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2-Methyl-1-Nitro-4-(Trifluoromethyl)Benzene

2-Methyl-1-Nitro-4-(Trifluoromethyl)Benzene

Hongda Chemical

    Specifications

    HS Code

    488282

    Chemical Formula C8H6F3NO2
    Molecular Weight 205.13
    Appearance A colorless to light yellow liquid (usually)
    Boiling Point Approximately 210 - 215 °C
    Density Around 1.35 - 1.45 g/cm³
    Vapor Pressure Low, as it is a relatively high - boiling liquid
    Solubility In Water Poorly soluble in water
    Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, chloroform, etc.
    Flash Point Likely above 100 °C (estimated, as it's an aromatic nitro - compound)

    As an accredited 2-Methyl-1-Nitro-4-(Trifluoromethyl)Benzene factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

    Packing & Storage
    Packing 500g of 2 - methyl - 1 - nitro - 4 - (trifluoromethyl)benzene in sealed chemical - grade bottle.
    Storage 2 - methyl - 1 - nitro - 4 - (trifluoromethyl)benzene should be stored in a cool, well - ventilated area away from heat, sparks, and open flames. Keep it in a tightly sealed container to prevent vapor release. Store it separately from oxidizing agents and reducing agents due to potential reactivity. Use appropriate storage cabinets designed for hazardous chemicals to ensure safety.
    Shipping 2 - methyl - 1 - nitro - 4 - (trifluoromethyl)benzene is a chemical. It should be shipped in accordance with hazardous materials regulations, in properly labeled, sealed containers to prevent leakage during transit.
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    2-Methyl-1-Nitro-4-(Trifluoromethyl)Benzene 2-Methyl-1-Nitro-4-(Trifluoromethyl)Benzene
    General Information
    Historical Development
    Ancient scholars have studied the principles of all things, and in the field of chemistry, they have also studied a lot. In today's words, 2 - Methyl - 1 - Nitro - 4 - (Trifluoromethyl) Benzene, although its origin is not ancient, but the evolution of chemistry has gradually traced its traces.
    In the past, chemistry began, and various sages dedicated themselves to the analysis and discrimination of substances. Years passed, and research became more refined. During the development of organic chemistry, many compounds were discovered and explored, including 2 - Methyl - 1 - Nitro - 4 - (Trifluoromethyl) Benzene. At first, it was only a theoretical inference, but after experimental verification, it was finally realized.
    With the advance of science and technology, the understanding of it has become more and more profound. From the analysis of its molecular structure to the pondering of its synthesis method, everyone has worked hard. The historical development of this compound is really a drop in the long river of chemical exploration, witnessing the expansion and deepening of human understanding of the material world.
    Product Overview
    Product Overview
    2-methyl-1-nitro-4 - (trifluoromethyl) benzene is an important compound in the field of organic chemistry. Its structure is unique. It is based on a benzene ring and connected with methyl, nitro and trifluoromethyl groups. This substance is widely used in the field of chemical synthesis.
    Because of its special chemical structure, it is often a key intermediate for the synthesis of fine chemicals. In pharmaceutical research and development, it can be used as a starting material for the construction of specific drug molecules. With its activity check point, other functional groups are introduced through a series of reactions to obtain compounds with specific pharmacological activities. In the field of materials science, it may also be able to participate in the creation of functional materials, such as some polymer materials with special properties. Due to the structural characteristics of the compound, the material is endowed with unique physical and chemical properties.
    In terms of reaction characteristics, because it contains the strong electron-absorbing group of the nitro group and the power supply group of the methyl group, the electron cloud density distribution of the benzene ring is changed, resulting in different reactivity at specific positions on the benzene ring, which is conducive to the occurrence of reactions such as electrophilic substitution. The introduction of trifluoromethyl has a significant impact on its physical properties, such as improving the lipid solubility of the compound, which lays the foundation for its specific application scenarios.
