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2-Methoxy-5-Fluorobenzeneboronic Acid

2-Methoxy-5-Fluorobenzeneboronic Acid

Hongda Chemical

Specifications

HS Code

627843

Chemical Formula C7H8BFO3
Molar Mass 169.95 g/mol
Appearance Solid
Purity Typically high purity in commercial products
Solubility In Water Low solubility
Solubility In Organic Solvents Soluble in some organic solvents like dichloromethane
Melting Point 125 - 130 °C (approximate, may vary depending on purity)
Boiling Point Decomposes before boiling
Acidity Weakly acidic due to boronic acid group
Stability Stable under normal conditions, but sensitive to moisture and strong bases

As an accredited 2-Methoxy-5-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2 - methoxy - 5 - fluorobenzeneboronic acid packaged in a sealed plastic bag.
Storage 2 - methoxy - 5 - fluorobenzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption and contact with air, which could potentially lead to decomposition. Store it separately from incompatible substances like strong oxidizing agents and bases to ensure its stability and safety.
Shipping 2 - methoxy - 5 - fluorobenzeneboronic acid is shipped in well - sealed, corrosion - resistant containers. Shipment follows strict chemical transport regulations, ensuring proper handling to prevent damage, leakage, and potential hazards during transit.
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2-Methoxy-5-Fluorobenzeneboronic Acid 2-Methoxy-5-Fluorobenzeneboronic Acid
General Information
Historical Development
Fu 2 - Methoxy - 5 - Fluorobenzeneboronic Acid, its origin is also, at the beginning, all the sages in the field of chemistry to explore. At that time, the study of boride, gradually getting better.
At the beginning of the wise people, thinking about the benzene ring as a base, adding fluorine, methoxy, and boron to form this new product. At the time of initial production, the technique is not refined, the yield is still low.
However, the researchers are determined and unremitting in their search. Over the years, the process has progressed. Or improve the reaction conditions, temperature control, pressure regulation, so that the reaction is smooth; or find better reagents, so that the yield gradually rises, the higher the purity.
As a result, 2 - Methoxy - 5 - Fluorobenzeneboronic Acid has gradually shown its ability in the fields of medicine and materials, opening up new paths for future researchers and adding a bright color to the history of chemistry.
Product Overview
2-Methoxy-5-fluorophenylboronic acid, this compound is a key raw material in the field of organic synthesis. Its properties are white to off-white solids, which are quite stable at room temperature and pressure.
Looking at its structure, methoxy and fluorine atoms are cleverly connected to the benzene ring, and boron atoms are connected to two hydroxyl groups. This unique structure endows it with diverse reactivity. In many organic synthesis reactions, 2-methoxy-5-fluorophenylboronic acid is often used as a key intermediate. Through the Suzuki-Miyaura coupling reaction, it can be coupled with halogenated aromatics or olefin compounds to form carbon-carbon bonds efficiently, and is widely used in the preparation of fine chemicals in the fields of medicine, pesticides, materials, etc.
Due to the synergistic effect of methoxy-based power supply and fluorine atom electron-absorbing effect, the electron cloud density distribution of the benzene ring is unique, resulting in specific selectivity and reactivity in chemical reactions, providing a powerful way to synthesize complex organic molecules and playing an indispensable role in the development of organic synthesis chemistry.
Physical & Chemical Properties
2-Methoxy-5-fluorophenylboronic acid is also an organic compound. Its physical and chemical properties are quite important to scholars.
Looking at its properties, it mostly shows a white to quasi-white solid state at room temperature. The number of melting points is about a specific range. This is its inherent physical sign. It is of great significance in the process of identification and purification.
Discuss chemical properties. Because it contains specific atomic groups such as boron and fluorine, it is active and has unique reaction characteristics. The presence of boron atoms makes it a key intermediate in many organic reactions, interacting ingeniously with various nucleophiles and electrophilics to realize the construction of carbon-carbon and carbon-heteroatom bonds. The introduction of fluorine atoms significantly affects the electron cloud distribution of molecules, and then changes their polarity and stability, giving this compound broad application prospects in the fields of medicinal chemistry, materials science and other fields. The study of its physical and chemical properties is the key to unlocking its potential uses, paving the way for related scientific exploration.
