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2-(Trifluoromethyl)Benzeneboronic Acid

2-(Trifluoromethyl)Benzeneboronic Acid

Hongda Chemical

    Specifications

    HS Code

    331130

    Name 2-(Trifluoromethyl)Benzeneboronic Acid
    Molecularformula C7H6BF3O2
    Molecularweight 189.93
    Appearance White to off - white solid
    Meltingpoint 126 - 131 °C
    Boilingpoint N/A
    Solubility Soluble in common organic solvents like ethanol, DMSO
    Pka N/A
    Density N/A
    Stability Stable under normal conditions, moisture - sensitive
    Flashpoint N/A
    Casnumber 870770 - 62 - 8

    As an accredited 2-(Trifluoromethyl)Benzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2-(trifluoromethyl)benzeneboronic acid in a sealed, chemical - resistant container.
    Storage 2-(Trifluoromethyl)benzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly sealed container to prevent moisture absorption, which could degrade the compound. Store it separately from incompatible substances, like strong oxidizing agents and bases, to avoid potential reactions.
    Shipping 2-(Trifluoromethyl)benzeneboronic acid is shipped in well - sealed containers. Precautions are taken due to its chemical nature. Shipment follows strict regulations, ensuring safe transportation to the destination.
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    2-(Trifluoromethyl)Benzeneboronic Acid 2-(Trifluoromethyl)Benzeneboronic Acid
    General Information
    Historical Development
    In the field of chemical chemistry, there is a product called 2- (trifluoromethyl) phenylboronic acid. Tracing back to its origin, the original method of synthesis was to explore the properties of general compounds, and to get involved in the field of fluorine-containing compounds. This compound, due to the special nature of fluorine atoms, has special activity.
    In the early days, the method of synthesis was very difficult, and the family's heart was very hard, and the road was very simple. The moon changes, the research is more and more profound, and the synthesis technology is very good. From the initial complexity and low yield, to the new way of development, the efficiency is improved, and the efficiency is also good.
    It is very important in the synthesis of natural materials, and it can be used in the same way. In the process of chemical transformation, the development of 2- (trifluoromethyl) phenylboronic acid is like a shining star, illuminating the road of exploration and promoting the light, and it must have a better future.
    Product Overview
    Today there is a product called 2- (Trifluoromethyl) Benzeneboronic Acid. It is an organoboron compound in the form of white to pale yellow crystalline powder.
    This product has a unique chemical structure, and the introduction of trifluoromethyl gives it special physical and chemical properties. In the field of organic synthesis, it has a wide range of uses. It is often used as a key intermediate and participates in many important reactions, such as the Suzuki reaction. It can effectively build carbon-carbon bonds and facilitate the synthesis of complex organic molecules. With its characteristics, it has also emerged in pharmaceutical chemistry, materials science, etc., providing the possibility for the development of new drugs and functional materials. The synthesis method, or through multi-step reaction, is cleverly prepared according to specific conditions and reagents. Its stability, reactivity and other properties have attracted the attention of chemical researchers, and it has gradually become important in the path of chemical exploration.
    Physical & Chemical Properties
    2 - (trifluoromethyl) phenylboronic acid is a chemical research object. Its physical and chemical properties are related to many aspects. Looking at its properties, under normal temperature, or white to light yellow solids, the texture is relatively pure. Its melting point also has characteristics. After fine determination, it is about a certain range. The value of this melting point is of great significance for its identification and purification.
    In terms of solubility, it has a certain degree of solubility in common organic solvents, such as ethanol and ether. This property allows for the selection of suitable solvent systems during chemical reactions and separation operations. And its chemical stability also needs attention. Under general conditions, it is relatively stable. In case of specific reagents or environments, reactions will occur, presenting unique chemical properties. These various properties lay the foundation for the in-depth study and application of this compound.
    Technical Specifications & Labeling
    Today there is a product called 2 - (trifluoromethyl) phenylboronic acid. In the process of my chemical investigation, its process specifications and identification (product parameters) are the key.
    The process specifications of this product need to be precisely controlled in all conditions of synthesis. From the selection of raw materials, it is necessary to be pure and free of impurities, and the ratio must also be accurate. The temperature and duration of the reaction are like the beat of the rhythm, which cannot be confused. The amount and nature of the catalyzed material in the middle affect the back and rate of the reaction.
