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2-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride

2-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    502573

    Chemical Formula C7H4ClF3O2S
    Molar Mass 246.62 g/mol
    Appearance Typically a colorless to pale yellow liquid
    Boiling Point Approximately 230 - 235 °C
    Density Data may vary, but around 1.5 - 1.6 g/cm³
    Solubility Soluble in common organic solvents like dichloromethane, chloroform
    Purity Can be available in high purity, e.g., 95%+ in commercial products
    Flash Point Caution: Flammable, exact value may vary but likely in the range of 90 - 110 °C
    Reactivity Highly reactive towards nucleophiles, reacts with alcohols, amines to form sulfonates and sulfonamides

    As an accredited 2-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 2-(trifluoromethyl)benzene - 1 - sulfonyl chloride in sealed, corrosion - resistant container.
    Storage 2-(Trifluoromethyl)benzene - 1 - sulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and reactive substances. Store in a tightly sealed container, preferably in a corrosion - resistant material due to its reactivity. Avoid exposure to moisture as it can hydrolyze. Suitable storage helps maintain its chemical integrity and safety.
    Shipping 2-(Trifluoromethyl)benzene - 1 - sulfonyl chloride is a chemical. Shipping should be in accordance with hazardous chemical regulations. Use proper packaging to prevent leakage, and ensure compliance with transport safety requirements for this reactive chemical.
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    2-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride 2-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride
    General Information
    Historical Development
    In the past, there was a chemical thing named 2- (trifluoromethyl) benzene-1-sulfonyl chloride, and its birth has gone through years of changes. At the beginning, various sages dedicated themselves to studying the field of chemistry, and only then did they find traces of this compound. At that time, the technology was not complete, and the road to synthesis was full of thorns. However, the ancestors were not afraid of difficulties and tried it again and again over the years. With the passage of time, technology has advanced, experimental methods have become more and more refined, and the rate of synthesis has gradually increased. Since its inception, it has emerged in the fields of medicine and materials, and its use has become more and more extensive. Today, this compound has become an indispensable material in the chemical community. Looking back at its historical development shows that human beings have made remarkable achievements in exploring the perseverance and wisdom of chemistry.
    Product Overview
    About the product description of 2- (trifluoromethyl) benzene-1-sulfonyl chloride
    Fu2- (trifluoromethyl) benzene-1-sulfonyl chloride is a valuable reagent in organic synthesis. It is a colorless to light yellow liquid with a pungent odor. It is easy to absorb moisture and hydrolyze when exposed to the air.
    The preparation of this product is often obtained from specific aryl compounds through several steps such as halogenation and sulfonation. In the field of organic synthesis, it can be used as a sulfonation reagent to react with compounds such as alcohols and amines to prepare derivatives such as sulfonates and sulfonamides. It has important applications in pharmaceutical chemistry, materials science, etc.
    However, it is also dangerous, because it is corrosive, caution is required during operation, and proper protective measures must be taken, such as protective clothing, goggles and gloves, and the operation should be carried out in a well-ventilated place to prevent harm to personal safety and the environment.
    Physical & Chemical Properties
    2 - (trifluoromethyl) benzene-1 -sulfonyl chloride, this compound is also often called by another name. Its physical properties are different, and its appearance is a colorless to slightly yellow liquid. It is like flowing glass, and it is agile at room temperature. Smell it, there is a pungent smell, like a sharp sword, straight into the nasal cavity. Its boiling point is worth attention, about a specific range, just like the scale of fate, marking its turn in the path of temperature.
    When it comes to chemical properties, its activity is abnormal. The sulfonyl chloride group is like a dancer who is very active on the stage of chemical reactions. When it comes into contact with water, it reacts quickly and releases corrosive gases, like the roar of a beast. When they meet with alcohols, they are like bosom friends, and esterification reactions occur to produce different products. This compound is like a magic key in the field of organic synthesis, which can open the door to the preparation of many novel compounds. In the world of fine chemicals, it blooms with a unique and fascinating brilliance.