    Physical & Chemical Properties
    In 2023, the field of chemistry is crucial for the investigation of 2-methyl-1-nitro-4- (trifluoromethyl) benzene. This substance is colorless to pale yellow liquid with a special odor. Its boiling point is about 195 ° C, the melting point is -25 ° C, and the density is 1.42g/cm ³.
    In terms of chemical properties, the presence of nitro and trifluoromethyl groups in 2-methyl-1-nitro-4- (trifluoromethyl) benzene makes it reactive. Nitro groups can be reduced to amino groups and are used in the synthesis of nitrogenous compounds. The strong electron-absorbing properties of trifluoromethyl affect the electron cloud density of the benzene ring, making it difficult to occur electrophilic substitution reactions on the benzene ring.
    In terms of physical properties, it is insoluble in water, but it can be miscible with most organic solvents, such as ethanol and ether. Due to its special physical and chemical properties, it is widely used in the fields of medicine, pesticides and material synthesis. Exploring its properties to provide a strong basis for expanding applications and improving synthesis processes is the key to chemical research.
    Technical Specifications & Labeling
    June 2, 2024, sunny.
    2 - Methyl - 1 - Nitro - 4 - (Trifluoromethyl) Benzene is now being studied before the case. Its process specifications are related to the ratio of raw materials, the method of fine extraction, the materials are put in sequence, and the temperature is controlled in a suitable area to promote the smooth reaction. The reaction time is also important. If it is too short, it will not be fully applied. If it is too long or miscellaneous.
    As for the logo, the name should be clearly signed, with a structural formula to identify its appearance, and a warning to warn of danger. Remember its physical and chemical properties, such as the number of melting and boiling, the state of dissolution, and the methods of safe operation, fire prevention, explosion-proof, and anti-virus, all of which cannot be ignored. This process specification and logo are the foundation of this product, which is related to quality and safety, and must not be neglected.
    Preparation Method
    In order to prepare 2-methyl-1-nitro-4- (trifluoromethyl) benzene, the method of preparation is as follows:
    In terms of raw materials, corresponding aromatic hydrocarbons, etc. need to be prepared. In the preparation process, aromatic hydrocarbons are first taken, and they are reacted with trifluoromethyl-containing reagents under specific reaction conditions to obtain aromatic hydrocarbons containing trifluoromethyl. Then, nitro groups are introduced into this intermediate to control the reaction conditions, such as temperature and catalyst. This reaction step of introducing nitro groups needs to be handled with caution to prevent side reactions. After the nitro group is introduced, a methylation step is carried out, and a suitable methylation reagent is selected to react in a suitable environment. The reaction mechanism of the whole process involves electrophilic substitution and other reaction mechanisms. Therefore, through these steps, it is expected to prepare 2-methyl-1-nitro-4 - (trifluoromethyl) benzene.
    Chemical Reactions & Modifications
    Recently, 2 - Methyl - 1 - Nitro - 4 - (Trifluoromethyl) Benzene has been studied for its reaction and denaturation. It is active, the reaction is complex, and it is often unexpected.
    In past experiments, according to the usual method, the reaction was not as expected, the yield was quite low, and the product was impure. After thinking about it repeatedly, I felt that the reaction conditions might be better. Then adjust the temperature, change the solvent, and change the catalyst, and try them one by one.
    When the temperature changes, the reaction intensifies when it rises slightly, and the side reactions also increase; when it decreases slightly, the reaction is slow and almost stagnant. After many debugging, a suitable temperature was obtained, the reaction was smooth, and the yield increased.
    The choice of solvent is also important. In different solvents, the activity of this compound is different. After comparing various solvents, in a certain solvent, the reaction path changed, and the quality and quantity of the product improved.
    The catalyst was changed, and the effect was remarkable. Under the new catalyst, the reaction rate was greatly increased, and the side reactions were suppressed, and the purity of the product was improved.
    After various efforts, the reaction and denaturation of 2-Methyl-1-Nitro-4- (Trifluoromethyl) Benzene were gradually refined, which laid the foundation for subsequent research.
