As a leading 2-[(Methoxycarbonyl)Amino]-1H-Benzimidazol-6-Yl 4-Fluorobenzenesulfonate supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.
What is the chemical structure of 2- [ (Methoxycarbonyl) Amino] -1H-Benzimidazol-6-Yl 4-Fluorobenzenesulfonate
This is about the chemical structure of "2- [ (methoxycarbonyl) amino] -1H-benzimidazole-6-yl 4-fluorobenzenesulfonate". I will use the words of Gu Ya to solve this doubt for you.
The structure of this compound is made up of several parts. "2- [ (methoxycarbonyl) amino]" part, the methoxy group is connected to the carbonyl group, and the carbonyl group is related to the amino group. This structure is like a corner of a building and has its unique structure and function. " 1H-benzimidazole-6-yl ", the ring system of benzimidazole, has unique aromaticity and stability, like a solid cornerstone, receiving connections elsewhere at the 6-position, laying the foundation for the entire molecule." 4-Fluorobenzenesulfonate ", fluorine atoms are connected to the benzene ring, giving it special electronic effects and chemical activities. The benzene ring is connected to the sulfonate, and the sulfonate part is like a flexible wing, affecting the solubility of the molecule and other properties.
Its overall structure is like a carefully constructed chemical pavilion. Each part complements each other and is chemically bonded in a unique spatial arrangement to form this specific chemical entity, which shows its unique chemical and physical characteristics in the field of chemistry. In this way, you can know a thing or two about its chemical structure.
What are the physical properties of 2- [ (Methoxycarbonyl) Amino] -1H-Benzimidazol-6-Yl 4-Fluorobenzenesulfonate
2-% 5B% 28 Methoxycarbonyl% 29 Amino% 5D-1H-benzimidazole-6-yl 4-fluorobenzenesulfonate This substance has the following physical properties.
Viewed its state, under room temperature, or solid. Its color, or white to off-white powder, with fine texture, like snow falling into the world, under sunlight, or shimmering.
Smell its smell, or have a faint special smell, but this smell is neither fragrant nor pungent, and its unique smell can only be felt when you smell it.
When it comes to solubility, it may show some differences in common organic solvents. In polar organic solvents, such as methanol and ethanol, there may be a certain solubility, just like salt merging into water, quietly dispersing in it to form a uniform solution. In non-polar organic solvents, such as n-hexane, toluene, etc., the solubility may be very low, just like oil dripping in water, and it is difficult to melt.
Looking at its melting point, this substance has been determined, or has a specific melting point value. When heated to this temperature, its solid state gradually melts, just like ice and snow meeting warm sun, slowly turning into a liquid state. The characteristics of this melting point are also an important indicator for identifying this substance.
Furthermore, its density is also one of the key characteristics of physical properties. Through accurate measurement, the mass per unit volume can be obtained. This value is of great significance in the storage, transportation and application of substances, and is related to the selection of containers and the measurement of loading.
Its stability may remain relatively stable under normal conditions. However, in case of extreme conditions such as high temperature, strong light, high humidity, or chemical changes, resulting in changes in its structure and properties, it is necessary to choose a suitable environment for storage to ensure its quality.
What is the use of 2- [ (Methoxycarbonyl) Amino] -1H-Benzimidazol-6-Yl 4-Fluorobenzenesulfonate
2-% 5B% 28 methoxycarbonyl% 29 amino% 5D-1H-benzimidazole-6-yl 4-fluorobenzenesulfonate is useful in the fields of medicine and chemical industry.
In the process of pharmaceutical research and development, it is often an intermediate for active pharmaceutical ingredients. With its unique chemical structure, it can participate in a variety of chemical reactions and help build complex drug molecular structures. For example, by condensation and substitution reactions with other compounds containing specific functional groups, new compounds with specific pharmacological activities can be formed, paving the way for the creation of new drugs for the treatment of difficult diseases.
In the process of chemical production, it can be used as a key raw material for the synthesis of functional materials. In the field of fine chemistry, it can be used to prepare polymer materials and surfactants with special properties. If it is introduced into the structure of a polymer, it can endow the material with unique properties such as better solubility, thermal stability, biocompatibility, etc., thereby expanding the application of the material in different scenarios, such as biomedical engineering, electronic materials and other fields.