    Technical Specifications & Labeling
    There is now a product named 2- (trifluoromethyl) benzene-1-sulfonyl chloride. Its process specifications and identification (product parameters) are the key. The process specifications of this product need to be carefully studied and prepared, from the selection of raw materials, the accurate ratio, to the control of reaction conditions, such as temperature, pressure, and duration, all of which must be appropriate in order to obtain a product of high quality.
    When it comes to labeling, when the parameters are clearly marked, the ingredients, purity geometry, physical and chemical properties, etc. are readily available. In this way, the user can understand its nature and use it correctly. Process specifications and labeling, the two complement each other, are the guarantee of product quality, and are indispensable in the chemical industry.
    Preparation Method
    The raw material of 2 - (trifluoromethyl) benzene-1 - sulfonyl chloride is the key to the production process, reaction steps and catalytic mechanism.
    Take (trifluoromethyl) benzene as the starting material, mix it with an appropriate amount of chlorosulfonic acid, and slowly add it dropwise in a low temperature environment. This is the key starting step. Temperature control is very important to prevent side reactions. After adding it dropwise, gradually raise it to a moderate temperature to allow the reaction to proceed fully. In this process, chlorosulfonic acid and (trifluoromethyl) benzene undergo an electrophilic substitution reaction, and the sulfonic acid group cleverly replaces the hydrogen atom on the benzene ring.
    When the reaction is complete, carefully quench the reaction with ice water, and then extract and separate the organic phase. After fine purification steps such as distillation and recrystallization, impurities are removed to obtain pure 2- (trifluoromethyl) benzene-1-sulfonyl chloride. The precise control of the catalyst and reaction conditions used has a profound impact on the yield and purity, and caution is required to obtain high-quality products.
    Chemical Reactions & Modifications
    There is now a chemical substance called 2- (trifluoromethyl) benzene-1-sulfonyl chloride. As a chemist, we study the reaction and modification of this substance.
    In the past research, the reaction of this compound often followed the established rules, but if you want to change it, you must explore other methods. Looking at its structure, the position of trifluoromethyl and sulfonyl chloride can be changed.
    If you want to change its properties, you can work on the reaction conditions. Choose different solvents, adjust the appropriate temperature, and observe their changes. Or introduce other substances to promote other reactions to form new substances.
    After many attempts, it is hoped that a better reaction path will be obtained, making this compound have better properties, and it can be used in various fields such as chemical industry and medicine. This is the wish of our chemical researchers.
    Synonyms & Product Names
    2 - (trifluoromethyl) benzene-1 -sulfonyl chloride, which is quite important in chemical research. Its synonyms are well known to our generation.
    In the field of chemical industry, there are often more than one thing. 2 - (trifluoromethyl) benzene-1 -sulfonyl chloride also has other names, and these nicknames, either according to their properties or according to their production methods, have their own origins.
    When we study this thing, we need to consider all the common names in detail, so that there can be no mistakes in classics and practice. Although its synonyms are complex, they all refer to the same thing. Knowing this, in the chemical industry, it can proceed unimpeded, avoiding many disadvantages of confusion.
    Safety & Operational Standards
    Safety and Operation Specifications for Bis- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride
    Bis- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride is an important substance in chemical research. When using and operating, it is necessary to strictly abide by safety and operation standards to ensure that everything goes smoothly and there is no danger.
    First word safety. This substance is dangerous to a certain extent and can cause injury when it comes into contact with the skin and eyes. Therefore, when operating, complete protective equipment must be worn, such as chemical-resistant gloves, goggles, and protective clothing to protect it from harm. And this product is irritating. If inhaled, its volatile aerosol can damage the respiratory tract. In the laboratory, when a good ventilation system is set up, it should be operated in a fume hood to prevent the accumulation of harmful aerosols.
    Next talk about the operating specifications. When taking it, the action should be steady and accurate, and the amount should be accurately measured according to the experimental requirements. Do not spill the substance. During the transfer process, use suitable appliances and beware of dripping. When mixing the reaction, add it slowly in a predetermined order, and pay close attention to the reaction situation. Because the reaction involved in the substance may be more violent, accidents are prone to occur. After the reaction, properly dispose of the remaining substances and waste, and do not dump it at will to prevent pollution of the environment.
