2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code	248060
Chemical Formula	C7H3ClF3NO4S
Molar Mass	289.616 g/mol
Appearance	Solid (usually)
Physical State At Room Temp	Solid
Odor	Pungent
Solubility In Water	Reacts with water
Solubility In Organic Solvents	Soluble in some organic solvents like dichloromethane
Melting Point	Data varies, needs specific experimental value
Boiling Point	Data varies, needs specific experimental value
Density	Data varies, needs specific experimental value
Reactivity	Reactive towards nucleophiles, reacts with water and alcohols

As an accredited 2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	500g of 2 - nitro - 4 - trifluoromethylbenzenesulfonyl chloride in sealed chemical - grade packaging.
Storage	2 - nitro - 4 - trifluoromethylbenzenesulfonyl chloride should be stored in a cool, dry, and well - ventilated area, away from heat and ignition sources. It should be kept in a tightly - sealed container, preferably made of corrosion - resistant materials due to its reactive nature. Store it separately from incompatible substances like bases, reducing agents, and moisture - sensitive compounds to prevent unwanted reactions.
Shipping	2 - nitro - 4 - trifluoromethylbenzenesulfonyl chloride is a chemical. Ship it in tightly sealed, corrosion - resistant containers. Follow all regulations for transporting hazardous chemicals, ensuring proper labeling and safety measures during transit.

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2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride

General Information

Historical Development

2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride, it is also a matter of transformation. Its origin, the past is transformed, the physical properties are studied, and the wonder of chemical combination is explored. At the beginning of time, there is a basic transformation of knowledge, and the nature of general things has not been deeply understood.
It is the first step of transformation, and the equipment is refined day by day, and the management is also completed. Those who are in the room,,, this 2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride will be reborn.
From its original life, it is used for transformation, such as synthesis, etc., it is useful. Researchers should not expand its application, so that it has a place in the path of chemical development, promote the development of the field, and lead to the future trend of chemical development.

Product Overview

2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride is also a chemical substance. It is active and has a wide range of uses in the field of organic synthesis. This compound has a unique structure, with nitro coexisting with trifluoromethyl and benzenesulfonyl chloride.
Because of its activity, it is often a key reagent for organic reactions. It can be used to construct a variety of organic molecular structures and assist in the preparation of complex compounds. In the chemical industry, it may be an important raw material for the preparation of special materials and pharmaceutical intermediates.
To observe its preparation, it requires exquisite technology and suitable conditions to obtain a pure product. Those who use it should carefully observe its reaction characteristics to achieve the best effect and avoid accidents. This substance is of great value in both chemical research and industrial practice, and is also a powerful tool for organic synthesis.

Physical & Chemical Properties

In June 2024, 2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride in the chemical world, its physical and chemical properties are worth exploring. This compound is light yellow in color, crystalline in shape, and has a pungent smell. Its melting point is about 45 to 48 degrees Celsius. At this temperature, it gradually melts from solid to liquid, and it looks like ice and snow melting. The boiling point is about 240 to 245 degrees Celsius. At this temperature, it liquefies into a gaseous state and rises.
Its solubility also has characteristics. It can be well dissolved in organic solvents such as dichloromethane and chloroform. It is like a salt melting in water and disperses uniformly. However, in water, the solubility is very small, just like oil floating in water, and it is difficult to dissolve.
And the chemical properties of this compound are active, and the sulfonyl chloride group is easy to react with nucleophiles. If it encounters alcohols, it can form sulfonates; if it encounters amines, it will form sulfonamides. This is due to the electron cloud distribution and chemical bond characteristics of the atoms in its structure. It is like a delicate machine, and the components interact to deduce unique chemical changes.

