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2-Nitro-4-(Trifluoromethyl)-Chlorobenzene

2-Nitro-4-(Trifluoromethyl)-Chlorobenzene

Hongda Chemical

    Specifications

    HS Code

    262379

    Chemical Formula C7H3ClF3NO2
    Molar Mass 225.55 g/mol
    Appearance A colorless to pale yellow liquid
    Boiling Point Around 200 - 205 °C
    Density Approx. 1.55 - 1.65 g/cm³
    Solubility In Water Insoluble
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
    Flash Point Relatively high, potentially around 80 - 90 °C
    Vapor Pressure Low at room temperature

    As an accredited 2-Nitro-4-(Trifluoromethyl)-Chlorobenzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 250 - gram bottle packaging for 2 - nitro - 4 - (trifluoromethyl) - chlorobenzene.
    Storage 2 - nitro - 4 - (trifluoromethyl) chlorobenzene should be stored in a cool, well - ventilated area, away from heat sources and ignition points. Keep it in a tightly closed container, preferably made of corrosion - resistant materials. Store it separately from oxidizing agents, reducing agents, and bases to prevent chemical reactions. Regularly check storage conditions to ensure safety.
    Shipping 2 - nitro - 4 - (trifluoromethyl) - chlorobenzene is shipped in sealed, corrosion - resistant containers. It follows strict hazardous chemical shipping regulations, with proper labeling and documentation for safe transport.
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    2-Nitro-4-(Trifluoromethyl)-Chlorobenzene 2-Nitro-4-(Trifluoromethyl)-Chlorobenzene
    General Information
    Historical Development
    2-Nitro-4- (Trifluoromethyl) -Chlorobenzene is an important compound in the field of organic synthesis. Looking back to the past, the research and development of this compound has gone through many stages. At the beginning, organic chemistry was still in its infancy, and the understanding of complex compounds containing fluorine, nitro and chlorine atoms was very shallow. However, with the evolution of science and technology, the determination of chemists to explore has not diminished.
    With the refinement of chemical analysis technology, the understanding of its structure and properties has gradually deepened. The early synthesis method was cumbersome and the yield was low. After repeated improvement, new synthesis paths emerged, and the yield and purity were improved. Today, in the fields of materials science and drug development, 2-Nitro-4- (Trifluoromethyl) -Chlorobenzene is widely used due to its unique chemical properties. Its historical development has witnessed the vigorous progress of organic chemistry and laid the foundation for more innovative applications in the future.
    Product Overview
    2-Nitro-4- (Trifluoromethyl) -Chlorobenzene is a chemical substance. It is a colorless to light yellow liquid with a special odor. The preparation of this substance is often obtained by a specific reaction path. In the field of organic synthesis, its use is quite extensive.
    Because its structure contains nitro, trifluoromethyl and chlorine atoms, this unique group combination gives it special chemical properties. Nitro has strong electron absorption, which can affect the distribution of electron clouds in molecules and change the reaction activity. The introduction of trifluoromethyl increases its lipid solubility and stability. Chlorine atoms are an important reaction check point in reactions such as nucleophilic substitution. Due to its special properties,
    is often used in the synthesis of medicines and pesticides, and is a key intermediate for the preparation of many bioactive compounds. And in the field of materials science, it also has potential application value and helps to develop new functional materials.
    Physical & Chemical Properties
    2-Nitro-4- (Trifluoromethyl) -Chlorobenzene is also a chemical substance. Its physical and chemical properties are quite specific. Looking at its color, it is often colorless to light yellow, just like the shimmer of morning light, clear and transparent. Smell its taste, it has a special smell, although not rich, but it is unique. Regarding its melting and boiling point, the melting point is about XX degree, just like the boundary of water ice initial condensation in winter; the boiling point is XX degree, like the moment when water boils and evaporates in hot summer. In terms of solubility, in organic solvents, it is like a fish in water, which is somewhat soluble, but in water it is difficult to dissolve, just like oil floating in water, and it is distinct. Its density is also fixed, about XX, between trade-offs, it is full of physical properties. This is a summary of the physicochemical properties of 2-Nitro-4- (Trifluoromethyl) -Chlorobenzene.
    Technical Specifications & Labeling
    Today there is a product called 2 - Nitro - 4 - (Trifluoromethyl) - Chlorobenzene. For this chemical product, its process specifications and identification (commodity parameters) are the key.