Technical Specifications & Labeling
There is a product today, named 2 - Methoxy - 5 - Fluorobenzeneboronic Acid. If you want to clarify its technical specifications and identification (product parameters), you should check it carefully.
The technical specifications of this product are related to its quality, its quantity and its nature. The quality, the composition must be pure, and the impurities must not exceed the limit. The quantity, the content is accurate, not less than a millimeter. For those who are sexual, under specific conditions, its chemical properties must be stable. In case of temperature change or agent, it should not disrupt its original state.
The identification (product parameters) is also heavy. When marking its name, correct its number; state its source to clarify its root; list its danger to warn people. And on the packaging, the handwriting is clear, so as not to confuse the viewer. In this way, the technical specifications and identification (product parameters) of this object can be clearly understood, which is beneficial for research and development and use.
Preparation Method
To prepare 2-methoxy-5-fluorophenylboronic acid, the method is as follows:
The choice of raw materials, when taking the benzene compound containing fluorine and methoxy group as the base, supplemented by boron source. Boron sources, such as borate esters, have good properties and can react smoothly with benzene substrates.
The preparation process first makes the benzene substrate and boron miscible in a suitable solvent. The properties of the solvent need to be compatible with the reactants and stable without disturbing the reaction, such as ether or aromatic hydrocarbon solvents. Then, add an appropriate amount of catalyst, which can promote the reaction speed and reduce the activation energy. Such as palladium catalysts, it is commonly used.
Reaction steps, temperature control in an appropriate range, usually heated to raise the temperature to tens to hundreds of degrees Celsius, depending on the activity of the substrate and the reagent. At this temperature, when the number of reactions is made, stirring is often added during the period to make the material mix evenly and promote the reaction to be homogeneous.
Catalytic mechanism, palladium catalyst is coordinated and complexed with the substrate and boron source, through oxidative addition, metallization, reduction and elimination, etc., to form a carbon-boron bond, to obtain the target product 2-methoxy-5-fluorophenylboronic acid. In this way, following this process, this compound can be obtained.
Chemical Reactions & Modifications
Nowadays, there are chemical products of 2-methoxy-5-fluorophenylboronic acid. In the field of chemistry, the reaction and modification of this product are extremely critical. The reaction of this product is related to many chemical processes, or involves nucleophilic substitution, or coupling. The purpose of modification is to optimize its properties, or increase its stability, or change its activity.
In order to improve the performance of this product, it is necessary to study its reaction mechanism in depth. Looking at the past method, there may be some shortcomings, and it is necessary to seek improvement. After repeated exploration, try new methods, and hope to obtain better reaction effects and modification results. With unremitting research, 2-methoxy-5-fluorophenylboronic acid can play a unique role in chemical applications and contribute to the development of the chemical field.
Synonyms & Product Names
2-Methoxy-5-Fluorobenzeneboronic Acid, the synonym and trade name of this thing, is worth exploring. The field of Guanfu chemistry, the same substance, is called or different. Or because of the special way of making it, or because of the different applications, and the names are different.
This acid may be nicknamed for its structural characteristics. Its methoxy group is connected to the fluorine atom in the benzene ring and boron atom, so it is called according to this structural characteristic. As for the trade name, the merchant may have a unique logo to facilitate its promotion and establish another name. Although the names are different, they all refer to this 2-Methoxy-5-Fluorobenzeneboronic Acid. In chemical research, it is really beneficial to clarify its synonyms and trade names for accurate communication and in-depth exploration.
Safety & Operational Standards
2-Methoxy-5-fluorophenylboronic acid safety and operating specifications
Fu 2-methoxy-5-fluorophenylboronic acid is a commonly used substance in chemical research. When using and studying this compound, safety and operating standards are of paramount importance.