Technical Specifications & Labeling

2-Nitro-4-trifluoromethylbenzenesulfonyl chloride is an important chemical substance. Its process specifications and identification (product parameters) are crucial.
Looking at its process specifications, it is necessary to prepare a precise synthesis process. From the start of the raw material, the reaction conditions of each step must be strictly controlled, such as temperature, pressure, reaction time, etc. This is all about the purity and yield of the product.
When it comes to the identification (product parameters), the purity should reach a very high standard, and the impurity content should be minimal. The appearance should also be clear, when it is a specific color state. In addition, the relevant physical and chemical properties parameters, such as melting point, boiling point, etc., need to be accurately measured and recorded. Only in this way can we ensure that this product can be accurately applied in various fields of chemical industry and play its due effectiveness.

Preparation Method

The method of preparing 2-nitro-4-trifluoromethylbenzenesulfonyl chloride is related to the raw material and production process, reaction steps and catalytic mechanism, which is the key.
First take an appropriate amount of 4-trifluoromethylbenzenesulfonyl chloride as the starting material, in a suitable reaction kettle, with the help of a specific catalyst, add an appropriate amount of nitrifying reagent, such as a mixture of concentrated nitric acid and concentrated sulfuric acid. Control the temperature in a certain range, about 50 to 60 degrees Celsius, and slowly add the nitrifying reagent dropwise to prevent the reaction from overheating.
Add it dropwise, maintain this temperature, and continue to stir the reaction for several hours, about 3 to 4 hours. During this period, closely observe the reaction process and monitor it by thin-layer chromatography. When the reaction is complete, pour the reaction liquid into ice water, extract and separate the liquid to collect the organic phase. Then dry with anhydrous sodium sulfate, filter, and distill under reduced pressure to remove the solvent to obtain the crude product.
Finally, after recrystallization, the crude product is refined with a suitable solvent, such as ethanol-water mixed solvent, to obtain a pure 2-nitro-4-trifluoromethylbenzenesulfonyl chloride product. This preparation method, each step is strictly controlled to ensure the quality and quantity of the product.

Chemical Reactions & Modifications

The new product of this chemical industry is named 2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride. In the reaction and modification of chemical, it is quite critical.
Looking at the reaction, it can be combined with various reagents to produce different products. Or nucleophilic substitution, so that the chlorine of sulfonyl chloride is replaced by other groups, to obtain new sulfonamides. Or hydrolysis, transsulfonyl chloride is turned into sulfonic acid, which is used to prepare sulfonic acid derivatives.
As for modification, the nitro group or trifluoromethyl group can be modified to adjust its chemical properties. Increase its stability, change its solubility, or change its reactivity. In this way, the use of this product in various fields such as medicine, agriculture, and materials can be expanded, making it more effective and contributing to the development of chemistry.

Synonyms & Product Names

Today there is a thing called "2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride". Its synonymous name is quite crucial, which is related to the recognition and use of this thing. In the field of chemical industry, synonymous names and trade names are often interoperable words.
This "2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride", or has another name, or has a unique trade name. Like all things in the market, there are many people who are the same but have different names. This chemical, in the way of reaction, its synonymous name may help practitioners to accurately identify, and there is no risk of misuse. And the design of the trade name may be to identify unique qualities, or to meet the needs of the market.
If you explore its synonymous name, you may be able to find clues in ancient books and old records. Although times change and the laws of chemical industry are changing day by day, there are still some things to be studied in the old name. Its trade name must also be determined according to its characteristics and uses, in recognition of its superiority over others. Therefore, studying the synonymous name and trade name of this thing is of great benefit to chemical research and production applications.

