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2-​Fluoro-​6-​(Trifluoromethyl)​-Benzenesulfonyl Chloride

2-​Fluoro-​6-​(Trifluoromethyl)​-Benzenesulfonyl Chloride

Hongda Chemical

Specifications

HS Code

182925

Chemical Formula C7H3ClF4O2S
Molar Mass 278.61 g/mol
Appearance Typically a solid
Melting Point Specific value would need literature search
Boiling Point Specific value would need literature search
Density Specific value would need literature search
Solubility In Water Likely low, being an organosulfonyl chloride
Solubility In Organic Solvents Soluble in common organic solvents like dichloromethane, toluene
Reactivity Reactive towards nucleophiles (amines, alcohols etc.) due to the sulfonyl chloride group
Odor Pungent, characteristic of sulfonyl chlorides

As an accredited 2-​Fluoro-​6-​(Trifluoromethyl)​-Benzenesulfonyl Chloride factory, we enforce strict quality protocols—every batch undergoes rigorous testing to ensure consistent efficacy and safety standards.

Packing & Storage
Packing 100g of 2 - fluoro - 6 - (trifluoromethyl) - benzenesulfonyl Chloride in sealed chemical - grade vial.
Storage 2 - fluoro - 6 - (trifluoromethyl) - benzenesulfonyl chloride should be stored in a cool, dry, well - ventilated area away from heat sources and open flames. It must be kept in a tightly sealed container to prevent contact with moisture and air, as it may react with them. Store it separately from incompatible substances like bases and reactive metals to avoid hazardous reactions.
Shipping 2 - fluoro - 6 - (trifluoromethyl) - benzenesulfonyl Chloride is shipped in specialized, well - sealed containers. Care is taken to comply with chemical shipping regulations to prevent leakage and ensure safe transportation due to its potentially hazardous nature.
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2-​Fluoro-​6-​(Trifluoromethyl)​-Benzenesulfonyl Chloride 2-​Fluoro-​6-​(Trifluoromethyl)​-Benzenesulfonyl Chloride
General Information
Historical Development
2 - Fluoro - 6- (Trifluoromethyl) - Benzenesulfonyl Chloride, its origin is also a sign of the evolution of chemical technology. In the past, the research of sulfonyl chloride was studied by many sages, and fluorine-containing aryl groups were gradually used. The specific nature of fluorine is often changed by its molecular structure.
At first, scholars explored the synthesis of fluorine-containing organics, but it was difficult. At some point, there was a way to make this 2 - Fluoro - 6- (Trifluoromethyl) - Benzenesulfonyl Chloride. The method of first obtaining it was complicated and inefficient, but the scientific researchers were reluctant to study it.
The years have passed, and the techniques have become more and more refined. New synthetic paths have emerged, with increasing yields and excellent purity. This compound has gradually shown its use in the fields of medicine and materials, adding a splendor to the progress of chemistry, witnessing the process of synthesis from simple to complex and increasingly exquisite.
Product Overview
2 - 氟 - 6 - (三氟甲基)苯磺酰氯,此化合物乃化学研究之重要材料。其性状独特,为白色至类白色结晶粉末,于特定实验条件下性质稳定。其合成需精准控制反应步骤,涉及多种化学原料及特定反应环境,各环节皆关乎产物纯度与产率。在有机合成领域,它常作关键中间体,能与诸多有机化合物发生反应,为构建复杂有机结构提供可能。因其含氟及磺酰氯基团,赋予其特殊化学活性与性质,可用于制备具有特殊性能之材料或药物,在化学科研进程中具不可或缺之地位,助力科研人员探索更多化学奥秘与应用途径。
Physical & Chemical Properties
2024年诺贝尔化学奖授予了开发和应用氟代芳烃的科学家。氟代芳烃,特别是2 - Fluoro - 6 - (Trifluoromethyl)-Benzenesulfonyl Chloride这类化合物,在材料科学、药物化学等领域展现出独特的物理化学性质。

从物理性质看,其含氟基团使得分子具有较高的脂溶性与稳定性,这有利于跨越生物膜,在药物传输上极具潜力。从化学性质而言,该化合物中的磺酰氯官能团反应活性高,可通过亲核取代等反应,构建多样的化学结构,为新材料合成提供丰富途径。它独特的电子效应与空间位阻,还能精准调控反应位点与速率,为有机合成化学开拓新方向。这些特性让2 - Fluoro - 6 - (Trifluoromethyl)-Benzenesulfonyl Chloride成为化学研究与工业生产中备受瞩目的关键中间体。
Technical Specifications & Labeling
今有一物,名曰2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride 。其工艺规格与标识(商品参数),至为关键。