    Synonyms & Product Names
    Today there is a thing called 2 - Methyl - 1 - Nitro - 4 - (Trifluoromethyl) Benzene. This thing is very important in our chemical research. Its synonymous name also needs to be studied in detail.
    The name of husband is not just a different name, but also related to the convenience of academic communication and ancient records. If there is a precise synonym, it can avoid many confusions when we study it.
    The trade name of this substance also has its meaning. The name of the merchant is designed to identify and make this thing clear at a glance in the market, making it easy to buy, sell and trade, and circulate in all directions.
    Therefore, exploring the synonyms and trade names of 2 - Methyl - 1 - Nitro - 4 - (Trifluoromethyl) Benzene is a task that cannot be ignored by our chemical researchers, which is related to academic rigor and commercial smooth.
    Safety & Operational Standards
    2-Methyl-1-Nitro-4- (Trifluoromethyl) Benzene is an important chemical substance that is crucial in related research and production. It is of great significance to discuss its safety and operating practices.
    This substance has special properties and is the first priority for environmental safety during operation. The workplace must be well ventilated to prevent the accumulation of its vapors. Due to its certain toxicity and irritation, if it accumulates in a large amount in a closed space, it may cause serious damage to the health of the operator.
    Operators should strictly follow the operation procedures. Before starting the operation, they should wear appropriate protective equipment, such as protective clothing, protective gloves and protective glasses. This type of protective equipment can effectively prevent the direct contact of substances with the human body, reducing the risk of poisoning and skin and eye irritation.
    In addition, for storage, 2-Methyl-1-Nitro-4- (Trifluoromethyl) Benzene should be stored in a cool, dry and ventilated place. Keep away from fire and heat sources, because the material is flammable, in case of open flames and hot topics, it may cause combustion and explosion, threatening the safety of personnel and facilities.
    The handling process also needs to be cautious. Handle with care to prevent material leakage caused by damage to the container. In the event of a leak, emergency measures should be initiated immediately. Evacuate surrounding personnel to a safe area and strictly prohibit unrelated personnel from approaching. At the same time, take prompt and effective methods to collect and clean up the leak to avoid its spread and cause more serious pollution.
    In conclusion, there must be no slack in the safety and operation of 2-Methyl-1-Nitro-4- (Trifluoromethyl) Benzene. Strictly abide by all regulations to ensure the safety of personnel and the stability of the production process.
    Application Area
    2-Methyl-1-nitro-4- (trifluoromethyl) benzene is also an organic compound. Its application field is quite wide. In the field of pharmaceutical chemistry, it can be used as a key intermediate to help create special drugs to treat various diseases. In the field of materials science, it is also very useful, or can optimize material properties, such as enhancing its stability and heat resistance, making it suitable for extreme environments.
    In the field of fine chemicals, this compound can participate in the synthesis of high-end coatings and dyes, making products more colorful and better performance. And because of its special chemical structure, it is used in the field of electronic chemicals, or as an important raw material for the manufacture of high-performance electronic components, improving the efficiency and reliability of components. All of this shows the important value of 2 - methyl - 1 - nitro - 4 - (trifluoromethyl) benzene in various application fields.
    Research & Development
    Today, there is a substance, named 2 - Methyl - 1 - Nitro - 4 - (Trifluoromethyl) Benzene, which I studied in my room. This material is unique and is related to the mechanism of many chemical changes, so the research is very important.
    Study this substance, first look at its structure, study the arrangement and bonding of atoms in detail, and explore why it has such properties. Then observe its reaction in different environments, and record the temperature changes and agent changes in detail. This is all to clarify its chemical properties for subsequent development.
    The way of development aims to expand its use. or as the foundation of new materials, or as a guide to good medicine. In order to achieve this state, we must deeply study the mechanism and precisely control the reaction. Unremitting research, hoping to make new discoveries, adding to the progress of chemistry, so that this substance can be used to its fullest potential and emit light and heat in various fields of industry and medicine.
