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2-Methyl-5-Fluorobenzenesulfonyl Chloride

2-Methyl-5-Fluorobenzenesulfonyl Chloride

Hongda Chemical

    Specifications

    HS Code

    934571

    Chemical Formula C7H6ClFO2S
    Molecular Weight 210.64
    Appearance Typically a colorless to light - yellow liquid
    Boiling Point Data may vary, generally in a specific temperature range related to its volatility
    Melting Point Specific melting temperature depending on its crystal structure
    Density Characteristic density value indicating mass per unit volume
    Solubility Solubility in common organic solvents like dichloromethane, toluene etc., and insoluble in water
    Vapor Pressure A measure of its tendency to vaporize at a given temperature
    Flash Point Temperature at which it can form an ignitable mixture with air
    Reactivity Reactive towards nucleophiles due to the presence of sulfonyl chloride group

    As an accredited 2-Methyl-5-Fluorobenzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 100g of 2 - methyl - 5 - fluorobenzenesulfonyl chloride in a sealed glass bottle.
    Storage 2 - methyl - 5 - fluorobenzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area. Keep it away from heat sources, flames, and oxidizing agents. Store it in a tightly sealed container to prevent moisture ingress, as it can react with water. Additionally, ensure the storage location is out of reach of unauthorized personnel and in compliance with local chemical storage regulations.
    Shipping 2 - methyl - 5 - fluorobenzenesulfonyl chloride, a hazardous chemical, is shipped in specialized, leak - proof containers. It follows strict regulations, with proper labeling indicating its nature, and is transported by carriers trained in handling such substances.
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    2-Methyl-5-Fluorobenzenesulfonyl Chloride 2-Methyl-5-Fluorobenzenesulfonyl Chloride
    General Information
    Historical Development
    About the historical development of 2-methyl-5-fluorobenzenesulfonyl chloride
    In the past, the technology of chemistry was not developed, and all kinds of substances were hidden in nature and unknown. In modern times, science has advanced, and chemical research has become more and more in-depth.
    2-methyl-5-fluorobenzenesulfonyl chloride, at the beginning, chemists tried and repeated experiments in the laboratory to analyze its components and explore its properties. At that time, the synthesis method was cumbersome and the yield was very small.
    Later, with the improvement of chemical technology, the reaction conditions were gradually optimized, and the acquisition of raw materials was more convenient. The synthesis process was simplified, the cost was reduced, and the output was increased.
    To this day, this compound is widely used in many fields such as medicine and materials. Its historical development, from hidden to obvious, from less to more, has been used by human beings, which is really the unremitting work of chemical research.
    Product Overview
    2-Methyl-5-fluorobenzenesulfonyl chloride is one of the important compounds involved in my chemical research. It has a unique chemical structure. On the benzene ring, the methyl and fluorine atoms are on each side, and the sulfonyl chloride group is also connected to it. This structure gives it specific chemical activity.
    In the process of synthesis, it is necessary to carefully control the reaction conditions, such as temperature, ratio of reactants, and use of catalysts. Precise operation can achieve the ideal yield and purity.
    It has a wide range of uses and is often a key building block for building complex molecular structures in the field of organic synthesis. It can react with a variety of nucleophiles to generate a series of compounds with special properties, which have potential application value in the fields of medicine and materials science. It is an indispensable material in chemical research.
    Physical & Chemical Properties
    2-Methyl-5-fluorobenzenesulfonyl chloride, this compound has unique physical and chemical properties. Its shape may be colorless to slightly yellow liquid, with a pungent smell and strong corrosiveness. The melting point and boiling point are specific, the melting point is about XX ° C, and the boiling point is about XX ° C. It has good solubility in organic solvents, such as with dichloromethane and chloroform.
    Chemical activity is quite high, and the sulfonyl chloride group is active. It is easy to react with nucleophiles such as alcohols and amines to generate corresponding sulfonates and sulfonamides. It is a key intermediate in the field of organic synthesis and can be used to create a variety of drugs, pesticides and functional materials. Because of its fluorine atom, it imparts special properties to the product, such as enhancing lipophilicity and improving chemical stability. When operating, caution is required. Due to its corrosive and irritating nature, safety procedures should be strictly followed and protective measures taken.
    Technical Specifications & Labeling
    Today there is a product called 2 - Methyl - 5 - Fluorobenzenesulfonyl Chloride. To clarify its technical specifications and identification (product parameters), it should be reviewed in detail. Its specifications are related to the composition, purity and properties of the substance. If the composition must be accurate, the impurity content must be low to meet the needs of use.
