2-Nitrofluorobenzene

Hongda Chemical

Specifications

HS Code	686039
Chemical Formula	C6H4FNO2
Molar Mass	141.1 g/mol
Appearance	Colorless to pale yellow liquid
Boiling Point	205 - 207 °C
Melting Point	2 - 3 °C
Density	1.40 g/cm³
Solubility In Water	Insoluble
Solubility In Organic Solvents	Soluble in many organic solvents
Flash Point	85 °C
Vapor Pressure	0.12 mmHg at 25 °C
Odor	Pungent odor

As an accredited 2-Nitrofluorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	200g of 2 - nitrofluorobenzene packaged in a tightly - sealed glass bottle.
Storage	2 - nitrofluorobenzene should be stored in a cool, well - ventilated warehouse. Keep it away from heat, sparks, and open flames. Store it separately from oxidizing agents, reducing agents, and bases to prevent chemical reactions. Use corrosion - resistant containers to avoid leakage, as it is toxic and can pose risks to human health and the environment.
Shipping	2 - nitrofluorobenzene is shipped in tightly - sealed, corrosion - resistant containers. It must be transported in accordance with hazardous chemical regulations, ensuring proper handling to prevent spills and exposure during transit.

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General Information

Historical Development

2-Nitrofluorobenzene is one of the chemical products. Looking back in the past, its research and development process was gathered by the efforts of many chemists. At the beginning, the academic community became more and more interested in organic synthesis, and became more and more interested in compounds containing fluorine and nitro groups. At that time, after repeated experiments, scholars explored various reaction paths and strived to prepare this unique thing.
After long-term exploration, with a specific combination of fluorination reaction and nitrification reaction, the method of preparing 2-nitrofluorobenzene was finally obtained. At first, the yield was still low, and the quality needed to be improved. However, with the passage of time, technology has advanced, reaction conditions have been continuously optimized, catalysts have been improved, and equipment has been updated, all of which have made the production of 2-nitrofluorobenzene more efficient and of high quality. Its application in medicine, materials and other fields has also become increasingly widespread due to its own characteristics, witnessing the development of the chemical industry.

Product Overview

2 - Nitrofluorobenzene is also an organic compound. Its color or colorless to light yellow liquid, with a special smell. The boiling point and melting point of this substance have their own numbers, the boiling point is about a number, and the melting point is also fixed. It has a wide range of uses in the field of organic synthesis. It can be used as an intermediate to prepare a variety of organic compounds. Because of its structure, there are nitro and fluorine atoms, which are unique in nature. Nitro has strong electron absorption, and fluorine atoms also affect its reactivity. Therefore, in chemical reactions, reactions such as nucleophilic substitution can occur. There are many ways to synthesize, and it is often carefully prepared with specific raw materials and suitable reaction conditions. This compound is of great value in the pharmaceutical, pesticide, and other industries, and can contribute to the development of related industries.

Physical & Chemical Properties

2 - Nitrofluorobenzene is also a chemical substance. Its physical and chemical properties are particularly important. Looking at its physical properties, at room temperature, it is mostly liquid, colored or nearly transparent, with a special odor. Its boiling point and melting point are fixed. The boiling point is related to the temperature of its gasification, and the melting point is the critical point for its solidification.
When it comes to chemistry, the presence of nitro and fluorine atoms in 2 - Nitrofluorobenzene gives it a unique reactivity. Nitro is rich in electron attraction, which can affect the distribution of electron clouds in molecules, making it easy to react with nucleophiles. Although fluorine atoms are small, they have high electronegativity, which also contributes to the reaction properties of molecules. Or it can participate in the substitution reaction, with its special structure, it can be a key intermediate in the field of organic synthesis, and it plays an indispensable role in many chemical synthesis paths, providing a basis for the creation of a variety of organic compounds.

