will also affect the solubility.
The density is related to the mass per unit volume of the substance. In view of the complex atomic composition and spatial arrangement of this compound, the density may be different from that of common organic compounds. Its exact density needs to be determined by precise experimental instruments, or due to the presence of heavy atoms such as fluorine, the density increases.
In addition, the refractive index of this compound is also an important physical property. The refractive index is related to the molecular structure and the distribution of electron clouds. The complex benzene ring structure and the electronic effect of fluorine atoms may give the refractive index a unique value, which is of great significance for its optical applications. However, the specific value still needs to be obtained experimentally.
What is the synthesis method of (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, 4-methylbenzene sulfonate?
To prepare (2R, 3S) - 2 - [ (1R) - L - [3,5 - bis (trifluoromethyl) phenyl] ethoxy] - 3 - (4 - fluorophenyl) pentadiene, 4 - methylbenzoic anhydride, the method is as follows:
First take an appropriate amount of (1R) - L - [3,5 - bis (trifluoromethyl) phenyl] ethanol, in a suitable reaction vessel, add an appropriate amount of base, such as potassium carbonate, etc., to activate the alcohol hydroxyl group. Then slowly add the halogenate containing 2-halogenated ethyl-3- (4-fluorophenyl) pentadiene structure, control the reaction temperature and time, and make the two undergo nucleophilic substitution reaction to obtain (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) pentadiene precursor.
Then, the obtained precursor is appropriately purified, and column chromatography can be used to remove impurities.
As for the preparation of 4-methylbenzoic anhydride, take 4-methylbenzoic acid, add an appropriate amount of dehydrating agent, such as the mixture of acetic anhydride and concentrated sulfuric acid, heat and stir to promote the dehydration reaction to generate 4-methylbenzoic anhydride. After the reaction is completed, the pure 4-methylbenzoic anhydride can be obtained through cooling, liquid separation, washing and other steps.
Thus, according to the above steps, the desired (2R, 3S) - 2 - [ (1R) - L - [3,5 - bis (trifluoromethyl) phenyl] ethoxy] - 3 - (4 - fluorophenyl) pentadiene and 4 - methylbenzoic anhydride can be prepared.
What are the uses of (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, 4-methylbenzene sulfonate?
(This is a very complex organic compound naming, in order to clarify its use, and let me explain it in detail.) The path involved in this compound is the first in the field of medicine. Because of its unique structure or specific biological activity, it can be used as a key intermediate for drug research and development. In the path of drug synthesis, based on this, through delicate chemical reactions, it may be able to produce new drugs with excellent efficacy and strong targeting, providing assistance for the treatment of difficult diseases.
Furthermore, in the field of organic synthetic chemistry, it is also of great significance. With its complex and unique structure, chemists can use it to explore new synthetic methods and strategies. By modifying and modifying it, the mechanism of organic reactions can be deeply studied, the boundaries of organic synthesis can be expanded, and the foundation for the creation of more novel and complex organic compounds can be laid.
In addition, in the field of materials science, if some of its properties are properly regulated, it may be applied to the creation of new functional materials. If it has special optical and electrical properties, it is expected to be used to manufacture high-performance optoelectronic materials and promote technological innovation in related fields.
In short, although the structure of this compound is complex and difficult to distinguish, it has unlimited possibilities in many fields such as medicine, chemistry, and materials. It is waiting for scientific researchers to deeply explore and tap its hidden value, so as to contribute to human well-being.
What are the market prospects for (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine, 4-methylbenzene sulfonate?
Guanfu (2R, 3S) -2- [ (1R) -L- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) butene, 4-methylbenzenesulfonate. The market prospect of this product is quite promising.
In today's world, the pharmaceutical and chemical industry is booming, and the demand for fine chemicals is increasing day by day. This compound has a unique structure and may be of extraordinary use in pharmaceutical research and development. It has a complex spatial configuration or can accurately fit with specific biological targets. When new drugs are created, it is a key intermediate, such as the development of targeted anti-cancer drugs and drugs for the treatment of nervous system diseases.
Furthermore, in the field of materials science, it may have potential value. Due to its fluorine content and specific phenyl structure, it may endow materials with unique physical and chemical properties, such as improving material stability, corrosion resistance, and even optical properties, so it may emerge when high-performance materials are prepared.
However, its market prospects also pose challenges. The synthesis process may be difficult due to complex structures, and cost control and yield increase are all priorities. And the market competition is fierce. If similar substitutes or exist, if they want to gain a place in the market, they must work quickly on technological innovation and cost optimization.
In summary, (2R, 3S) -2- [ (1R) -L- [3,5-Bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) butene, 4-methylbenzenesulfonate Although promising, it also needs to face challenges in order to shine in the market.