Safety & Operational Standards

2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride Safety and Practice
2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride is an important object in chemical research. It is active and safety regulations are of paramount importance during experimental operation.
First word safety. This object is irritating and corrosive, and can cause skin burns and eye damage when in contact with the human body. Therefore, when handling, protective equipment such as acid and alkali resistant protective clothing, protective gloves, and goggles are necessary to keep the body safe. And a local exhaust device should be installed in a well-ventilated area to prevent the accumulation of harmful gases and damage to breathing.
Times and operating specifications. When taking it, use clean and dry utensils to avoid contact with water and moisture, because it is easy to react violently when exposed to water. When weighing, the action should be slow and accurate to prevent spilling. During the reaction process, strictly control the temperature and operate according to the established procedures. Do not change the reaction conditions without changing the reaction conditions. If there is a spill, immediately cover it with an inert adsorption material, collect it and dispose of it according to regulations, and do not discard it at will. After the reaction, the utensils used should be washed and dried in time for reuse.
All these are the specifications for the safety and operation of 2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride. From it, the experiment will be smooth and the personnel will be healthy; if it is not, the disaster will easily arise, and it must not be careless.

Application Area

2-Nitro-4-trifluoromethylbenzenesulfonyl chloride is a wonderful chemical. Its application field is quite extensive. In the field of pharmaceutical research and development, it can be a key intermediate, help create new drugs, and treat various diseases. In the field of materials science, it can participate in the synthesis of special materials, giving materials unique properties, such as corrosion resistance and heat resistance. In the field of fine chemicals, it can prepare high-end fine chemicals for high-end daily chemicals, special coatings, etc. This compound, with its unique structure and activity, blooms in many application fields, like a bright pearl in the long river of scientific and technological development, contributes to the progress of various fields, leads the frontier exploration, helps the industry innovation, and promotes the technology boat.

Research & Development

Recently, in the field of chemistry, I have focused on the study of "2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride". Its unique properties and different performance in various reactions have led me to think deeply.
When I first came into this substance, I felt that its structure was exquisite, containing nitro, trifluoromethyl and sulfonyl chloride groups, and the interaction of each group gave it different chemical activities. Then I carefully explored its synthesis method, tried several times, improved the old system, and strived for high efficiency and purity.
Then I observed its reaction characteristics, and when it interacted with various reagents, different products were formed. Detailed analysis of the mechanism, insight into the changes in each step, and hope to expand its application.
We have developed new synthetic paths based on this substance, spawning more beneficial compounds, shining in the fields of medicine, materials, etc. And will continue to study, promote its development, and contribute to chemistry.

Toxicity Research

2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride is very important for the study of its toxicity. Looking at the structure of its molecule, the nitro group and trifluoromethyl group are attached to the benzenesulfonyl chloride. The nitro group has strong electricity absorption, and the trifluoromethyl group also adds its chemical activity.
With common sense, it enters the organism or interacts with biological macromolecules due to the active group. Such as the amino group of the protein and the base of the nucleic acid, it may be its target. Protein denaturation, the conformation of the nucleic acid is changed, the biochemical route is chaotic, and the physiological performance is damaged.
And such fluorine-containing and nitro compounds are difficult to degrade in the environment. Or accumulated in water and soil, bioaccumulation, and the ecological balance of disaster. Therefore, studying its toxicity and understanding its harm is the foundation of protection and governance, which cannot be ignored.

Future Prospects

Prospects of the future, in 2 - Nitro - 4 - Trifluoromethylbenzenesulfonyl Chloride, this product is the most important. Its characteristics are unique, and its use is limited.
We expect it to be able to reveal its potential in multiple domains. In the field of chemical industry, it may be possible to combine new raw materials to help reverse the production and improve the quality of the product. In the world of chemistry, it may be possible to create special effects, saving patients and suffering.
Furthermore, its research process is expected to be accelerated. Researchers have improved their understanding, broken it, and made the method of production better, and the cost has dropped. In this way, this product will definitely be able to be used in the world before it is used, creating the well-being of the people.

Where to Buy 2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride in China?

As a trusted 2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.

Frequently Asked Questions

As a leading 2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride?