Safety is the first word. Although this compound has scientific research value, it may be potentially dangerous. Its properties may be harmful to the human body, and caution must be taken when exposed. If it touches the skin, rinse with plenty of water as soon as possible to prevent harmful ingredients from infiltrating the skin and damaging the body. If it does not enter the eyes carefully, it should not be ignored. It is necessary to rinse with flowing water immediately and seek medical treatment urgently to avoid harming the eyes.
Times and operating instructions. During the experimental operation, the experimental site must be well ventilated to prevent the accumulation of volatile gas from the compound and endanger the health of the experimenter. When taking it, use a precise instrument and measure it carefully according to the amount required for the experiment. Do not be greedy for too much or take it by mistake. The weighing operation should also be carried out in a clean and dry environment to ensure that the purity of the compound is not affected.
Furthermore, storage is also exquisite. 2-methoxy-5-fluorophenylboronic acid should be stored in a dry and cool place, away from fire and heat sources. And it should be stored in a classified manner with other chemical substances to prevent mutual reaction and cause danger.
In short, in the research and application of 2-methoxy-5-fluorophenylboronic acid, following safety and operation standards can ensure the smooth operation of the experiment, protect the health of personnel, and promote the progress of scientific research.
Application Area
2-Methoxy-5-fluorophenylboronic acid, this chemical substance, is quite useful in various application fields. In the field of pharmaceutical creation, it can be used as a key intermediate to help synthesize special drugs, or to cure specific diseases. In the field of material science, it may participate in the construction of new functional materials, giving materials unique properties, such as optical, electrical and other properties. Also in organic synthesis reactions, with its unique chemical structure, it can be used as an efficient reagent to promote the construction of complex organic molecules. This chemical, like a sharp blade, cuts into many application fields, contributes to scientific progress and technological development, and helps the extraordinary. It has an indispensable position in contemporary scientific research and industrial processes.
Research & Development
At present, 2-methoxy-5-fluorophenylboronic acid is studied, and its use in various fields of chemistry is becoming more and more widespread. At the beginning, the method of its synthesis was explored, and after many attempts, a feasible path was obtained. First, a certain raw material was used, and the product was reacted under suitable conditions according to specific steps.
Study its properties, observe its chemical activity, and measure its stability. In different environmental factors, observe its changes. It exhibits unique reaction characteristics in specific solvents and reaction systems.
In order to promote its development, the synthesis process was considered to optimize, in order to improve the yield and reduce the cost. And study its application in more reactions to expand its use. With time, 2-methoxy-5-fluorophenylboronic acid will gain more achievements in chemical research and industrial application, and develop its broad development prospects.
Toxicity Research
Toxicity study of 2-methoxy-5-fluorophenylboronic acid
Fu 2-methoxy-5-fluorophenylboronic acid is the object of chemical research. It is crucial for toxicity research.
Today, the detailed investigation of this compound, its unique structure, the substitution of 2-methoxy group with 5-fluorine may affect its chemical activity and toxicity. Although it is not widely known, it should not be ignored.
After various experiments, animals were used as samples to observe the reaction after ingestion of this compound. It is seen that some animals have abnormal behavior, or the compound interferes with their biochemical processes in vivo. And in cell experiments, it is also seen to have an impact on the growth and metabolism of specific cells.
From this point of view, 2-methoxy-5-fluorophenylboronic acid has a certain toxicity, and subsequent studies need to be more cautious. When applying, the pros and cons should also be weighed to ensure safety.
Future Prospects
Fu 2 - Methoxy - 5 - Fluorobenzeneboronic Acid This substance, in today's chemical research, has emerged, and is quite promising for future expansion. Its unique nature and exquisite structure, in the field of organic synthesis, such as Xingyao Road.
View the way of organic synthesis, many reactions rely on it as the basis, catalytic guidance, so that the reaction is smooth and the product is pure. In the future, it is expected that it will be used in the creation of medicine, or it will be able to help the development of new drugs, overcome chronic diseases, and save the common people's diseases. In material science, it is also expected to give birth to new materials, with specific properties, for electronics and energy.
Our generation of chemical researchers should study diligently, study its properties, and make good use of its properties. With unremitting efforts, this 2 - Methoxy - 5 - Fluorobenzeneboronic Acid will shine in the future, be used by the world, promote the progress of science and technology, and create a blessing for mankind.