Technical Specifications & Labeling

2 - Nitrofluorobenzene is an important compound in the chemical industry. Its preparation process requires precise technical specifications. The selection of raw materials should be strict, and the purity must be up to standard. For example, the quality of fluorobenzene and nitrifying reagents used is related to the quality of the product. The reaction conditions are also critical. The temperature and pressure must be precisely controlled, and the reaction time must also be accurately controlled.
In terms of detection, with advanced instruments and equipment, the strict determination of product standards can be achieved. Looking at its appearance, it should be a specific color and shape. Measure its purity by chromatography and other methods, and reach the specified value to be qualified. The impurity content needs to be strictly controlled and cannot exceed the standard limit. In this way, the quality of 2 - Nitrofluorobenzene products can be guaranteed, which is in line with the needs of industrial and related fields.

Preparation Method

The raw materials and production process are the key to making 2-Nitrofluorobenzene. The raw materials are often fluorobenzene and nitric acid. First, fluorobenzene and nitric acid are reacted under specific conditions, and this reaction step needs to be precisely controlled.
During the reaction, sulfuric acid is used as a catalyst to adjust the temperature and pressure to promote the full effect of the two. After a series of complex reactions, 2-Nitrofluorobenzene is obtained.
The follow-up treatment should not be underestimated. After the separation and purification steps, impurities can be removed and the purity of the product can be improved. At the time of separation, suitable methods can be selected according to their physical and chemical properties, such as distillation and extraction. The purification process requires fine operation to ensure the quality of the product. In this way, qualified 2-Nitrofluorobenzene products can be obtained.

Chemical Reactions & Modifications

F 2 - Nitrofluorobenzene is also an organic compound. Its chemical reaction and modification are really related to many chemical processes.
At one end of the reaction, the nucleophilic substitution of halogenated aromatics is a common reaction. 2 - Nitrofluorobenzene, the activity of fluorine atoms is greatly increased due to the electron-absorbing effect of the ortho-nitro group. Nucleophilic reagents such as alkoxides and amines are easy to attack the carbon position where the fluorine atom is located, resulting in the formation of substitution products.
When it comes to modification, nitrification, halogenation and other means can be used. Taking nitrification as an example, due to the localization effect of nitro groups, the newly introduced nitro groups can be at specific positions, which changes the chemical and physical properties of the products. Or by reducing the nitro group to form amino derivatives, it broadens its application field and has important value in medicine, pesticide synthesis, etc. All kinds of reactions and modifications are the key to the improvement of chemical research, so as to promote the wider application of this compound in industrial practice, scientific research and exploration.

Synonyms & Product Names

2 - Nitrofluorobenzene is a chemical substance. Its synonymous name, also known as fluoro-o-nitrobenzene. This substance has a wide range of uses. In the chemical industry, it is often used as a raw material to produce many other substances. Its appearance may be colorless to light yellow liquid, with a special smell.
Sold in the market, most merchants are named 2 - Nitrofluorobenzene, and there are also those marked with fluoro-o-nitrobenzene. Although the two names are different, they actually refer to the same thing. Chemical research and industrial production need to clarify their synonymous names and trade names, so that they can be used accurately and operated without error. It is crucial for all things in the chemical industry.

Safety & Operational Standards

2-Nitrofluorobenzene is an important chemical compound in the chemical field, and its safe production and standardized operation are extremely critical.
When preparing and using 2-Nitrofluorobenzene, the first thing to ensure is that the place is well ventilated. Because of its certain toxicity and irritation, if the air circulation is not smooth, the accumulation of harmful gases can easily endanger the health of the operator.
Furthermore, the operator must strictly wear protective equipment. Professional protective clothing is required, which can effectively block the compound from direct contact with the body; protective gloves are worn to prevent hand skin contamination; at the same time, goggles and gas masks are also indispensable to protect the eyes and respiratory tract from damage.
In terms of operating procedures, established norms should be followed accurately. When taking 2-Nitrofluorobenzene, the utensils used must be clean, dry and accurately measured to avoid waste and errors. During the reaction process, temperature, pressure and other conditions need to be strictly controlled. Due to its active chemical properties, improper conditions can easily cause unexpected reactions.
When storing 2-Nitrofluorobenzene, it should be placed in a cool, dry and ventilated place, away from fire sources and oxidants. It needs to be stored in a specific container to ensure a good seal and prevent leakage.
In the event of a leakage accident, do not panic. The surrounding personnel should be evacuated immediately, and fire should not be allowed to approach. At the same time, emergency measures should be taken quickly, according to the size of the leakage, or adsorbed with inert materials such as sand, or neutralized with specific chemical reagents.
Only by strictly adhering to safety and operating standards can we ensure the smooth progress of 2-Nitrofluorobenzene in production, use and other links, minimize risks, and ensure personnel safety and environmental safety.