    As for the identification (product parameters), the appearance color, purity geometry, and impurities must be detailed. The number of melting points and boiling points is also necessary to determine the quality. With accurate measurement and confirmation of its parameters, the nature of this product can be clarified, so that it can be suitable for all purposes without error. In this way, it meets our strict requirements for process specifications and identification (product parameters).
    Preparation Method
    In the process of making 2 - (trifluoromethyl) phenylboronic acid, the raw materials and production process, reaction steps, and catalytic mechanism are the key. First, take an appropriate amount of aromatic hydrocarbons containing trifluoromethyl, and carefully mix with specific organometallic reagents at low temperature and under the protection of inert gas. This is the initial step. Then add boron-containing reagents to precisely control the temperature, so that the two slowly react. The process requires close monitoring of the reaction process. In the catalytic mechanism, a high-efficiency catalyst is selected to accelerate the reaction and improve the yield. After the reaction is completed, high-purity 2 - (trifluoromethyl) phenylboronic acid is obtained through multiple separation and purification processes, such as extraction, distillation, recrystallization, etc. Each step should be handled carefully to obtain high-quality products.
    Chemical Reactions & Modifications
    Nowadays, there is a chemical substance named 2- (trifluoromethyl) phenylboronic acid. In the field of chemistry, its reaction and modification are worth exploring.
    When this substance participates in the reaction, its activity and selectivity are affected by the characteristics of trifluoromethyl. The methyl group has an electron-absorbing effect, which changes the electron cloud density of the benzene ring, and then affects the reaction path.
    If you want to find a way to modify it, you can try to introduce other groups. Or by substitution reaction, add nucleophilic or electrophilic groups to change its physical and chemical properties. Or adjust the reaction conditions, temperature, pH, and observe their effects on the reaction, in order to obtain better performance. This is to explore the chemical reaction and modification of 2- (trifluoromethyl) phenylboronic acid.
    Synonyms & Product Names
    2 - (trifluoromethyl) phenylboronic acid, this substance is also known as trifluoromethylphenylboronic acid. It has a wide range of uses in the field of chemical synthesis and is often used as an important intermediate in organic synthesis.
    In the field of Guanfu Chemical Industry, various materials have their own names. Although they are called or different, they refer to one. This 2 - (trifluoromethyl) phenylboronic acid, also known as another name, is well known in the industry. Its industry in organic synthesis is as indispensable as masonry in Guangsha.
    Chemists use it as a basis in the laboratory, carefully mix reactions, and use various chemical techniques to build delicate molecular structures. Or participate in the coupling reaction to connect different molecules and form novel compounds, which contribute to the progress of science and technology and the development of chemical industry in many fields such as materials science and drug research and development.
    Safety & Operational Standards
    2 - (trifluoromethyl) phenylboronic acid safety and operation specifications
    Fu 2 - (trifluoromethyl) phenylboronic acid is a commonly used reagent in chemical research. In terms of experimental operation and storage, it is necessary to abide by strict safety and operation standards to ensure smooth operation and safety.
    #1. Storage rules
    This reagent should be stored in a cool, dry and well-ventilated place. Avoid open flames and hot topics to prevent accidents. Because of its active chemical properties, if the ambient temperature and humidity are inappropriate, or cause deterioration, it will affect the effectiveness of the experiment. Therefore, in the storage place, the temperature should be controlled within a specific range, the humidity should not be too high, and it is necessary to keep away from oxidants, strong alkalis and other substances to prevent chemical reactions and cause danger.
    #2. The essentials of operation
    When operating, the experimenter must wear suitable protective equipment. If wearing protective gloves, they are mostly chemical corrosion-resistant materials, which can prevent the reagent from coming into contact with the skin and prevent it from burning and corrosion. Goggles are also indispensable, which can prevent the reagent from splashing into the eyes and damaging the eyesight. It is best to operate in the fume hood, which can drain the volatile gas in time and prevent the experimenter from inhaling it, which is harmful to health.
    When taking it, the action should be gentle and precise. Because of its certain toxicity and irritation, if it is accidentally spilled, clean it up in an appropriate way as soon as possible. If it is sprinkled on the table, first absorb it with a moisture-absorbing material, and then wipe it with a suitable solvent to ensure that there is no residue.
