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2-Trifluoromethoxybenzenesulfonamide

2-Trifluoromethoxybenzenesulfonamide

Hongda Chemical

Specifications

HS Code

392027

Chemical Formula C7H6F3NO3S
Molecular Weight 241.19
Appearance Typically a solid (physical state can vary based on conditions)
Melting Point Data may vary, but solid - state melting point exists
Solubility In Water Low solubility, as it has non - polar benzene ring and relatively hydrophobic trifluoromethoxy group
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform due to its organic nature
Pka Related to the sulfonamide group, can participate in acid - base reactions
Density Data may vary, but density value would be characteristic for the compound
Flash Point Flash point exists, relevant for handling in case of fire - related safety

As an accredited 2-Trifluoromethoxybenzenesulfonamide factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 1 kg of 2 - trifluoromethoxybenzenesulfonamide in a sealed, chemical - resistant bag.
Storage 2 - trifluoromethoxybenzenesulfonamide should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, open flames, and oxidizing agents. Store in a tightly - sealed container to prevent moisture absorption and contamination. Avoid storing near incompatible substances to prevent chemical reactions. This storage method helps maintain its chemical stability.
Shipping 2 - trifluoromethoxybenzenesulfonamide is shipped in well - sealed containers, compliant with chemical transport regulations. Special care is taken to prevent exposure, with proper labeling indicating its nature for safe and proper handling during transit.
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2-Trifluoromethoxybenzenesulfonamide 2-Trifluoromethoxybenzenesulfonamide
General Information
Historical Development
Husband 2 - Trifluoromethoxybenzenesulfonamide, the thing that is transformed is also. Its initial research, It has been used in many fields such as engineering, engineering, etc. Therefore, it has been widely used in different aspects, and it has become today's model, which is one of the important aspects of the research process.
Product Overview
2-Trifluoromethoxy benzenesulfonamide is a key substance involved in my research on chemical products. This product has a unique chemical structure, containing trifluoromethoxy and benzenesulfonamide groups. Trifluoromethoxy gives it special physical and chemical properties, such as enhancing lipophilicity, affecting the distribution of electron clouds, and then affecting its reactivity. Benzenesulfonamide groups are also extraordinary, often found in many bioactive molecules, and can participate in various chemical reactions or interact with biological targets.
When I studied this product, I carefully investigated its synthesis path and optimized it through many experiments to achieve efficient preparation. Looking at its properties, its stability is quite good under certain conditions, and its solubility is good in some organic solvents. This product may emerge in the field of pharmaceutical research and development, providing an opportunity to create new drug molecules; or it may have unique uses in the field of materials science, such as the preparation of special functional materials. Its potential is vast, and I should continue to study it to uncover more functions.
Physical & Chemical Properties
2 - Trifluoromethoxybenzenesulfonamide is a unique compound. Its physical properties are unique. It is mostly white crystalline at room temperature. Those with pure quality have a high melting point. It has good solubility in specific organic solvents, such as acetone and dichloromethane. This characteristic is derived from the fluoromethoxy group and sulfonamide group contained in its molecular structure. The interaction between the two affects the intermolecular force.
From the perspective of chemical properties, the sulfonamide group in this compound has a certain reactivity and can be substituted with a variety of nucleophiles to form new carbon-nitrogen or carbon-oxygen bonds. Due to the strong electron-absorbing effect of trifluoromethoxy, the electron cloud density of benzene ring decreases, which changes its aromatic electrophilic substitution activity, and the reaction check point is also different from that of ordinary benzene series. This compound has shown broad application prospects in the field of organic synthesis and has potential value in the development of new drugs and the creation of functional materials.
Technical Specifications & Labeling
