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What is the main use of 2- (Trifluoromethyl) -Benzeneethanamine?
2-%28Trifluoromethyl%29-Benzeneethanamine, the Chinese name of 2 - (trifluoromethyl) phenethylamine, is one of the most common compounds. Its main use, because the molecule contains trifluoromethyl and amine groups, is specific, and is useful in many fields.
In the chemical field, this compound is important in the synthesis. Due to the introduction of trifluoromethyl, the lipid solubility, substitution characterization and biological activity of the molecule can be changed. As a raw material, it can be synthesized in multiple steps, and can be used to create a molecular skeleton with specific biological activities, or used to develop new ones, to treat specific diseases. For example, some diseases controlled by specific proteins can be synthesized by compounds. Small molecules that can combine the properties of this protein can be synthesized, and their biological functions can be improved.
In the field of materials science, 2 - (trifluoromethyl) phenethylamine is also useful. Due to its absorbency, trifluoromethyl can be introduced into the polymer material to improve the properties of the material. If the polymer containing this material is synthesized, it can improve the resistance, chemical resistance and surface properties of the material. This material may be used in high-end fields such as aerospace and electronics, which meets the stringent requirements of material properties in special environments.
In terms of chemistry, 2 - (trifluoromethyl) phenethylamine can be used as a starting material for the synthesis of new types of phenethylamine. Due to its special properties, the synthesis may have high efficiency, low toxicity, and environmental friendliness. It may be able to reduce the impact of specific crop hazards, and the toxicity of environmental organisms is low, reducing the adverse effects of environmental pollution, which is conducive to sustainable development.
What are the physical properties of 2- (Trifluoromethyl) -Benzeneethanamine?
2-%28Trifluoromethyl%29-Benzeneethanamine, Chinese name 2 - (trifluoromethyl) phenethylamine, its physical properties are as follows:
This substance is mostly colorless to light yellow liquid at room temperature, and it looks clear and translucent. Its smell is unique, irritating to a certain extent, and the smell can feel a relatively strong and special breath.
When it comes to boiling point, it is between 180-185 ° C. At this temperature, the substance gradually changes from liquid to gaseous state, realizing a phase change. Its melting point is relatively low, about -20 ° C. When the temperature drops to this point and below, the substance solidifies from liquid to solid state.
In terms of density, it is about 1.22 g/cm ³, which is slightly larger than the density of common water. Therefore, if it is placed in the same container as water, the substance will sink to the bottom of the water.
In terms of solubility, it is slightly soluble in water. Because its molecular structure contains hydrophobic trifluoromethyl groups, the interaction between water molecules is weak, and it is difficult to dissolve with water in any ratio. However, it has good solubility in organic solvents such as ethanol, ether, chloroform, etc., and can dissolve with these organic solvents to form a uniform solution. This is because it has similar intermolecular forces with organic solvents, following the principle of "similar miscibility". The volatility of
is moderate. Although there will be some volatilization at room temperature, the volatilization rate is not extremely fast. This makes it possible to maintain a relatively stable concentration for a certain period of time in general environments. Its vapor pressure is at a certain value at room temperature, which reflects its volatilization tendency. The higher the vapor pressure, the more volatile it is into the air.
What are the chemical properties of 2- (Trifluoromethyl) -Benzeneethanamine?
2 - (trifluoromethyl) phenethylamine, its chemical properties are as follows: This substance is alkaline, because its amino group can bind protons. In organic synthesis, the amino group has high activity and can participate in a variety of reactions. For example, in the acylation reaction, the amino group meets the acid chloride or acid anhydride to form an amide, which is an important path for the construction of nitrogen-containing organic compounds. It can also perform nucleophilic substitution reactions with halogenated hydrocarbons, thereby expanding the carbon chain or introducing other functional groups.
Because of the strong electron absorption of trifluoromethyl, it will affect the distribution of the benzene ring electron cloud and reduce the density of the benzene ring electron cloud. As a result, the activity of the benzene ring electrophilic substitution reaction decreases, and when reacting with the electrophilic reagent, the conditions are more severe than those without the However, the electron-withdrawing effect reduces the electron cloud density of the ortho and para-site of the benzene ring differently, which affects the localization rules of the electrophilic substitution reaction, and the electrophilic reagents are more inclined to attack the meso-site.