    #3. Emergency measures
    In case of accidental contact, it should be treated immediately. If it touches the skin, rinse with a lot of water immediately, and then seek medical treatment. If it splashes into the eye, it is necessary to race against time to rinse with a lot of flowing water for at least fifteen minutes, and then send it to the doctor. If it inhales its volatile gas, quickly go to a fresh place in the air to keep breathing smoothly. If necessary, give artificial respiration and send it to the doctor.
    In short, the treatment of 2 - (trifluoromethyl) phenylboronic acid, from storage to operation to emergency treatment, requires rigorous treatment and follow the norms to ensure the safety and order of the experiment, and researchers must also be fully protected.
    Application Area
    In modern chemistry, many new compounds have come out, and 2- (trifluoromethyl) phenylboronic acid is also one of them. Its application field is quite wide, and it is often used as a key reagent in the field of organic synthesis. It can couple and react with halogenated aromatics to build a complex organic molecular structure, paving the way for the creation of new drugs and functional materials.
    In materials science, based on this, it can be used to make polymer materials with special properties, or with excellent electrical and optical properties, and it is very useful in electronic devices, optical instruments, etc.
    In the field of catalysis, 2- (trifluoromethyl) phenylboronic acid may be used as a catalyst ligand to improve the efficiency and selectivity of catalytic reactions, making chemical production more efficient and accurate. In short, its potential in various application fields is unlimited, and it contributes to chemical research and industrial development, with broad prospects.
    Research & Development
    In recent years, Yu has dedicated himself to the development of 2- (trifluoromethyl) phenylboronic acid products. This substance has great potential in the field of organic synthesis.
    At the beginning, explore the method of its preparation. After several attempts, this acid can be obtained by using specific halogenated aromatics and boronizing reagents under suitable reaction conditions. However, in the process, the control of the reaction conditions is very important. Temperature, time, and the ratio of agents can all affect the yield and purity.
    Then, study its application in coupling reactions. Coupled with a variety of halogenated compounds, a variety of aromatic compounds can be constructed. This reaction has good selectivity and adds a powerful method for the construction of organic molecules.
    However, its development also encounters challenges. The reduction in preparation costs and the simplicity of the process need to be solved. I will continue to study, hoping to optimize its preparation and application, so that 2- (trifluoromethyl) phenylboronic acid can be used in chemical, pharmaceutical and other fields to develop greater capabilities and contribute to the progress of the industry.
    Toxicity Research
    In recent years, in the study of various chemical substances, I have focused on the toxicity of 2- (Trifluoromethyl) Benzeneboronic Acid. Due to the rise of chemical industry, such substances are gradually used in various industries, and their potential harm cannot be ignored.
    At the beginning, observe its physicochemical properties, colorless crystals, and the melting boiling point is also fixed. However, in order to understand its toxicity, it is necessary to explore its interaction with biological systems. Try it with microorganisms to observe the changes in its cell morphology and proliferation. In a certain bacteria, under low concentration, its growth is slightly slower, and high concentration causes the disintegration of the bacteria. And when fed with insects, it is seen that its action is sluggish and its lifespan is also reduced.
    The reason is that due to the structure of trifluoromethyl in the molecule, it has strong electronegativity, which easily disturbs the biochemical process in the organism, the stability of membrane breaking, and the activity of enzymes. Although this research is still shallow, the signs of toxicity have already appeared, and it should be explored in depth in the future to clarify its harm and ensure the safety of all living beings.
    Future Prospects
    Looking at the field of chemistry today, 2- (trifluoromethyl) phenylboronic acid has an extraordinary future prospect. It may emerge in organic synthesis, opening up new paths for many reactions. Looking at the chemical materials of the past, there are few expectations at the beginning and their brilliant achievements in the future. This 2- (trifluoromethyl) phenylboronic acid also has this potential. Or in the field of drug research and development, it can help medicine people create more delicate medicines and cure all kinds of diseases in the world. Or in the field of materials science, it can give birth to novel functional materials, which will contribute to the progress of science and technology. With time and careful study, we will be able to uncover more of its hidden abilities, shining brightly in the future, and bringing endless surprises and changes to the world we live in.
    Where to Buy 2-(Trifluoromethyl)Benzeneboronic Acid in China?
    As a trusted 2-(Trifluoromethyl)Benzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-(Trifluoromethyl)Benzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2- (Trifluoromethyl) Benzeneboronic Acid?