    In terms of identification, there should be a clear name, which should be marked on the utensils to make it clear to people at a glance. Its parameters should also be detailed, such as the melting point, boiling point of physical properties, and the reactivity of chemical properties, etc., all need to be accurately marked. In this way, the product can be fully displayed in front of the user, without the risk of misuse, and can meet the requirements of accuracy in technical specifications and labels to achieve the purpose of use.
    Preparation Method
    To prepare 2-methyl-5-fluorobenzenesulfonyl chloride, the method is as follows:
    Select the raw materials, use 2-methyl-5-fluorobenzene as the base, and supplement with chlorosulfonic acid. The combination of the two needs to be accurately measured and combined in proportion.
    Delay the injection of 2-methyl-5-fluorobenzene into the chlorosulfonic acid, and control the temperature during the period to stabilize it. Do not overheat and boil. When the two blend, the reaction gradually begins.
    When the reaction is carried out, add stirring often to make it fully contact and promote the complete reaction. Depending on the reaction, observe its changes and adjust it in a timely manner.
    After the reaction is completed, the follow-up treatment is also heavy. After neutralization, extraction, distillation and other steps, its impurities are removed and the product is purified. Each step is carefully operated to obtain pure 2-methyl-5-fluorobenzenesulfonyl chloride. And in the whole process, a control mechanism is set up to prevent unexpected changes and ensure the stability of production.
    Chemical Reactions & Modifications
    There are chemical things today, called 2 - Methyl - 5 - Fluorobenzenesulfonyl Chloride. In the chemical reaction and modification, it is really meaningful.
    Looking at its reaction, or combining with other things, the molecular structure is rearranged, the new bond is born and the old bond is broken, such as the ancient art of war, the layout changes, and it is planned to move later. When it encounters nucleophiles, chlorine atoms are easily replaced. This is a common way of reaction. It is like a soldier's attack and defense, and each has its own method.
    As for modification, specific groups can be introduced to adjust their physical and chemical properties. Or increase its stability, or change its solubility, such as good work to carve jade, carefully crafted to become a beautiful tool. It can be used in medicine and materials to exert its strengths and have great uses. The wonders of chemistry can be seen in the reaction and modification of this substance.
    Synonyms & Product Names
    2-Methyl-5-Fluorobenzenesulfonyl Chloride, it is also a chemical substance. Its name is the same, or 2-methyl-5-fluorobenzenesulfonyl chloride. It is sold in the market, and it is also a trade name. This substance is useful in chemical research, and its properties and functions are explored by Multiple people.
    Research and development, different classics,
    Safety & Operational Standards
    2-Methyl-5-Fluorobenzenesulfonyl Chloride is an important chemical substance and must be regulated in detail for its laboratory operation and safety.
    In terms of operating practices, all instruments must be clean and dry before the experiment. When taking this compound, use a clean and accurate measuring tool, and measure it accurately according to the needs of the experiment to avoid waste and pollution. During the operation, it should be carried out in a well-ventilated fume hood to prevent the accumulation of harmful gases. And the operator must wear laboratory clothes, protective gloves and goggles to fully protect himself.
    When it comes to safety, 2-Methyl-5-Fluorobenzenesulfonyl Chloride is corrosive and irritating. If it comes into contact with the skin accidentally, rinse it with plenty of water immediately, and then seek medical treatment according to the specific situation. If it comes into contact with the eyes, it is necessary to rinse the eyes with plenty of water immediately and seek medical attention as soon as possible. This compound is prone to reaction in contact with water or humid air, so it needs to be properly stored in a dry, cool and ventilated place, away from fire and heat sources. Discarded compounds must not be discarded at will, and should be properly disposed of in accordance with relevant regulations to prevent pollution to the environment.
    In short, when using 2-Methyl-5-Fluorobenzenesulfonyl Chloride, operators must strictly follow safety and operating practices, so as to ensure the safe and orderly conduct of experiments, while ensuring the safety of themselves and the environment.
    Application Area
    Today there is a substance called 2-methyl-5-fluorobenzenesulfonyl chloride. This substance has its uses in many fields.
    In the field of medicine, it can be used as a key intermediate. Through delicate chemical reactions, it can make special drugs to treat various diseases in the world. Or help antibacterial drugs to kill pathogenic bacteria; or used as anti-cancer agents to inhibit the growth of tumors.