In addition, in the field of chemical research, as a model compound, it has made great contributions to exploring the reaction mechanism and optimizing the reaction conditions. Chemists can conduct in-depth studies of the chemical reactions they participate in, clarify the influence of various factors on the reaction process and products, and contribute to the innovation of chemical synthesis methods and the improvement of theories. Overall, although 2-% 5B% 28 methoxycarbonyl% 29 amino% 5D-1H-benzimidazole-6-yl 4-fluorobenzenesulfonate is small, it plays a significant role in many fields and has broad future development prospects.
What is the synthesis method of 2- [ (Methoxycarbonyl) Amino] -1H-Benzimidazol-6-Yl 4-Fluorobenzenesulfonate
To prepare 2- [ (methoxycarbonyl) amino] -1H-benzimidazole-6-yl 4-fluorobenzenesulfonate, the method is as follows:
First take an appropriate amount of 1H-benzimidazole-6-amine, place it in a clean reactor, and dissolve it with an appropriate amount of organic solvent. This organic solvent needs to be mild in nature and not react with the reactants and products too much, such as dichloromethane. Then, under stirring, slowly add a methoxycarbonylating agent, such as methyl chloroformate. When reacting, the temperature should be controlled in a moderate range, about 0-5 ° C is better, because the reaction is more sensitive, too high temperature is easy to cause side reactions to breed. At the same time, add an appropriate amount of acid binding agent, such as triethylamine, to help the reaction proceed to the right. The amount of acid binding agent needs to be precisely controlled. Too much or too little will affect the reaction effect. Keep stirring for a few times until the reaction reaches the desired level, and the reaction process can be monitored by means of thin-layer chromatography.
After the methoxycarbonylation reaction of 1H-benzimidazole-6-amine is completed, the reaction solution is properly treated, and impurities are removed by conventional extraction, washing, drying, etc., to obtain 2- [ (methoxycarbonyl) amino] -1H-benzimidazole-6-derivative crude product, and then refined by recrystallization to obtain pure 2- [ (methoxycarbonyl) amino] -1H-benzimidazole-6-derivative.
Then, take the 2- [ (methoxycarbonyl) amino] -1H-benzimidazole-6-derivative obtained from the above refining, add it to a new reactor, and dissolve it with a suitable solvent. This solvent can be selected as N, N-dimethylformamide. Add 4-fluorobenzenesulfonyl chloride, and add an appropriate amount of base, such as potassium carbonate, which can promote the reaction. The reaction temperature should be raised to an appropriate height, about 50-60 ° C, and the reaction should be continuously stirred for a period of time. During the reaction, the progress should also be observed by suitable monitoring methods.
When the reaction is complete, the reaction solution is separated and purified through steps such as column chromatography, carefully separating the product, removing unreacted raw materials and by-products. Finally, pure 2- [ (methoxycarbonyl) amino] -1H-benzimidazole-6-yl 4-fluorobenzenesulfonate can be obtained. Throughout the synthesis process, attention should be paid to the precise control of reaction conditions, the purity of raw materials and reagents, and the operation of each step must be standardized, so as to obtain the ideal yield and purity.
2- [ (Methoxycarbonyl) Amino] -1H-Benzimidazol-6-Yl 4-Fluorobenzenesulfonate
2-% 5B% 28 Methoxycarbonyl% 29 Amino% 5D-1H-benzimidazole-6-yl 4-fluorobenzenesulfonate This material is related to safety and requires caution.
First, many chemical substances have unique properties, and this compound may be potentially harmful. When storing, it should be stored in a dry, cool and well-ventilated place, away from fire and heat sources. It may cause fire or explosion due to heat or chemical reactions. And it should be stored separately from oxidizing and reducing substances to prevent interaction and lead to safety accidents.
Second, the operation process must be strictly followed. Operators should wear protective clothing, protective gloves and goggles to avoid skin contact and eye splashing. If inadvertently contact, should immediately rinse with a large amount of water, and timely medical treatment. Operate in the fume hood to prevent the inhalation of harmful gases. If it is uncomfortable to inhale, quickly leave the scene, breathe fresh air, and seek medical treatment if necessary.
Third, the disposal of waste should not be ignored. It should not be dumped at will, and it should be handed over to a professional treatment agency in accordance with relevant regulations. Due to its composition or harmful to the environment, improper disposal will cause soil and water pollution, endangering the ecology.
Fourth, special care should also be taken during transportation. Ensure that the packaging is in good condition, shockproof and leak-proof, and handle it according to the requirements of dangerous chemical transportation. Select qualified transportation enterprises and personnel to ensure transportation safety. Overall, this chemical substance should be treated with caution, from storage and handling to disposal and transportation, to ensure personal safety and environmental safety.