Application Area

2 - Nitrofluorobenzene is also a chemical substance. Its application is not limited. In the field of synthesis, it can be used in the field of synthesis, to help the development of many kinds of substances, and to improve the health of all kinds of diseases. In the field of research and development, it can use raw materials to create the equivalent energy of transportation and weeding, and to ensure the safety of crops. It is also in the field of material science. It can be used to make something, or it can be used to make certain characteristics of materials. These are all 2 - The application of Nitrofluorobenzene is important for the development of various industries.

Research & Development

Nowadays, there is a chemical substance, named 2-Nitrofluorobenzene. I am a researcher of this substance, and I often study it. This material quality is related to its research and progress.
At the beginning, explore the method of its synthesis. After several trials, we have obtained various pathways. It is either obtained by nitrification of fluorobenzene, or by other methods. In the meantime, it is important to observe the reaction conditions, temperature, pressure, and catalyst. Under suitable conditions, its yield can be increased and its quality can be improved.
It also examines its application field. It is useful in medicine, pesticides, and other industries. Based on it, various drugs can be prepared to prevent diseases and diseases.
However, the study of this substance also encounters problems. If the synthetic pollution, how to reduce it? And its nature is complicated, how to make good use of it? We think about it day and night, hoping to break it. With unremitting research, we hope to make 2-Nitrofluorobenzene more capable in various industries, and help research and progress smoothly.

Toxicity Research

2 - Nitrofluorobenzene is an important chemical substance, and its toxicity research is crucial. Today's detailed investigation of the toxicity of this substance requires careful investigation. It may have certain toxicity, and it may lead to complex reactions in living organisms.
Ancient books say: "The nature of things needs to be investigated carefully." To study the toxicity of this substance, it is necessary to start from multiple channels. Observe its direct impact on organisms, observe cell changes, and explore its effects on organs. It is also necessary to examine its diffusion and transformation in the environment to prevent it from becoming a four-way disaster.
The road of toxicity research is like walking down a hidden path, and you need to be cautious step by step. If you neglect this, you may have unbearable consequences. Therefore, the toxicity study of 2 - Nitrofluorobenzene must be rigorous and study its essence to ensure the well-being of all beings and the tranquility of the environment.

Future Prospects

I have studied the product of 2-Nitrofluorobenzene. Looking at this substance, its properties are unique and it has a wide range of uses. Although the current process has made progress, there are still some shortcomings.
Looking to the future, we can change the synthesis method. Or we can find better raw materials, reduce its cost and increase its yield. And hope to improve the purification technology to make the product purer.
And think about its application, or we can expand it in the development of new drugs. With its characteristics, it can help to become a special medicine and solve the disease of everyone. In the field of materials, it is also expected to emerge and make novel materials to meet the needs of all parties. In the future, 2-Nitrofluorobenzene can be used by the world and benefit everyone.

Where to Buy 2-Nitrofluorobenzene in China?

As a trusted 2-Nitrofluorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 2-Nitrofluorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the physical properties of 2-Nitrofluorobenzene?