2-Nitro-4-trifluoromethylbenzenesulfonyl chloride is also an important agent in organic synthesis. Its use is widely used in various chemical fields.
In the process of pharmaceutical synthesis, it is often a key intermediate. With its unique chemical structure, a sulfonyl chloride group can be introduced. This group has good activity and can react with many compounds containing nitrogen, oxygen and sulfur to construct complex drug molecular structures. For example, condensation with amine compounds to form sulfonamide derivatives. Many drugs with biological activity, including antibacterial, anti-inflammatory, anti-tumor and other effects, are synthesized by this route.
In the field of pesticides, it is also important. With its reactivity, pesticides with high insecticidal, bactericidal and herbicidal properties are created. The pesticides it participates in the synthesis can effectively act on specific targets of pests and pathogens due to their unique chemical structure, improve the efficacy and selectivity of pesticides, and are environmentally friendly and have little residue.
Furthermore, in the field of materials science, 2-nitro-4-trifluoromethylbenzenesulfonyl chloride is also useful. It can be used to synthesize polymer materials with special functions, such as polymers with high heat resistance and chemical corrosion resistance. The introduction of polymer backbone or side chains can significantly improve the physical and chemical properties of materials, making it suitable for high-end fields such as aerospace and electronics.
In addition, in the dye industry, it can be used as an important raw material for the synthesis of new dyes. By reacting with different aromatic compounds, dye molecules with special colors and properties are constructed to meet the needs of high-quality and high-performance dyes in textile, printing and other industries. Because of its special substituent structure, it helps to improve the color fastness, light resistance and other key performance indicators of dyes.

What are the physical properties of 2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride?

2-Nitro-4-trifluoromethylbenzenesulfonyl chloride, this substance is colorless to light yellow liquid or crystalline, irritating, pungent smell. Its melting point is about 38-42 ° C, boiling point is 138-140 ° C/2.0kPa, in case of open flame, hot topic flammable, thermal decomposition will release toxic fluoride, nitrogen oxides and sulfur oxides and other gases.
2-nitro-4-trifluoromethylbenzenesulfonyl chloride is soluble in most organic solvents, such as dichloromethane, chloroform, toluene, etc. Due to its chemical structure containing sulfonyl chloride groups and active chemical properties, it can participate in many organic synthesis reactions, such as reacting with alcohols to form sulfonates, reacting with amines to form sulfonamides, which are used in the field of organic synthesis to construct various compounds containing sulfonyl groups. It is widely used in medicine, pesticides, materials and other industries.
However, due to its corrosive and irritating properties, it is highly irritating to the eyes, skin and respiratory mucosa. Strict protective measures must be taken during operation, such as wearing protective gloves, goggles and gas masks, and working in a well-ventilated environment. In case of accidental contact, rinse with plenty of water immediately and seek medical attention. When storing, it should be placed in a cool, dry and ventilated place, away from fire and heat sources, and stored separately from oxidants and alkalis.

2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride chemically stable?

The stability of the chemical properties of 2-nitro-4-trifluoromethylbenzenesulfonyl chloride is related to many aspects. This compound has a specific structure, and the presence of nitro and trifluoromethyl groups significantly affects its chemical behavior.
Nitro is a strong electron-absorbing group, which reduces the electron cloud density of the benzene ring and makes the benzene ring more prone to nucleophilic substitution. At the same time, its strong electron-absorbing property also affects the stability of the molecule. Trifluoromethyl also has a strong electron-absorbing effect, further changing the electron cloud distribution of the benzene ring, and its fluorine-containing properties give the molecule unique physical and chemical properties.
In terms of stability, under generally mild conditions, if there is no specific reactant or catalyst in the environment, 2-nitro-4-trifluoromethylbenzene sulfonyl chloride can still maintain relative stability. However, when encountering nucleophilic reagents, such as alcohols and amines containing active hydrogen, its sulfonyl chloride group is very easy to undergo nucleophilic substitution reaction with it, resulting in molecular structure changes.
And the compound is also more sensitive to water. Water can hydrolyze the sulfonyl chloride group to generate the corresponding sulfonic acid and hydrogen chloride. This hydrolysis reaction can be carried out spontaneously in a humid environment, which seriously affects its stability.
Furthermore, when heated, 2-nitro-4-trifluoromethylbenzenesulfonyl chloride may undergo reactions such as decomposition. Due to the heating of nitro and sulfonyl chloride groups, chemical bonds can be broken and rearranged.
In summary, the chemical properties of 2-nitro-4-trifluoromethylbenzenesulfonyl chloride are not absolutely stable, and its stability will change significantly in the presence of different environmental conditions and reactants. During storage and use, care must be taken to avoid contact with water, nucleophiles, and high temperatures that can cause it to react, so as to maintain the relative stability of its structure and properties.