Where to Buy 2-Methoxy-5-Fluorobenzeneboronic Acid in China?
As a trusted 2-Methoxy-5-Fluorobenzeneboronic Acid manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-Methoxy-5-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main application fields of 2-methoxy-5-fluorophenylboronic acid
2-% methoxy-5-fluorouracil is an important organic compound that has significant applications in many fields.
In the field of medicine, it is a key component of anti-tumor drugs. The proliferation and metabolism of tumor cells are abnormally active, and this compound can interfere with the nucleic acid synthesis process of tumor cells by virtue of a specific mechanism. Specifically, it can mimic the raw materials required for normal nucleic acid synthesis and is incorporated into the nucleic acid chain being synthesized by tumor cells, causing nucleic acid synthesis to be blocked, thereby inhibiting the division and growth of tumor cells. It provides a powerful means for the treatment of cancer and is widely used in clinical tumor treatment.
In the field of pesticides, 2-% methoxy-5-fluorouracil also shows unique value. It can be used as an active ingredient in herbicides. The growth of weeds depends on normal cell division and nucleic acid synthesis. The compound can precisely act on the relevant metabolic pathways of weed cells, hinder the normal synthesis of weed nucleic acid, inhibit weed growth, and achieve the purpose of weeding. It contributes an important force to the prevention and control of weeds in agricultural production.
Furthermore, in the field of organic synthesis, 2-% methoxy-5-fluorouracil plays an indispensable role as a key intermediate. Organic synthesis often requires the construction of complex molecular structures. Due to its unique chemical structure and activity, this compound can participate in many organic reactions, serving as a starting material or intermediate link to assist in the synthesis of various organic compounds with specific functions and structures, promoting the development of organic synthetic chemistry and providing an important foundation for the creation of new substances.
What are the physical properties of 2-methoxy-5-fluorophenylboronic acid?
2-% methoxy-5-fluorouracil is also an organic compound. Its physical properties are quite characteristic. Looking at its morphology, under room temperature and pressure, it often appears as a white to light yellow crystalline powder, which makes it easy to identify and resolve.
The melting point is between 200 and 204 degrees Celsius. The melting point is one of the important physical properties of the substance. This specific melting point range is helpful for the identification and purification of the substance through temperature control during experiments and production.
Its solubility is also regular. In water, it is slightly soluble, but the degree of solubility is limited. In organic solvents such as dimethyl sulfoxide, the solubility is relatively better. This difference in solubility is of great significance for its application in different chemical reaction systems and the choice of solvents in the process of pharmaceutical preparations.
In terms of stability, 2-methoxy-5-fluorouracil is relatively stable under general conditions. However, when it encounters extreme chemical environments such as strong oxidants, strong acids, and strong bases, chemical reactions may occur, resulting in changes in its structure and properties. Therefore, during storage and use, it is necessary to properly avoid it, and choose a suitable environment to survive to ensure that its properties remain unchanged and its efficacy can be exerted.
In addition, its physical properties such as density and odor are also similar to those of similar compounds. Density allows it to follow certain laws when participating in certain reactions involving the relationship between mass and volume. In terms of odor, there is usually no obvious special odor, which is also conducive to its application in various scenarios and does not cause discomfort due to strong odor or affect the properties of other substances.
What are the synthesis methods of 2-methoxy-5-fluorophenylboronic acid?
To prepare 2-methyl-5-bromobenzoic acid, the following methods can be used:
First, start with toluene and brominate it first. Under the condition of light or heating, toluene and bromine are reacted with free radicals to obtain benzyl bromide. Then benzyl bromide is oxidized with a strong oxidant such as potassium permanganate to convert the benzyl group into a carboxyl group, so that 2-methyl-5-bromobenzoic acid can be obtained. In this way, it is first brominated in the side chain and then oxidized to an acid. The steps are still simple, but the selectivity of free radical bromination is poor, or by-products such as benzyl polybrominates are produced.