    In the world of materials, it also has extraordinary power. It can participate in the synthesis of polymer materials and give materials special properties. Such as enhancing its stability and making it resistant to erosion over time; or changing its surface properties to make materials suitable for diverse needs.
    In chemical production, it is an important raw material. Through a series of processes, various useful products are produced, which are widely used in industrial production and daily use, and benefit the world.
    Research & Development
    Since modern times, chemistry has been refined, and the research of substances has become increasingly prosperous. Today, there is 2-Methyl-5-Fluorobenzenesulfonyl Chloride, which is of great significance in the way of research and development.
    We have investigated its properties in detail, studied its experimental methods, and explored the path of its synthesis. After repeated studies, we have known the law of its reaction and revealed its subtle nature. It may be a key agent in the field of organic synthesis, leading to various new paths.
    Looking at the chemical research in the past, many of them are found to be useful because of the quality of micro-ends. We also have high hopes for this material, hoping to develop its potential through continuous research and development, and make pioneering achievements in the fields of materials and medicine, so as to promote the research and development of this material, reach new territory, and contribute to the academic and industrial circles.
    Toxicity Research
    This research 2 - Methyl - 5 - Fluorobenzenesulfonyl Chloride is a chemical whose toxicity concerns everyone. The research on toxicity is my responsibility.
    Examine its properties carefully to show the toxicity. Or touch the skin, sensitize and hurt; or enter the breath, damage the lungs and organs. In the context of actual research, handle it cautiously, protect it well, and dare not slack off.
    Also observe the state of its chemical reaction, the toxicity of the product, all for consideration. To obtain detailed results, to clarify the rules of its toxicity, for the safety of use and the integrity of prevention, to exhaust my efforts, to explore the micro-knowledge, to protect the public from the danger of poisoning, so that this research benefits the world and is harmless to people.
    Future Prospects
    Fu 2 - Methyl - 5 - Fluorobenzenesulfonyl Chloride is gradually becoming more and more important in today's chemical research. Its structure is exquisite and its properties are also specific.
    Watching the future development of Fu, one of them may shine in the way of medical creation. With its characteristics, it can assist in the research of new drugs, treat various diseases, and prolong the disease of the common people. Second, in the field of material science, it may be able to contribute to the production of new materials. Make the material have better properties and apply it to a wide range of parties.
    Although there may be thorns in the road ahead, those who study chemistry in our generation should have a strong heart and explore the details. It is hoped that with unremitting efforts, it will reveal more secrets, expand the boundaries of its application, and lead to the future. This product can be used by the world, promoting advantages and eliminating disadvantages, becoming a great cause, and developing infinite possibilities.
    Where to Buy 2-Methyl-5-Fluorobenzenesulfonyl Chloride in China?
    As a trusted 2-Methyl-5-Fluorobenzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Methyl-5-Fluorobenzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-Methyl-5-Fluorobenzenesulfonyl Chloride?
    2-Methyl-5-fluorobenzenesulfonyl chloride is a crucial chemical reagent in the field of organic synthesis. It has a wide range of uses and has significant applications in many chemical processes and industrial fields.
    First, in the field of drug synthesis, 2-methyl-5-fluorobenzenesulfonyl chloride plays a key role. Medicinal chemists often use its reaction with specific nitrogenous and oxygen-containing nucleophiles to construct compound structures with specific pharmacological activities. For example, when reacted with amine compounds, sulfonamide structures can be formed. Many sulfonamide drugs show unique effects in antibacterial, anti-inflammatory, diuretic, etc. This reaction process can precisely achieve the synthesis of the target product by carefully regulating the reaction conditions, such as temperature, solvent, catalyst, etc., laying the foundation for the development of new drugs.
    Second, in the field of materials science, 2-methyl-5-fluorobenzenesulfonyl chloride also has extraordinary performance. It can be used to prepare polymer materials with special properties. By polymerizing with monomers containing active groups, the benzenesulfonyl chloride structure can be introduced into the polymer backbone or side chain. In this way, polymer materials are endowed with excellent thermal stability, chemical stability, and unique electrical properties. For example, in the synthesis of some high-performance engineering plastics, the clever use of such compounds can significantly improve the comprehensive properties of materials and meet the strict requirements of high-end industrial fields.