What is the synthesis method of 2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride?

The synthesis method of 2-nitro-4-trifluoromethylbenzene sulfonyl chloride is detailed as follows.
First take an appropriate amount of 4-trifluoromethylbenzene, place it in a reactor, and nitrate it with an appropriate amount of mixed acid (sulfuric acid and nitric acid in a specific ratio). During the reaction, the temperature should be strictly controlled in a specific range, such as 50 ° C to 60 ° C, because the temperature has a great influence on the reaction process and product purity. After several times of reaction, 2-nitro-4-trifluoromethylbenzene can be obtained.
Subsequently, 2-nitro-4-trifluoromethylbenzene is transferred to another reaction device and an appropriate amount of chlorosulfonic acid is added. During the reaction, close attention should also be paid to temperature changes and keep them in an appropriate range, such as 80 ° C to 90 ° C. Chlorosulfonic acid and 2-nitro-4-trifluoromethylbenzene undergo a sulfonation reaction, and after a period of time, 2-nitro-4-trifluoromethylbenzene sulfonic acid is formed.
Finally, 2-nitro-4-trifluoromethylbenzene sulfonic acid is reacted with chlorinated reagents such as phosphorus pentachloride or sulfinyl chloride under suitable conditions Taking phosphorus pentachloride as an example, in a heated and anhydrous environment, the two fully react to obtain 2-nitro-4-trifluoromethylbenzenesulfonyl chloride. After the reaction is completed, it needs to be separated and purified, such as distillation, recrystallization and other methods to obtain high-purity products. Throughout the synthesis process, the reaction conditions and reagent dosage of each step need to be precisely controlled to achieve the desired synthetic effect.

What to look out for when storing and transporting 2-Nitro-4-Trifluoromethylbenzenesulfonyl Chloride

2-Nitro-4-trifluoromethylbenzenesulfonyl chloride, this material is strong and sensitive, and many matters need to be carefully paid attention to during storage and transportation.
Store first, and choose the first environment. It should be placed in a cool, dry and well-ventilated place, away from fire and heat sources. Because it is quite sensitive to heat, it is easy to decompose when heated, and even cause danger. If the ambient temperature is too high, the molecular activity will increase and the reaction tendency will increase, so it is essential to control the temperature in a suitable range.
Furthermore, the storage place must be kept away from oxidants and alkali substances. 2-Nitro-4-trifluoromethylbenzenesulfonyl chloride is prone to violent reactions when it encounters oxidants, or the risk of combustion and explosion; when it encounters alkalis, it will also undergo chemical reactions, causing the substance to deteriorate, and may release a lot of heat, causing accidents.
Packaging should also not be underestimated. It is necessary to use well-sealed packaging materials to prevent it from coming into contact with air and moisture. Because of its hygroscopicity, hydrolysis reactions are prone to occur after moisture exposure, which not only affects quality, but also may produce harmful gases.
As for transportation, the transportation vehicle must be clean, dry and free of residual impurities. The loading and unloading process should be handled with care to avoid collisions and drops to prevent package damage. During transportation, closely monitor the temperature and humidity, prepare emergency treatment equipment, and respond in time if there is a leak. Escorts also need to be familiar with the characteristics of this object and emergency treatment methods to ensure the safety of the entire transportation process.