2-Nitrofluorobenzene is also an organic compound. It has the following physical properties:
In terms of color and taste, at room temperature, 2-nitrofluorobenzene is a colorless to light yellow liquid with a pungent odor. This odor is pungent and can be easily detected in the air.
At the melting point, the melting point is about -29 ° C, and the boiling point is 205-206 ° C. Due to its low melting point, it is liquid at room temperature; the boiling point is relatively high, and a higher temperature is required to boil it into a gaseous state.
The density characteristic is relative density (water = 1). The density of nitrofluorobenzene is about 1.4. If mixed with water, it will sink to the bottom of the water.
In terms of solubility, 2-nitrofluorobenzene is insoluble in water, but soluble in organic solvents such as ethanol, ether, and benzene. In water, it is difficult to dissolve due to its large polarity difference from water molecules and weak interaction force; in organic solvents, it can be better dissolved due to the principle of similar miscibility.
In addition, the vapor pressure of 2-nitrofluorobenzene has corresponding values under specific conditions, and its vapor density is greater than that of air. If it leaks, the steam will spread close to the ground, increasing the danger range. And because of its irritation, it can cause irritation and damage to the eyes, respiratory tract, and skin. When using and contacting, be careful and take protective measures.

What are the chemical properties of 2-Nitrofluorobenzene?

2-Nitrofluorobenzene is also an organic compound. It has many chemical properties, let me come to you.
First of all, the activity of fluorine atoms in this substance is quite high. Due to the electron-absorbing effect of nitro groups, the electron cloud density of the benzene ring decreases, making it easier for fluorine atoms to leave. When encountering nucleophilic reagents, such as alcohols, amines, phenols, etc., nucleophilic substitution reactions can occur. Taking alcohols as an example, under basic conditions, the alkoxy negative ions of alcohols nucleophilically attack the carbon connected to fluorine on the benzene ring, and the fluorine ions leave to produce corresponding ether compounds. The reaction mechanism is that the nucleophilic reagent provides electron pairs and bonds with the carbon atoms of the benzene ring, breaking the original chemical bond equilibrium.
Furthermore, the nitro properties in 2-nitrofluorobenzene cannot be ignored. Nitro is a strong electron-absorbing group, which passivates the benzene ring, which is not conducive to the occurrence of electrophilic substitution. However, under certain conditions, such as high temperature, strong protonic acid environment, etc., electrophilic substitution can still be carried out on the benzene ring, but the reaction conditions are more severe than those of benzene derivatives without nitro groups.
2-nitrofluorobenzene can also undergo reduction reactions. Nitro groups can be reduced gradually. For example, iron and hydrochloric acid are used as reducing agents. Nitro groups are first reduced to nitroso groups, and then reduced to amino groups to obtain 2-fluoroaniline. During this process, electron transfer reduces the oxidation state of nitrogen in nitro groups.
In addition, in alkaline aqueous solutions, although the hydrolysis reaction is not as fast as that of haloalkanes, under heating and other conditions, fluorine atoms can be replaced by hydroxyl groups to generate 2-nitrophenol. This reaction requires the help of an alkaline environment to promote the reaction process.
In summary, 2-nitrofluorobenzene contains fluorine atoms and nitro groups, and has unique chemical properties. It is widely used in the field of organic synthesis and can be prepared through various reaction paths.

What are the main uses of 2-Nitrofluorobenzene?

2-Nitrofluorobenzene is also an organic compound. It has a wide range of uses and is used in various fields of chemical industry.
Bearing the brunt, it is often used as a key intermediate in the synthesis of medicine. The nitro and fluorine atoms on the genbenzene ring have unique reactivity and can be converted into various pharmacoactive groups through many chemical reactions. For example, through reduction reaction, the nitro group can change the amino group, and then condense with other compounds containing carboxyl groups and other groups to synthesize drug molecules with specific pharmacological activities, which are essential in the creation of antibacterial, antiviral and other drugs.
Furthermore, in the field of pesticides, it also occupies an important position. Through a series of organic synthesis steps, high-efficiency pesticide molecular structures can be constructed. Due to its special structure, it can endow pesticides with good biological activity and environmental adaptability, which is beneficial to the control of crop diseases and pests, and improves the yield and quality of agricultural products.
In addition, in the synthesis of dyes, 2-nitrofluorobenzene is also a commonly used raw material. The benzene ring structure can endow the dyes with a good conjugate system, making the dyes present rich colors. By chemically modifying it and connecting different substituents, a variety of dyes with excellent properties and different colors can be prepared, which are widely used in textile printing and dyeing industries.
To sum up, 2-nitrofluorobenzene is an indispensable raw material in the chemical fields of medicine, pesticides, dye synthesis, etc., and plays a pivotal role in the development of related industries.

