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2-Trifluoromethylbenzenesulfonyl Chloride

2-Trifluoromethylbenzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code

402835

Chemical Formula C7H4ClF3O2S
Molecular Weight 258.62
Appearance Typically a colorless to light yellow liquid
Physical State At Room Temperature Liquid
Odor Pungent odor
Solubility In Common Solvents Soluble in organic solvents like dichloromethane, toluene
Boiling Point Approximately 233 - 235 °C
Density Around 1.58 g/cm³
Reactivity Highly reactive, reacts with nucleophiles like alcohols, amines
Packing & Storage
Packing 100g of 2 - trifluoromethylbenzenesulfonyl chloride in a sealed glass bottle.
Storage 2 - Trifluoromethylbenzenesulfonyl chloride should be stored in a cool, dry, and well - ventilated area, away from heat sources and direct sunlight. It should be kept in a tightly sealed container to prevent moisture ingress, as it can react with water. Store it separately from incompatible substances like bases, reducing agents, and reactive metals to avoid potential chemical reactions.
Shipping 2 - trifluoromethylbenzenesulfonyl chloride is a chemical. For shipping, it must be in a well - sealed, corrosion - resistant container. Label it clearly as a hazardous chemical. Ship via approved carriers following strict safety and regulatory guidelines.
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2-Trifluoromethylbenzenesulfonyl Chloride 2-Trifluoromethylbenzenesulfonyl Chloride
General Information
Historical Development
At the beginning of the 20th century, Western chemistry began to spread eastward, and the princes of our country began to study this industry. 2-Trifluoromethylbenzenesulfonyl chloride also gradually entered the field of Chinese chemistry at that time.
At the beginning, the domestic understanding of this thing was still shallow, and it relied on Western classics as a reference. Chemists, painstakingly researched, tried repeatedly in the laboratory. Although the equipment is simple, they are determined and not afraid of difficulties.
In the middle of the period, the domestic chemical industry gradually flourished, and the demand for 2-trifluoromethylbenzenesulfonyl chloride gradually increased. Everyone united, improved the process, and strived to increase the output and improve the quality.
And today, our country's chemistry has flourished, and the research and production of this chemical have also achieved remarkable results. The difficult situation in the past has turned into today's brilliant achievements, which proves that our country's chemists are diligent and forging ahead, promoting this industry to move forward and grow.
Product Overview
Today there is a product called 2-trifluoromethylbenzenesulfonyl chloride. Its color is pure and pure, and its properties are strong and active. This is an important agent in organic synthesis, and it is quite effective in many reactions. It can introduce sulfonyl groups into compounds, give novelty, and is very useful in the fields of medicine, pesticides, and materials.
The method of production, through specific processes, according to strict proportions, and fine operation, obtains this good product. However, because of its active nature, it is easy to change when exposed to water and alkali, so it needs to be stored carefully, and placed in a dry and cool place to avoid contact with various active substances.
2-trifluoromethylbenzene sulfonyl chloride, although its body is small, it is like a star in the chemical industry, shining brightly, contributing to the advancement of science and technology and the prosperity of industry.
Physical & Chemical Properties
The physical and chemical properties of this substance can be studied. Looking at its shape, it is often a colorless to slightly yellow liquid, with a pungent smell. Its boiling point is suitable for a certain degree, which is related to the intermolecular force. Its density also has a specific value, which is determined by its molecular structure and composition.
In terms of its chemistry, this substance is very active. Because it contains special groups, it is easy to react with other substances. In contact with water, it changes and can be hydrolyzed to release acidic substances. In the field of organic synthesis, it is often a key reagent, which can introduce specific functional groups and assist in the preparation of various organic compounds. Its physical and chemical properties are of great use in both industry and scientific research, and cannot be ignored.
Technical Specifications & Labeling
Today there is a product called 2-trifluoromethylbenzenesulfonyl chloride. In the field of chemical research in China, its technical specifications and identification (product parameters) are the key.
This 2-trifluoromethylbenzenesulfonyl chloride, looking at its properties, when it has a specific color and state, this is one end of the label. Its purity geometry is also an important parameter, which is related to the effectiveness of many chemical reactions. And its physical constants such as boiling point and melting point need to be accurately determined to characterize the technical specifications.