Second, toluene is oxidized to benzoic acid first. A suitable oxidant, such as potassium dichromate-sulfuric acid system, can oxidize toluene to benzoic acid. Then benzoic acid and bromine in iron or iron tribromide catalyzed by electrophilic substitution, bromine atoms are introduced at specific positions in the benzene ring. Because the carboxyl group is the meta-locator, bromine atoms can be guided into the meta-site. After controlling the reaction conditions, 2-methyl-5-bromobenzoic acid can be obtained. This way, acid is formed first, brominated later, and the positioning is accurate. However, the step of oxidizing toluene into benzoic acid may require severe conditions.
Third, m-methylaniline is used as the raw material. First, m-methylaniline and sodium nitrite undergo diazotization reaction under low temperature and acidic conditions to obtain diazonium Then the diazonium salt is reacted with copper salts such as cuprous bromide, and the diazonium group is replaced by a bromine atom through the Sandmeier reaction to obtain m-methyl bromobenzene. Finally, the side chain methyl of m-methyl bromobenzene is oxidized to a carboxyl group with a suitable oxidant to obtain the target product. This path step is slightly more complicated, but the diazotization and Sandmeier reaction have high selectivity and can accurately introduce bromine atoms.
What are the precautions for 2-methoxy-5-fluorophenylboronic acid during storage and transportation?
When storing and transporting 2-% methoxy-5-chlorobenzenesulfonic acid, many matters need to be paid attention to.
The properties of this agent are very critical. It has specific chemical activity. When storing, it needs to choose a dry, cool and well-ventilated place to prevent its properties from changing due to environmental moisture and heat. If placed in a humid place, it may absorb moisture and deliquescence, which will affect the quality; in a high temperature environment, it may cause chemical reactions and damage its active ingredients.
The packaging must be solid and intact. The substance may be corrosive to a certain extent, and the packaging material must be able to resist its erosion to prevent leakage. Once leaked, it will not only waste materials, but also endanger the surrounding environment and personnel safety. The sealing of the package is also extremely important, which can prevent it from contacting with the outside air and moisture, and ensure its chemical stability.
During transportation, shock resistance and collision resistance cannot be ignored. Violent vibration or collision or damage to the package, resulting in material leakage. The means of transportation should be clean and dry, and no impurities that can react with it should be retained. And the transportation should be operated in accordance with relevant regulations and standards, and equipped with necessary protective and emergency facilities.
When handling, the operator should be in front of suitable protective equipment, such as protective clothing, gloves, goggles, etc. If this substance comes into contact with the skin or eyes, it may cause burns and other injuries. During operation, it should also be handled with care to avoid brutal loading and unloading. When storing and transporting 2% methoxy-5-chlorobenzenesulfonic acid, all aspects of the environment, packaging, transportation and operation must be properly controlled to ensure its safety and quality.
What is the market price range of 2-methoxy-5-fluorophenylboronic acid?
In today's world, the market is prosperous, and the price of all kinds of goods varies. As for 2-methyl-5-methoxyphenylboronic acid, the price range in the market is actually influenced by various factors.
First, the balance between supply and demand is the key to the price. If there are many people in the market who want this product, but the quantity of production is small, the price will rise; on the contrary, the supply exceeds the demand, and the price should be suppressed.
Second, the simplicity of its production and the cost are also related to the price. If the production requires fine skills and consumables are expensive, the cost will be high, and the price will follow. If the production is simple, cost-effective, and frugal, the price may be slightly lower.
There is also competition in the market, which is also the main reason. There are many people in the same industry competing for profits, competing for the market share, or lowering their prices to attract customers; if they are alone, or control their products, the price can be manipulated.
Furthermore, changes in the world situation can also lead to price changes. In case of various changes, such as natural disasters, changes in political regulations, and disputes in trade, the circulation of goods and the regulations of products may change, and the price will also fluctuate.
Roughly speaking, the market price of 2-methyl-5-methoxyphenylboronic acid may be in the range of tens to hundreds of yuan per gram. However, this is only an approximate number. The market is volatile, and the price can change at any time, which is difficult to determine. Businesspeople need to constantly observe the market conditions and take advantage of the situation before they can obtain the true meaning of their price.