此品之工艺规格,需依精准之法制备。从原料之选,必求纯净无杂,配比亦须毫厘不差。反应之温、时,皆为要义,稍一偏差,或致品质有亏。如火候不当,或使产物不纯,效能不达预期。

标识方面,商品参数务必明晰。其名、性、用,皆应详述。使观者一阅便知其质,于用此物者,能依标识正确操之。如此,方得此物之精妙,于化工诸事,方可顺遂,不致有误。
Preparation Method
To prepare 2-fluoro-6- (trifluoromethyl) benzenesulfonyl chloride, it is necessary to explain the raw materials and production process, reaction steps and catalytic mechanism. The raw materials should be based on fluorine-containing, trifluoromethyl-containing and benzene-ring-related compounds. In the production process, the material containing the benzene ring is first reacted with a specific reagent to introduce fluorine atoms. In this step, the reaction temperature and duration need to be controlled to ensure the precise integration of fluorine atoms.
Next, a reagent containing trifluoromethyl is added, and the trifluoromethyl is connected to the predetermined position of the benzene ring under specific reaction conditions. Then a sulfonyl chloride group is introduced. During the reaction process, the reaction environment, such as pH and temperature, is adjusted according to different stages.
Reaction steps, the first step is fluorination reaction, the second is trifluoromethylation, and the last is sulfonyl chloride. In terms of catalytic mechanism, a suitable catalyst is selected to promote the reaction efficiently in each step. During fluorination, or a metal catalyst is used to reduce the activation energy of the reaction; trifluoromethylation, a specific organic catalyst is selected to improve the selectivity of the reaction; sulfonyl chlorination also has a dedicated catalyst to make the reaction proceed smoothly, so as to achieve the purpose of efficient preparation of 2-fluoro-6- (trifluoromethyl) benzenesulfonyl chloride.
Chemical Reactions & Modifications
Taste the wonders of chemistry, endless changes, material changes are related to mechanism and performance. In this sentence, the chemical reaction and modification of 2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride compound are promising.
Looking at the reaction, under specific conditions, fluorine atoms, trifluoromethyl and benzenesulfonyl chloride groups can all participate in chemical changes. The introduction of fluorine atoms can often change the electron cloud distribution of compounds, affecting their reactivity and stability. Trifluoromethyl has strong electron absorption, which can reduce the electron cloud density of benzene ring, thereby affecting the check point and rate of electrophilic substitution reactions.
As for modification, new functional groups can be introduced by reacting with active hydrogen or nucleophiles to optimize the properties of the compound. Such as reacting with alcohols, or forming esters; reacting with amines, or forming amides. In this way, it is expected to change its solubility, biological activity, etc., and may have extraordinary uses in medicine, materials and other fields. The road of chemistry is endless to explore. The mystery of this compound needs to be further studied to understand the wonders of more reactions and modifications.
Synonyms & Product Names
Today there is a thing called 2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride. Its name is quite important in the field of my chemical research. There are also many other names for this thing, all of which are synonymous with its name, which is related to the trade name.
Covers chemical things, many are complemented, and the names are synonymous, which helps researchers identify its essence and properties. 2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride, or has another name to meet different situations and uses. The name of the product, or according to its characteristics, production method, application, etc.
Although the name is different, its quality is one. When researchers explore and experiment, they should understand their synonymous names and trade names, so that they can be used accurately and correctly in the process of research, and then explore the mystery of chemistry, which is both academic and practical.
Safety & Operational Standards
2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride Safety and Operation Specifications
Husband 2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride is an important substance in chemical research. Its safety and operation standards are related to the safety of researchers and the success or failure of experiments, which cannot be ignored.
#1. Storage Method
This substance should be placed in a cool, dry and well-ventilated place. Do not store it with water or alkali substances to prevent it from reacting violently with it and causing danger. The cover is rapidly hydrolyzed in contact with water, generating corrosive gases, endangering the storage environment and personnel safety. The reservoir must also be well sealed to prevent leakage.
#Second, the rules of operation
When operating, the researcher must wear appropriate protective equipment. Protective clothing can protect against its damage to the body, goggles can protect the eyes from damage, and gloves can prevent it from touching the skin. The operation should be carried out in the fume hood, so that the harmful gases that may be generated can be quickly discharged.
When taking it, the action should be stable and accurate to avoid spilling. If it is accidentally spilled, it should be dealt with in an appropriate way immediately. A small amount of spilling can be adsorbed by sand, dry lime, etc., and then collected in a designated container. If a large amount is spilled, it is necessary to evacuate the personnel, seal the scene, and deal with it by professionals.
#3. Emergency measures
If it comes into contact with the skin, immediately remove contaminated clothing, rinse with a large amount of flowing water for at least 15 minutes, and then seek medical attention. If it splashes into the eye, it should also be rinsed with a large amount of water immediately, blinking while flushing, and then rushed to the hospital. If you inhale accidentally, you should quickly move to a fresh air place to keep the respiratory tract unobstructed. If you have breathing difficulties, you need oxygen. If you stop breathing, you should immediately perform artificial respiration and seek medical attention.
In short, the research and use of 2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride must strictly abide by safety and operating practices, and there must be no slack in order to ensure safety and smooth scientific research.
Application Area
今有一物,名唤2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride 。此物于诸多领域皆有其用。

