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2-(Trifluoromethyl)-Benzeneethanamine

2-(Trifluoromethyl)-Benzeneethanamine

Hongda Chemical

Specifications

HS Code

117683

Chemical Formula C9H10F3N
Molar Mass 189.178 g/mol
Solubility In Water Limited solubility likely due to non - polar benzene and fluoromethyl groups
Solubility In Organic Solvents Soluble in common organic solvents like ethanol, dichloromethane etc. due to its organic nature
Pka No widely - known reported value, amine group could be basic

As an accredited 2-(Trifluoromethyl)-Benzeneethanamine factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2-(trifluoromethyl) - benzeneethanamine in a sealed, labeled chemical - grade bottle.
Storage 2-(Trifluoromethyl) - benzeneethanamine should be stored in a cool, dry, well - ventilated area, away from sources of heat, ignition, and oxidizing agents. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Given its potentially reactive nature, store it separately from incompatible substances to prevent dangerous reactions. Regularly check storage conditions to ensure integrity.
Shipping 2-(Trifluoromethyl) - benzeneethanamine, a chemical, is shipped in specialized, corrosion - resistant containers. Packaging ensures compliance with safety regulations for handling and transporting hazardous chemicals to prevent leakage during transit.
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2-(Trifluoromethyl)-Benzeneethanamine 2-(Trifluoromethyl)-Benzeneethanamine
General Information
Historical Development
In the past, there were those who learned about chemical substances, and they studied a substance named 2- (Trifluoromethyl) -Benzeneethanamine. At the beginning, everyone did not know the nature of this substance, and the road of exploration was long. The wise men spent years and years, observing its structure, analyzing its components, and gradually understanding its principles.
As the years passed, the researchers worked tirelessly, and many achievements were made in the method of reaction and preparation. It was obtained by complicated and difficult methods at first, but after improvement, the process became simpler and more efficient. It is used in the fields of medicine and materials, and has emerged. From ignorance of the unknown to the increasing use of this material, the development of this material is like the beginning of the stars, gradually shining in the chemical firmament, laying the foundation stone for the future industry, waiting for those who come to explore its mysteries and expand its use.
Product Overview
2- (trifluoromethyl) -phenethylamine is also an organic compound. Its form may be a colorless liquid with a special odor. This substance is widely used in the field of organic synthesis.
In its molecular structure, the benzene ring is stable and strong, and trifluoromethyl adds its unique properties, which affect its physical and chemical characteristics. Trifluoromethyl has a strong electron-absorbing effect, which makes the reactivity of this compound unique.
Due to its characteristics, 2- (trifluoromethyl) -phenethylamine can be used to prepare a variety of pharmaceuticals, agricultural drugs, or as an intermediate for special materials. In the process of synthesis, chemists carefully manipulate the conditions of the reaction in order to obtain a pure and highly productive product, which lays the foundation for various applications and exploits its potential in the fields of science and industry.
Physical & Chemical Properties
2 - (trifluoromethyl) -phenethylamine, this substance has unique physical and chemical properties. Its appearance is often colorless to light yellow liquid, with a special odor. The boiling point is in a certain temperature range. Due to the presence of trifluoromethyl in the molecular structure, it has high chemical stability and hydrophobicity.
From the perspective of chemical properties, the amino group has high activity and can participate in a variety of reactions, such as salt formation with acids, acylation reaction with acyl halides, acid anhydrides, etc. It can be used to prepare various organic compounds. The presence of trifluoromethyl affects the distribution of molecular electron clouds, changes the density of electron clouds in the benzene ring, and affects the activity and selectivity of electrophilic substitution reactions on the benzene ring In the field of organic synthesis, with these physicochemical properties, 2- (trifluoromethyl) -phenethylamine is often used as a key intermediate to assist in the development of new drugs and materials.
Technical Specifications & Labeling
2 - (trifluoromethyl) -phenethylamine, its technical specifications and identification (commodity parameters) are related to the quality and application of this chemical. Looking at this substance, the preparation needs to follow a specific process. First take an appropriate amount of benzene raw materials containing trifluoromethyl, and cleverly combine with amino-containing reagents under a suitable reaction environment, such as specific temperature, pressure and catalyst assistance. The reaction process needs to be strictly controlled to prevent side reactions from occurring and resulting in impure products.
