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2-(Trifluoromethoxy)Bromobenzene

2-(Trifluoromethoxy)Bromobenzene

Hongda Chemical

Specifications

HS Code

474372

Chemical Formula C7H4BrF3O
Molar Mass 255.006 g/mol
Appearance Colorless to light yellow liquid
Boiling Point 185 - 187 °C
Density 1.706 g/cm³
Solubility In Water Insoluble
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, ethyl acetate
Vapor Pressure Low vapor pressure at room temperature
Flash Point 73 °C

As an accredited 2-(Trifluoromethoxy)Bromobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100 mL glass bottle with tight - seal cap for 500 g of 2-(trifluoromethoxy)bromobenzene.
Storage 2-(Trifluoromethoxy)bromobenzene should be stored in a cool, well - ventilated area away from heat sources and ignition sources. Keep it in a tightly closed container, preferably made of corrosion - resistant materials due to its chemical nature. Store it separately from oxidizing agents and reactive chemicals to prevent potential reactions. Ensure proper labeling for easy identification and safety compliance.
Shipping 2-(Trifluoromethoxy)bromobenzene is shipped in accordance with strict chemical regulations. Packed in suitable, leak - proof containers, it is transported by carriers trained in handling hazardous chemicals to ensure safe and compliant delivery.
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2-(Trifluoromethoxy)Bromobenzene 2-(Trifluoromethoxy)Bromobenzene
General Information
Historical Development
In the past, those who studied chemical things tried to study the formation of 2- (trifluoromethoxy) bromobenzene. At the beginning, the technique was not refined, and it was difficult to obtain this thing. Everyone exhausted their wisdom and thought, and tried all kinds of things, but they failed to achieve a complete solution.
However, the determination of scholars, unremitting exploration. Years go by, knowledge accumulates, and various theories gradually come to light. After that, new techniques gradually emerged, and it was possible to obtain this 2- (trifluoromethoxy) bromobenzene more steadily.
From the difficulties of the past to today, the progress of this chemistry depends on the research of scholars, not afraid of difficulties, and finally able to make breakthroughs in the research of substances, so that the formation of 2- (trifluoromethoxy) bromobenzene can be followed as a method for future generations.
Product Overview
Product Overview of 2- (trifluoromethoxy) bromobenzene
I will now describe this 2- (trifluoromethoxy) bromobenzene. It is a key intermediate in organic synthesis and is widely used in medicine, pesticides and other fields.
Looking at its properties, at room temperature, it is a colorless to light yellow transparent liquid with a specific odor. Its chemical properties are active, due to the presence of trifluoromethoxy and bromine atoms in the molecule, which can participate in a variety of chemical reactions.
In terms of preparation, specific benzene derivatives are often used as starting materials, obtained by a series of reactions such as halogenation and etherification. During the preparation process, the control of reaction conditions is crucial, such as temperature, pressure, and catalyst dosage, which all have a significant impact on the purity and yield of the product.
In application, in pharmaceutical synthesis, it can be used as a key structural unit to construct molecules with specific biological activities; in the field of pesticides, it can help develop high-efficiency and low-toxicity pesticide products. This 2- (trifluoromethoxy) bromobenzene is a valuable compound in the chemical industry.
Physical & Chemical Properties
The year 2023 is the Year of the Rabbit. The following is a passage written in ancient Chinese about the physical and chemical properties of "2- (trifluoromethoxy) bromobenzene":
Fu 2- (trifluoromethoxy) bromobenzene, like a clear liquid, exists quietly under normal circumstances. Its color is transparent, without the disturbance of variegated colors, and the view is clear. Smell it, it has a specific smell. Although it is not pungent, it also has a unique smell.
In terms of its physical properties, the boiling point is quite different, about a certain degree. At this temperature, it liquefies into gas and changes shape. Its density is also fixed, slightly heavier than water, and sinks when placed in water. As for solubility, it is soluble in various organic solvents, but insoluble in water.
As far as its chemical properties are concerned, the structure of the benzene ring gives it chemical activity. The presence of trifluoromethoxy makes its electron cloud distribution change, showing unique properties in nucleophilic and electrophilic reactions. Bromine atoms are also active check points, which can participate in many substitution reactions, leading to the formation of new compounds. Its chemical properties pave a different path for organic synthesis.