Today there is a thing called 2-Trifluoromethoxybenzenesulfonamide. Its technical specifications and identification (product parameters) are the gist of our research. The technical specifications of this product need to clarify the method of synthesis, the geometry of the materials used, and the sequence of steps. As for the logo, when indicating its properties, such as color, taste, and state, it is also necessary to indicate the parameters of content and purity. In this way, the technical specifications and identification of this product can be made clear, and when used by people, it can be correct and play its effect. It is also easy to identify the advantages and disadvantages, so as to promote the good use and refinement of this product.
Preparation Method
To make 2 - Trifluoromethoxybenzenesulfonamide this product, the first thing to know is its raw materials. With trifluoromethoxybenzene sulfonic acid anhydride and ammonia as the base material, both are easy to buy and pure.
The preparation process is as follows: In a clean reactor, the temperature is controlled at about 0 ° C. The trifluoromethoxybenzene sulfonic acid anhydride is slowly injected into the liquid ammonia, and stirred at the same time to make the two fully blend. After the injection is completed, gradually heat up to room temperature, and continue to stir for a few times to promote a comprehensive reaction.
The reaction step is also critical. At the beginning of the reaction, the sulfonic acid anhydride and ammonia react quickly to form an intermediate product. Then, through a series of changes such as molecular rearrangement and deproton, the final target product
In order to achieve good yield and purity, a purification mechanism needs to be set up. After the reaction, it is extracted with an organic solvent, and then distilled under reduced pressure, except for the raw materials and by-products. Complex with silica gel column chromatography to obtain high purity 2-Trifluoromethoxybenzenesulfonamide.
Chemical Reactions & Modifications
There are chemical things today, called 2-Trifluoromethoxybenzenesulfonamide. The reaction and change of its transformation are related to the importance of our research.
Looking at its transformation, the method of the past may not be good. The old reaction rate is not high, and there are many miscellaneous ones, and the pure products obtained are fresh. It takes a long time, and it also costs a lot of materials. It is not a good strategy for the production of work.
To change its shape, we are poor in thought. Observe the state of the reaction, adjust the temperature and pressure, and make it easy to use the agent. After various tests, I have gradually made progress. The new method, the rate is greatly increased, and the complex ones are reduced, and the pure products produced are abundant. And the time-consuming is short, the material is saved, and it is beneficial for the production of work.
The response and change of chemistry, the infinite realm. We should constantly research and seek good methods to make this product better and more widely used in the world.
Synonyms & Product Names
Today there is a thing called 2 - Trifluoromethoxybenzenesulfonamide. Its synonymous name is also the need to explore. This thing, in the field of chemistry, has unique characteristics. Its synonymous name may vary depending on the researcher and the region.
In all kinds of research, the synonymous name helps scholars to communicate and accurately grasp the characteristics of this thing. Merchants also value its trade name, hoping to use it as a good name, to recognize its superiority, and to attract the attention of the world.
Exploring its synonymous name and trade name is like a journey to find treasure. After much study and comparison, you may get its details. Knowing its synonymous name, we can see the various titles of this thing in the academic forest; knowing its commodity name, we can see its positioning in the market. Both of these are indispensable ways to understand 2-Trifluoromethoxybenzenesulfonamide.
Safety & Operational Standards
2-Trifluoromethoxybenzenesulfonamide is an important chemical product that has attracted much attention in research and production. The safety and operation specifications of this product need to be investigated in detail.
