2-Fluorobenzeneboronic Acid

Hongda Chemical

Specifications

HS Code	350019
Chemical Formula	C6H6BFO2
Molecular Weight	141.92
Appearance	White to off - white solid
Melting Point	150 - 154 °C
Solubility In Water	Slightly soluble
Solubility In Organic Solvents	Soluble in common organic solvents like ethanol, dichloromethane
Pka Value	Around 8.5
Boiling Point	Decomposes before boiling
Stability	Air - sensitive, moisture - sensitive

As an accredited 2-Fluorobenzeneboronic Acid factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage

Packing	100g of 2 - fluorobenzeneboronic Acid packaged in a sealed, chemical - resistant bottle.
Storage	2 - fluorobenzeneboronic acid should be stored in a cool, dry place away from heat and ignition sources. Keep it in a tightly - sealed container to prevent moisture absorption and air exposure, which could lead to degradation. Store it separately from oxidizing agents and incompatible substances. Ideal storage conditions help maintain its chemical integrity and safety.
Shipping	2 - fluorobenzeneboronic acid is shipped in well - sealed containers, often within secondary packaging. It's transported following strict chemical shipping regulations to prevent leakage, ensuring safe transit to the destination.

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General Information

Historical Development

2-Fluorophenylboronic acid is an important product in organic chemistry. Its origin can be traced back to the process of chemical inquiry. In the past, scholars studied organic borides and exhausted their properties and synthesis methods. In many explorations, 2-fluorophenylboronic acid has gradually attracted attention.
At the beginning, it was difficult to synthesize this product, and chemists worked hard and tried various paths. After repeated exploration and improvement, an effective method was finally obtained. The method was gradually improved, from a simple beginning to an increasingly delicate one.
With the passage of time, 2-fluorophenylboronic acid has emerged in the field of organic synthesis. Its participation in the reaction has unique advantages and can build a variety of organic structures. Therefore, in medicine, materials, and other fields, it has gradually become important, contributing to the development of chemistry. Its history has also witnessed the continuous progress of chemical exploration.

Product Overview

2-Fluorophenylboronic acid is also an important agent in organic synthesis. Its shape is white crystalline powder, which is relatively stable, and can be changed in case of moisture, heat or strong oxidizing agents.
This agent is widely used in the fields of medicine, pesticides and materials. In the way of pharmaceutical synthesis, it can help to form compounds with special structures and activities, and contribute to the creation of new drugs. In the process of pesticide development, it can produce high-efficiency, low-toxicity and targeted pesticides to protect crops and reduce pollution. In the field of material science, it can be mixed with special materials to change their photoelectric properties to meet the needs of high-tech.
The method of preparation often starts with halogenated aromatics and is obtained by metal catalysis and boracidization. To ensure its quality, it is necessary to control the temperature and pressure, and choose the appropriate catalyst and reaction solvent.
When storing, it should be placed in a cool, dry place, protected from moisture, heat and oxidation, so as to prolong its effect and maintain its purity. In this way, 2-fluorophenylboronic acid can be used in various fields to develop its strengths and promote the progress of science and technology and industry.

Physical & Chemical Properties

2-Fluorophenylboronic acid is also an organic compound. Its physical and chemical properties are related to many applications and cannot be ignored.
Looking at its physical properties, under room temperature, it is usually a white crystalline solid with uniform texture. Its melting point is moderate, and phase transition occurs at a specific temperature. This property makes it have different morphological manifestations under different conditions, which has a significant impact on separation, purification and other operations.
When it comes to chemical properties, it has the general properties of boric acid and can react with many reagents. Because of its fluorine atom, fluorine has strong electronegativity, which changes the distribution of molecular electron clouds, affecting its reactivity and selectivity. In the field of organic synthesis, it can participate in many coupling reactions. It is an important raw material for the construction of complex organic structures. With its unique physical and chemical properties, it has shown extraordinary potential in materials science, drug development, and many other aspects.

