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What are the main uses of 2-Fluorobenzenesulfonyl Fluoride?
2-Fluorobenzenesulfonyl fluoride is an important compound in organic chemistry. Its main use can be found in the field of organic synthesis.
In the field of pharmaceutical chemistry, 2-fluorobenzenesulfonyl fluoride can be used as a key intermediate. Because it contains fluorine and sulfonyl fluoride functional groups, it has unique chemical activities and physical properties. The introduction of fluorine atoms can often change the fat solubility and metabolic stability of compounds, which is crucial in drug development. With the activity of sulfonyl fluoride, it can react with a variety of compounds containing nucleophilic groups, such as amines, alcohols, etc. Through this reaction, compounds with diverse structures can be constructed, laying the foundation for the creation of novel structures and biological activities of drug molecules.
In the field of materials science, 2-fluorobenzenesulfonyl fluoride also has its uses. Due to the characteristics of sulfonyl fluoride, it can participate in some polymerization reactions to prepare polymer materials with special properties. For example, it can react with monomers containing hydroxyl groups or amine groups to form polymer chains, endowing materials with unique properties such as chemical resistance and surface activity, and play a role in the improvement of materials such as coatings and plastics.
In addition, in agricultural chemistry, 2-fluorobenzenesulfonyl fluoride can be used to synthesize biologically active pesticide components. With its chemical structure characteristics, the synthesized pesticides may be highly efficient, low toxic and environmentally friendly, providing a new way for crop pest control. In short, 2-fluorobenzenesulfonyl fluoride has shown important application value in many fields such as organic synthesis, medicine, materials and agricultural chemistry, and is of great significance to promote the development of related fields.
What are the physical properties of 2-Fluorobenzenesulfonyl Fluoride?
2-Fluorobenzenesulfonyl fluoride, this is an organic compound. Its physical properties are crucial and related to many chemical applications.
First appearance, under room temperature and pressure, 2-fluorobenzenesulfonyl fluoride is often colorless to light yellow liquid, with clear texture and good visibility. This appearance feature is easy to visually determine its state and purity. If the color is different or cloudy, or there are impurities mixed in.
Secondary and boiling point, about 195-197 ° C. The boiling point property is crucial for the separation and purification of this compound. In the distillation operation, control the appropriate temperature, near its boiling point, 2-fluorobenzenesulfonyl fluoride can be vaporized and separated from other substances to achieve the purpose of purification.
In addition to the melting point, its melting point is about -35 ° C. The low melting point indicates that the compound can still maintain a liquid state in a relatively low temperature environment, which is beneficial for some scenarios that require low temperature liquid phase reaction, and can provide a suitable reaction medium.
Its density is about 1.465g/cm ³. The physical quantity of density plays a significant role in the measurement of materials in chemical production. With the known density, the quality can be accurately calculated according to the volume, and the proportion of reaction materials can be ensured to be appropriate, so that the reaction can proceed smoothly.
2-fluorobenzenesulfonyl fluoride has poor solubility in water and is a hydrophobic substance. This property has a significant impact on heterogeneous reactions or extraction operations. Because it is insoluble in water, it can be separated from the mixture by extraction due to the difference between the aqueous phase and the organic phase.
In addition, 2-fluorobenzenesulfonyl fluoride is volatile and will slowly evaporate into the air in an open environment. Pay attention to this point when operating. It is advisable to operate in a well-ventilated place or take appropriate protective measures to prevent volatile gases from causing harm to humans and the environment.
In summary, the physical properties of 2-fluorobenzenesulfonyl fluoride, from appearance to density, solubility, volatility, etc., play a key role in its application, processing, and storage in the chemical field. Chemical practitioners must be familiar with and make good use of it.
2-Fluorobenzenesulfonyl is Fluoride chemically stable?