As for the label, in addition to the name of "2-trifluoromethylbenzenesulfonyl chloride", its molecular formula and molecular weight need to be marked so that researchers can see it at a glance. During storage and transportation, appropriate conditions shall be marked according to their characteristics, so as to ensure the quality and safety of this product and to give full play to its due effectiveness in the course of chemical research.
Preparation Method
To make 2-trifluoromethylbenzene sulfonyl chloride, the raw materials and production process, reaction steps and catalytic mechanism are very important. First take trifluoromethylbenzene, add an appropriate amount of chlorosulfonic acid, and the two meet in a specific container. Anhydrous aluminum trichloride is used as a catalyst and added to it, which can improve the reaction process.
The temperature is controlled in a moderate range, about 60 to 80 degrees Celsius. This temperature is just right to make the reaction smooth. The two blend and respond slowly. After a few days, the reaction gradually becomes complete.
After the reaction is completed, move the product to a liquid separation funnel, and remove its impurities by liquid separation. Through distillation, the product can be purified to obtain pure 2-trifluoromethylbenzenesulfonyl chloride. During this process, the proportion of raw materials, reaction temperature and time must be precisely controlled to obtain the ideal product.
Chemical Reactions & Modifications
Today, there is a chemical substance 2 - Trifluoromethylbenzenesulfonyl Chloride, which is crucial in the study of chemical reactions and modifications. The chemical changes in which this substance participates are often related to reaction paths such as sulfonylation. In the past, the reaction conditions were harsh, requiring specific temperature, pressure and catalyst coordination, and the yield was limited, resulting in frequent side reactions.
The way to improve the view of the man, chemists have worked hard. After repeated trials, it was found that the new catalyst can optimize the reaction, reduce the conditions, increase the yield, and inhibit side reactions. Or adjust the ratio of reactants and the type of solvent, which can also make the reaction more ideal. After many changes, this substance has been widely used in the field of organic synthesis, providing a solid foundation for new material research and development, drug creation, etc. It is expected to shine in more fields in the future and continue to promote the progress of chemical research.
Synonyms & Product Names
2-Trifluoromethylbenzenesulfonyl Chloride, this substance is also known as trifluoromethylbenzenesulfonyl chloride. Although its name is different, it actually refers to the same substance.
This chemical is widely used in various fields of chemical industry. It can be used as a reagent for organic synthesis and plays an important role in the preparation of fine chemical products.
Gu Yun: "The name is the real object." Although the name is different, its chemical properties and functions are consistent. Chemists are well aware of its various names when studying, so that they can use it freely in experiments without confusion, so as to achieve the purpose of scientific research, promote the progress of the chemical field, and contribute to industrial production and academic inquiry.
Safety & Operational Standards
2-Trifluoromethylbenzenesulfonyl chloride safety and operating specifications
2-trifluoromethylbenzenesulfonyl chloride, this chemical substance is very important in our field of chemical research. However, its properties are special, so safety and operating standards cannot be ignored.
In terms of safety, this substance is corrosive, and it can cause injury when it touches the skin and enters the eyes. Therefore, when operating, protective gear is indispensable. Wear protective clothing, its quality must be able to resist the erosion of this chemical; wear protective gloves on your hands, and choose chemical-resistant materials; wear protective glasses for your eyes to prevent accidental splashing.
There are also many details in the operating specifications. First, when taking it, the action should be slow and steady to prevent spillage. Second, the reaction environment should be well ventilated, because of its volatile gas, or harmful to the human body. Third, the utensils used should be purified to prevent subsequent reaction deviations caused by residual substances.
If you accidentally touch the skin, you should quickly rinse with a large amount of water, followed by an appropriate neutralizing agent, and seek medical treatment. If it enters the eyes, you need to rinse immediately, and do not rub it, and go to the medical office quickly.
Store this substance in a cool, dry place, away from fire and heat sources, and do not store it with easily reactive substances. In this way, the safety of the experiment can be guaranteed and the research can be smooth. We, chemical researchers, shall adhere to these safety and operating practices to protect ourselves and the stability of the research environment.