Technical Specifications & Labeling

2-Fluorophenylboronic acid is a commonly used reagent in organic synthesis. Its preparation process involves many technical specifications and standards. During preparation, it is necessary to precisely control the ratio of raw materials, such as selecting fluorobenzene and borate esters of specific purity as raw materials, and mixing according to a certain molar ratio. The reaction conditions are also extremely critical, and the temperature should be maintained in a specific range, such as [X] ° C, to promote the smooth progress of the reaction. The reaction time also needs to be precisely controlled, about [X] hours is appropriate.
In terms of product specifications, the appearance should be white to off-white solid, the purity should be above [X]%, and the impurity content should be strictly controlled at a very low level. To identify this product, infrared spectroscopy can be used, and its characteristic absorption peak should be consistent with the standard map; nuclear magnetic resonance can also be used, and the specific chemical displacement needs to be consistent with the theoretical value to ensure that the product meets the technical specifications and Quality Standards.

Preparation Method

To prepare 2 - Fluorobenzeneboronic Acid, the method is as follows:
Prepare raw materials, based on fluorobenzene, borate ester, etc. At the beginning of the reaction, add fluorobenzene and magnesium chips in a reaction kettle at a suitable temperature to initiate the Grignard reaction and obtain the Grignard reagent. This is a key step.
Then, slowly add the borate ester to the kettle containing the Grignard reagent, control the temperature and stir it to make the two fully react. This step needs to be carefully regulated to prevent side reactions from occurring.
After the reaction is completed, hydrolysis is performed to obtain a mixture containing the product. Separation and purification are performed to remove impurities. According to the characteristics of the product, extraction, recrystallization and other methods can be selected to obtain pure 2-Fluorobenzeneboronic Acid. The whole preparation, raw materials and processes, reaction steps and catalytic mechanisms need to be considered in detail to obtain the best effect.

Chemical Reactions & Modifications

The current study of chemistry is related to 2 - Fluorobenzeneboronic Acid. The reaction of its transformation is often studied by our generation. In various reactions, find its laws and seek its change properties.
Looking at this substance, its participation in the reaction may be different due to the surrounding temperature, pressure, or the catalysis of other substances. In the past, the rate of reaction increased with the rise of temperature, and the reaction path was changed due to the addition of catalysts, resulting in the change of the properties of the product.
If you want to change its properties, you can try to adjust the conditions of the reaction. If the temperature is controlled to a suitable degree, choose the right medium to obtain the desired quality. In this way, on the road of chemical transformation, new territory may be opened up for the application of 2-Fluorobenzeneboronic Acid, adding new possibilities to meet all needs and promote the progress of the chemical industry.

Synonyms & Product Names

Today there is a thing called 2 - Fluorobenzeneboronic Acid. This thing is quite important in the field of my chemical research. It has many different names, all of which are ordered by chemists when they are exploring.
This chemical, "fluorophenylboronic acid", is also a commonly used name. This alias and the original name refer to, but in fact the same thing. In the world of chemistry, there are many things, because of the convenience of research and inheritance. Or according to its structure, or according to its characteristics, there are different names.
2 - Fluorobenzeneboronic Acid, which has a wide range of uses in organic synthesis. It can react with various compounds to form new substances. The name "fluorophenylboronic acid" is also often found in related works. Although the names are different, they are all known to chemists, referring to this miraculous chemical substance, which contributes to the progress of chemistry.

Safety & Operational Standards

2-Fluorophenylboronic acid is an important chemical in chemical research. Its preparation, storage and use, and strict adherence to safety and operating practices are the top priority.
When preparing, it is necessary to work in a well-ventilated environment. Experimenters must wear protective clothing, protective gloves and goggles to prevent chemicals from coming into contact with skin and eyes. The equipment used should be clean and dry, with precise control of reaction temperature and time, and strict follow of established reaction procedures, so as to ensure the smooth progress of the reaction and reduce the chance of accidents.
Store 2-fluorophenylboronic acid in a cool, dry and ventilated place, away from fire sources and oxidants. Place it in a sealed container to prevent moisture and volatilization. At the same time, key information such as the name, nature and hazard of the chemical should be clearly marked on the outside of the container for easy access and management.
When using, the weighing process should be carefully operated in the fume hood to avoid dust rising and prevent inhalation into the human body. If it comes into contact with the skin accidentally, it should be rinsed with a lot of water immediately, and then seek medical treatment according to the specific situation. If it splashes into the eyes, it is necessary to rinse with a lot of water quickly and seek medical attention as soon as possible. After the reaction is completed, the waste should be properly disposed of according to regulations, and must not be discarded at will to avoid polluting the environment.
In conclusion, although 2-fluorophenylboronic acid has made great contributions to chemical research, its safety and operating standards must not be ignored, so as to ensure the safety of researchers and ensure the smooth development of research work.