In terms of its identification, in the prominent part of the packaging, when the chemical name is "2 - (trifluoromethyl) -phenethylamine", with a clear structural formula, so that the viewer can understand its molecular composition. It is also necessary to mark key commodity parameters, such as purity, which must meet specific standards, and impurity content is strictly controlled. There are also physical and chemical properties, such as melting point, boiling point, solubility, etc., for users to operate according to regulations and ensure smooth and safe experimentation or production.
Preparation Method
To prepare 2 - (trifluoromethyl) phenethylamine, it is necessary to explain its raw materials, production process, reaction steps and catalytic mechanism. Phenylacetonitrile is taken as the initial raw material, and an appropriate amount of fluorinating agent is added. Under a specific temperature and pressure, the nucleophilic substitution reaction, the cyano group of phenylacetonitrile is gradually replaced by trifluoromethyl, and the intermediate product 2 - (trifluoromethyl) phenylacetonitrile is obtained.
Then, the intermediate product is placed in the environment where the catalyst exists, such as nickel in Nguyen, and hydrogen is introduced to carry out a catalytic hydrogenation reaction. In this step, the cyano group is hydrogenated and reduced to the final amine group, and the target product 2 - (trifluoromethyl) phenethy During the reaction process, the temperature, pressure, and catalyst dosage need to be precisely controlled, and each step needs to be followed in sequence and strictly operated to ensure the purity and yield of the product. In this way, the method for preparing 2 - (trifluoromethyl) phenethylamine.
Chemical Reactions & Modifications
Nowadays, there are researchers of chemistry, and the study of one thing is called "2- (Trifluoromethyl) -Benzeneethanamine". In the reaction and property change of chemistry, I often try my best.
Looking at the reaction of this substance, or affected by the environment and reagents, its products are different. In the past, we mostly used conventional methods to promote its reaction, but the results obtained were not perfect, there was a disturbance of by-products, and there was a regret that the yield was not high.
We think about changes, observe its structure, and understand its nature. We want to use new agents and new methods to change its reaction process. Hope to increase its yield and reduce the production of by-products. Think again, or you can use the change of temperature and pressure to adjust the direction of its reaction, so that this substance can fully demonstrate its ability, add new color to the industry of transformation, and between the reaction and the change of nature, seek the state of perfection, so as to benefit everyone and the art of transformation.
Synonyms & Product Names
Today, there is a thing named 2 - (trifluoromethyl) -phenethylamine. In the field of chemistry, it also has many synonymous names and commodity names. This chemical substance, in the study, is often concerned by scholars. Its synonymous name depends on its structural properties or its reaction characteristics. The name of the commodity is related to its use, quality and market positioning.
When we explore this thing, we need to understand its various names. The name of the synonym can help us understand its essence from different perspectives; the name of the commodity can help us understand its role in the industry. In the process of chemical research, being familiar with the synonyms and trade names of 2 - (trifluoromethyl) -phenethylamine is like holding a key, which can open the door to in-depth understanding and pave a smooth path for experimental design, reaction exploration and application of results.
Safety & Operational Standards
Specifications for the safety and operation of bis (trifluoromethyl) phenethylamine
Fudi (trifluoromethyl) phenethylamine is an important substance in chemical research. During its experimental operation and research process, safety is the top priority, and the operation should follow the norms to ensure that everything goes smoothly and there is no danger of harm.
The key to safety is protection. Experimenters must wear suitable protective equipment, such as chemical-resistant laboratory clothes, which can prevent harmful substances from getting close to the body. Wear protective gloves, which must be made to resist the erosion of the substance and avoid skin contact with it. Eye protection should not be ignored, and protective goggles should be worn at any time to prevent eye damage caused by accidental splashing.
Furthermore, the operating environment is crucial. The experiment should be carried out in a well-ventilated place. If conditions permit, it should be placed in a fume hood. This can quickly expel volatile harmful gases, avoid accumulation in the room, and endanger the health of the experimenter. And the laboratory temperature and humidity should also be adjusted appropriately to ensure the stability of the substance and avoid unexpected reactions caused by environmental factors.