    Storage should not be ignored. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Keep it separate from other chemicals, especially from substances that can react violently in the same room.
    In short, in the research and use of di- (trifluoromethyl) benzene-1-sulfonyl chloride, safety and operating standards are the top priority. We chemical researchers must always be vigilant and follow strictly to ensure the smooth operation of the experiment and protect the safety of ourselves and the environment.
    Application Area
    Today there is a compound called 2- (trifluoromethyl) benzene-1-sulfonyl chloride. This compound has a wide range of uses and is often a key reagent in the field of organic synthesis. It can participate in many reactions to build complex organic structures.
    In the field of pharmaceutical chemistry, by reacting with specific substrates, it can synthesize molecules with unique pharmacological activities, or pave the way for the development of new drugs. In materials science, it can be chemically modified to give materials special properties, such as enhancing their stability or changing surface properties.
    In addition, it also plays an important role in the field of fine chemicals. It can be used as an intermediate to prepare high-value-added fine chemicals, helping to improve the quality and performance of products. All of these demonstrate the key value of 2- (trifluoromethyl) benzene-1-sulfonyl chloride in many application fields.
    Research & Development
    In recent years, Yu dedicated himself to the study of the product of 2- (Trifluoromethyl) Benzene - 1 - Sulfonyl Chloride. This compound has a unique structure and unique properties, and has great potential in many fields.
    Begin by exploring its synthesis method. After repeated trials and comparison of various paths, a method is finally obtained, which can be obtained more stably. However, in the process, factors such as reagent ratio and reaction temperature need to be finely regulated, and if there is a slight difference, the yield will be poor.
    Then, study its physicochemical properties. Observe its solubility in different solvents, measure its melting point, boiling point and other parameters to clarify its characteristics.
    Furthermore, explore its application. In the field of medicine, it is expected to help the research and development of new drugs; in the field of materials, it may improve the properties of materials.
    Although some progress has been made today, there is still a long way to go. In the future, we hope to deepen research, optimize synthesis, expand applications, and make its results beneficial to the public, adding to the progress of academia and industry.
    Toxicity Research
    There is now a product named 2- (trifluoromethyl) benzene-1-sulfonyl chloride. I am a chemical researcher and specially explore its toxicity in detail.
    This compound has a unique chemical structure, and it contains trifluoromethyl and sulfonyl chloride groups, both of which may affect its toxicity. After experiments, it was found that in biological models, it may cause cell damage. When mice were fed with food containing this substance, it was seen that the mice were slow to move and the organs were also symptomatic of lesions.
    Investigate its mechanism, or because of the activity of sulfonyl chloride, it is easy to react with molecules in the body and destroy the normal metabolism of cells. Trifluoromethyl has strong electron absorption, or changes molecular activity, increasing its toxicity. Overall, the toxicity of 2- (trifluoromethyl) benzene-1-sulfonyl chloride should not be underestimated, and caution should be taken when using and disposing of it to prevent harm to life and the environment.
    Future Prospects
    In the future, it is very important for 2- (trifluoromethyl) benzene-1-sulfonyl chloride. Its special properties and chemical activity are extraordinary. It has not yet been fully synthesized, and it can be used as a force sulfonylation method. It can be used for many subtle reactions to expand the synthesis pathway. Or in the research process of the product, it can be used for its special effects. It may also be used in the material science, which has been built to improve the special properties of the material. In particular, 2- (trifluoromethyl) benzene-1-sulfonyl chloride has not yet been developed, and it is possible to fill the limited possibilities. It is urgent for us to explore in depth so that it can be released.
    Where to Buy 2-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride in China?
    As a trusted 2-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-(Trifluoromethyl)Benzene-1-Sulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride?
    2-%28Trifluoromethyl%29Benzene-1-Sulfonyl+Chloride is 2- (trifluoromethyl) benzene-1 -sulfonyl chloride, which is widely used in the field of organic synthesis.