Technical Specifications & Labeling
Today there is a product called 2- (trifluoromethoxy) bromobenzene. To make this product, the process specifications and identification (product parameters) are the key.
Its process specifications need to be based on exquisite methods. The ratio of materials must be accurate, and the temperature and time of reaction are fixed. For example, the amount of starting material should be in an appropriate proportion, and there should be no slight difference. At the time of reaction, or under a certain temperature, after a certain period of time, the best effect will be achieved.
As for the identification (product parameters), the appearance, purity, impurity content, etc. of this product should be clear. The appearance should have a specific color and state, which can be recognized by people at a glance. The purity must be extremely high, and the impurity content must be low. In this way, only qualified 2- (trifluoromethoxy) bromobenzene products can meet the requirements of process specifications and identification (product parameters) according to the needs of all parties.
Preparation Method
To prepare 2 - (trifluoromethoxy) bromobenzene, the raw material and production process, reaction steps and catalytic mechanism are the key.
First take an appropriate amount of o-bromophenol as the initial raw material, use potassium carbonate as the base, in the organic solvent acetonitrile, and co-heat with sodium trifluoromethanesulfonate. This reaction system needs to be in a nitrogen-protected atmosphere, the temperature is controlled at 80 to 100 degrees Celsius, and the stirring time is continuous. The oxygen of the hydroxyl group of o-bromophenol nucleophilic attacks the sulfur of sodium trifluoromethanesulfonate to form an intermediate, and then rearrange the target product.
After the reaction is completed, the solvent acetonitrile is removed by reduced pressure distillation. Pure 2 - (trifluoromethoxy) bromobenzene can be obtained by using petroleum ether and ethyl acetate as an eluent in a certain proportion after the residue was separated by silica gel column chromatography.
Chemical Reactions & Modifications
In the study of modern chemistry, many achievements have been made in organic substances. In this article, the chemical reaction and modification of 2- (trifluoromethoxy) bromobenzene are worth exploring.
In the past, when you wanted to obtain this 2- (trifluoromethoxy) bromobenzene, bromobenzene was often used as the beginning, and it went through multiple steps. However, the initial reaction method was difficult, required harsh conditions, and the yield was not abundant.
Later, scholars thought about changes and changed to other methods. There are benzene derivatives with active groups as the base, and special catalysts are used to make it meet with reagents containing trifluoromethoxy. The reaction of this new method is mild, the conditions are easy to control, and the yield has also increased.
Furthermore, on top of the modification, by adding other groups, its properties can be reduced, making 2- (trifluoromethoxy) bromobenzene more suitable for various fields of medicine and materials. Looking at this chemical change, the method of reaction and modification is gradually refined, and it is hoped that there will be a new chapter in the future, pushing this product forward in various industries.
Synonyms & Product Names
Today there is a product called 2 - (trifluoromethoxy) bromobenzene. This product has a wide range of uses in the field of chemical industry. Its aliases are also widely known in the industry.
For us chemical researchers, it is essential to know the same name and the name of the product. Because of chemical transactions and academic research, if there is a mistake in the title, it is easy to cause confusion, mislead research, and even make mistakes.
2 - (trifluoromethoxy) bromobenzene, or has an alias called by its characteristics, or according to its preparation method and use, different names are derived. We should carefully screen, so that the name is true, in the chemical industry, can be smooth, promote research and development, and benefit the prosperity of the industry.
Safety & Operational Standards
2 - (trifluoromethoxy) bromobenzene safety and operating practices
Fu 2 - (trifluoromethoxy) bromobenzene is an important chemical compound in chemical research. In its experimental and production process, safety and operating practices are of paramount importance.
In terms of safety, this compound has certain chemical activity and potential danger. First pay attention to its effects on the human body. If you accidentally come into contact with the skin, rinse with plenty of water as soon as possible. If you still feel unwell, seek medical attention immediately. When entering the eyes, you need to rinse the eyes with running water immediately for a few minutes, and do not rub the eyes, and then rush to the hospital for treatment. If inhaling its volatile gas, it should be quickly moved to a fresh air place to keep the respiratory tract unobstructed; if breathing is abnormal or uncomfortable, it must also be treated quickly.