What are 2-Nitrofluorobenzene synthesis methods?

There are two ways to synthesize 2-nitrofluorobenzene. First, fluorobenzene is used as the starting material and obtained by nitrification. Fluorobenzene is co-heated with mixed acid (mixed with nitric acid and sulfuric acid), and the benzene ring of fluorobenzene is substituted by nitro groups to obtain 2-nitrofluorobenzene. In this reaction, sulfuric acid is used as a catalyst to promote nitric acid to produce nitroyl positive ions (NO 2), which are electrophilic reagents and attack the higher electron cloud density of the benzene ring. Because the fluorine atom is an ortho-para-position group, although its induction effect is electron-absorbing, but the conjugation effect is electron-supplying, under the synthesis, the ortho-para-position electron cloud density is slightly higher, so the nitro group can be replaced in the ortho-position to obtain During the reaction, the temperature and the proportion of mixed acids must be strictly controlled. If the temperature is too high, it is feared that more by-products will occur, such as polynitro substitutions.
Second, 2-nitrochlorobenzene is used as the raw material and prepared by halogen exchange reaction. 2-Nitrochlorobenzene and potassium fluoride are heated in an appropriate solvent, such as dimethyl sulfoxide (DMSO). In this reaction, fluoride ions (F) nucleophilically replace chlorine atoms of chlorobenzene to obtain 2-nitrofluorobenzene. This reaction requires appropriate catalysts, such as crown ethers, to increase the activity of fluoride ions. Crown ethers can complex with potassium ions to free fluoride ions, greatly increasing the activity and promoting the reaction. The solvent of the reaction is also crucial, it must have good solubility to the reactants and be able to stabilize the reaction intermediates, so that the reaction can be smooth and the yield and purity of the product can be improved.

2-Nitrofluorobenzene What are the precautions during storage and transportation?

2-Nitrofluorobenzene is a commonly used raw material in organic synthesis. However, it is toxic and dangerous. When storing and transporting, many matters must be paid attention to.
First words storage. This substance should be placed in a cool and ventilated warehouse, away from fire and heat sources. It is easy to decompose due to heat, releasing toxic gases, endangering the surrounding environment and personal safety. The temperature of the warehouse should be strictly controlled, generally not exceeding 30 ° C. And it must be stored separately from oxidants, reducing agents, alkalis, etc., and must not be mixed to prevent violent chemical reactions. Because of its corrosive nature, storage containers must also be carefully selected, corrosion-resistant materials should be used, and good sealing should be ensured to prevent leakage. At the same time, the warehouse should be equipped with suitable equipment for containing and handling leaks.
As for transportation, there are also many precautions. Before transportation, the packaging must be carefully inspected to ensure that there is no damage or leakage. During transportation, the car or ship must be kept stable to avoid violent vibration and impact to prevent damage to the packaging. Transportation vehicles must follow the specified route and do not stop in densely populated areas and traffic arteries. Escort personnel must also be familiar with the nature of 2-nitrofluorobenzene and emergency treatment methods, so that they can properly respond to emergencies on the way. In the event of a leak, the surrounding people should be evacuated quickly to isolate the leaked contaminated area. Emergency responders must wear protective equipment to clean up and do not act rashly. In this way, the safety of storage and transportation can be guaranteed, and disasters can be avoided.