During the preparation process, the first thing is to ensure that the experimental site is well ventilated. Because some of the raw materials may be volatile and irritating, good ventilation can effectively disperse harmful gases and protect the health of the experimenter. When taking raw materials, they must be accurately measured according to the established dosage. 2-Trifluoromethoxybenzenesulfonamide synthesis requires strict requirements for the proportion of raw materials, slight deviation, or poor reaction results, and may cause safety hazards.
There are also specific specifications for operating equipment. The reaction vessel must be able to withstand the corresponding temperature and pressure, and should be carefully checked for damage before use. The temperature control of the heating device should be precise. 2-Trifluoromethoxybenzenesulfonamide reaction is sensitive to temperature. If the temperature is too high or too low, it will affect the quality of the product and the reaction process.
Product storage should not be ignored. It should be placed in a dry, cool and ventilated place, away from fire sources and oxidants. Due to its active chemical nature, improper storage or danger. When using the product, wear appropriate protective equipment, such as gloves and masks, to avoid direct contact and inhalation.
2-Trifluoromethoxybenzenesulfonamide safety and operation specifications cover all aspects of preparation, storage and use. Strict compliance with the specifications can ensure the safety of personnel, obtain high-quality products, and promote the orderly progress of chemical research and production.
Application Area
2-Trifluoromethoxylbenzenesulfonamide, its field of use is very critical. In the field of medicine, with its unique structure, it may help to synthesize special drugs, and by accurately acting on specific targets in the human body, it may be of great help to the treatment of many diseases. In materials science, it can also show extraordinary power. By ingeniously adding, the properties of materials can be improved, such as improving their chemical stability and making them more durable in special environments. And in the field of agricultural chemistry, it may become an important component in the creation of new pesticides. With its chemical properties, it can achieve efficient prevention and control of pests and diseases. All of these highlight the broad prospects and important value of 2-trifluoromethoxylbenzenesulfonamide in various fields.
Research & Development
Modern chemistry has advanced, and all kinds of new substances have come out frequently. There are 2-Trifluoromethoxybenzenesulfonamide of this substance today, and I have been studying it for a while. At the beginning, I wanted to get this agent, and after several trials, I learned how to synthesize it. With a specific material, precise temperature control, and delicate order, this product has become this product.
Research its properties, with unique quality, in the reaction, often the key agent. Either help the reaction to go fast, or make the product pure and excellent. It is available in the field of medicine and materials.
Looking to the future, we should study its use in depth. In medicine, it is hoped to become a good medicine for curing diseases; in materials, it is hoped to be the cornerstone of innovation. I will make unremitting efforts to promote the development of this agent and add new colors to the academic and industry, with a view to gaining ground in the world.
Toxicity Research
Recently, in my laboratory, I focused on the toxicity study of 2-Trifluoromethoxybenzenesulfonamide. This compound has a unique structure, contains trifluoromethoxy and benzenesulfonamide groups, or has special chemical activity, but its toxicity is unknown, which needs to be explored urgently.
Then a variety of experimental organisms were taken and administered to this substance in different doses. In mouse experiments, at low doses, it can be seen that its action is slightly slower and its feeding is slightly reduced; at high doses, some mice convulsed and even died. Looking at cell experiments, high concentrations of this substance caused a significant increase in apoptosis, cell membrane damage, and cell organelles were damaged.
After analysis, 2-Trifluoromethoxybenzenesulfonamide may interfere with normal biochemical reactions in organisms, affecting cell metabolism and signal transduction. Therefore, this substance is quite toxic, and subsequent use and production require careful protection to prevent harm to organisms and the environment.
Future Prospects
Husband 2 - Trifluoromethoxybenzenesulfonamide, it is also a new thing to be transformed. Its nature is special, and it is as wonderful as it is.