    Furthermore, in the basic research of organic synthetic chemistry, 2-methyl-5-fluorobenzenesulfonyl chloride is a commonly used intermediate, which helps chemists to explore new reaction pathways and reaction mechanisms. Due to the presence of methyl groups and fluorine atoms on the benzene ring, the molecules have unique electronic and spatial effects, providing opportunities for the design of novel chemical reactions. Based on this, scientists can deeply study their reaction characteristics with various reagents, expand the boundaries of organic synthetic chemistry, and contribute to the development of organic chemistry theory.
    In summary, 2-methyl-5-fluorobenzenesulfonyl chloride, with its diverse reactivity and unique structural characteristics, plays an indispensable role in the fields of drug synthesis, materials science and basic research in organic synthesis, and promotes the continuous development of related fields.
    What are the physical properties of 2-Methyl-5-Fluorobenzenesulfonyl Chloride?
    2-Methyl-5-fluorobenzenesulfonyl chloride, this is an important compound in organic chemistry. Its physical properties are quite critical and have far-reaching effects in chemical, pharmaceutical and other fields.
    Looking at its appearance, under room temperature and pressure, 2-methyl-5-fluorobenzenesulfonyl chloride is often in the form of a colorless to light yellow liquid, with a pure color and clear texture. It glows under the light, as if it contains endless mysterious power.
    Smell it, it emits a strong and pungent smell. This smell is very unique, like a wake-up call, warning everyone of its high chemical activity. If people accidentally come into contact with this smell, it may cause discomfort, so extreme caution is required when operating.
    When it comes to boiling point, this material has a high boiling point. Under a specific pressure environment, it needs a higher temperature to boil into a gaseous state. This characteristic determines its stability in high temperature environments and also provides a basis for its application in some chemical reactions.
    In terms of melting point, its melting point is a specific value. When the temperature drops to this point, the material gradually changes from liquid to solid, and the change of shape marks the adjustment of intermolecular forces, which puts forward special requirements for its storage and transportation conditions.
    The density of 2-methyl-5-fluorobenzenesulfonyl chloride is different from that of water. In chemical operations, this density difference has a significant impact on the separation, mixing and other steps, which is related to the accuracy and efficiency of the process.
    In terms of solubility, it exhibits good solubility in some organic solvents, such as common aromatic hydrocarbons and halogenated hydrocarbon solvents, which can be mixed with it to form a uniform and stable system. However, in water, its solubility is poor. This property is crucial in the design of reaction systems and product separation processes, and must be carefully considered.
    The above physical properties are intertwined to form a unique "chemical profile" of 2-methyl-5-fluorobenzenesulfonyl chloride, which lays the foundation for its application in different fields and is a key consideration for scientific research and industrial production.
    2-Methyl-5-Fluorobenzenesulfonyl the chemistry of Chloride
    2-Methyl-5-fluorobenzenesulfonyl chloride, this is an organic compound with active chemical properties. Its sulfonyl chloride group (-SO 2O Cl) is extremely active and is often an important intermediate in organic synthesis.
    In chemical reactions, sulfonyl chloride groups are prone to react with nucleophiles. In case of alcohols, sulfonates can be formed. If reacted with ethanol, after nucleophilic substitution, alcohol hydroxyl oxygen attacks the sulfonyl chloride sulfur atom, and the negative chloride ions leave to form 2-methyl-5-fluorobenzenesulfonate ethyl ester and hydrogen chloride.
    In case of amine compounds, sulfonamides can be formed. Like aniline reacts with it, the nitrogen atom of aniline attacks the sulfonyl chloride nucleophilically, resulting in N - (2-methyl-5-fluorophenyl) benzenesulfonamide and hydrogen chloride.
    In addition, the hydrolysis reaction is also an important property. In the presence of water, the sulfonyl chloride group will hydrolyze to form 2-methyl-5-fluorobenzenesulfonic acid and hydrogen chloride. This hydrolysis reaction is catalyzed by acid and base, and the rate will be significantly accelerated.
    Its methyl and fluorine atoms also affect the molecular properties. Methyl has a certain electron-giving effect, which can affect the electron cloud density of the benzene ring, and has an effect on the reaction activity and selectivity. Fluorine atoms have high electronegativity and electron-absorbing induction effect, which can reduce the electron cloud density of benzene ring and change the activity of ortho-para-substitution reaction. Fluorinated compounds often have unique biological activities in the fields of medicine and pesticides.
    2-methyl-5-fluorobenzenesulfonyl chloride is widely used in the field of organic synthesis due to its active chemical properties. It can be used to prepare a variety of sulfonyl compounds and plays a key role in many fields such as medicine, pesticides, and materials science.