2-Fluorobenzenesulfonyl fluoride, the chemical properties of this substance are not very stable. In its molecule, the fluorine atom is connected to the benzene ring, and the electron cloud density of the benzene ring is changed by the influence of the fluorine atom, resulting in a relatively low electron cloud density of the benzene ring. Under certain conditions, it is easy to initiate an electrophilic substitution reaction, and the stability is thus damaged. In the sulfonyl fluoride group (-SO ² F)
, the sulfur atom is in a high oxidation state and has a strong electron-absorbing ability. This structure makes the sulfonyl fluoride group easily hydrolyzed when 2-fluorobenzenesulfonyl fluoride encounters water. During hydrolysis, the hydroxyl group in the water molecule attacks the sulfur atom, and the fluoride ion leaves to form
Furthermore, the fluorine atoms in 2-fluorobenzenesulfonyl fluoride are relatively special when bonding with other atoms due to their high electronegativity. Under specific chemical reaction conditions, fluorine-containing chemical bonds are prone to fracture and rearrangement, which also makes it difficult for 2-fluorobenzenesulfonyl fluoride to maintain structural stability in various environments.
In summary, 2-fluorobenzenesulfonyl fluoride is difficult to maintain stability under many common conditions due to the interaction of various groups in the molecular structure. Its chemical properties are active and changeable, and it needs to be stored and used with caution to prevent accidental chemical reactions.
What is the preparation method of 2-Fluorobenzenesulfonyl Fluoride?
To prepare 2-fluorobenzenesulfonyl fluoride, the following method can be used.
First take 2-fluorobenzenesulfonic acid and react with it with phosphorus pentachloride. The two are slowly mixed in an appropriate reaction vessel at a suitable temperature and under the protection of inert gas. Phosphorus pentachloride has strong dehydration and nucleophilicity, and can be substituted with hydroxyl groups in 2-fluorobenzenesulfonic acid. During the reaction, the temperature should be controlled in the range of low temperature to medium temperature to prevent the growth of side reactions. This reaction formula is roughly: 2-fluorobenzenesulfonic acid + PCl → 2-fluorobenzenesulfonyl chloride + POCl 🥰 + HCl. After the reaction is completed, 2-fluorobenzenesulfonyl chloride is separated by distillation and other methods.
Next, take 2-fluorobenzenesulfonyl chloride, use anhydrous potassium fluoride as the fluorine source, and react in a polar aprotic solvent such as N, N-dimethylformamide (DMF). This reaction needs to be heated to maintain a certain temperature in the system to promote the nucleophilic substitution of fluoride ions to chlorine atoms. Due to the strong nucleophilicity of fluoride ions, it can replace chlorine atoms in sulfonyl chloride to form the target product 2-fluorobenzenesulfonyl fluoride. The reaction formula is about: 2-fluorobenzenesulfonyl chloride + KF → 2-fluorobenzenesulfonyl fluoride + KCl. After the reaction is completed, the product can be purified by extraction, rectification and other means to obtain pure 2-fluorobenzenesulfonyl fluoride.
Another way can be started from benzene. First, the electrophilic substitution reaction is used to make benzene react with fluorosulfonic acid, and the fluorosulfonyl group is introduced to form benzenesulfonyl fluoride. Then, in the presence of a specific halogenating agent such as N-fluorobisulfonamide (NFSI), the benzenesulfonyl fluoride is fluorinated on the aromatic ring, so that the fluorine atom replaces the hydrogen atom on the benzene ring to obtain 2-fluorobenzenesulfonyl fluoride. However, this approach is slightly complicated, and the reaction conditions of each step need to be carefully adjusted to ensure
2-Fluorobenzenesulfonyl Fluoride needs to pay attention to when storing and transporting
2-Fluorobenzenesulfonyl fluoride. Many things should be paid attention to during storage and transportation.
It is active and has strong reactivity. When storing, choose the first heavy container. Special corrosion-resistant containers need to be used, such as those lined with special materials, to avoid chemical reaction with the container and leakage. And it must be placed in a cool, dry and well-ventilated place, away from heat and fire sources. Due to heat or exposure to open flames, or severe reactions, it may cause safety risks.
During transportation, the packaging must be strong and tight. According to relevant regulations and standards, suitable packaging materials should be used to ensure that there is no leakage under the vibration and turbulence of transportation. The temperature of the transportation environment should also be controlled, and it should not be too high or too low. Too high will easily promote its reaction, and too low will cause some physical properties to change. Transport personnel should also be professionally trained to be familiar with its characteristics and emergency treatment methods. In case of leakage, etc., it can be handled quickly and properly to minimize harm.
In addition, because of its toxicity and corrosion, storage and transportation sites should be equipped with protective equipment and emergency equipment, such as gas masks, protective gloves, eye washers and corresponding neutralizers, etc., to protect personnel safety and environmental safety.