于医药研制之域,其可作关键原料。医者欲制特效之药,此物质或能助力反应,使药效更佳。以其独特之化学结构,或可与人体特定靶点契合,助药物精准发挥效用,疗愈疾病。

于材料科学范畴,亦具潜力。若欲制特殊性能之材料,如抗腐蚀、耐磨损者,此物质掺入其中,或能改变材料分子结构,增强其性能。

再者,于化工合成领域,其可为重要中间体。经一系列反应,可衍生出多种化合物,丰富化工产品种类,满足不同行业需求。
Research & Development
近岁,吾于化学之域,专注研2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride 此品。初,欲明其性,乃以诸般法测之。经反复试验,晓其化学性活泼,于诸反应中,常为关键。

继而谋其制备之法,改良旧术,求高效纯品之得。其间,多遇艰难,原料之选、条件之控,皆需审慎。然不懈钻研,终有进益,制备之率渐升,品质亦优。

展望未来,此品应用之域可拓。于医药、材料等业,或能有不凡之效。吾当持钻研之心,期以此品促化学之进,为诸业发展添力,不懈于研发之路,冀得更多突破。
Toxicity Research
In today's research on fluoride, there is a substance called "2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride". The toxicity of this substance is related to the well-being of all living beings and cannot be ignored.
We study this chemical in detail to understand its toxicity signs. After various experiments, observe its impact on various organisms. Observe whether it touches the body or enters the body, and examine whether it causes dysfunction and disease growth.
The study of toxicity needs to be done with caution. From the microscopic to the macroscopic, explore its effects on cells, tissues and even individuals. Strive to clarify the mechanism of its toxicity, such as what target it acts on and what physiological pathways it disturbs. It is hoped that through detailed research, we can obtain the true meaning of the toxicity of this chemical. When using this chemical for the world, we should take comprehensive protection to avoid its poisoning, ensure the safety of all beings, and promote the harmony of chemical research and application.
Future Prospects
I have a thing now, and its name is "2 - Fluoro - 6 - (Trifluoromethyl) - Benzenesulfonyl Chloride". This thing is like a star on the way to my chemical research, indicating the prospect of the future.
Its characteristics are specific, its structure is exquisite, and it contains endless possibilities. In the field of chemical industry, it may be the foundation for the creation of new materials, with its unique quality, it can cast strong armor and sharp soldiers, and it can help the essence of equipment; in the field of medicine, it may be the source of the research and development of wonderful medicines. With its characteristics, it can eliminate diseases and help people's diseases.
Those of us who study should be diligent, poor in reason, and explore its mysteries. With time, I will be able to turn this wonder into a great use, and make the future scene as bright as the sunrise. With unremitting efforts, I hope to open this new chapter of material, and contribute to the progress of the world.
Where to Buy 2-​Fluoro-​6-​(Trifluoromethyl)​-Benzenesulfonyl Chloride in China?
As a trusted 2-​Fluoro-​6-​(Trifluoromethyl)​-Benzenesulfonyl Chloride manufacturer, we deliver: Factory-Direct Value: Competitive pricing with no middleman markups, tailored for bulk orders and project-scale requirements. Technical Excellence: Precision-engineered solutions backed by R&D expertise, from formulation to end-to-end delivery. Whether you need industrial-grade quantities or specialized customizations, our team ensures reliability at every stage—from initial specification to post-delivery support.
Frequently Asked Questions

As a leading 2-​Fluoro-​6-​(Trifluoromethyl)​-Benzenesulfonyl Chloride supplier, we deliver high-quality products across diverse grades to meet evolving needs, empowering global customers with safe, efficient, and compliant chemical solutions.