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Frequently Asked Questions

As a leading 2-Trifluoromethoxybenzenesulfonamide supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main application fields of 2-Trifluoromethoxybenzenesulfonamide?
2-Trifluoromethoxybenzenesulfonamide has a wide range of main application fields. In the field of medicine, this compound is often used as a key intermediate. The structure of Gain sulfonamide has various biological activities and can be chemically modified to produce a variety of drugs. By adjusting its substituents, drugs that target specific diseases can be designed, such as anti-cancer drugs, antibacterial drugs, etc. In drug development, it can help scientists explore new mechanisms of action and therapeutic strategies.
In the field of pesticides, 2-trifluoromethoxybenzenesulfonamide also has important uses. Sulfonamide compounds often have unique modes of action on pests, or can interfere with physiological functions such as the nervous system and respiratory system of pests. Pesticides developed on the basis of it may have the characteristics of high efficiency, low toxicity and environmental friendliness, which can effectively control crop diseases and pests, and ensure crop yield and quality.
Furthermore, in the field of materials science, this compound can also play a role. Because of its fluorine and sulfonamide groups, it can endow materials with special properties. If used in the preparation of functional polymer materials, it can improve the corrosion resistance, thermal stability and surface properties of materials. Adding compounds containing such structures to coatings, plastics and other materials can improve the comprehensive properties of materials and expand the application range of materials.
In organic synthetic chemistry, 2-trifluoromethoxybenzenesulfonamide is an important synthetic block. Chemists can use its activity check point to construct complex organic molecular structures through various chemical reactions. By reacting with different reagents, various functional groups can be introduced to synthesize organic compounds with specific structures and functions, providing an important foundation for the development of organic synthetic chemistry.
What are the physical and chemical properties of 2-Trifluoromethoxybenzenesulfonamide?
2-Trifluoromethoxybenzenesulfonamide is also an organic compound. Its physical and chemical properties are quite critical and useful in many fields.
Let's talk about its physical properties first. This compound is at room temperature, or white to off-white solid, and has a certain crystalline form. The melting point is about a specific temperature range, but the exact value will vary depending on factors such as purity. Its solubility varies in common organic solvents, and it may have good solubility in some organic solvents such as dichloromethane, N, N-dimethylformamide. This property is convenient for separation and purification as a reactant or product in the process of organic synthesis.
As for chemical properties, its sulfonamide group is quite active. The hydrogen atom on the nitrogen atom of sulfonamide has a certain acidity and can react with bases to form corresponding salts. This reaction is often used as a strategy in organic synthesis to adjust the solubility and reactivity of compounds. And its benzene ring part can undergo typical electrophilic substitution reactions of aromatic compounds, such as halogenation, nitrification, sulfonation and other reactions. Due to the strong electron-absorbing effect of trifluoromethoxy, it will affect the electron cloud density distribution on the benzene ring, making the electrophilic substitution reaction check point biased. Usually, the electron cloud density of the adjacent and para-position is relatively reduced, and the meta-position is relatively high, so the electrophilic reagents are more inclined to attack the meta-position.
In addition, the presence of trifluoromethoxy gives the compound unique chemical stability and physiological activity. Due to its fluorine-containing structure, it has a certain lipid solubility and hydrophobicity, which has a significant impact on the transmembrane transportation and bioavailability of drug molecules in the field of medicinal chemistry. In materials science, the properties of such fluorinated compounds may be used to prepare materials with special properties, such as chemical corrosion resistance and low surface energy materials.
What are 2-Trifluoromethoxybenzenesulfonamide synthesis methods?
The synthesis method of 2-trifluoromethoxy benzene sulfonamide has existed in ancient times, and it has gradually become more and more refined with the changes of time. The method includes benzene as the starting material, and through the sulfonation technique, the benzene sulfonic acid is first prepared. In this step, strong sulfonating agents such as concentrated sulfuric acid and fuming sulfuric acid are used. At an appropriate temperature, after stirring and time-controlled operation, the benzene and the sulfonating agent are fully interacted to obtain benzene sulfonic acid. Then trifluoromethoxy is introduced, which is a key move. The alkali metal salt of trifluoromethyl halide and benzene sulfonic acid is often reacted in an organic solvent with the help of a phase transfer catalyst to form 2-trifluoromethoxy benzene sulfonic acid. After amidation, ammonia or amine compounds are reacted with it to obtain the target product 2-trifluoromethoxy benzene sulfonamide.