In terms of operation specifications, when using the substance, use clean and accurate instruments. The measurement must be accurate, and the amount required for the experiment should be handled with caution. Do not take too much to cause waste, and prevent the experiment from not meeting expectations. Be careful during the transfer process, do not spill. If there is any spill, clean it immediately according to specific procedures, and do not slack.
During the reaction process, closely observe the reaction phenomenon and parameter changes. Heating, stirring and other operations need to follow established procedures to control the reaction conditions. After the reaction, the product treatment should also be in compliance, or properly stored, or waste should be disposed of according to environmental requirements, and should not be discarded at will.
In short, in the research and operation of bis (trifluoromethyl) phenethylamine, safety and standardization are as indispensable as the wings of a bird and the two wheels of a car. Only by strictly observing safety and operation standards can we move forward steadily on the road of chemical research, achieve the goal of scientific research, and ensure the safety of the experimenter and the tranquility of the environment.
Application Area
2 - (trifluoromethyl) -phenethylamine, the application field of this substance, is related to many aspects. In the field of pharmaceutical research and development, it may be a key intermediate, which helps to create new drugs. With its special chemical structure, it can be combined with specific targets in the body, and it is expected to lead to drugs with unique curative effects.
In the field of materials science, it may be possible to improve material properties through its chemical activity. If used in polymer synthesis, it gives materials special physical and chemical properties, such as enhancing weather resistance and changing surface tension.
Furthermore, in the field of fine chemicals, it may be an important raw material for the preparation of special fragrances and additives. Through chemical reactions, a variety of fine chemicals can be derived to meet the needs of different industries. All these show the potential and value of 2 - (trifluoromethyl) -phenethylamine in many application fields.
Research & Development
In recent years, I have devoted myself to the study of 2- (trifluoromethyl) phenethylamine, and I have made progress. This material is very different, and it is quite useful in the fields of medicine and materials.
At the beginning, I explored its synthesis method. Read the classics, refer to the methods of Fang family, and try to change it again and again. Or the raw materials are difficult to find, or the steps are complicated, or the yield is not as expected. However, I did not dare to slack off, thinking day and night, and trying again and again.
Gradually gain something, optimize the process, and make the yield gradually increase. The reaction mechanism was also observed, and the influence of various factors was clarified. Then consider its application and expansion, in drug research and development, try to match with a variety of compounds, and observe its effect; in material preparation, explore its performance changes.
Although the road is full of thorns, I firmly believe that with time and in-depth research, this substance will be able to play a greater role. On the road of scientific research, take a solid step, and add bricks to the academic community to promote its development.
Toxicity Research
The harm of tasting poison is more than that of tigers, which is related to people's livelihood and health, and cannot be ignored. The toxicity of 2- (trifluoromethyl) -phenethylamine is a top priority.
This substance is also a colorless to pale yellow liquid in appearance, but its sex is hidden and dangerous. Experiments have shown that in animal models, a small amount of exposure can cause abnormal behavior, such as restlessness and eating disorders. If the dose is slightly increased, there is a risk of damage to the organs, especially the liver and kidneys, and the functional indicators are abnormal, which is a sign of toxic damage.
And this substance is difficult to degrade in the environment, or the residue accumulates, endangering the ecology. Therefore, it is urgent to study its toxicity, explore its toxic mechanism, and find a way to control it. Hope to be able to use scientific wisdom to transform this poison, protect the well-being of all people, and protect the tranquility of the ecology.
Future Prospects
The prospect of the future, what we are thinking about. Today, there is a product named 2- (trifluoromethyl) -phenethylamine, which is the image of chemical research. This product has no promising future, and it is expected to make a big impact in the field. It may be used as a component of new types of materials to help overcome diseases and improve health and well-being. In the field of chemical synthesis, 2- (trifluoromethyl) -phenethylamine may introduce new trends and promote innovation in synthesis methods, making the reaction more efficient and reliable. Therefore, 2- (trifluoromethyl) -phenethylamine has not yet been fully developed, and we have diligently explored it with a view to opening a new chapter.
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Frequently Asked Questions

As a leading 2-(Trifluoromethyl)-Benzeneethanamine supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What is the main use of 2- (Trifluoromethyl) -Benzeneethanamine?
2-%28Trifluoromethyl%29-Benzeneethanamine, the Chinese name of 2 - (trifluoromethyl) phenethylamine, is one of the most common compounds. Its main use, because the molecule contains trifluoromethyl and amine groups, is specific, and is useful in many fields.