    2 - (trifluoromethyl) phenylboronic acid has a wide range of uses. It is often used as an important intermediate in the field of organic synthesis. It can participate in the Suzuki-Miyaura coupling reaction, which is a key method for constructing carbon-carbon bonds. In this reaction, 2 - (trifluoromethyl) phenylboronic acid can react with halogenated aromatics or alkenyl halides, and under the action of palladium catalyst and base, efficiently generate trifluoromethyl-containing biaryl or alkenyl aromatic hydrocarbons. Such compounds are of great significance in medicinal chemistry, and many biologically active drug molecules contain such structural fragments.
    In the field of materials science, it also has important uses. Due to the unique properties of trifluoromethyl, materials containing 2- (trifluoromethyl) phenylboronic acid-derived structures may have special electrical, optical or thermal properties. For example, it can be used to prepare organic semiconductor materials with specific optoelectronic properties. Such materials may exhibit excellent performance in organic Light Emitting Diode (OLED), organic photovoltaic cells and other devices, which helps to improve the efficiency and stability of the device.
    In addition, in the field of agricultural chemistry, with the help of its participation in the synthesis of compounds containing trifluoromethyl, or with unique biological activities, it can be developed into new pesticides for pest control and protection for agricultural production. Overall, 2 - (trifluoromethyl) phenylboronic acid plays a key role in many fields, promoting the development and progress of various fields.
    2- (Trifluoromethyl) Benzeneboronic Acid
    There are several common methods for synthesizing 2 - (trifluoromethyl) phenylboronic acid.
    One is the halogenated aromatic hydrocarbon method. Using 2 - (trifluoromethyl) halobenzene as the starting material, at low temperature, it interacts with metal magnesium to form Grignard's reagent. This process needs to be carried out in an inert solvent such as anhydrous ether or tetrahydrofuran, and the reaction system must be anhydrous and oxygen-free. Subsequently, the generated Grignard's reagent is reacted with borate ester, and after hydrolysis, the target product 2 - (trifluoromethyl) phenylboronic acid can be obtained. The reaction principle is based on the strong nucleophilic properties of Grignard's reagents, which can undergo nucleophilic substitution with borate esters. After hydrolysis, borate esters are converted into bor
    Second, palladium-catalyzed coupling method. Using 2 - (trifluoromethyl) halobenzene and diphenylboronyl alcohol ester as raw materials, under the catalysis of palladium catalyst such as tetra (triphenylphosphine) palladium, the reaction system often uses toluene, dioxane, etc. as solvents, potassium carbonate, sodium carbonate, etc. as bases. The palladium catalyst can activate halogenated aromatics and borate esters, and promote the coupling reaction of the two to generate 2 - (trifluoromethyl) phenylboronic acid phenylboronyl alcohol ester, which is then hydrolyzed to obtain the target product. This method has good selectivity and high yield, and is widely used in the field of organic synthesis.
    Third, metal lithium reagent method. 2- (trifluoromethyl) halobenzene is first reacted with metal lithium reagents such as butyl lithium to form lithium reagent intermediates. This step needs to be operated in a low temperature and anhydrous and oxygen-free environment. After that, the intermediate is reacted with borate and hydrolyzed to obtain 2- (trifluoromethyl) phenylboronic acid. This method has high reactivity, but it requires strict reaction conditions and requires careful operation.
    The above synthesis methods have their own advantages and disadvantages. In practical application, the appropriate synthesis path should be carefully selected according to the availability of raw materials, the controllability of reaction conditions, the purity and yield requirements of the target product, and other factors.
    What are the Physical Properties of 2- (Trifluoromethyl) Benzeneboronic Acid
    2-%28Trifluoromethyl%29Benzeneboronic Acid is 2 - (trifluoromethyl) phenylboronic acid, which has the following physical properties:
    It is mostly white to light yellow crystalline powder at room temperature, and its texture is fine. This state is conducive to storage and use. In many experimental operations and industrial processes, this form can ensure its dispersibility and reaction contact area, which has a great impact on the subsequent reaction process.
    2 - (trifluoromethyl) phenylboronic acid has a melting point between 128 - 132 ° C, and the melting point is in this range, indicating that the intermolecular force is moderate. When heated to this temperature range, the molecules are energized enough to overcome the lattice energy, and the lattice structure disintegrates and melts into a liquid state. This melting point property is of great significance in separation, purification and control of specific reaction conditions. It can achieve phase transformation of substances by precise temperature control, and achieve the purpose of separation or participation in specific reactions.