In addition, in 2- (trifluoromethyl) phenethylamine, trifluoromethyl is itself stable, and many compounds containing this group have certain physical and chemical properties, such as high fat solubility, which may affect its absorption and distribution in vivo. In some reactions, trifluoromethyl can enhance molecular stability and chemical inertness, which in turn affects the overall reactivity and product properties.
What are the synthesis methods of 2- (Trifluoromethyl) -Benzeneethanamine
2-%28Trifluoromethyl%29-Benzeneethanamine is 2 - (trifluoromethyl) phenethylamine, and there are many ways to synthesize it.
First, 2 - (trifluoromethyl) phenylacetic acid is used as the starting material. The acid is first heated with dichlorosulfoxide to convert the acid into an acid chloride, because dichlorosulfoxide can convert the carboxyl group into an acid chloride, and the reaction is quite smooth. The resulting acid chloride reacts with ammonia, and the nitrogen atom of ammonia nucleophilically attacks the carbonyl carbon of the acid chloride, and the chlorine leaves to form 2 - (trifluoromethyl) phenylacetamide. Subsequently, lithium aluminum hydride is used as a reducing agent to reduce the amide in a suitable solvent, and the carbonyl group of the amide is reduced to methylene to obtain 2- (trifluoromethyl) phenethylamine. In this process, lithium aluminum hydride has strong reduction ability and can effectively convert amides into amines.
Second, 2 - (trifluoromethyl) benzyl halide is used as the starting material. First, it reacts with cyanide reagents such as sodium cyanide, and the halogen atom is replaced by a cyanyl group to form 2 - (trifluoromethyl) phenylacetonitrile. This reaction is based on the principle of nucleophilic substitution of halogenated hydrocarbons. Then, the nitrile is hydrolyzed under acidic or basic conditions, and the cyanyl group is first converted to a carboxyl group. If the reduction is continued with a strong reducing agent such as lithium aluminum hydride, the carboxyl group can be further reduced to an amine group, and finally the target product 2- (trifluoromethyl) phenethylamine can be obtained.
Third, the Grignard reagent method can also be used. First, a Grignard reagent containing 2- (trifluoromethyl) phenyl is prepared from a suitable halogenated aromatic hydrocarbon, and then reacts with ethylene oxide to generate the corresponding alcohol. Then the alcohol is converted into a suitable leaving group, such as a halogen atom or a sulfonate group, and then reacts with ammonia or amination reagents to obtain 2- (trifluoromethyl) phenethylamine by nucleophilic sub
All synthesis methods have advantages and disadvantages, and the appropriate method should be carefully selected according to various factors such as the availability of raw materials, the difficulty of reaction conditions, and the purity of the product.
2- (Trifluoromethyl) -Benzeneethanamine in storage and transportation
2-%28Trifluoromethyl%29-Benzeneethanamine, the Chinese name or 2 - (trifluoromethyl) phenethylamine, this substance needs careful attention when storing and transporting.
First, about storage. This substance is sensitive to environmental conditions and should be stored in a cool, dry and well-ventilated place. Because of its active chemical nature, high temperature and humid environment can easily cause it to deteriorate, or even cause dangerous chemical reactions. If placed in a high temperature environment, molecular movement intensifies, or chemical bonds break or rearrange, changing the structure and properties of the substance. In a humid environment, moisture may react with the substance such as hydrolysis, which affects its purity and stability. Therefore, the warehouse temperature should be strictly controlled within a specific range, and the humidity should be kept at a low level.
Second, the packaging must be solid and well sealed. This substance is volatile and irritating. If the packaging is not strict, the volatile gas will not only damage the environment, but also pose a threat to the health of the surrounding people. Packaging materials should also be carefully selected, and should be able to withstand chemical corrosion of the substance to avoid reactions between the package and the substance. If special plastic or glass containers are used, ensure that the sealing gasket is intact to prevent leakage.
Third, when transporting, strict rules and regulations must be followed. Because it may belong to the category of hazardous chemicals, the transportation vehicle must be equipped with professional protective equipment and emergency equipment. Drivers and escorts should also be professionally trained to be familiar with the characteristics of the substance and emergency response methods. During transportation, avoid violent bumps and collisions of vehicles to prevent material leakage caused by damaged packaging. And transportation routes should avoid densely populated areas and environmentally sensitive areas to reduce hazards in the event of accidents.
Storage and transportation of 2 - (trifluoromethyl) phenethylamine must be carefully controlled from various aspects such as the environment, packaging, personnel and routes to ensure its safety and stability and prevent accidents.