Application Area
Today there is a product called 2-trifluoromethylbenzenesulfonyl chloride. This product is available in various fields. In the field of pharmaceutical synthesis, it can be used as a key reagent to help create special drugs to treat various diseases. In the field of material science, it can be used as a modification aid to give material specificity, such as enhancing its corrosion resistance and wear resistance. In the field of organic synthesis, it is often used as a sulfonylation reagent to introduce trifluoromethylbenzenesulfonyl group, which makes the product have unique chemical properties and opens up a new path for organic synthesis. From this perspective, 2-trifluoromethylbenzenesulfonyl chloride has important value in many application fields and has broad prospects. It should be valued by researchers and explored in depth to make the best use of it.
Research & Development
Modern chemistry has been refined, and all kinds of new substances have been produced one after another. I have been working hard on this 2-Trifluoromethylbenzenesulfonyl Chloride for a long time.
Its unique nature is quite useful in organic synthesis. It can be used as a sulfonylation reagent to make many reactions smooth and the product is also good.
I began to explore the method of its preparation, and strive to make the raw materials easy to obtain, the steps are simple and the yield is considerable. At the beginning, there were many obstacles, the reaction conditions were harsh, and the yield was not as satisfactory. However, I was not discouraged, and it was easier to repeatedly test various raw materials, and finally obtained a method. Compared with the former, it was quite effective.
As for its application, the prospect is broad. In the field of medicine, it is expected to help the creation of new drugs; in materials science, it may add new materials. I should continue to study, hoping to tap its potential, add a boost to the academic community and industry, and promote its development, so as to achieve the effect of benefiting the world.
Toxicity Research
Toxicity Study of 2-Trifluoromethylbenzenesulfonyl Chloride
The toxicity of 2-trifluoromethylbenzenesulfonyl chloride is studied now. This compound is strong in nature and has strong irritating and corrosive properties. When it touches the skin of the body, it can cause burning pain, redness and swelling, and even ulceration. If it enters the eyes, it will harm the eyes and vision. Its breath is pungent, and if inhaled, it will hurt the respiratory tract, cause cough, asthma, and severe pulmonary edema.
According to experimental views, this substance has toxic effects on living beings. In small animals fed in small amounts, it can be seen that they are sluggish, eat less, and their organs will be damaged for a long time. And in the aquatic genus, a small amount can also disturb its ecology, causing lack of vitality
Therefore, when researching this object, the protection must be strict. When handling it, walk in a well-ventilated place in front of protective gear. If you accidentally touch it, quickly wash it with clean water and seek medical treatment. This is all an act of protecting people and ecology, and cannot be ignored.
Future Prospects
Fu 2 - Trifluoromethylbenzenesulfonyl Chloride is very useful in today's chemical research. Its unique nature can involve various reactions, and it has emerged in the field of organic synthesis.
Looking at its future, it is expected to expand in the way of pharmaceutical creation. With its special structure, it may become the basis for new agents to treat various diseases and relieve worries. And in material science, it can also be traced. It can help produce materials with specific properties, which can be used in electronics and aerospace, and promote their advancement.
Or in the art of catalysis, develop its longevity. Make the reaction faster and purer, improve the yield and reduce energy consumption. Therefore, its future development is full of hope. We scientific researchers should study it diligently to explore its endless potential, use it for the world, and benefit people.
Frequently Asked Questions
What are the physical properties of 2-trifluoromethylbenzenesulfonyl chloride?
2-%E4%B8%89%E6%B0%9F%E7%94%B2%E5%9F%BA%E8%8B%AF%E7%A3%BA%E9%85%B0%E6%B0%AF, it is a unique chemical substance. Its physical properties are quite interesting.
Looking at its color, under room temperature and pressure, this substance is mostly colorless, clear like clear water, without the disturbance of variegated colors, and it makes people feel pure and unsullied. As for its taste, it has a slight and special smell, not pungent and intolerable, but also not pleasant fragrance. I only feel that its taste is unique and very different from ordinary things.
When it comes to form, it is a flowing liquid under normal circumstances, just like smart water, which can change according to the shape of the container. The fluidity is quite good, and it is smooth and unobstructed. Its density is slightly heavier than that of common water. When placed in water, it can slowly settle, such as stone entering water and gradually sinking to the bottom.
Furthermore, the boiling point is also one of its important physical properties. After research, the boiling point of this substance is quite high, and it needs intense heat to make it boil and vaporize. This characteristic makes it able to maintain a liquid state under relatively high temperature environments, and it is not easy to vaporize and dissipate. The melting point is relatively low. In a slightly colder environment, it condenses into a solid state, and after condensation, the texture is hard but brittle, and it is easily broken if a little external force is applied.