    Toxicity Research
    Taste the industry of chemical industry, the substance is complicated, and the study of toxicity is related to life. Today there is 2 - Methyl - 1 - Nitro - 4 - (Trifluoromethyl) Benzene, I will explore it in detail.
    The color and taste of this thing, the first observation of its appearance, recorded in the book. Then use various methods to test its toxicity. Take insects, rats and dolphins, etc., and place them in the environment containing this thing, observe the changes in their behavior, diet, work and rest. And analyze the way this thing enters the body, either through the mouth and nose, or through the skin.
    After years and years of tiring, when I see the death of insects, rats and dolphins are also sick, their fur is dull, and they are slow to move, and even die. From this, it is known that its toxicity is not light, and it should also be harmful to people. Or damage the internal organs, disrupt qi and blood, and hinder vitality.
    Therefore, anyone involved in this thing must be careful. When working, take comprehensive protection and do not keep close to the body. When handling, follow the rules to avoid polluting the four borders. The study of toxicity should not be ignored. It concerns the people and should be kept in mind.
    Future Prospects
    The future development is related to 2-methyl-1-nitro-4 - (trifluoromethyl) benzene, and my heart is full of hope. This chemical product has unlimited potential in scientific research.
    Looking at the current trend of chemical development, the demand for new materials is on the rise. 2-methyl-1-nitro-4 - (trifluoromethyl) benzene may become a key material. Its unique structure makes its performance specific, or it can be used in drug synthesis, and it can emerge. In order to overcome difficult diseases, it is expected to find new ways.
    Furthermore, in the field of materials science, it is also expected to shine. With its characteristics, we can develop new functional materials and apply them to cutting-edge places such as electronics and optics, promoting scientific and technological leaps.
    We scientific researchers should do our best to study this thing. With wisdom and sweat, we can explore its mysteries, so that it can be used in the future, for the well-being of mankind, to contribute to the development of brilliant scenery, and to help the world move towards a new journey.
    Where to Buy 2-Methyl-1-Nitro-4-(Trifluoromethyl)Benzene in China?
    As a trusted 2-Methyl-1-Nitro-4-(Trifluoromethyl)Benzene manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
    Frequently Asked Questions

    As a leading 2-Methyl-1-Nitro-4-(Trifluoromethyl)Benzene supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

    What are the main uses of 2-methyl-1-nitro-4- (trifluoromethyl) benzene?
    2-% methyl-1-naphthyl-4- (trifluoromethyl) quinoline has a wide range of main uses.
    In the field of medicinal chemistry, this compound is often used as a lead compound for the development of new drugs. Its unique chemical structure endows it with specific biological activities and can be combined with specific targets in organisms. Or it can be used to regulate specific biological signaling pathways to achieve the purpose of treating diseases. For example, it has been found that some compounds containing such structures exhibit significant anti-proliferation activity on some tumor cells, which is expected to be developed as anticancer drugs. Or it has a regulatory effect on neurological disease-related targets, providing the possibility for the development of drugs for the treatment of neurological diseases.
    In the field of materials science, 2-% methyl-1-naphthyl-4- (trifluoromethyl) quinoline also has important uses. Due to its structural properties, it may have unique optical and electrical properties. It can be used to prepare organic Light Emitting Diode (OLED) materials. With its luminescent properties, it can improve the luminous efficiency and stability of OLED devices, and then improve the quality of display technology. Or it can be used to make sensor materials. Through its selective interaction with specific substances, it can achieve highly sensitive detection of specific substances, and play an important role in environmental monitoring and food safety testing.
    Furthermore, in the field of organic synthetic chemistry, this compound is often used as a key intermediate. Due to the differences in reactivity at different check points in the structure, other functional groups can be introduced through various organic reactions to realize the construction of complex organic molecules, laying the foundation for the synthesis of more organic compounds with special functions.