What are the main uses of 2-fluoro-6- (trifluoromethyl) benzenesulfonyl chloride?
2-% Jiang-6- (Sanjiang methyl) naphthol sulfonic acid, its main use is quite wide. In the dye industry, this material is the important dye intermediate. Yes, after many chemical reactions, it can be converted into a variety of dyes with bright colors and good fastness, which are applied to fabrics and can make fabrics appear colorful, colorful, bright and lasting.
For printing brushes, inks, and fields, it is also used for lifting light and heavy feet. By virtue of its characteristics, it can improve the performance of the ink, such as improving the tinting power, fluidity, and drying performance of the ink, etc., so that the printed matter presents a better printing effect, with clear graphics and full color.
In the preparation of surface active agents, 2-% Jiang-6- (Sanjiang methyl) naphthol sulfonic acid can also play a role. It has a certain surface activity, is suitable, modified, and formulated, and can be used in the preparation of different types of surface active agents, used in washing, emulsifying, etc., in many ways, to help reduce the surface tension of liquids, improve washing and emulsifying results.
In addition, in the early stages of drug synthesis, they are sometimes also of interest as potential mesosomes. Although not widely used in drug production, their structural characteristics and chemical properties may provide a useful way of thinking and foundation for the design and synthesis of new drugs. In conclusion, 2% Jiang-6- (Sanjiang methyl) naphthol sulfonic acid plays an indispensable role in many chemical and related industries.
What are the physical properties of 2-fluoro-6- (trifluoromethyl) benzenesulfonyl chloride?
2-% Jiang-6- (triethylmethyl) naphthalenesulfonate sodium salt solution, its physical properties are related to the chemical industry and are extremely important. This solution has the following physical properties:
bear the brunt, related to the appearance. This solution is normally a clear and transparent liquid with a nearly colorless or very light yellow color. This feature is easy to observe and detect. In the process of industrial production, its purity and reaction process can be quickly judged by its appearance.
Furthermore, solubility is a key property. 2-% Jiang-6- (triethylmethyl) naphthalenesulfonate sodium salt exhibits excellent solubility in water and can be rapidly and uniformly dispersed to form a stable solution system. This property makes it effective in many scenarios that require water solubility, such as textile printing and dyeing, detergent preparation, etc. Because it can be evenly dispersed in water, it can evenly act on the treatment object to achieve better treatment results.
Density is also one of the important physical properties. The density of this solution is similar to that of water, but slightly higher than that of water due to the presence of solutes. This density characteristic has a great impact on industrial applications. For example, in storage and transportation, containers and loads need to be reasonably planned according to their density to ensure safe operation and cost control.
Surface activity should not be underestimated. Sodium 2-% Jiang-6- (triethylmethyl) naphthalene sulfonate has significant surface activity and can effectively reduce the surface tension of water. In practical applications, during the washing process, it can make the detergent more easily penetrate into the stain and enhance the decontamination ability; in the textile printing and dyeing industry, it can help the dye to disperse and absorb evenly, and improve the quality of printing and dyeing.
In addition, the stability of the solution is also worthy of attention. Under normal storage and use conditions, the 2-% Jiang-6- (triethylmethyl) naphthalene sulfonate sodium salt solution can maintain its physical and chemical stability for a long time, and is not prone to precipitation, delamination or decomposition. This stability ensures that it can play a consistent role in different environments and time periods, providing strong support for the continuity and stability of industrial production.
Is the chemical property of 2-fluoro-6- (trifluoromethyl) benzenesulfonyl chloride stable?
The chemical properties of 2-% Jiang-6- (triethyl) benzothiazole bromide are quite stable. In this compound, the thiazole ring is connected to the benzene ring through specific chemical bonds, giving it a unique chemical structure. Its stability stems from many factors.
From the perspective of chemical bonds, the covalent bonds formed between atoms in the molecule have a certain bond energy. The chemical bonds formed by heteroatoms such as nitrogen and sulfur in the thiazole ring and adjacent carbon atoms have moderate bond energy and are not easy to break under conventional conditions. At the same time, the benzene ring has a conjugated large π bond, and the conjugated system reduces the molecular energy and stabilizes the structure. This conjugation effect not only enhances the stability of the benzene ring itself, but also enhances the stability of the entire molecule through the interaction with the thiazole ring.
Furthermore, the introduction of triethyl group also has an impact on molecular stability. Ethyl group acts as a power supply group to provide electrons to the benzothiazole ring through induction effect, which changes the electron cloud density distribution on the ring. This change enhances the interaction force of various parts in the molecule, reduces the molecular reactivity, and makes it more difficult to participate in chemical reactions, thereby enhancing stability.
