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What is the chemical structure of (2R, 3S) -2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine 4-methylbenzenesulfonate
What I am asking you is about the chemical structure of\ ((2R, 3S) -2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine-4-methylbenzoic acid. The structure description of this compound contains specific chiral information, such as\ (2R\),\ (3S\),\ (1R\), etc., indicating the configuration of each chiral center. The main body is a morpholine ring with a specific ethoxy substituent at the\ (2\) position. The carbon at the\ (1\) position on the ethyl of this ethoxy group is of the\ (R\) configuration and is connected to the\ (3,5 -bis (trifluoromethyl) phenyl\). It is connected to the\ (3\) position of the morpholine ring and the methylbenzoic acid group at the\ (4\) position of the morpholine ring. In this way, the chemical structure of this compound is formed by connecting specific groups according to specific chirality and positional relationship. The complexity of its structure highlights the subtlety of organic chemistry, and the interaction of various groups affects the physical, chemical and biological activities of the compound.
What is the main use of (2R, 3S) -2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate
(2R, 3S) - 2 - [ (1R) - 1 - [3,5 - bis (trifluoromethyl) phenyl] ethoxy] - 3 - (4 - fluorophenyl) morpholine - 4 - methylbenzoate This compound is a key intermediate in the field of organic synthesis. Its main uses cover both pharmaceutical chemistry and materials science.
In the field of pharmaceutical chemistry, due to its unique molecular structure, it can be used as the cornerstone for the construction of new drug molecules. For example, by modifying and optimizing its structure, it can interact specifically with specific biological targets. For example, for some disease-related protein receptors, carefully designed derivatives of this compound may be able to develop innovative drugs with excellent efficacy and mild side effects. And because of the fluorine atoms in its structure, it can significantly enhance the lipophilicity of the compound, enhance its cell membrane penetration ability, and then improve the bioavailability of drugs.
In the field of materials science, this compound can be used as a key monomer for the synthesis of functional polymer materials. After polymerization, its unique structural properties can be introduced into the polymer chain, imparting special optical, electrical or thermal properties to the material. For example, using its rigid benzene ring structure and fluorine-containing groups, new polymer materials with high transparency, low dielectric constant and good thermal stability can be prepared, which have broad application prospects in electronic devices, optical films and other fields.
What are the synthesis methods of (2R, 3S) -2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate
To prepare\ ((2R, 3S) -2- [ (1R) -1- [3,5-Bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine-4-methylbenzoate, there are many methods for its synthesis.
First, the method of gradually constructing key structural units can be used. First, with appropriate raw materials, through nucleophilic substitution reaction, fluorophenyl and other groups are introduced at specific positions. For example, select a suitable halogen and the corresponding alcohol or phenol, and under the action of a base, nucleophilic substitution occurs to form a carbon-oxygen bond.
Furthermore, the construction of morpholine ring structure is also a key step. It can be formed by cyclization of nitrogen-containing compounds with suitable bifunctional compounds. For example, dihalides and amines, under appropriate conditions, through nucleophilic substitution in molecules, close the ring to obtain morpholine rings.
In addition, the control of stereochemistry is extremely important. In the reaction process, chiral auxiliaries or chiral catalysts can be selected to guide the reaction to selectively generate the desired\ (2R, 3S) \) and\ ((1R) \) configurations. For example, metal-catalyzed reactions in the presence of chiral ligands can precisely control the stereochemistry of the reaction.
Or by pre-modifying the substrate, introducing a chiral center, and then undergoing a stereospecific reaction in the subsequent reaction to maintain and transfer the chirality to achieve the purpose of generating the target product. In short, the synthesis of this compound requires fine design of the reaction route, consideration of the reaction conditions of each step and stereochemical control, in order to obtain it efficiently.
What are the physical properties of (2R, 3S) -2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate
(This is an extremely complex organic compound, its name: (2R, 3S) -2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine-4-methylbenzoate. Its physical properties are briefly described below)
The properties of this compound may be crystalline powder, and it is easy to form a crystalline state due to the interaction of many aromatic rings and polar groups in its structure, resulting in an orderly arrangement of intermolecular forces. Its melting point or in a specific interval, aromatic rings and ester groups form a tight lattice, requiring specific energy to break the lattice, and the melting point is relatively high.
In terms of solubility, it may have a certain solubility in organic solvents. Because the molecule contains hydrophobic groups such as benzene rings, it can be dissolved by hydrophobic interaction in non-polar organic solvents such as toluene and dichloromethane; however, it also contains polar groups such as ester groups and ether bonds. In polar organic solvents such as ethanol and acetone, it also has a certain solubility through dipole-dipole interaction.
Density or similar to similar structural compounds, determined by its molecular composition and packing mode. Although the atomic weight of fluorine atoms in the molecule is relatively large, the spatial distribution may affect the packing tightness, which in turn affects the density.
Its stability is acceptable under normal conditions, but it encounters strong acids, strong bases, ester groups or hydrolysis; under high temperature and strong oxidation conditions, aromatic rings and other groups may also react.
The physical properties of this compound have a significant impact on its synthesis, separation, application, etc. Understanding it is helpful for the control and optimization of related chemical processes.
What are the market prospects for (2R, 3S) 2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine 4-methylbenzene sulfonate?
There is now a product named\ ((2R, 3S) -2- [ (1R) -1- [3,5-bis (trifluoromethyl) phenyl] ethoxy] -3- (4-fluorophenyl) morpholine-4-methylbenzoate\). The situation of this product in the market is related to many aspects.
Looking at the field of medicine, such compounds may have unique pharmacological activities and may become key intermediates when developing new drugs. Due to their specific spatial configuration and chemical structure, they may be precisely compatible with specific targets in organisms, thus demonstrating the potential to treat specific diseases. Therefore, in the forefront of medical research, there are many in-depth explorers of it, hoping to open up new treatment paths, so its prospects in the pharmaceutical research and development market may be good, and the demand may also grow.
As for the chemical industry, this compound may emerge in the field of material synthesis. Because its structure contains special groups such as fluorine, it may endow materials with excellent properties such as chemical resistance and low surface energy. Chemical developers may focus on this, explore its application in the preparation of high-end materials, and over time, or find a place in the chemical new materials market.
However, the road ahead for its market is not smooth sailing. The process of synthesizing this compound may have technical difficulties and high costs, which may restrict its large-scale production and wide application. And the market competition is fierce, and similar or alternative products also pose challenges to it. Only by overcoming technical barriers, reducing costs, and highlighting their own advantages can they take the initiative in the market and seek long-term development.