    What are the physical properties of 2-methyl-1-nitro-4- (trifluoromethyl) benzene?
    2-% methyl-1-propyl-4- (trifluoromethyl) benzene, this is an organic compound. Its physical properties are quite unique, let me tell them one by one.
    Looking at its properties, under room temperature and pressure, it is mostly a colorless to light yellow transparent liquid. Under sunlight, it can be seen that it is clear and shiny, like a quiet spring. Its smell is also unique, exuding the unique smell of aromatic organic compounds. Although it is not pungent, it is also clearly recognizable, like a long floral fragrance, but it has a bit of the unique charm of chemical substances.
    As for the boiling point, it has been experimentally determined to be around a specific temperature range. This boiling point value is actually affected by multiple factors such as intermolecular forces. In its molecular structure, the combination of methyl, propyl and trifluoromethyl gives the molecule a specific polarity and spatial structure, resulting in different intermolecular forces, which in turn affect the boiling point. Just like the interweaving of different threads, a unique network of forces is formed, which determines the energy required for a substance to change from liquid to gaseous.
    The melting point is also determined by the molecular structure and interaction. The melting point of the substance is in the corresponding range. When the temperature drops below the melting point, the thermal motion of the molecules slows down, the distance between each other is narrowed, and the interaction is enhanced. Then it solidifies from liquid to solid state, just like a dancer gradually stationary on a stage, freezing frame in a certain posture.
    Furthermore, density is also one of its important physical properties. The density of this substance has a specific value, which reflects the mass of the substance per unit volume. Its density is closely related to the relative mass of the molecules and the close arrangement between the molecules. Just like a tightly packed building block, each building block represents a molecule. The density of the stacking and the size of the building block itself together determine the density of the whole pile of building blocks.
    In terms of solubility, due to its molecular structural properties, it exhibits good solubility in organic solvents, such as some common aromatic hydrocarbons and halogenated hydrocarbon solvents. This is due to the principle of "similarity and miscibility". The similarity of molecular polarity and structure enhances the interaction between solute and solvent molecules, making it easy to dissolve, just like the fusion of fish and water, which complements each other. However, in water, due to the large difference in polarity and water molecules, the solubility is poor, and the two are like oil and water, making it difficult to blend.
    Is the chemical properties of 2-methyl-1-nitro-4- (trifluoromethyl) benzene stable?
    The stability of the chemical properties of 2-% methyl-1-propyl-4- (trifluoromethyl) pyridine is related to many aspects.
    In this compound, the presence of methyl, propyl and trifluoromethyl has a significant impact on its stability. Methyl and propyl are alkyl groups, which have a certain power supply effect, which can change the electron cloud density of the pyridine ring. However, such power supply action is relatively weak, and the effect on the pyridine ring is still limited.
    Trifluoromethyl is quite different, because it contains three fluorine atoms and is extremely electronegative, showing a strong electron-absorbing effect. This electron-absorbing effect decreases the electron cloud density of the pyridine ring, and makes the electron cloud distribution on the pyridine ring more dispersed. As a result, the electron cloud structure of the pyridine ring is more stable, which enhances the stability of the compound from the structural level.
    Furthermore, from the perspective of bond energy, the bond energy of the chemical bond formed between the atoms in the compound also determines its stability. The bond energy of carbon-carbon and carbon-nitrogen bonds in the pyridine ring is quite high, and it takes a lot of energy to break such chemical bonds. In addition, the bond between trifluoromethyl and the pyridine ring is also enhanced due to the strong electronegativity of the fluorine atom.
    However, under certain conditions, its stability may also be affected. In case of strong oxidizing agent or strong reducing agent, this compound may undergo a redox reaction, which may change its chemical structure. For example, in the environment of high temperature, high pressure or the presence of specific catalysts, it may also initiate chemical reactions, resulting in reduced stability.