Operating norms should not be underestimated. In the laboratory, when operating in a well-ventilated place to prevent the accumulation of volatile gas. When taking it, use a precise measuring device, and strictly control the dosage according to the needs of the experiment. Its storage should also be careful. It should be placed in a cool, dry and ventilated place, away from fire sources and oxidants, to prevent accidental chemical reactions.
Furthermore, the equipment used in the experiment should be carefully checked before use to ensure that there is no risk of leakage. During the operation, the experimenter must wear appropriate protective equipment, such as protective gloves, goggles, laboratory clothes, etc., to ensure safety.
In short, in the research and use of 2 - (trifluoromethoxy) bromobenzene, strict adherence to safety and operating standards can ensure the smooth progress of the experiment, protect the safety of personnel, and avoid accidents.
Application Area
Today, there is a product called 2- (trifluoromethoxy) bromobenzene, which has considerable strengths in various application fields. In the field of medicinal chemistry, it can be used as a key intermediate to help create new drugs, or drugs related to disease resistance and physiological function. In the field of materials science, it can contribute to the synthesis of special materials, such as materials with excellent chemical stability and thermal stability, used in high-end electronic devices and protective coatings. In agricultural chemistry, it can be used to create the basis for high-efficiency and low-toxicity pesticides to protect crops and increase yield. Looking at its uses, it covers many fields such as medicine, materials, agriculture, etc. It is actually widely used and has promising prospects. It is also important for chemical research and industrial production.
Research & Development
Today, we are studying di- (trifluoromethoxy) bromobenzene, which is a crucial raw material in organic synthesis. We began to study its synthesis path and investigated the reaction conditions and influencing factors in detail. At the beginning, we tried various traditional methods, but the yield did not meet expectations.
Then we turned to a new path. After repeated experiments, we finally found an optimized method that can effectively improve the yield. At the same time, we also worked hard to control the purity of the product, and used advanced analytical methods to ensure that it met high purity standards.
Looking to the future, we want to expand the application field of this product. We plan to cooperate with the materials science team to explore the possibility of its preparation in new functional materials. We hope to use our unremitting research to make di- (trifluoromethoxy) bromobenzene shine in more fields and promote the progress and development of related industries.
Toxicity Research
When you taste chemical substances, their properties are very different, which is related to people's health and health, and cannot be ignored. In this sentence, the study of toxicity of 2- (trifluoromethoxy) bromobenzene is of paramount importance.
This substance also enters the body through inhalation or skin contact. The harm of inhalation can cause damage to the respiratory tract, mild coughing, asthma, and severe cases endanger the lungs and organs. If the skin touches it, it may cause redness, swelling, and itching. If it seeps into the interior, it may hurt the organs.
It is also observed in the environment, or sewage, harmful to life. Although its long-term effects are not detailed, the suspicion of toxicity should not be underestimated.
Therefore, it is the responsibility of chemical researchers to study its toxicity, detect its harm to the human body and the environment, and set preventive measures to avoid disasters before they occur, and also to ensure the harmony of all things.
Future Prospects
In today's world, science and technology are advancing day by day, and there is no end to the research and development of chemical substances. Today there is a thing named 2- (trifluoromethoxy) bromobenzene, and its development in the future is promising.
View this 2- (trifluoromethoxy) bromobenzene, which is widely used in a variety of properties. In the field of organic synthesis, it can be a key raw material for the creation of such delicate compounds. Its unique structure contains trifluoromethoxy and bromine atoms, which cooperate to give it a specific chemical activity.
In the future, it is expected that it will be used in pharmaceutical research and development, or it will be able to shine. It can be used as the base of the lead compound, modified by ingenuity, to develop a cure and solve the suffering of everyone. In material science, it is also expected to emerge, and contribute to the preparation of new functional materials, so that the materials have better properties, so as to meet the needs of all kinds of high-tech.
Therefore, our chemical researchers should carefully study this 2- (trifluoromethoxy) bromobenzene, make the best use of it, hoping to open up new frontiers in the future and benefit the world.