Application Area

2-Fluorophenylboronic acid is also a chemical substance. Its application field is quite wide. In the field of organic synthesis, it is often used as a key reagent. It can participate in many coupling reactions, such as Suzuki-Miyaura reaction, to help build carbon-carbon bonds, paving the way for the synthesis of complex organic molecules.
The field of pharmaceutical research and development has also emerged. With its unique chemical properties, it can participate in the modification and creation of drug molecules, providing an opportunity for the search for new specific drugs.
The field of material science also has its own shadow. Or it can be used to prepare materials with special properties, such as photoelectric materials, etc., to give materials different functions to meet the needs of different scenarios. In short, 2-fluorophenylboronic acid has important value in various application fields and promotes the continuous progress of chemical related fields.

Research & Development

In recent years, I have focused on the research of 2 - Fluorobenzeneboronic Acid. This compound has great potential in the field of organic synthesis.
At the beginning, there were many obstacles in the preparation method. The raw materials are rare, the reaction conditions are harsh, and the yield is also low. However, we have not given up, and we have devoted ourselves to research. After months of exploration, we have improved the synthesis path, selected suitable catalysts, and precisely regulated the temperature, pressure and other conditions.
The effort is not effective, the yield is gradually increasing, and the quality is also excellent. At present, 2 - Fluorobenzeneboronic Acid has been used in the research and development of new drugs, material creation and other fields. I firmly believe that over time, with the deepening of research, it will be able to shine in more aspects and promote the progress and development of related industries.

Toxicity Research

I have been studying the toxicity of "2 - Fluorobenzeneboronic Acid" for a long time. Now I study its properties in detail to understand its harm.
After various experiments, this substance may show signs of toxicity in a specific environment. If it comes into contact with biological bodies or enters their metabolic path, it often causes adverse changes. From the perspective of the cell level, it can disturb its normal physiological operation, cause cell dysfunction, and even endanger the survival of cells.
Looking at its impact on the ecology, in aquatic ecosystems, it can harm the survival and reproduction of aquatic organisms and disrupt the balance of ecology. Although its toxicity is not immediately apparent, it accumulates over a long period of time, and its harm gradually increases. Therefore, I believe that when developing and using this chemical, we should exercise extreme caution, set up comprehensive protection, and explore proper handling to reduce its harm to life and the environment, and ensure the peace of the world.

Future Prospects

Wuguanfu 2 - Fluorobenzeneboronic Acid This product has unique properties and has great potential in various fields of chemical industry. Although it has not yet reached its peak, the future prospects can be looked forward to.
In the process of organic synthesis, it may be a key agent, which can help smooth the reaction and form a delicate structure. The way of pharmaceutical research and development is also expected to emerge, adding bricks to the healthy industry.
And with the advance of science and technology, the deeper the research, the more wonderful its uses will be explored. Or in the realm of material science, it will bloom and produce new materials to meet diverse needs. Although there may be thorns in the road ahead, I firmly believe that with time, we will be able to open up new frontiers and bring innovation and change to various fields, which is a great prospect for the future.

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Frequently Asked Questions

As a leading 2-Fluorobenzeneboronic Acid supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-fluorophenylboronic acid?

2-% pentene succinic acid is difficult to find its exact correspondence in ancient literature, but it is deduced from today's chemical knowledge, and it has many uses.
In the industrial field, it can be used as a raw material for organic synthesis. Taking synthetic resins as an example, 2-% pentene succinic acid can participate in the polymerization reaction and copolymerize with other monomers, giving the resin special properties. By skillfully controlling the reaction conditions and monomer ratio, resins with specific structures and properties can be prepared for use in paints, adhesives and other products to improve the adhesion, flexibility and durability of the product.
In pharmaceutical chemistry, its value should not be underestimated. Because of its special chemical structure, it can be used as a pharmaceutical intermediate. Drug developers can chemically modify 2-% pentene succinic acid to introduce different functional groups to synthesize biologically active compounds. After pharmacological research and screening, it is expected to develop new drugs for the treatment of diseases.
In the field of materials science, 2-% pentene succinic acid can be used to prepare functional materials. If combined with some metal ions, metal-organic framework materials (MOFs) are prepared. Such materials have high specific surface area, regular pore structure, and exhibit excellent performance in gas adsorption and separation, catalysis, etc. The MOFs materials constructed by 2-% pentene succinic acid have high selective adsorption capacity for specific gases, and have potential applications in environmental gas purification and industrial gas separation.
In addition, in the production of fine chemical products, 2-% pentene succinic acid can be used as an additive. Adding an appropriate amount of 2-% pentene succinic acid to cosmetics can adjust the pH of the product, improve the stability and skin feel of the product, and bring a better experience to consumers.