    The process specifications must be carefully selected from the selection of raw materials, and the impurities need to be small. The reaction process, temperature, humidity and pressure should be precisely controlled. If the reaction temperature is stable in a certain range, if it is too high, the quality will be variable, and if it is too low, the speed will be slow. And the speed of stirring also affects its quality. It is not appropriate to be too fast or too slow.
    In terms of identification, its name should be clearly identified and the ingredients should be clearly marked. On the packaging, warnings are indispensable to inform people of its sexual hazards, such as flammability and toxicity. Commodity parameters, such as purity geometry, must not be lower than a certain value, and the impurity content should be specified at most. In this way, the essence of the process specifications and labels (commodity parameters) of this object can be obtained to ensure its quality and safe use.
    Preparation Method
    Now to prepare 2 - Nitro - 4 - (Trifluoromethyl) - Chlorobenzene, the method of making it is crucial to the raw materials and production process, reaction steps and catalytic mechanism.
    First take the appropriate raw materials and go through specific reaction steps. Initially, use a certain raw material and put it into the reactor according to a certain ratio. Control the temperature to a suitable degree, during which the reaction process needs to be carefully monitored. Next, add a certain catalyst to promote the reaction rate and optimize the production process. This catalyst, in the catalytic mechanism, can effectively reduce the activation energy of the reaction, making the reaction more prone to occur.
    Then according to the set reaction steps, advance in an orderly manner, or go through several reaction stages, and the connection between each stage must be accurate. After the reaction is completed, subsequent treatment, purification and refining, the 2-Nitro-4- (Trifluoromethyl) -Chlorobenzene product can be obtained, and its quality can meet the required standards.
    Chemical Reactions & Modifications
    Yu studied the chemical industry, and in the case of 2-Nitro-4- (Trifluoromethyl) -Chlorobenzene, he thought deeply about its chemical reaction and modification.
    To observe its chemical reaction, the position of nitro and halogenated groups, the direction of the reaction. Nitro has the property of absorbing electricity, which reduces the electron cloud density of benzene ring, and the electrophilic substitution is slow, but the adjacent para-site activity is different from the meta-site. Although the chlorine atom is conjugated with the electron, it also has an overall effect due to electronegativity. The coexistence of the two makes the reaction very complicated.
    As for the modification, the side chain can be easily modified by means of substitution, and its polarity and melting boiling properties can be adjusted. The introduction of nitrogen-containing heterocycles may increase its biological activity, which is beneficial for pharmaceutical agrochemical. Or change the structure of fluoromethyl, change its lipid solubility, and expand the field of application.
    Our unremitting research hopes to explore its secrets, so that this compound can shine in various industries and benefit the world.
    Synonyms & Product Names
    About the same name and trade name of 2-nitro-4- (trifluoromethyl) chlorobenzene
    There is now a chemical substance 2-nitro-4- (trifluoromethyl) chlorobenzene, which may have similarities and differences in academia and industry. In academic discussions, according to chemical naming rules, this name accurately defines its molecular structure and is a common name in academia.
    However, in commercial circulation, merchants often take another trade name in order to recognize its characteristics or facilitate market identification. This substance has unique effects in the field of synthesis of specific materials or pharmaceutical intermediates due to its chemical properties, and the trade name adopted by merchants aims to highlight its application advantages. Such as "fine fluoride, nitrochlorobenzene" and the like (for example only), use the word "fine" to indicate its high purity, "fluorine", "nitrate" and "chlorine" to point out the key elements, so that users can know their properties.
    Although the academic name and the trade name are different, they all refer to the same chemical substance. The academic community strictly explores the scientific name, and the industry widely promotes the market with the trade name. The two complement each other and promote the development of this chemical substance in scientific research and industry.
    Safety & Operational Standards
    2 - Nitro - 4 - (Trifluoromethyl) - Code of Safety and Operation of Chlorobenzene
    Husband 2 - Nitro - 4 - (Trifluoromethyl) - Chlorobenzene, one of the chemical products. Its properties are special, so safe operation is of paramount importance.
    As far as safety is concerned, this product may be toxic, and it is dangerous to contact the skin, eyes and respiratory systems. Therefore, it is necessary to prevent damage during operation. The author Use protective clothing and wear it to protect the eyes from damage. It is also necessary to wear protective gloves to prevent skin contamination. If you accidentally touch the skin, wash it with plenty of water immediately. If you still feel uncomfortable, treat it as soon as possible. If it enters the eyes, it should also be washed with water immediately for rescue.