In addition, the solubility of 2-%E4%B8%89%E6%B0%9F%E7%94%B2%E5%9F%BA%E8%8B%AF%E7%A3%BA%E9%85%B0%E6%B0%AF in water is also limited. The two are mixed, such as oil and water, which are difficult to blend. Each is a state and can be clearly identified. However, in specific organic solvents, it can dissolve well, just like a fish entering a river or sea, blending seamlessly. These physical properties are the key to understanding this substance, and they also lay the foundation for its use in various fields.
What are the chemical properties of 2-trifluoromethylbenzenesulfonyl chloride?
Triethylsilane magnesium bromide is an important reagent in organic chemistry. It is active and plays a key role in many organic synthesis reactions.
This reagent has strong nucleophilicity. Because magnesium atoms are connected to silicon atoms, part of the electron cloud density of silane increases, thereby enhancing its nucleophilic ability. In the reaction, it can launch a nucleophilic attack on many electrophilic reagents, such as carbonyl compounds. When encountering aldose and ketone, nucleophilic addition reactions can occur, forming new carbon-silicon bonds. After subsequent processing, the products can be converted into various silicon-containing organic compounds, or specific functional groups can be introduced, laying the foundation for the construction of complex organic molecules.
Furthermore, triethylsilane magnesium bromide is not stable. It is extremely sensitive to water and oxygen. Water can react violently with it, making the reagent ineffective. Therefore, when storing and using, it is necessary to ensure that the system is anhydrous and oxygen-free. It often needs to be operated under the protection of inert gases, such as nitrogen or argon. Moreover, it is easily oxidized in air, so it needs to be properly stored. Generally, it is prepared and used now to maintain its reactivity.
In addition, the reagent is also highly alkaline. In some reactions, it can be used as both a nucleophilic reagent and a base to capture acidic hydrogen from substrate molecules and initiate other types of reactions such as elimination reactions. This requires careful consideration of the reaction conditions and substrate structure in the design of organic synthesis to guide the reaction in the desired direction and obtain the target product. In short, triethylsilane magnesium bromide has a wide range of applications in the field of organic synthesis due to its unique chemical properties, but it requires strict reaction conditions and needs to be treated with caution.
What are the common uses of 2-trifluoromethylbenzenesulfonyl chloride?
The common use of di-triethylaminopropylsilane coupling agent has its remarkable functions in many fields.
In the preparation of composite materials, it can build a bridge between the reinforcing phase and the matrix phase. Due to the properties of the material, it often depends on the synergistic effect of the reinforcing phase and the matrix phase, but the surface properties of the two are different, and it is difficult to have a good combination. Triethylaminopropylsilane coupling agent can be connected with the active group on the surface of the reinforcing phase at one end, such as the hydroxyl group on the surface of glass fibers, by chemical bonds; the other end is combined with the matrix phase, such as polymers such as resins, by chemical reaction or physical winding. In this way, the inner cohesive energy of the composite material is enhanced, and the interfacial stress is dispersed, thereby improving the strength, toughness, water resistance and other properties of the material.
In the field of coatings, it is also indispensable. When the coating is applied to the surface of the substrate, it needs good adhesion in order to exert the functions of protection and decoration. Triethylaminopropylsilane coupling agent can first interact with the surface of the substrate, change the surface properties, and make the coating better fit with it. And its participation in the coating film formation process can optimize the structure and performance of the coating, such as improving the wear resistance and corrosion resistance of the coating, enhancing its tolerance to the environment, and making the coating more durable.
In terms of adhesives, its role should not be underestimated. When adhesives bond different materials, the interfacial force is crucial. This coupling agent can form a transition layer between the adhesive and the adhesive, enhancing the interaction between the two, and improving the bonding strength and durability. Whether it is the bonding of different materials such as metals, ceramics, or plastics, adding an appropriate amount of triethylaminopropylsilane coupling agent can significantly improve the bonding effect, so that the adhesive joint can withstand greater external force and maintain stability in different environments.
What are the application steps of 2-trifluoromethylbenzenesulfonyl chloride in synthesis?
2-%E4%B8%89%E6%B0%9F%E7%94%B2%E5%9F%BA%E8%8B%AF%E7%A3%BA%E9%85%B0%E6%B0%AF, its chemical name is 2-trifluoromethylbenzothiazole-6-formaldehyde, which has important applications in the field of organic synthesis. The following briefly describes the application steps in its synthesis.
