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What are the main uses of 2- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride?
2-%28Trifluoromethyl%29Benzene-1-Sulfonyl+Chloride is 2- (trifluoromethyl) benzene-1 -sulfonyl chloride, which is widely used in the field of organic synthesis.
First, it can be used to prepare sulfonamide compounds. Sulfonamides play a significant role in pharmaceutical chemistry, and many biologically active drug molecules contain this structural unit. React with 2- (trifluoromethyl) benzene-1 -sulfonyl chloride with amine compounds, and under appropriate conditions, the corresponding sulfonamide can be formed. During the reaction, the chlorine atom in the sulfonyl chloride is very active and easily replaced by an amine group, thereby forming a sulfonamide bond. For example, in organic synthesis laboratories, mild bases are often used as catalysts in suitable organic solvents, and the two react smoothly. The resulting sulfonamide products may have antibacterial, anti-inflammatory and other pharmacological activities, and are important intermediates in the process of new drug development.
Second, it can prepare sulfonate compounds. Sulfonates are often used as leaving groups in organic synthesis to construct carbon-carbon bonds, carbon-heteroatomic bonds, etc. 2 - (trifluoromethyl) benzene-1 - sulfonyl chloride reacts with alcohols to form sulfonates. This reaction condition is relatively mild. In the design of organic synthesis routes, sulfonates can participate in nucleophilic substitution reactions, etc., to build specific structures for target molecules. For example, in the total synthesis of complex natural products, with the help of the reactivity of sulfonates, the formation of key carbon-heteroatomic bonds is realized, and the synthesis step is advanced.
Third, 2 - (trifluoromethyl) benzene-1 - sulfonyl chloride is also used in the field of materials science. It can be used as a functionalizing agent to modify the surface of materials. For example, on the surface treatment of some polymer materials, the introduction of this compound can change the chemical properties of the surface of the material, such as hydrophilicity and surface energy, thereby improving the performance of the material in specific environments. For example, in coatings, films and other materials, this modification can improve the compatibility of the material with other substances and optimize the overall performance of the material.
What are the physical properties of 2- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride
2 - (trifluoromethyl) benzene-1 -sulfonyl chloride, this material property is special, related to chemical industry, and is quite important.
Its shape is mostly colorless to slightly yellow liquid at room temperature, and it is clear and has a certain fluidity. Smell it, there is a pungent odor. This smell is strong and can be uncomfortable. It warns everyone to take precautions when operating.
Its boiling point has a fixed number, about a specific temperature, and varies slightly according to different pressure conditions. This boiling point characteristic plays a key role in chemical processes such as separation and purification, helping craftsmen to distinguish it from others according to temperature control. The melting point is also an important physical property, which is the boundary point between solid and liquid states, and has a fixed state for its storage and transportation.
In terms of solubility, it is soluble in common organic solvents such as dichloromethane and chloroform. This property makes it well miscible with many reactants in organic synthesis reactions, and promotes the smooth progress of the reaction. However, it is insoluble in water, and it is easy to react in water, and the corresponding sulfonic acid and hydrogen chloride gas are produced by hydrolysis. This hydrolysis reaction requires chemical workers to be careful when operating in a humid environment.
Its density is higher than that of water, and it can be seen that it sinks at the bottom when placed in water. This density characteristic can be used for the separation and separation of chemical phases. The physical properties of 2 - (trifluoromethyl) benzene - 1 - sulfonyl chloride are used in the chemical industry, from synthesis to storage and transportation, depending on their properties.
What are the synthesis methods of 2- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride
The method of synthesizing 2- (trifluoromethyl) benzene-1 -sulfonyl chloride has been used in various ways throughout the ages, and each has its own advantages.
First, 2 - (trifluoromethyl) benzene-1 -sulfonic acid is used as the starting material. This sulfonic acid first reacts with phosphorus pentachloride ($PCl_5 $). Phosphorus pentachloride is strongly chlorinated. When the two are stirred at an appropriate temperature, such as between 80 dollars - 100 ^ {\ circ} C $, in an inert solvent, such as dichloromethane. The hydroxyl group of the sulfonic acid is then replaced by a chlorine atom to form the target 2 - (trifluoromethyl) benzene-1 -sulfonyl chloride. After the reaction is completed, the product is purified by distillation, extraction, etc.