Where to Buy 2-(Trifluoromethoxy)Bromobenzene in China?
As a trusted 2-(Trifluoromethoxy)Bromobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-(Trifluoromethoxy)Bromobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2- (trifluoromethoxy) bromobenzene?
The main use of (tribromoacetoxy) bromobenzene is an important question. This is a valuable reagent in the field of organic synthesis.
In organic synthesis reactions, it is often used as a brominating agent. It can cause bromination of many organic compounds, which is crucial when forming carbon-bromine bonds. For example, in the bromination reaction of aromatic compounds, (tribromoacetoxy) bromobenzene can selectively introduce bromine atoms to specific locations. By adjusting the appropriate reaction conditions, it can achieve exquisite control of the reaction check point and product selectivity, thus providing an effective way for the synthesis of aromatic bromides of specific structures.
Furthermore, it also plays a key role in the construction of complex organic molecular structures. In some multi-step organic synthesis routes, the bromination reaction initiated by (tribromoacetoxy) bromobenzene can be used as a key step, and then through subsequent reactions with other reagents, such as nucleophilic substitution reactions, a complex and orderly organic molecular structure can be gradually established, laying the foundation for the synthesis of organic compounds with specific physiological activities or functions.
In addition, in the field of medicinal chemistry, for the synthesis of some drug molecules, the bromination reaction of (tribromoacetoxy) bromobenzene can be used to introduce key bromine atomic functional groups, which may have a significant impact on the interaction between drug molecules and biological targets, the metabolic process of drugs, etc., thus contributing to the development of new drugs with better pharmacokinetic properties.
What are the synthesis methods of 2- (trifluoromethoxy) bromobenzene?
There are many ways to make di- (triethoxy) silyl propyl ether, and the details are as follows:
First, hydrosilylation. Silane containing Si-H bonds and alcohol ethers containing alkenyl groups are catalyzed by transition metal catalysts such as platinum and rhodium. In this process, the activity and selectivity of the catalyst are crucial, which can effectively promote the addition of Si-H bonds and carbon-carbon double bonds to obtain the target product. Whether the reaction conditions are mild or not depends on the purity and yield of the product, and usually requires precise temperature control, pressure control and material ratio. If triethoxysilane and allyl glycidyl ether are used as raw materials, under the action of appropriate catalysts, di- (triethoxy) silyl propyl ether can be obtained. This method has high atomic utilization and good product purity.
Second, the substitution reaction method. Halogenated silane is prepared by substitution reaction with alkoxides or phenolates. Halogen atoms in halogenated silanes are highly active and easily combine with oxygen atoms in alkoxides or phenolates to form the target product. However, there are many side reactions or impurities such as halogenated salts, which need to be carefully separated and purified. If trichlorosilane is reacted with triethoxy alkoxides, the yield and purity of the product can be improved by optimizing the reaction conditions.
Third, transesterification method. The transesterification reaction is carried out with silicon ester and alcohol ether in the presence of catalyst. This reaction involves the transfer of ester groups. Through the rational selection of catalysts and reaction conditions, the reaction can proceed in the direction of generating di- (triethoxy) silyl propyl ether. This method has a wide range of raw materials and is relatively simple to operate. However, the regulation of the reaction balance is quite important. It is necessary to remove the small molecule alcohol generated by the reaction in a timely manner to promote the positive progress of the reaction.
What is the market price of 2- (trifluoromethoxy) bromobenzene?
Today, it is difficult to know the market price of (trihydroxyethyl) cellulose in the market. Its price often changes for many reasons and is complex.
The first to bear the brunt is the price of raw materials. The production of trihydroxyethyl cellulose involves many raw materials. If the price of these raw materials fluctuates due to the origin, age, and supply and demand, the price of (trihydroxyethyl) cellulose will also be affected. For example, if the raw materials are harvested, the supply exceeds the demand, and the price may decline; conversely, the raw materials are scarce and the supply exceeds the demand, and the price will rise.
Furthermore, the quality of the process also has a great impact. Sophisticated craftsmanship can make the quality of (trihydroxyethyl) cellulose produced better, so that its price in the market is high; and those with poor craftsmanship cannot guarantee the quality and price.