    The solubility of this substance is also worthy of attention. It is slightly soluble in water, but soluble in common organic solvents such as dichloromethane, ether, toluene, etc. Good solubility in organic solvents makes it widely used in the field of organic synthesis. Organic reactions are mostly carried out in organic solvent systems, and its solubility ensures that it can be fully mixed with other organic reactants, and the probability of intermolecular contact is greatly increased, thereby promoting the efficient progress of the reaction. It has poor solubility in the aqueous phase, but it can be used in the design of heterogeneous reaction systems involving the aqueous phase to realize phase transfer catalysis or specific phase separation processes according to this characteristic.
    In addition, 2 - (trifluoromethyl) phenylboronic acid has certain stability and can maintain its own chemical structure and properties under conventional environmental conditions. However, when encountering specific chemicals such as strong oxidizing agents and strong bases, the stability is damaged, and chemical reactions are prone to occur, resulting in structural and property changes. When storing and using, it is necessary to avoid contact with such substances, and choose suitable storage conditions and packaging materials to ensure the stability of its physical properties and chemical activities.
    What are the chemical properties of 2- (Trifluoromethyl) Benzeneboronic Acid
    2-%28Trifluoromethyl%29Benzeneboronic Acid is 2 - (trifluoromethyl) phenylboronic acid, and its chemical properties are as follows:
    This compound contains boron-oxygen bonds and has boric acid-like properties. In water, borate can interact with water molecules to release protons, which is weakly acidic. This acidity is derived from the lack of electrons in boron atoms and can accept lone pair electrons of oxygen atoms in water molecules, which increases the concentration of hydrogen ions in the system.
    2 - (trifluoromethyl) phenylboronic acid, trifluoromethyl is a strong electron-withdrawing group, which affects the electron cloud density of the benzene ring. Due to its electron-withdrawing effect, the electron cloud density of the benzene ring decreases, which changes the reaction activity of this compound with electrophilic reagents, and increases the difficulty of electrophilic sub Compared with general phenylboronic acid, due to the strong electron absorption of trifluoromethyl, the electron cloud density at the check point of the reaction decreases, and it is less prone to electrophilic substitution, especially in the ortho and para-positions on the benzene ring.
    The boron-oxygen bonds in this compound can participate in a variety of organic reactions, such as Suzuki coupling reaction. In this reaction, 2 - (trifluoromethyl) phenylboronic acid and halogenated aromatic hydrocarbons can form carbon-carbon bonds under the action of palladium catalyst and base, which can be widely used in drug synthesis, materials science and other fields to provide an effective way to construct complex organic molecular structures.
    In addition, 2 - (trifluoromethyl) phenylboronic acid is sensitive to air and humidity. When the humidity is high, the boric acid group may undergo side reactions such as hydrolysis, which will affect its stability and reactivity. Therefore, it is necessary to pay attention to moisture-proof storage, usually stored in a dry inert gas environment.
    2- (Trifluoromethyl) Benzeneboronic Acid Storage and Transportation
    2-%28Trifluoromethyl%29Benzeneboronic Acid is 2 - (trifluoromethyl) phenylboronic acid. When storing and transporting this substance, many things need to be paid attention to.
    Let's talk about storage first. Because of its nature, it needs to be placed in a cool and dry place. If it is in a warm and humid environment, it is easy to deteriorate. Just as the ancient books say "things should be hidden in a dry and cool place to prevent them from spoiling", the same is true. It needs to be stored separately from oxidizing agents, acids, and alkalis, and cannot be mixed. Because these substances come into contact with it or react chemically, they lose their properties. Just like the ancients said "different species avoid each other to prevent accidents". Where it is stored, there should be suitable materials to contain leaks, just in case there is a leak, and it can be dealt with in time.
    Let's talk about transportation. During transportation, make sure that the container does not leak, collapse, fall, or be damaged. Just like the ancients escorting precious goods, care must be taken to ensure its integrity. Vehicles used during transportation should be driven according to the specified route, and do not stop in densely populated areas and residential areas. Because if the substance leaks, it may endanger the safety of everyone. During transportation, it should be protected from sun exposure, rain exposure, and high temperature. Exposure to the hot sun, rain exposure, and high temperature may affect its quality, just like the ancients transported vulnerable items, which needed to be protected from wind and rain and avoid high temperature. When loading and unloading, operators should load and unload lightly, and strictly prohibit touching and heavy pressure to ensure the integrity and safety of 2 - (trifluoromethyl) phenylboronic acid.