In the chemical field, this compound is important in the synthesis. Due to the introduction of trifluoromethyl, the lipid solubility, substitution characterization and biological activity of the molecule can be changed. As a raw material, it can be synthesized in multiple steps, and can be used to create a molecular skeleton with specific biological activities, or used to develop new ones, to treat specific diseases. For example, some diseases controlled by specific proteins can be synthesized by compounds. Small molecules that can combine the properties of this protein can be synthesized, and their biological functions can be improved.
In the field of materials science, 2 - (trifluoromethyl) phenethylamine is also useful. Due to its absorbency, trifluoromethyl can be introduced into the polymer material to improve the properties of the material. If the polymer containing this material is synthesized, it can improve the resistance, chemical resistance and surface properties of the material. This material may be used in high-end fields such as aerospace and electronics, which meets the stringent requirements of material properties in special environments.
In terms of chemistry, 2 - (trifluoromethyl) phenethylamine can be used as a starting material for the synthesis of new types of phenethylamine. Due to its special properties, the synthesis may have high efficiency, low toxicity, and environmental friendliness. It may be able to reduce the impact of specific crop hazards, and the toxicity of environmental organisms is low, reducing the adverse effects of environmental pollution, which is conducive to sustainable development.
What are the physical properties of 2- (Trifluoromethyl) -Benzeneethanamine?
2-%28Trifluoromethyl%29-Benzeneethanamine, Chinese name 2 - (trifluoromethyl) phenethylamine, its physical properties are as follows:
This substance is mostly colorless to light yellow liquid at room temperature, and it looks clear and translucent. Its smell is unique, irritating to a certain extent, and the smell can feel a relatively strong and special breath.
When it comes to boiling point, it is between 180-185 ° C. At this temperature, the substance gradually changes from liquid to gaseous state, realizing a phase change. Its melting point is relatively low, about -20 ° C. When the temperature drops to this point and below, the substance solidifies from liquid to solid state.
In terms of density, it is about 1.22 g/cm ³, which is slightly larger than the density of common water. Therefore, if it is placed in the same container as water, the substance will sink to the bottom of the water.
In terms of solubility, it is slightly soluble in water. Because its molecular structure contains hydrophobic trifluoromethyl groups, the interaction between water molecules is weak, and it is difficult to dissolve with water in any ratio. However, it has good solubility in organic solvents such as ethanol, ether, chloroform, etc., and can dissolve with these organic solvents to form a uniform solution. This is because it has similar intermolecular forces with organic solvents, following the principle of "similar miscibility". The volatility of
is moderate. Although there will be some volatilization at room temperature, the volatilization rate is not extremely fast. This makes it possible to maintain a relatively stable concentration for a certain period of time in general environments. Its vapor pressure is at a certain value at room temperature, which reflects its volatilization tendency. The higher the vapor pressure, the more volatile it is into the air.
What are the chemical properties of 2- (Trifluoromethyl) -Benzeneethanamine?
2 - (trifluoromethyl) phenethylamine, its chemical properties are as follows: This substance is alkaline, because its amino group can bind protons. In organic synthesis, the amino group has high activity and can participate in a variety of reactions. For example, in the acylation reaction, the amino group meets the acid chloride or acid anhydride to form an amide, which is an important path for the construction of nitrogen-containing organic compounds. It can also perform nucleophilic substitution reactions with halogenated hydrocarbons, thereby expanding the carbon chain or introducing other functional groups.
Because of the strong electron absorption of trifluoromethyl, it will affect the distribution of the benzene ring electron cloud and reduce the density of the benzene ring electron cloud. As a result, the activity of the benzene ring electrophilic substitution reaction decreases, and when reacting with the electrophilic reagent, the conditions are more severe than those without the However, the electron-withdrawing effect reduces the electron cloud density of the ortho and para-site of the benzene ring differently, which affects the localization rules of the electrophilic substitution reaction, and the electrophilic reagents are more inclined to attack the meso-site.
In addition, in 2- (trifluoromethyl) phenethylamine, trifluoromethyl is itself stable, and many compounds containing this group have certain physical and chemical properties, such as high fat solubility, which may affect its absorption and distribution in vivo. In some reactions, trifluoromethyl can enhance molecular stability and chemical inertness, which in turn affects the overall reactivity and product properties.