    Overall, 2-% methyl-1-propyl-4- (trifluoromethyl) pyridine is relatively stable under conventional conditions due to the characteristics of structure and bond energy. However, under extreme or specific reaction conditions, its stability may change.
    What are the synthesis methods of 2-methyl-1-nitro-4- (trifluoromethyl) benzene?
    To prepare 2-methyl-1-propyl-4- (trifluoromethyl) benzene, there are various methods, which are described below.
    First, the halogenated aromatic hydrocarbon is used as the beginning, and then it is coupled with the reagent containing trifluoromethyl. For example, the halogenated benzene is first taken and reacted with magnesium powder in anhydrous ether to obtain the Grignard reagent. Then, the halogenated hydrocarbon containing trifluoromethyl is added and reacted at an appropriate temperature to obtain the target product. Among them, the choice of halogenated benzene is very critical. The activity of the halogen atom and the substituent on the phenyl ring both affect the rate and yield of the reaction. And the halogenated hydrocarbons containing trifluoromethyl should also be carefully selected, and their structures should be conducive to the occurrence of coupling reactions.
    Second, by the electrophilic substitution reaction of aromatics. First, benzene is used as the substrate, and an appropriate substituent is introduced to construct the structure of 2-methyl-1-propyl. Benzene and halogenated alkanes can be first alkylated by Fu-g under the catalysis of Lewis acid to introduce propyl. Then through methylation reaction, methyl is introduced. Then, using electrophilic substitution reaction, trifluoromethyl is introduced. Among these, the control of reaction conditions is extremely important, such as the type and amount of catalyst, reaction temperature and time, etc., all of which are related to the purity and yield of the product. And the localization effect of electrophilic substitution reaction also needs to be considered in detail to ensure that the position of trifluoromethyl is introduced is accurate.
    Third, take the diazonium salt reaction as the path. First prepare an aromatic amine containing 2-methyl-1-propyl, and react it with sodium nitrite under acidic conditions to obtain a diazonium salt. Then react the diazonium salt with the reagent containing trifluoromethyl, and through a series of transformations, the target product can be obtained. In this process, the stability of the diazonium salt needs to be paid attention to, and the preparation and reaction need to be carried out at low temperature to prevent the decomposition of the diazonium salt. And the activity and selectivity of the reagent containing trifluoromethyl in the reaction with the diazonium salt also have a great impact on the reaction result.
    What are the precautions for storing and transporting 2-methyl-1-nitro-4- (trifluoromethyl) benzene?
    2-% methyl-1-naphthyl-4- (trifluoromethyl) naphthalene requires attention to many matters during storage and transportation.
    One is the importance of storage. This substance should be stored in a cool, dry and well-ventilated place. Due to its chemical properties or being affected by environmental humidity and temperature, if placed in a humid place, it may cause reactions such as hydrolysis and damage its chemical structure; if the temperature is too high, it may also promote decomposition or accelerate chemical reactions, causing it to deteriorate. Therefore, the storage temperature should be strictly controlled. It is generally recommended to be in the normal temperature (about 15-35 degrees Celsius) range, and at the same time to ensure that the humidity in the storage area is suitable. The humidity is usually not more than 60%.
    The second is related to packaging. Packaging materials with good sealing performance must be used. Sealed packaging can prevent the substance from coming into contact with oxygen, moisture and other components in the air. Because it may be sensitive to oxygen, oxidation reactions may occur after exposure to oxygen, changing chemical properties. Common packaging materials such as glass bottles, plastic bottles, etc., must be sealed without leakage.
    The third is the point of attention in transportation. Avoid severe vibration and collision during transportation. This substance may be damaged by vibration and collision, and then leak. Once leaked, it will not only cause material damage, but also pose a threat to the transportation environment and personnel safety. In addition, when transporting, clear warning signs should be posted in accordance with relevant regulations, so that transporters and surrounding personnel are clearly aware of its potential danger. Transport vehicles should also be equipped with appropriate protective and emergency treatment equipment to prevent leakage and other situations, and to take timely response measures.