The first step is to prepare the raw material, and it is necessary to prepare the compound containing the benzene ring structure, the compound containing the thiazole ring structure and the reagent that can introduce the trifluoromethyl group. Among the benzene-containing compounds, benzene derivatives with suitable substituents are often selected, and thiazole-containing compounds have more active check points, while reagents such as trifluoromethylation reagents that introduce trifluoromethylation reagents have good reactivity.
The second step is the key cyclization reaction. The raw materials are mixed in a suitable organic solvent in an appropriate proportion, and a specific catalyst is added. Organic solvents are often selected from dichloromethane, N, N-dimethylformamide, etc., to ensure that each raw material can be well dissolved and promote the reaction. The catalyst is selected according to the characteristics of the raw material, such as metal catalyst or organic base catalyst. At a suitable temperature and reaction time, the compounds containing benzene ring and thiazole ring undergo cyclization reaction to initially construct the benzothiazole ring structure.
The third step is the introduction of trifluoromethyl. Trifluoromethylation reagents and cocatalysts are added to the cyclization product to promote the successful introduction of trifluoromethyl into the specific position of the benzothiazole ring under specific reaction conditions, that is, to generate 2-trifluoromethylbenzothiazole intermediates. This step requires precise control of reaction conditions, such as temperature, pH, etc., to ensure that trifluoromethyl can be introduced at the expected position to improve product purity and yield.
The last step is aldehyde modification. The benzothiazole intermediate containing trifluoromethyl is reacted with an aldehyde reagent in a suitable reaction system. By optimizing the reaction conditions, such as selecting a suitable base, controlling the reaction temperature and time, etc., the aldehyde group is successfully introduced at the 6-position of the benzothiazole ring to obtain 2-trifluoromethylbenzothiazole-6-formaldehyde.
The whole synthesis process needs to be carefully regulated for each step of the reaction conditions, and each step of the product needs to be separated and purified to ensure the quality and purity of the final product, and to achieve efficient synthesis of 2-trifluoromethylbenzothiazole-6-formaldehyde.
What are the preparation methods of 2-trifluoromethylbenzenesulfonyl chloride?
To prepare di-triethylaminophenylselenyl cyanate, the method is as follows:
First, all raw materials need to be prepared, di-triethylaminophenylselenol and cyanide are indispensable. For cyanide agents, potassium cyanide, sodium cyanide, etc. can be selected, but the two are quite toxic. Be sure to use them with caution and strictly abide by safety procedures.
In the reaction vessel, put an appropriate amount of organic solvents, such as dichloromethane, chloroform, etc., such solvents can evenly disperse the reactants and facilitate the reaction. Diethylaminophenylselenol is slowly poured into the solvent and stirred evenly to form a homogeneous phase system. When stirring, the speed should be moderate. If it is too fast, it will easily cause the system to be unstable, and if it is too slow, the reaction rate will not be good.
Then, when stirring, add cyanide agent gradually. When adding, pay close attention to the change of reaction temperature. This reaction may release heat. If the temperature rises sharply, it may cause the reaction to go out of control. The method of ice bath or cold water bath can be used to maintain the temperature within a suitable range.
During the reaction process, the reaction process can be monitored in real time by means of thin layer chromatography (TLC). When the reactants are almost exhausted and the amount of product generated no longer increases significantly, it can be regarded as the reaction is approaching completion.
After the reaction is completed, pour the reaction mixture into the separation funnel, and extract and separate the liquid with an appropriate amount of water and organic solvent. The aqueous phase can be discarded, and the organic phase is dried with a desiccant such as anhydrous sodium sulfate to remove the moisture. After drying, the organic solvent is removed by vacuum distillation with equipment such as a rotary evaporator, and then the crude product is obtained.
The crude product needs to be further purified, and column chromatography can be used. Silica gel is used as the stationary phase, and a suitable eluent is selected, such as the mixture of petroleum ether and ethyl acetate, and the ratio is adjusted according to the specific situation. After column chromatography separation, pure di-triethylamino phenylselenocyanate can be obtained.
The entire preparation process requires strict adherence to operating procedures and attention to safety protection in order to successfully prepare the target product.