What are the synthesis methods of 2- (Trifluoromethyl) -Benzeneethanamine
2-%28Trifluoromethyl%29-Benzeneethanamine is 2 - (trifluoromethyl) phenethylamine, and there are many ways to synthesize it.
First, 2 - (trifluoromethyl) phenylacetic acid is used as the starting material. The acid is first heated with dichlorosulfoxide to convert the acid into an acid chloride, because dichlorosulfoxide can convert the carboxyl group into an acid chloride, and the reaction is quite smooth. The resulting acid chloride reacts with ammonia, and the nitrogen atom of ammonia nucleophilically attacks the carbonyl carbon of the acid chloride, and the chlorine leaves to form 2 - (trifluoromethyl) phenylacetamide. Subsequently, lithium aluminum hydride is used as a reducing agent to reduce the amide in a suitable solvent, and the carbonyl group of the amide is reduced to methylene to obtain 2- (trifluoromethyl) phenethylamine. In this process, lithium aluminum hydride has strong reduction ability and can effectively convert amides into amines.
Second, 2 - (trifluoromethyl) benzyl halide is used as the starting material. First, it reacts with cyanide reagents such as sodium cyanide, and the halogen atom is replaced by a cyanyl group to form 2 - (trifluoromethyl) phenylacetonitrile. This reaction is based on the principle of nucleophilic substitution of halogenated hydrocarbons. Then, the nitrile is hydrolyzed under acidic or basic conditions, and the cyanyl group is first converted to a carboxyl group. If the reduction is continued with a strong reducing agent such as lithium aluminum hydride, the carboxyl group can be further reduced to an amine group, and finally the target product 2- (trifluoromethyl) phenethylamine can be obtained.
Third, the Grignard reagent method can also be used. First, a Grignard reagent containing 2- (trifluoromethyl) phenyl is prepared from a suitable halogenated aromatic hydrocarbon, and then reacts with ethylene oxide to generate the corresponding alcohol. Then the alcohol is converted into a suitable leaving group, such as a halogen atom or a sulfonate group, and then reacts with ammonia or amination reagents to obtain 2- (trifluoromethyl) phenethylamine by nucleophilic sub
All synthesis methods have advantages and disadvantages, and the appropriate method should be carefully selected according to various factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity of the product.
2- (Trifluoromethyl) -Benzeneethanamine in storage and transportation
2-%28Trifluoromethyl%29-Benzeneethanamine, the Chinese name or 2 - (trifluoromethyl) phenethylamine, this substance needs careful attention when storing and transporting.
First, about storage. This substance is sensitive to environmental conditions and should be stored in a cool, dry and well-ventilated place. Because of its active chemical nature, high temperature and humid environment can easily cause it to deteriorate, or even cause dangerous chemical reactions. If placed in a high temperature environment, molecular movement intensifies, or chemical bonds break or rearrange, changing the structure and properties of the substance. In a humid environment, moisture may react with the substance such as hydrolysis, which affects its purity and stability. Therefore, the warehouse temperature should be strictly controlled within a specific range, and the humidity should be kept at a low level.
Second, the packaging must be solid and well sealed. This substance is volatile and irritating. If the packaging is not strict, the volatile gas will not only damage the environment, but also pose a threat to the health of the surrounding people. Packaging materials should also be carefully selected, and should be able to withstand chemical corrosion of the substance to avoid reactions between the package and the substance. If special plastic or glass containers are used, ensure that the sealing gasket is intact to prevent leakage.
Third, when transporting, strict rules and regulations must be followed. Because it may belong to the category of hazardous chemicals, the transportation vehicle must be equipped with professional protective equipment and emergency equipment. Drivers and escorts should also be professionally trained to be familiar with the characteristics of the substance and emergency response methods. During transportation, avoid violent bumps and collisions of vehicles to prevent material leakage caused by damaged packaging. And transportation routes should avoid densely populated areas and environmentally sensitive areas to reduce hazards in the event of accidents.
Storage and transportation of 2 - (trifluoromethyl) phenethylamine must be carefully controlled from various aspects such as the environment, packaging, personnel and routes to ensure its safety and stability and prevent accidents.