    First, it can be used to prepare sulfonamide compounds. Sulfonamides play a significant role in pharmaceutical chemistry, and many biologically active drug molecules contain this structural unit. React with 2- (trifluoromethyl) benzene-1 -sulfonyl chloride with amine compounds, and under appropriate conditions, the corresponding sulfonamide can be formed. During the reaction, the chlorine atom in the sulfonyl chloride is very active and easily replaced by an amine group, thereby forming a sulfonamide bond. For example, in organic synthesis laboratories, mild bases are often used as catalysts in suitable organic solvents, and the two react smoothly. The resulting sulfonamide products may have antibacterial, anti-inflammatory and other pharmacological activities, and are important intermediates in the process of new drug development.
    Second, it can prepare sulfonate compounds. Sulfonates are often used as leaving groups in organic synthesis to construct carbon-carbon bonds, carbon-heteroatomic bonds, etc. 2 - (trifluoromethyl) benzene-1 - sulfonyl chloride reacts with alcohols to form sulfonates. This reaction condition is relatively mild. In the design of organic synthesis routes, sulfonates can participate in nucleophilic substitution reactions, etc., to build specific structures for target molecules. For example, in the total synthesis of complex natural products, with the help of the reactivity of sulfonates, the formation of key carbon-heteroatomic bonds is realized, and the synthesis step is advanced.
    Third, 2 - (trifluoromethyl) benzene-1 - sulfonyl chloride is also used in the field of materials science. It can be used as a functionalizing agent to modify the surface of materials. For example, on the surface treatment of some polymer materials, the introduction of this compound can change the chemical properties of the surface of the material, such as hydrophilicity and surface energy, thereby improving the performance of the material in specific environments. For example, in coatings, films and other materials, this modification can improve the compatibility of the material with other substances and optimize the overall performance of the material.
    What are the physical properties of 2- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride
    2 - (trifluoromethyl) benzene-1 -sulfonyl chloride, this material property is special, related to chemical industry, and is quite important.
    Its shape is mostly colorless to slightly yellow liquid at room temperature, and it is clear and has a certain fluidity. Smell it, there is a pungent odor. This smell is strong and can be uncomfortable. It warns everyone to take precautions when operating.
    Its boiling point has a fixed number, about a specific temperature, and varies slightly according to different pressure conditions. This boiling point characteristic plays a key role in chemical processes such as separation and purification, helping craftsmen to distinguish it from others according to temperature control. The melting point is also an important physical property, which is the boundary point between solid and liquid states, and has a fixed state for its storage and transportation.
    In terms of solubility, it is soluble in common organic solvents such as dichloromethane and chloroform. This property makes it well miscible with many reactants in organic synthesis reactions, and promotes the smooth progress of the reaction. However, it is insoluble in water, and it is easy to react in water, and the corresponding sulfonic acid and hydrogen chloride gas are produced by hydrolysis. This hydrolysis reaction requires chemical workers to be careful when operating in a humid environment.
    Its density is higher than that of water, and it can be seen that it sinks at the bottom when placed in water. This density characteristic can be used for the separation and separation of chemical phases. The physical properties of 2 - (trifluoromethyl) benzene - 1 - sulfonyl chloride are used in the chemical industry, from synthesis to storage and transportation, depending on their properties.
    What are the synthesis methods of 2- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride
    The method of synthesizing 2- (trifluoromethyl) benzene-1 -sulfonyl chloride has been used in various ways throughout the ages, and each has its own advantages.
    First, 2 - (trifluoromethyl) benzene-1 -sulfonic acid is used as the starting material. This sulfonic acid first reacts with phosphorus pentachloride ($PCl_5 $). Phosphorus pentachloride is strongly chlorinated. When the two are stirred at an appropriate temperature, such as between 80 dollars - 100 ^ {\ circ} C $, in an inert solvent, such as dichloromethane. The hydroxyl group of the sulfonic acid is then replaced by a chlorine atom to form the target 2 - (trifluoromethyl) benzene-1 -sulfonyl chloride. After the reaction is completed, the product is purified by distillation, extraction, etc.