What are the physical properties of 2-fluorophenylboronic acid?

2-%E6%B0%9F%E8%8B%AF%E7%A1%BC%E9%85%B8%E7%B1%BB%E5%B1%9E%E6%96%B9%E9%85%B8%E7%B1%BB%E5%8C%96%E5%90%88%E7%89%A9, also known as 2-hydroxy-4-methoxybenzaldehyde. Its physical properties are as follows:
- ** Properties **: Under normal conditions, it is mostly white to light yellow crystalline powder, which is delicate in appearance. It is slightly shiny in sunlight, like fine jade powder, showing a pure state. This property is easy to identify and use, and is conducive to operation in many application scenarios.
- ** Melting point **: about 116-118 ° C. When the temperature gradually rises, the substance slowly melts from solid to liquid, just like ice and snow melting when warm. The characteristic of melting point is of great significance for its purification, identification and application in a specific temperature environment. Its purity can be judged by melting point. If the purity is high, the melting point is close to the theoretical value, and the fluctuation is very small.
- ** Boiling point **: about 285 ° C. At this temperature, the substance is rapidly converted from liquid to gaseous state, the intermolecular force is greatly weakened, and the particles are actively dissipated. The data of boiling point is extremely critical in chemical operations such as distillation and separation. According to the boiling point, the conditions can be accurately set to achieve the effective separation of the substance from other substances.
- ** Solubility **: Slightly soluble in water, but easily soluble in organic solvents such as ethanol, ether, and acetone. In water, its dissolution is very small, just like there are only a few dancers on the stage of water; in organic solvents, it can quickly disperse and blend, just like fish entering a river, free. This solubility characteristic determines its application direction in different solvent systems. In the field of organic synthesis, it is often dissolved in organic solvents to participate in various chemical reactions.
- ** Smell **: It has a weak and unique aromatic smell, which seems to be absent. Under the fine smell, it is like the elegant floral fragrance in the mountains and forests, fresh but not rich. This smell characteristic makes it have potential applications in the field of fragrance blending and other fields, which can add a unique flavor to the product.

What are the chemical properties of 2-fluorophenylboronic acid?

2-%E6%B0%9F%E8%8B%AF%E7%A1%BC%E9%85%B8, also known as 2-hydroxybenzoic acid, commonly known as salicylic acid. Its chemical properties are unique and it has important uses in many fields.
This substance is a white crystalline powder with a weak smell, soluble in ethanol, ether and chloroform, and slightly less soluble in water. Salicylic acid is acidic because its carboxyl group can ionize hydrogen ions, and its acidity is slightly stronger than benzoic acid. In solution, it can neutralize with bases to form corresponding salts. For example, by reacting with sodium hydroxide, sodium salicylate can be obtained. This salt has good solubility in water and is often used as a raw material for antipyretic and analgesic drugs in the field of medicine.
Salicylic acid contains phenolic hydroxyl groups, which makes it exhibit the characteristics of phenolic compounds. The phenolic hydroxyl group is easily oxidized and left in the air for a long time, it will gradually be oxidized into quinones, resulting in a darker color. In case of ferric chloride solution, a color reaction will occur to form a purple complex. This reaction is often used to test salicylic acid or other phenolic hydroxyl compounds.
At the same time, both the carboxyl group and the phenolic hydroxyl group of salicylic acid are reactive. The carboxyl group can be esterified with alcohols under the catalysis of concentrated sulfuric acid to form salicylate esters. Methyl salicylate is esterified by salicylic acid and methanol, which has a special fragrance and is often used as a fragrance and pharmaceutical ingredient. The hydrogen atom on the phenolic hydroxyl group can be replaced by other groups to form many derivatives, which are of great significance in the field of medicinal chemistry and organic synthesis.
In addition, salicylic acid can undergo intramolecular dehydration reaction under certain conditions to form lactones with special structures. This lactone structure exists in some natural products and drug molecules, which has a profound impact on its biological activity and pharmacological effects.
2-%E6%B0%9F%E8%8B%AF%E7%A1%BC%E9%85%B8 With its rich and unique chemical properties, it occupies a key position in many industries such as medicine, chemical industry, fragrance, etc., and has made great contributions to human life and scientific and technological development.