The state of supply and demand in the market is also the key. If at a certain time in a certain field, the demand for (trihydroxyethyl) cellulose increases sharply, and the supply is difficult for a while, the price will rise; if the demand is low and the supply is excessive, the price may fall.
In addition, the price varies from region to region. In prosperous places, logistics is convenient, demand is strong, and the price may be high; in remote places, transportation is inconvenient, demand is limited, and the price may be slightly lower.
And there are merchants who adjust the price by themselves due to the amount of inventory, competition situation, etc. Therefore, in order to know the exact market price of (trihydroxyethyl) cellulose, we can obtain a relatively accurate number when we carefully observe the status of raw materials, processes, supply and demand, regions and merchants at that time.
What should be paid attention to when storing and transporting 2- (trifluoromethoxy) bromobenzene?
When storing and transporting di- (triethoxy) silane, everyone should pay attention to it.
The first step is to control the temperature. This silane is delicate and easy to change when heated, so it is appropriate to store it in a cool place. Its temperature should be controlled within a specific range, and it should not be too high to prevent it from decomposing or causing other unexpected changes. During transportation, it should also be avoided from high temperature environments. When it is hot in summer, it is especially necessary to be cautious, or cooling methods can be used to ensure its stability.
The second is moisture-proof. It is easy to hydrolyze in contact with water and loses its original effect. The storage device must be tightly sealed to prevent moisture from invading; when transporting, it should also be selected as a dry car, and it should be packaged in a package, or put in a moisture-proof material to prevent the danger of water vapor.
Furthermore, avoid coexistence with strong oxidants, strong acids and alkalis. Because of its chemical activity, it is easy to react violently when it comes into contact with such substances, resulting in danger. The place of storage should be classified and stored at an appropriate distance; during transportation, it should not be mixed to avoid accidents.
Packaging is also a priority. The device used must be sturdy and durable enough to bear its weight and prevent it from leaking. The seal must be tight to prevent leakage and pollution or accidents. On the packaging, when stating its characteristics and warnings, so that visitors are aware of its risks and handle it with caution.
During transportation, the stability of driving should not be ignored. Avoid sudden brakes and bumps to prevent silane leakage due to damage to the packaging. The escort should be aware of its nature and be familiar with emergency measures to prepare for emergencies. In this way, the two- (triethoxy) silane can be safely stored and transported.
What are the physical and chemical properties of 2- (trifluoromethoxy) bromobenzene?
(Triethoxy) silane is one of the organosilicon compounds. Its physical and chemical properties are unique and useful in many fields.
In terms of its physical properties, under normal conditions, (triethoxy) silane is mostly a colorless and transparent liquid with a specific odor. Its boiling point and melting point depend on the characteristics of the molecular structure. The boiling point is moderate, which is conducive to distillation separation and purification. And its density is slightly smaller than that of water, it can float in water, insoluble or slightly soluble in water, but it can be miscible with most organic solvents. This property makes it convenient for applications in organic synthesis and coatings and other industries.
As for chemical properties, (triethoxy) silane is very active. The ethoxy group in its molecule is prone to hydrolysis. When exposed to water, ethoxy groups can be gradually replaced by hydroxyl groups to form silanol intermediates, during which ethanol can be released. Silanol intermediates are unstable and easily condensed with each other to form siloxane bonds (-Si-O-Si-), thus forming a complex three-dimensional network structure. This reaction property is crucial in the preparation of silicon-based materials and organic-inorganic hybrid materials, which can give the material unique properties.
In addition, (triethoxy) silanes can chemically react with compounds containing active hydrogen, such as alcohols, amines, and carboxylic acids. Reaction with alcohols can achieve the exchange of ethoxy groups and adjust the chemical structure and properties of silanes; reaction with amines can introduce nitrogen-containing functional groups, endowing materials with new chemical activity and functionality; reaction with carboxylic acids can form ester groups, expand the application scope of materials, and are of great significance in the fields of material surface modification and adhesives.
Due to its unique physical and chemical properties, (triethoxy) silane is widely used in coatings, adhesives, composites and other industries, and is an indispensable and important substance in the chemical industry.