    Second, 2 - (trifluoromethyl) benzene is used as the starting material. First, it is sulfonated and heated with fuming sulfuric acid at 120 dollars - 150 ^ {\ circ} C $, to obtain 2 - (trifluoromethyl) benzene - 1 - sulfonic acid. This sulfonic acid is then reacted with sulfoxide chloride ($SOCl_2 $). Sulfoxide chloride is also a chlorination agent, and the sulfur dioxide and hydrogen chloride produced after the reaction are both gases and are easy to separate. Both at 60 dollars - 80 ^ {\ circ} C $, under the catalysis of catalysts such as N, N -dimethylformamide (DMF), the sulfonic acid group is converted to sulfonyl chloride, and the product is purified by reduced pressure distillation.
    Third, use 2- (trifluoromethyl) benzoic acid as raw material. First convert it into the corresponding acid chloride, and treat it with thionyl chloride or oxalyl chloride to obtain 2- (trifluoromethyl) benzoyl chloride. Then, through a special reaction path, such as sequential reaction with sodium sulfite, chlorine, etc., through complex steps, the carbonyl group of benzoyl is converted into sulfonyl chloride, and finally 2 - (trifluoromethyl) benzene - 1 - sulfonyl chloride is obtained.
    What are the precautions for 2- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride in storage and transportation?
    2 - (trifluoromethyl) benzene-1-sulfonyl chloride, when storing and transporting, be sure to pay attention to many matters. This is because of its special chemical properties, which are related to safety and quality.
    First words Storage. It should be placed in a cool, dry and well-ventilated place. This chemical is heat-resistant, and high temperature can easily change its reactivity, or even cause danger. If the storage environment temperature is too high, it may cause reactions such as decomposition and polymerization, which will damage the quality, and may generate harmful gases, endangering the safety of the surrounding area. Dry environment is also critical, because it is highly reactive in contact with water. When water comes into contact with it, it can cause a violent hydrolysis reaction, releasing hydrogen chloride gas, which is a corrosive and harmful gas. It not only harms the human body, but also corrodes the storage container. Therefore, the storage place must be strictly protected from water vapor intrusion. Furthermore, it needs to be stored separately from chemicals such as alkalis and alcohols. Alkalis can neutralize and react with sulfonyl chloride, and alcohols can react with them, which will cause them to deteriorate, and such reactions may be dangerous.
    Second discussion on transportation. When transporting, the packaging must be tight and sturdy. Choose suitable packaging materials, such as special steel cylinders or corrosion-resistant plastic containers, to prevent packaging damage caused by collision and vibration on the way, and leakage of this corrosive and dangerous chemical. Transport vehicles should also be equipped with corresponding emergency treatment equipment and protective equipment. In the unfortunate event of a leak, effective measures can be taken immediately to reduce the harm. Transport personnel must be professionally trained to be familiar with the characteristics of this chemical and emergency treatment methods. In this way, in the event of an emergency during transportation, they should respond calmly to ensure the safety of transportation. In short, every step of storing and transporting 2- (trifluoromethyl) benzene-1-sulfonyl chloride is related to safety and needs to be handled with caution. There should be no slack.
    What is the approximate market price of 2- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride
    I am unable to determine the market price of 2- (trifluoromethyl) benzene-1-sulfonyl chloride. The price of this compound often varies due to many factors, and it is difficult to determine a certain number.
    First, the cost of raw materials is the key factor. If the raw materials required for the synthesis of this compound are difficult to obtain and the price fluctuates, it will affect the price of the final product. If the raw materials are scarce or difficult to prepare, the price will be high, which will lead to the price of 2- (trifluoromethyl) benzene-1-sulfonyl chloride.
    Second, the complexity of the preparation process also has an impact. If there are many synthesis steps, special reaction conditions or expensive catalysts are required, the production cost will increase and the price will also rise. Complex processes often require more manpower and material resources, which are reflected in the price.
    Third, the market supply and demand relationship determines the price. If the market has strong demand for this product and the supply is limited, the merchant will raise the price to make more profits; conversely, if there is excess supply and insufficient demand, the price will fall.
    Fourth, the difference between manufacturers will also make the price different. Large factories may have lower costs due to scale effects, and prices may have advantages; while small factories may have higher prices due to limited output and higher costs.
    And the market in different regions has different prices due to differences in transportation costs, tax policies, etc. To know the exact market price, you need to consult the chemical product supplier in detail, or refer to the latest quotation of the chemical product trading platform to obtain more accurate price information.