    In terms of operation, it is suitable for good operation. Because it may be harmful, good operation can reduce the degree of harmful substances in the air. Operate the source of ignition or smoke, and this material may be flammable. In case of open flame or high temperature, it may be dangerous to life. After use, store it properly, place it in a place where it is dry, dry, and open, and seal it to prevent leakage. If there is a leakage accident, take urgent measures immediately. A small amount of leakage can be absorbed by inert materials such as sand and vermiculite. A large amount of leakage needs to be plugged and contained to avoid its dispersion, and then properly handled. Therefore, the safe operation of 2 - Nitro - 4 - (Trifluoromethyl) - Chlorobenzene must be maintained to ensure human safety and environmental safety.
    Application Area
    2-Nitro-4- (trifluoromethyl) chlorobenzene is also a chemical product. Its application field is quite wide. In the field of pharmaceutical synthesis, it can be used as a key intermediate to help create special drugs and cure various diseases. In the process of pesticide research and development, it can contribute to the synthesis of high-efficiency and low-toxicity pesticides, protect crop growth, and resist pests and diseases. And in the field of material science, it also has important functions, or can improve material properties to make it more suitable for special scenarios. Looking at the past, the application of many chemical products has promoted the progress of the industry. Today, 2-nitro-4 - (trifluoromethyl) chlorobenzene has emerged in many fields due to its unique properties. With time, it will surely contribute more to the development of various industries, lead the progress of science and technology, and benefit all people.
    Research & Development
    Today, there is a product called 2-Nitro-4- (Trifluoromethyl) -Chlorobenzene. Our generation studied it chemically, and its properties and uses are all important for our investigation.
    This product has a unique structure, containing nitro groups, trifluoromethyl groups and chlorine atoms, and each group affects each other, resulting in different physical and chemical properties. In terms of reactivity, the strong electron-absorbing properties of nitro groups reduce the electron cloud density of the benzene ring and make the electrophilic substitution reaction more difficult. Although chlorine atoms are also electron-absorbing groups, their adjacent pairs still have certain reactivity, and the two are checked and balanced with each other, so that the reaction check point and path need to be investigated in detail.
    To study its preparation method, it is necessary to precisely control the reaction conditions, and the ratio of raw materials, temperature, catalyst, etc. are all key. Different paths have advantages and disadvantages, or high cost, or low yield, or many side reactions, so optimizing the preparation process is an important task to improve yield and purity.
    Looking forward to its development, if it can explore unique uses in the fields of medicine and pesticides, or make new breakthroughs in material synthesis, it will be able to expand its wide application, and the prospect will be even brighter.
    Toxicity Research
    Wenfu 2 - Nitro - 4 - (Trifluoromethyl) - Chlorobenzene This substance, its sex is related to the study of toxicity, and it is an important matter. My generation studied the toxicity of this substance, and I tried my best.
    Looking at its structure, nitro coexists with trifluoromethyl, or it may cause its toxicity to be extraordinary. In the experimental environment, try it with all kinds of creatures. The genus of rodents is infected by it, and at first they are irritable, and then they lose their diet and become weaker. Observe its physiological changes, and the organs are damaged, especially the liver and kidney.
    And this substance is difficult to degrade in the environment, and long-term accumulation will cause harm to the ecology. In the realm of water and swamp, when plankton encounter it, their vitality is completely destroyed. From this perspective, the toxicity of 2-Nitro-4- (Trifluoromethyl) -Chlorobenzene cannot be ignored. It is urgent to study its toxicity in order to avoid disasters to sentient beings and maintain the tranquility of the environment.
    Future Prospects
    Wuguanfu 2-Nitro-4- (Trifluoromethyl) -Chlorobenzene is unique and has a wide range of uses. In today's world, the demand for it in the chemical industry is growing. Although the current production method has been developed, there is still hope for improvement.
    Looking to the future, we hope to develop more efficient and environmentally friendly production methods. It is in line with the way of nature. And hope that it will have better applications and expansion in the fields of medicine and materials. With the advancement of science and technology, this product will contribute to human well-being and create a new situation. At that time, 2-Nitro-4- (Trifluoromethyl) -Chlorobenzene will be able to shine brightly, opening up infinite possibilities for future development and paving the way for future generations.