Second, 2 - (trifluoromethyl) benzene is used as the starting material. First, it is sulfonated and heated with fuming sulfuric acid at 120 dollars - 150 ^ {\ circ} C $, to obtain 2 - (trifluoromethyl) benzene - 1 - sulfonic acid. This sulfonic acid is then reacted with sulfoxide chloride ($SOCl_2 $). Sulfoxide chloride is also a chlorination agent, and the sulfur dioxide and hydrogen chloride produced after the reaction are both gases and are easy to separate. Both at 60 dollars - 80 ^ {\ circ} C $, under the catalysis of catalysts such as N, N -dimethylformamide (DMF), the sulfonic acid group is converted to sulfonyl chloride, and the product is purified by reduced pressure distillation.
Third, use 2- (trifluoromethyl) benzoic acid as raw material. First convert it into the corresponding acid chloride, and treat it with thionyl chloride or oxalyl chloride to obtain 2- (trifluoromethyl) benzoyl chloride. Then, through a special reaction path, such as sequential reaction with sodium sulfite, chlorine, etc., through complex steps, the carbonyl group of benzoyl is converted into sulfonyl chloride, and finally 2 - (trifluoromethyl) benzene - 1 - sulfonyl chloride is obtained.
What are the precautions for 2- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride in storage and transportation?
2 - (trifluoromethyl) benzene-1-sulfonyl chloride, when storing and transporting, be sure to pay attention to many matters. This is because of its special chemical properties, which are related to safety and quality.
First words Storage. It should be placed in a cool, dry and well-ventilated place. This chemical is heat-resistant, and high temperature can easily change its reactivity, or even cause danger. If the storage environment temperature is too high, it may cause reactions such as decomposition and polymerization, which will damage the quality, and may generate harmful gases, endangering the safety of the surrounding area. Dry environment is also critical, because it is highly reactive in contact with water. When water comes into contact with it, it can cause a violent hydrolysis reaction, releasing hydrogen chloride gas, which is a corrosive and harmful gas. It not only harms the human body, but also corrodes the storage container. Therefore, the storage place must be strictly protected from water vapor intrusion. Furthermore, it needs to be stored separately from chemicals such as alkalis and alcohols. Alkalis can neutralize and react with sulfonyl chloride, and alcohols can react with them, which will cause them to deteriorate, and such reactions may be dangerous.
Second discussion on transportation. When transporting, the packaging must be tight and sturdy. Choose suitable packaging materials, such as special steel cylinders or corrosion-resistant plastic containers, to prevent packaging damage caused by collision and vibration on the way, and leakage of this corrosive and dangerous chemical. Transport vehicles should also be equipped with corresponding emergency treatment equipment and protective equipment. In the unfortunate event of a leak, effective measures can be taken immediately to reduce the harm. Transport personnel must be professionally trained to be familiar with the characteristics of this chemical and emergency treatment methods. In this way, in the event of an emergency during transportation, they should respond calmly to ensure the safety of transportation. In short, every step of storing and transporting 2- (trifluoromethyl) benzene-1-sulfonyl chloride is related to safety and needs to be handled with caution. There should be no slack.
What is the approximate market price of 2- (Trifluoromethyl) Benzene-1-Sulfonyl Chloride
I am unable to determine the market price of 2- (trifluoromethyl) benzene-1-sulfonyl chloride. The price of this compound often varies due to many factors, and it is difficult to determine a certain number.
First, the cost of raw materials is the key factor. If the raw materials required for the synthesis of this compound are difficult to obtain and the price fluctuates, it will affect the price of the final product. If the raw materials are scarce or difficult to prepare, the price will be high, which will lead to the price of 2- (trifluoromethyl) benzene-1-sulfonyl chloride.
Second, the complexity of the preparation process also has an impact. If there are many synthesis steps, special reaction conditions or expensive catalysts are required, the production cost will increase and the price will also rise. Complex processes often require more manpower and material resources, which are reflected in the price.
Third, the market supply and demand relationship determines the price. If the market has strong demand for this product and the supply is limited, the merchant will raise the price to make more profits; conversely, if there is excess supply and insufficient demand, the price will fall.
Fourth, the difference between manufacturers will also make the price different. Large factories may have lower costs due to scale effects, and prices may have advantages; while small factories may have higher prices due to limited output and higher costs.
And the market in different regions has different prices due to differences in transportation costs, tax policies, etc. To know the exact market price, you need to consult the chemical product supplier in detail, or refer to the latest quotation of the chemical product trading platform to obtain more accurate price information.