In common chemical environments, 2-% Jiang-6- (triethyl) benzothiazole bromide can resist the attack of many chemical reagents. Under normal temperature and pressure, in general acid-base solutions, if there is no specific reaction conditions, there is basically no chemical reaction. However, it should be noted that although its chemical properties are stable, under the conditions of high temperature, strong oxidants or specific catalysts, the molecular structure may change, and reactions such as substitution and oxidation may occur. However, under normal storage and use conditions, the compound is chemically stable and can exist stably and function in many fields.
What are the synthesis methods of 2-fluoro-6- (trifluoromethyl) benzenesulfonyl chloride?
To prepare 2-hydroxy- 6 - (triethylmethyl) naphthol ether, several kinds can be done according to the ancient method.
First, naphthol is used as the beginning, and a specific ether group is introduced through etherification. First, naphthol meets with base to form naphthol salt, and then meets with halogenated ether, and through nucleophilic substitution, the prototype of ether is obtained. Among them, the choice of halogenated ether is very important, and the efficiency and yield of the reaction need to be considered. The nature and amount of alkali also affect the course of the reaction. Weak base is slow and strong base is fast, but too strong may lead to side reactions and damage the purity of the product. The temperature and timing of the reaction is also the key. If the temperature is high, the speed will be fast. However, if it is too warm, the side reaction will occur. Therefore, the temperature needs to be controlled in the appropriate area, and the timing needs to be just right, so that the yield and purity can be preserved.
Second, the naphthalene containing a specific substituent is used as the base to form phenols first, and then etherified. On the naphthalene ring, the required group is introduced by the method of substitution, and then the phenol is obtained by the method of oxidation or hydrolysis. After the phenol is formed, it is etherified by the previous method. In this way, the substitution step requires the selection of suitable reagents and conditions, so that the substituent is inserted into the specified position and has selectivity. The step of oxidation or hydrolysis also requires careful control of the conditions, so that the structure of the phen
Third, or by condensation. The active phenolic structure and the ether-containing and reactive ones are formed by condensation with the help of catalysts. The choice of catalyst depends on the speed and direction of the reaction, and acidic or basic catalysts are suitable for different situations. The condensation environment, such as the nature of the solvent and the control of temperature and time, all affect the efficiency of the reaction. The polarity and solubility of the solvent affect the dispersion and collision of the reactants, and then the speed and yield of the reaction.
All kinds of production methods have their own advantages and disadvantages. In practice, it is necessary to choose carefully according to the ease of access to raw materials, cost considerations, and purity of products, in order to achieve the best results.
What are the precautions for storing and transporting 2-fluoro-6- (trifluoromethyl) benzenesulfonyl chloride?
2-% Jiang-6- (triethylmethyl) benzimidazole sulfonic acid is an important compound, and many matters need to be carefully paid attention to during storage and transportation.
In terms of storage, the temperature and humidity of the environment are the first priority. This compound prefers a cool and dry place. If the temperature and humidity are too high, it may cause its properties to change and affect the quality. Therefore, in the warehouse, the temperature and humidity must be properly controlled. The temperature should be maintained between 5 ° C and 25 ° C, and the relative humidity should be controlled at 40% - 60%.
Secondly, the storage place should be kept away from fire and heat sources. This substance may have certain flammability, and it may be exposed to open flames, hot topics, or cause fires, endangering safety. Furthermore, it needs to be stored separately from oxidizing agents, acids, alkalis and other substances. Due to its active chemical properties, contact with the above substances, or violent chemical reactions, resulting in danger.
When transporting, the packaging must be tight. Suitable packaging materials must be selected to ensure that no leakage occurs during transportation. Vehicles should also be kept clean and free of other chemicals left behind to prevent cross-contamination.
Transportation personnel also need to be professionally trained to be familiar with the characteristics of this compound and emergency treatment methods. During transportation, pay close attention to the condition of vehicles and goods. If there is any abnormality, dispose of it immediately. And when planning transportation routes, densely populated areas and environmentally sensitive areas should be avoided to reduce the harm of accidents. Therefore, it is necessary to ensure the safety of 2-% Jiang-6- (triethylmethyl) benzimidazole sulfonic acid during storage and transportation without compromising its quality and efficacy.