    Where to Buy 2-Nitro-4-(Trifluoromethyl)-Chlorobenzene in China?
    As a trusted 2-Nitro-4-(Trifluoromethyl)-Chlorobenzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Nitro-4-(Trifluoromethyl)-Chlorobenzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the physical properties of 2-nitro-4- (trifluoromethyl) chlorobenzene?
    2-% cyano-4- (trifluoromethyl) phenylhydrazine is a kind of organic compound. Its physical properties are unique and worthy of investigation.
    Looking at its properties, under normal temperature and pressure, it is mostly in a solid state. Due to the force between molecules, it has a certain stability and cohesion.
    As for the melting point, it is about a certain range. This value is an important physical parameter. The determination of the melting point can help to identify the characteristics of its purity and molecular structure. When heated to the melting point, the thermal motion of the molecule intensifies enough to overcome the lattice energy, causing the substance to change from a solid state to a liquid state.
    In terms of solubility, it has a certain solubility in organic solvents, such as common ethanol, ether, etc. This is due to the principle of similarity and miscibility. There is a suitable interaction force between its molecular structure and the molecules of the organic solvent, which can promote its dispersion in the solvent. However, in water, the solubility is very small, and it is difficult to form an effective interaction because of the large difference between the molecular polarity and the polarity of water.
    Its density is also a key physical property. The density reflects the compactness and mass distribution of the molecules of a substance. A specific density value can be used for the identification of substances and the consideration of related chemical processes.
    Furthermore, the color state of 2-% cyano-4- (trifluoromethyl) phenylhydrazine can be white to light yellow. This color characteristic may be related to the electron transition and conjugation system in the molecular structure, which can be used as the basis for preliminary identification.
    All these physical properties are of great significance in the fields of organic synthesis and materials science. During the synthesis process, properties such as melting point and solubility can help optimize the reaction conditions and improve the purity of the product. In the application of materials, factors such as density and color state are related to the properties and appearance of the material. Therefore, detailed knowledge of its physical properties is the basis for in-depth research and rational application of this compound.
    What are the chemical properties of 2-nitro-4- (trifluoromethyl) chlorobenzene?
    2-% hydroxy-4- (trifluoromethyl) quinoline, this is a special organic compound with multiple unique chemical properties.
    It has certain acidity. Due to the presence of hydroxyl groups in the molecule, the hydroxyl hydrogen atom can be partially dissociated, showing acidic properties in a suitable environment, and can neutralize with bases to generate corresponding salts.
    It also has nucleophilic substitution reaction activity. Atoms or groups at specific locations in the molecule are easily attacked by nucleophilic reagents due to the distribution of surrounding electron clouds and atomic electronegativity, and then nucleophilic substitution reactions occur. For example, the position of halogen atoms or other leaving groups can be replaced by nucleophiles to construct new compound structures, which are widely used in the field of organic synthesis.
    The compound also has properties related to the conjugate system. The conjugate structure in the molecule gives it special electron delocalization properties, which affects its physical and chemical properties. The conjugate system reduces the energy and stability of the molecule, and has a significant impact on its spectral properties. There will be specific absorption peaks in the ultraviolet-visible spectrum, which can be used for qualitative and quantitative analysis of compounds.
    Furthermore, due to the presence of trifluoromethyl, it has strong electron absorption. The presence of trifluoromethyl alters the molecular electron cloud distribution, decreases the electron cloud density of neighboring atoms, and affects the reactivity and physical properties of compounds, such as enhancing molecular polarity, which plays a role in its solubility, boiling point and other physical properties. In chemical reactions, the electron-absorbing effect of trifluoromethyl can affect the selectivity of the reaction check point and the reaction rate.
    What are the main uses of 2-nitro-4- (trifluoromethyl) chlorobenzene?
    2-% carboxyl-4- (trifluoromethyl) phenylhydrazine has a wide range of uses. In the field of medicinal chemistry, it can be used as an important synthesis intermediate. Due to its unique chemical structure, containing carboxyl groups and trifluoromethyl groups, it is endowed with special physical and chemical properties, and can react with many compounds to build complex drug molecular structures.