There are also those who use halogenated benzene as the starting material, and the halogenated benzene is reacted with the trifluoromethoxylated reagent to form 2-trifluoromethoxy halobenzene. This reaction requires the participation of suitable metal catalysts and ligands to improve the reaction efficiency and selectivity. Afterwards, 2-trifluoromethoxy halobenzene is sulfonated, and the sulfonating agent and conditions used are similar to those of the above-mentioned benzene as raw materials. After 2-trifluoromethoxy benzene sulfonic acid is prepared, it is also amidated to obtain the product.
In addition, other aromatic compounds are used as starting materials. After multiple steps of reaction, the molecular structure is ingeniously constructed, and finally 2-trifluoromethoxy benzene sulfonamide can be obtained. These synthesis methods have their own advantages and disadvantages. It is necessary to choose carefully according to the actual needs, considering the availability of raw materials, the difficulty of reaction conditions, the purity and yield of the product, and many other factors.
2-Trifluoromethoxybenzenesulfonamide What are the precautions during storage and transportation?
2-Trifluoromethoxybenzenesulfonamide is an important chemical raw material in fine chemicals. When storing and transporting, pay attention to many key matters to ensure its quality and safety.
First storage environment. This substance should be stored in a cool, dry and well-ventilated place. If the environment is humid, it is easy to cause deliquescence, which will cause its chemical properties to change and affect the subsequent use effect. And it must be kept away from fire and heat sources. Because 2-trifluoromethoxybenzenesulfonamide poses a serious threat to personnel and facilities in case of open fire, hot topic or risk of combustion and explosion.
Furthermore, when storing, attention should be paid to classified storage. Do not mix with oxidizing agents, acids, alkalis and other substances. Due to its active chemical properties, contact with the above substances may occur violent chemical reactions, such as oxidation, acid-base neutralization, etc., which not only destroy the 2-trifluoromethoxybenzenesulfonamide itself, but also generate harmful or even dangerous products.
There are also many key points in transportation. Packaging must be tight to prevent leakage. The selected packaging materials must be able to withstand certain external impact and chemical corrosion to ensure that the product is not damaged during transportation. Transportation vehicles should also have good ventilation and fire protection facilities to deal with emergencies. During transportation, avoid severe bumps and vibrations of the vehicle to prevent packaging from breaking.
In addition, relevant regulations and standards must be strictly followed regardless of storage or transportation. Operators should also receive professional training, be familiar with the characteristics and safety precautions of 2-trifluoromethoxybenzenesulfonamide, and operate carefully in all aspects, so as to ensure the safety and stability of 2-trifluoromethoxybenzenesulfonamide during storage and transportation.
What is the market outlook for 2-Trifluoromethoxybenzenesulfonamide?
2-Trifluoromethoxybenzenesulfonamide, a compound that has attracted much attention in the field of fine chemicals. Looking at its market prospects, it is like the morning sun, slowly rising, with infinite potential.
In the field of medicine, it has emerged. Many drug developers regard it as a treasure, because of its unique chemical structure, it can give extraordinary properties to drug molecules. It can optimize the solubility and permeability of drugs, and enhance the affinity between drugs and targets. In recent years, it has been used in the development of many new antibacterial and anti-inflammatory drugs. With the increasing emphasis on health and the continuous expansion of the pharmaceutical market, the demand for 2-trifluoromethoxybenzenesulfonamide is also rising.
In the field of pesticides, it also plays a key role. It can effectively improve the efficacy of pesticides, enhance their ability to control diseases and pests, and is relatively friendly to the environment, in line with the current trend of green environmental protection. With the acceleration of agricultural modernization process, the demand for high-efficiency and low-toxicity pesticides is increasingly strong, and the market space of 2-trifluoromethoxybenzenesulfonamide in this field is extremely broad.
Furthermore, in the field of materials science, it has emerged. It can be used as a special additive to improve the properties of materials, such as improving the weather resistance and chemical stability of polymers. With the continuous innovation and development of materials science, the demand for additives with unique properties continues to rise, and 2-trifluoromethoxybenzenesulfonamide is expected to shine in this field.
However, its market development is not smooth sailing. The complex synthesis process and high cost limit its large-scale application. And the market awareness needs to be improved, and some potential application fields need to be further explored. However, in time, with technological innovation, synthesis costs may be reduced, and its market prospects will become brighter and shine in many fields.