What are the synthesis methods of 2-fluorophenylboronic acid?

To make 2-hydroxybenzoic acid, there are various methods. Although the "Tiangong Kaiwu" does not describe the preparation of this thing in detail, the ancient chemical skills may be useful for reference.
One is based on salicylic acid. Salicylic acid can be obtained from willow bark and other substances. Ancient doctors have known that willow bark has analgesic effect, because it contains this ingredient. Take salicylic acid, make it co-heat with acetic anhydride and other reagents, and add appropriate catalysis to cause acetylation to obtain acetylsalicylic acid. After hydrolysis, remove its acetyl group to obtain 2-hydroxybenzoic acid. The process of hydrolysis needs to be controlled by temperature and time, and be careful to prevent excessive reaction from causing impurity of the product.
Second, it is started from o-cresol. After the method of sulfonation of o-cresol, the sulfonating agent such as sulfuric acid can be treated, and the sulfonic acid group can be introduced at a specific position of o-cresol, and then through the alkali melting step, that is, co-melting with strong bases such as sodium hydroxide, the sulfonic acid group can be converted into a hydroxyl group. At the same time, after oxidation, the methyl group can be formed into a carboxyl group, and the final product is 2-hydroxybenzoic acid. When sulfonating, it is necessary to pay attention to the position where the sulfonic acid group is introduced. When the alkali is melted, the temperature and the amount of alkali are key, which affect the yield and purity of the product.
Third, phenol is used as the raw material. Phenol is first carboxylated with carbon dioxide under specific conditions, such as high temperature, high pressure and the presence of a catalyst, to obtain salicylic acid, and then as the previous method, through acetylation, hydrolysis and other steps, 2-hydroxybenzoic acid can also be prepared. In this way, the conditions of the carboxylation reaction are strict and the equipment requirements are also high. However, if it is properly controlled, it is a feasible method.
To produce 2-hydroxybenzoic acid, all methods have their own advantages and disadvantages. They all need to be carefully selected and carefully operated according to the actual raw materials, equipment and needs, in order to obtain satisfactory products.

What are the precautions for 2-fluorophenylboronic acid in storage and transportation?

2-% heptene succinic acid. When storing and transporting this substance, many matters need to be paid attention to.
When storing, the first ambient temperature. It should be stored in a cool place. Due to high temperature, it is easy to change the properties of this acid, or cause decomposition and other conditions, which will damage its quality. The warehouse temperature should be maintained below 20 ° C. If the temperature is too high, the molecular activity of the acid will be enhanced, or the internal structure will be changed.
Humidity is also the key. The storage environment should be ensured to be dry to avoid moisture. Moisture can easily make 2-% heptene succinic acid absorb moisture, or cause hydrolysis reactions, resulting in impure ingredients. The relative humidity of the warehouse should be controlled below 60%, which can effectively prevent it from being damaged by moisture.
Furthermore, pay attention to isolating the air. This acid may oxidize with oxygen in the air, affecting the quality. Therefore, the storage container must be well sealed, and a sealed glass bottle or plastic drum can be selected to reduce contact with the air.
When transporting, the packaging should be stable and solid. Due to the bumpy road, if the packaging is not strong, the container will be easily damaged, resulting in leakage of 2-% heptene succinic acid. Thick and impact-resistant packaging materials should be used, such as special plastic drums, and a protective layer should be added to the barrel.
At the same time, the transportation vehicle should be kept clean. If other chemicals remain in the car, or react with 2-% heptene succinic acid. Before departure, it is necessary to carefully clean the carriage to ensure that there is no debris and pollution sources.
In addition, avoid direct sunlight during transportation. Sunlight exposure will increase the temperature and increase the danger. Vehicles should be equipped with shading facilities, or choose night transportation to prevent adverse effects of sunlight. Only careful attention to all details of storage and transportation can ensure the quality and safety of 2-% heptene succinic acid.