    Taking the creation of drugs for the treatment of specific diseases as an example, it can be used to connect with other active groups to precisely adjust the activity, solubility and bioavailability of drugs. In the field of organic synthesis chemistry, it provides an effective way to synthesize organic materials with special properties. When preparing materials with specific optical and electrical properties, this structural unit can be ingeniously introduced to achieve the desired purpose of material property regulation.
    In the field of pesticide chemistry, it also has its uses. It can be used to develop new pesticides, because its special structure may endow pesticides with better biological activity and environmental adaptability, stronger inhibition and killing effects on pests and pathogens, and good degradation characteristics in the environment, reducing the negative impact on the ecological environment. In scientific research and exploration, it is also an important chemical reagent, helping researchers to deeply study the mechanism of organic chemical reactions, and through the reactions it participates in, to understand the essence of chemical changes. It provides a basis for the development and optimization of new reaction paths, and promotes the continuous development of organic chemistry.
    What are the methods for preparing 2-nitro-4- (trifluoromethyl) chlorobenzene?
    To prepare 2-cyano-4- (trifluoromethyl) phenylhydrazine, you can follow the ancient method.
    First, use benzene containing cyanogen and trifluoromethyl as the starting material. First, the benzene is exposed to a specific halogenating agent, and the halogenate is obtained in a temperature-appropriate and catalytic environment. The halogenating agent used, such as bromine or chlorine, uses iron salts or aluminum salts as catalysts, and the temperature is controlled at tens of degrees Celsius to fully react. The halogenate is then combined with a hydrazine reagent and heated and refluxed in a solvent. When reacting with common solvents such as alcohols, pay attention to the control of temperature and time. After several hours, the target product may be obtained.
    Second, starting from aniline with corresponding substituents. First, aniline is diazotized, sodium nitrite and inorganic acid are mixed to form a solution, and slowly added to the aniline solution at low temperature, and the temperature is controlled at zero to five degrees Celsius to form a diazonium salt. After that, the diazonium salt acts with cyano and trifluoromethyl related reagents. Active reagents containing cyanyl and trifluoromethyl can be selected. React under mild conditions. After several steps of regulation, it is also expected to obtain 2-cyano-4- (trifluoromethyl) phenylhydrazine.
    Third, start with benzoic acid containing appropriate substituents. First, benzoic acid is converted into acid chloride, which is heated with thionyl chloride and other reagents to complete the reaction. The acid chloride is then condensed with hydrazine to obtain benzoyl hydrazide derivatives. Then through specific reactions, such as dehydration, introduction of cyano groups and trifluoromethyl groups, the reaction conditions are carefully adjusted, such as temperature, pH and reagent dosage, step by step, or 2-cyano-4- (trifluoromethyl) phenylhydrazine can be made.
    All these methods need to be operated in strict accordance with the procedures, careful management of reagents, and good control of conditions, in order to achieve satisfactory yield and purity.
    What are the precautions for using 2-nitro-4- (trifluoromethyl) chlorobenzene?
    2-% hydroxy-4- (tri, ethyl) thiophene is a medicinal substance. When using it, it is necessary to keep in mind that all kinds of things are important.
    First, it must be clear about its nature. The chemical structure of this substance is specific, and it is related to its rationalization, characteristics, or is soluble in some solvents, while it is insoluble in others. When storing, when, avoid light, avoid tide, choose dry, dry and cool places, so as to avoid its deterioration and damage to its medicinal properties due to the influence of the external environment.
    For the second time, the dosage must be accurate. No matter what kind or use, it should be used according to the doctor's advice or experimental regulations. If the dosage is too small, it may be difficult to achieve the expected effect; if the dosage is too large, it may cause damage to the organs of the organism, or cause hypersensitivity.
    Furthermore, pay attention to its compatibility with other things. When used in combination or compatibility, it is necessary to find out whether there will be a chemical reaction between it and other chemical reagents and drugs. If there is an adverse reaction, harmful substances may be generated, which not only destroys its own efficacy, but also may bring safety and hidden diseases.
    In addition, the operation should be regulated. In the laboratory, when taking it out, prepare it in front of suitable protective equipment, such as hand covers, goggles, etc., to prevent it from coming into contact with the skin, eyes, etc., causing damage. And, after taking it out, seal it in time to prevent it from evaporating or reacting with the components in the air.
    In short, although 2-% hydroxy-4- (tri, ethyl) thiophene has medicinal value, it can be used safely and effectively.