    What are the synthesis methods of 2-Methyl-5-Fluorobenzenesulfonyl Chloride?
    The synthesis of 2-methyl-5-fluorobenzenesulfonyl chloride is an important topic in the field of organic synthesis. There are several common ways to synthesize this compound.
    First, 2-methyl-5-fluorobenzene is used as the starting material. First, 2-methyl-5-fluorobenzene interacts with fuming sulfuric acid and sulfur trioxide. After sulfonation, a sulfonic acid group is introduced into the benzene ring to obtain 2-methyl-5-fluorobenzenesulfonic acid. This step requires attention to the control of reaction temperature and time. If the temperature is too high or the time is too long, it is easy to cause side reactions and affect the yield. Then, 2-methyl-5-fluorobenzenesulfonic acid is reacted with thionyl chloride, and the sulfonic acid group is replaced by a chlorine atom to obtain 2-methyl-5-fluorobenzenesulfonyl chloride. In this reaction, thionyl chloride is both a reactant and a solvent. Catalysts such as pyridine can be added appropriately during the reaction to accelerate the reaction process.
    Second, 2-methyl-5-fluoroaniline can be started. First, 2-methyl-5-fluoroaniline is diazotized, and sodium nitrite and hydrochloric acid are treated at low temperature to form a diazonium salt. The diazonium salt is unstable, and the next reaction needs to be carried out in time. Next, the diazonium salt is reacted with sodium sulfite to generate 2-methyl-5-fluorobenzenesulfonate, and then acidified to obtain 2-methyl-5-fluorobenzenesulfonic acid. The following steps are the same as those using 2-methyl-5-fluorobenzene as the raw material, that is, the target product is prepared by reacting with thionyl chloride. This route has a little more steps, but the raw material 2-methyl-5-fluoroaniline is relatively easy to obtain, which is also a feasible method.
    Third, if a benzene derivative containing a suitable substituent is used as the starting material, it can also be achieved through a multi-step reaction. For example, benzene derivatives with groups that can be converted into methyl and fluorine atoms are selected, and methyl and fluorine atoms are introduced in sequence through suitable reactions, and then sulfonation and chlorination are carried out. However, this approach requires precise control of the reaction conditions, and the selectivity of each step of the reaction is quite high to avoid the formation of too many by-products.
    When synthesizing 2-methyl-5-fluorobenzenesulfonyl chloride, no matter what method is used, it is necessary to pay attention to the optimization of the reaction conditions, such as temperature, pH, reactant ratio, etc., to improve the purity and yield of the product. At the same time, the post-treatment step is also very important, and it is necessary to obtain high-purity 2-methyl-5-fluorobenzenesulfonyl chloride through suitable separation and purification methods, such as distillation, recrystallization, column chromatography, etc.
    What to pay attention to when storing and transporting 2-Methyl-5-Fluorobenzenesulfonyl Chloride
    2-Methyl-5-fluorobenzenesulfonyl chloride is a chemical substance. When storing and transporting, many matters need to be paid attention to.
    Let's talk about storage first. This substance is very active and easy to react with other substances, so it needs to be stored in a cool, dry and well-ventilated place. Avoid heat sources and fire sources to prevent it from being decomposed by heat or triggering the risk of combustion. Because it is sensitive to moisture, it is very easy to hydrolyze. It is necessary to keep the storage environment dry and can be maintained with the help of desiccants. And it should be stored separately from alkalis, alcohols and other substances. These substances are easy to chemically react with 2-methyl-5-fluorobenzenesulfonyl chloride and cause it to deteriorate. In addition, storage containers should also be carefully selected, and corrosion-resistant materials, such as glass or specific plastic containers, should be used to ensure their tightness and prevent leakage.
    As for the time of transportation. The first thing to ensure is that the packaging is intact. The packaging materials must be able to resist vibration, collision and friction to prevent material leakage due to damage to the container. During transportation, the temperature should also be strictly controlled, and it should not be exposed to high temperature environments. At the same time, transportation personnel need to be professionally trained to be familiar with the dangerous characteristics of this substance and emergency treatment methods. Transportation vehicles should also be equipped with corresponding emergency treatment equipment and protective equipment. In the event of an accident such as leakage, they can be responded to in a timely manner. In short, whether it is storing or transporting 2-methyl-5-fluorobenzenesulfonyl chloride, we must exercise caution and strictly follow relevant norms and requirements to ensure safety and avoid accidents.